Abstract: 2'-N-Acyl and alkyl-6'-epi-fortimicin B and fortimicin B derivatives represented by the formula ##STR1## wherein: R is acyl, hydroxyacyl, aminoacyl, N-monoloweralkylamino, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, an amino acid residue, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl or N,N-diloweralkylaminohydroxyloweralkyl; and R.sub.1 is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, an amino acid residue, hydroxyacyl loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkylaminohydroxyloweralkyl or hydrogen; R.sub.2 is loweralkyl; and R.sub.

Abstract: Specific 4-amino pteridines carrying particular phenyl substituents in the 7-position and no substituents in the 2-position have been found to be excellent nonkaliuretic diuretics at doses of 30 to 500 mg/kg in warm-blooded animals.

Abstract: A new aminoglycoside antibiotic, Fortimicin E, is produced by fermentation of Micromonospora olivoasterospora ATCC 21819, 31009 and 31010 and isolated from the fermentation broth.

Abstract: Described are novel derivatives of seldomycin factor 5 (XK-88-5) and particularly 3'-deoxyseldomycin factor 5, which exhibit improved activity against gram-positive and gram-negative bacteria resistant to aminoglycoside antibiotics, and a method of preparing them.

Abstract: An apparatus and method for detecting leaks at a fast rate in plastic bottles or similar containers wherein the bottles are secured in a multiplicity of open pocket members and arranged in a plurality of rows on a rotatable turret. A detecting gas is introduced into the bottles and they are subsequently moved to a detecting station where a detection means in the form of a mass spectrometer is activated by any gas leaking from the bottles. In a preferred manner, air is utilized to effect a sweeping action over the bottle exterior to move the detecting gas in the direction of the mass spectrometer. Air is also utilized to purge detecting gas from the pockets and air with vacuum to purge the bottles so that a rapid detecting system can be effected. The preferred gas used as the detecting media is helium and the bottles described are of the semirigid, plastic type which are used to contain sterile liquids.

Abstract: An apparatus which can accurately determine the flow rate through a nipple orifice such as nipples which are used in conjunction with baby bottles. The testing apparatus utilizes a purging nozzle which will expel air into the nipple so as to remove any particulate matter so that a subsequent accurate reading can be obtained. The nipple is then placed on a test nozzle unit which is raised into contact with a nipple receiving head on a rotameter. When the nipple is placed in contact with the nipple receiving head, it will be maintained in contact automatically by means of air pressure in the test nozzle housing which ultimately will flow through the nipple orifice and into the rotameter. A reading on the rotameter will give an indication of the nipple flow rate. By a unique valving arrangement, the test nozzle will hold the nipple against the rotameter nipple receiving head so as to provide a uniform force and an accurate reading.

Abstract: By incorporating p-tolyl diiodomethyl sulfone into a topically acceptable base, the growth of yeast or fungi on the skin of warm-blooded animals can be alleviated, reversed or eliminated.

Abstract: A bacterial endotoxin lipopolysaccharide of reduced toxicity covalently coupled to a protein antigen exhibits enhanced adjuvant effects. The coupling was affected by reaction with haloacylhalide. Lipopolysaccharide acylated with an anhydride of a dibasic acid is detoxified; in combination with endotoxin polysaccharide covalently coupled to protein antigen it developed synergistic immunogenic effects.

Abstract: 4-N-Acyl, 2'-N-acyl and 4,2' -N,N' -diacylfortimicin E derivatives represented by the formula ##STR1## wherein R is hydrogen, acyl, aminoacyl, N-lower alkylamino acyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl or an amino acid residue; R.sub.1 is hydrogen, acyl, aminoacyl, N-loweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl or an amino acid residue, with the limitation that R cannot be hydrogen when R.sub.1 is hydrogen, and R.sub.1 cannot be hydrogen when R is hydrogen; the pharmaceutically acceptable salts thereof; intermediates therefor; pharmaceutical compositions; and methods of making and using the compounds. The compounds are useful as antibiotics.

Abstract: Specific 4-hydroxy-pteridines carrying particular phenyl substituents in the 7-position and no substituents in the 2-position have been found to be excellent nonkaliuretic diuretics at doses of 30 to 500 mg/kg in warm-blooded animals.

Abstract: High calorie solutions of low molecular weight glucose polymer mixtures useful for intravenous administration, preferably via a peripheral vein, are disclosed. Methods of preparing the solutions and their preferred rate of infusion at less than 5 mg./min./kg. of patient body weight are also disclosed. The solutions can be isotonic to human blood at 20-50% W/V as the glucose polymer mixtures have an average degree of polymerization ranging from 4 to 10. At the preferred rate of infusion high utilization of the glucose polymers infused occurs in human patients, including diabetics. The utilization can be further enhanced by concomitant injections of insulin. The solutions can be administered concomitantly with amino acids, lipid emulsions, vitamins and electrolytes.

Abstract: N-(2-Methyl-1-naphthyl) maleimide has been found to be a potent biocide capable of protecting fabrics, plastics, paints, etc. from fungal and/or bacterial attack.

Abstract: This invention provides 2-(N-substituted piperidino)-5-alkyl resorcinols of the structure ##STR1## wherein R.sub.1 is H, loweralkyl, loweralkynyl or aralkyl; R.sub.2 and R.sub.3 are each H or when taken together R.sub.2 R.sub.3 =CH.sub.2 CH.sub.2 ; R.sub.4 is a C.sub.1 -C.sub.10 alkyl and R.sub.5 is H or loweralkyl, and the pharmaceutically acceptable salts thereof.These compounds are useful as antisecretory agents.

Abstract: A preloaded, readily activated, disposable syringe wherein a first fluid diluent is sealed in a vial and is adapted to be received by a holding means in a syringe barrel. A second vial containing a fluid medicament is adapted to be engaged by a second holding means in the form of an adapter which is movable over the outside of the syringe barrel. A double-pointed cannula is positioned in the syringe barrel and has a hub with two frictional stop portions in conjunction with the syringe barrel. Upon movement of the adapter in the direction of the syringe barrel, one end of the cannula will pierce through the stopper secured to the adapter. Upon further movement of the adapter, it will contact the cannula hub and move it from a first retentive position to a second to thereby pierce the second stopper and provide fluid communication between the two vials. After mixing, the vial secured to the adapter will be emptied by moving it in a direction toward the syringe.

Abstract: It has been found that compounds of the structure ##STR1## wherein "pyr" stands for 2-, 3-, or 4-pyridyl; Z is CO or (CH.sub.2).sub.n ; n is 0, 1 or 2; R is hydrogen, halogen, loweralkyl, loweralkyloxy, nitro, or hydroxymethyl; and R' is hydrogen or halogen are excellent insect ovicides.

Abstract: It has been found that dialkanoylacetones can be reduced to the corresponding glycerols by a rapid process using ruthenium on an inert support as the hydrogenation catalyst.

Abstract: 2-Deoxy-2'-N-acyl and alkyl fortimicin B and derivatives, 4,2'-N,N'-diacyl and dialkyl fortimicin B derivatives, 4-N-acyl-2'-N-alkyl- and 4-N-alkyl-2'-N-acyl fortimicin B derivatives represented by the formula ##STR1## wherein R is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, hydroxyacyl, an amino acid residue, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl or N,N-diloweralkylaminohydroxyloweralkyl; and R.sub.

Abstract: This invention provides aminomethylene oxindole compounds represented by the formula ##STR1## wherein R is H or loweralkyl; R' is loweralkyl, aralkyl, or R and R' taken together form a chain of the formula--CH.sub.2 CH.sub.2 X CH.sub.2 CH.sub.2 --wherein X is CH.sub.2 or NR" where R" is loweralkyl, loweralkanoyl, aroyl, alkoxycarbonyl or aryl; and the pharmaceutically acceptable acid addition salts thereof.The compounds of this invention are useful as antihypertensive agents.

Abstract: This invention provides 4-N-acylfortimicin B derivatives of the structure ##STR1## wherein R is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, or substituted aminoacyl of the formula ##STR2## where R.sup.1 is an acyl radical derived from an amino acid or a short peptide, and the pharmaceutically acceptable salts thereof.The compounds are useful as intermediates for preparing 4-N-alkyl or substituted alkylfortimicin B derivatives. In addition to their utility as intermediates, some of the compounds of this invention are also useful as antimicrobial agents.