Abstract: Novel fortimicin antibiotics represented by the formula ##STR1## wherein R.sub.1 is loweralkyl, R.sub.2 is hydrogen or loweralkyl and R.sub.3 is selected from the group consisting of hydrogen, acyl, hydroxyacyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl or an aminoacid residue, loweralkyl, hydroxyloweralkyl, aminoloweralkyl, N-monoloweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl or hydroxy-substituted aminoloweralkyl; and the pharmaceutically acceptable salts thereof, intermediates useful in their preparation, compositions employing the compounds and methods of using the compounds.

Abstract: An additive transfer device for storing and transferring of a medicament to a solution container such as an I.V. bag having an exposed port. The transfer device is accommodated in the neck of an additive container having a pierceable sealing element. A piercing guide member has a projecting tubular portion which extends into the tubular neck and affords a guide passageway for a piercing member with interlocking means being disposed in conjunction with the piercing guide member and the piercing member whereupon after their interlocking, the sealing element in the neck of the additive container is pierced. Wall means are provided from either the piercing guide member or the piercing member and fits over the tubular port of the I.V. bag. In the preferred embodiment, a needle guard member is utilized to actuate the interlocking means and afford the piercing of the pierceable sealing element. When the opposing pointed end of the piercing element is pierced through the I.V.

Abstract: A connecting device which will provide a sterile connection between a container for sterile solutions and tubing for delivery of the fluid. A piercing pin is provided having a pointed end with a pin sheath surrounding the pointed end and in contact with it. The sheath surrounds the hub member of the pin and upon contact with a pierceable diaphragm, the sheath breaks away from the pointed end of the pin allowing it to become exposed with the sheath then surrounding in a uniform manner the hub member of the pin. To facilitate the uniform movement of the sheath around the hub, a shoulder section is provided in the sheath for contact with an accommodating shoulder portion of the container closure having the diaphragm. In a preferred manner, two pierceable diaphragms are provided in the closure system on the container.

Abstract: It has been found that compounds of the structure ##STR1## wherein X is O, S or SO.sub.2, R represents H or one or more halogen, loweralkyl, --CH.dbd.CH--CH.dbd.CH--, CN, NO.sub.2, loweralkyloxy, loweralkylcarbonyl or loweralkylmercapto, R' is H, loweralkyl, benzyl or R", and R" is CH.sub.2 C.tbd.CH, CMe.sub.2 C.tbd.CH or CHMeC.tbd.CH are excellent insect ovicides.

Abstract: A sealing assembly for a vacuum connection to a mixing apparatus so that the contents of the mixing apparatus are held under a vacuum during blending and the introduction of particulate matter is substantially reduced. The sealing assembly for the vacuum conduit is provided by means of a separate housing. A vacuum conduit is integrally attached to and rotates with the blender and an end portion of the conduit is sealed by means of bushings and packing in the assembly housing. The sealing assembly can be easily disconnected for maintenance purposes.

Abstract: Novel fortimicin derivatives represented by the formula ##STR1## wherein: R is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, hydroxyacyl, an amino acid residue, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl or N,N-diloweralkylaminohydroxyloweralkyl; R.sub.1 is loweralkyl, R.sub.2 is hydrogen or lower alkyl; and R.sub.3 is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, hydroxyacyl, an amino acid residue, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkylaminohydroxyloweralkyl or hydrogen and the pharmaceutically acceptable salts thereof; pharmaceutical compositions containing the compounds; and methods of making and using the compounds.

Abstract: New agriculturally useful compounds are described which are the 2,6-dibromo- or -dichloro- iso- nicotinoyl derivatives of aminoacids.

Abstract: A needle-inside, catheter placement assembly including a needle and a catheter unit comprising a catheter, winged catheter insertion means, flexible tubing and tube hub, wherein an area of reduced thickness on each wing of the insertion means provides improved flexibility for the wing and the needle is captured within the winged catheter insertion means when the wings are simultaneously held in a vertical position.

Abstract: 2-Deoxyfortimicin A, 2-deoxy-4-N-alkyl fortimicins and 2-deoxy-4-N-acyl fortimicins represented by the formula ##STR1## wherein R is selected from the group consisting of acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, an amino acid residue, hydroxyacyl, loweralkyl, aminoloweralkyl, N-monoloweralkylaminoloweralkyl, hydroxyloweralkyl, N-N-diloweralkylaminoloweralkyl or hydroxy-substituted aminoloweralkyl, and the pharmaceutically acceptable salts thereof; intermediates therefor; and pharmaceutical compositions containing the compounds of this invention.

Abstract: A needle-inside, catheter placement assembly including a needle and a catheter unit comprising a catheter, winged catheter insertion means, flexible tubing and tube hub, wherein axial and rotational alignment of the needle and catheter unit are maintained by mechanically interlocked complementary means associated with the needle and lumen of the winged catheter insertion means. Means for removably connecting the proximal ends of the catheter unit and needle to stretch the flexible tubing tautly are also provided.

Abstract: A needle-inside, catheter placement assembly including a spliced, two-part needle and a catheter unit comprising a catheter, winged catheter insertion means, flexible tubing and tube hub, wherein axial and rotational alignment of the needle and catheter unit are maintained by mechanically interlocked complementary portions of the needle and lumen of the winged catheter insertion means.

Abstract: This invention provides dibenzodiazepines represented by the formula ##STR1## The compounds of this invention are useful as antischizophrenics.

Abstract: A catheter-outside catheter placement unit wherein the catheter and stylet have connected hubs separable by a removable digit engageable means. Preferably, the removable digit engageable means is carried by a sleeve fitted over the catheter hub.

Abstract: Described are novel derivatives of seldomycin factor 5 (XK-88-5) and particularly 3'-Epi-seldomycin factor 5, which exhibit improved activity against gram-positive and gram-negative bacteria resistant to aminoglycoside antibiotics, and a method of preparing them.

Abstract: Prostaglandin type compounds of the formula ##STR1## where X is CH.sub.2 --CH.sub.2, CH.dbd.CH or C.tbd.C; Y is CH.sub.2 or O; Z is OH, CH.sub.3 or CH.sub.2 OH, R" is H or loweralkyl and R is a linear, branched or cyclic alkyl group of 3 to 7 carbon atoms, can be prepared by essentially a one-step reaction from a new intermediate of the formula ##STR2## wherein R' is hydrogen, R and Z are the same as shown above, and P is a removable protective group. The new compounds are useful as antihypertensives, gastric acid secretion inhibitors and smooth muscle stimulants.

Abstract: This invention provides intermediates which are essential for a new chemical method which converts terrein, a fungal metabolite, to an intermediate which is known to be useful for the preparation of prostaglandins of the C series and analogs of other prostaglandins.

Abstract: A single port is provided for a container such as an I.V. bag which can serve both as an additive port and also as an administration port. The combined administration and additive port has an inner diaphragm portion which is in open communication with the solution in the container and an outer resealable stopper unit which when pierced by a needle of a hypodermic syringe is self-sealing. The outer resealable unit is removable from the port so that the port subsequently serves as the usual administration port when utilizing the standard I.V. administration equipment.

Abstract: This invention provides 4-N-acylfortimicin B derivatives of the structure ##STR1## wherein R is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, or substituted aminoacyl of the formula ##STR2## where R.sup.1 is an acyl radical derived from an amino acid or a short peptide, and the pharmaceutically acceptable salts thereof.The compounds are useful as intermediates for preparing 4-N-alkyl or substituted alkylfortimicin B derivatives. In addition to their utility as intermediates, some of the compounds of this invention are also useful as antimicrobial agents.

Abstract: 3-De-O-methyl-2'-N-acyl and alkyl fortimicin B derivatives represented by the formula ##STR1## wherein R is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, hydroxyacyl, an amino acid residue, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl N,N-diloweralkylaminohydroxyloweralkyl; and R.sub.1 is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, an amino acid residue, hydroxyacyl, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkylaminohydroxyloweralkyl, hydrogen; the pharmaceutically acceptable salts thereof; pharmaceutical compositions containing the compounds; and methods of making and using the compounds. The compounds are antibiotics.

Abstract: 2'-N-Acyl and alkyl fortimicin B and fortimicin B derivatives, 4,2'-N,N'-diacyl and dialkyl derivatives, 4-N-acyl-2'-N-alkyl and 4-N-alkyl-2'-N-acyl fortimicin B derivatives represented by the formula ##STR1## wherein: R is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, hydroxyacyl, an amino acid residue, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl or N,N-diloweralkylaminohydroxyloweralkyl; and R.sub.