Abstract: A method of reducing intra-ocular pressure in mammalian patients comprising administering to a glaucoma patient a therapeutically effective amount of a compound of the formula ##STR1## wherein, in the C ring, X is CH.sub.2, S, ##STR2## or NR.sub.4 where R.sub.4 is H, loweralkyl, loweralkenyl, loweralkynyl or loweralkanoyl; n is an integer of 0 to 3; m is an integer of 0 to 3, or the C ring is a quinuclidine ring ##STR3## each R.sub.1 is loweralkyl, and when taken together, the substituents R.sub.1 R.sub.1 form oxygen; R.sub.2 is a C.sub.1 -C.sub.20 straight or branched chain alkyl, cycloalkyl, or ##STR4## wherein Y is a straight or branched chain alkylene group having from 1 to 10 carbon atoms, and each R.sub.5, R.sub.6 and R.sub.7 are the same or different members of the group consisting of H, halo or loweralkyl; R.sub.3 is H or ##STR5## wherein Y' is a straight or branched chain alkylene group having 1 to 8 carbon atoms, a is an integer from 1 to 4, b is an integer from 1 to 4, Z is CH.sub.2, O, S or NR.

Abstract: A flow control device for flexible tubing wherein the device utilizes a toggle action in compressing the tubing against an anvil surface. A ratchet element is employed in conjunction with the toggle-action clamp to incrementally compress the tubing against the anvil surface. The clamp can be inexpensively molded in one piece and easily assembled without the placement of additional parts in the clamp body. The ratchet and toggle mechanisms offer the advantage of a one-hand operation for incremental compression of the tubing as well as a release of the clamp member.

Abstract: A method of reducing intra-ocular pressure in mammalian patients comprising administering to a glaucoma patient a therapeutically effective amount of a compound of the formula ##STR1## wherein, in the C ring, X is CH.sub.2, S, ##STR2## or NR.sub.4 is H, loweralkyl, loweralkenyl, loweralkynyl or loweralkanoyl; n is an integer of 0 to 3; m is an integer of 0 to 3, or the C ring is a quinuclidine ring ##STR3## each R.sub.1 is loweralkyl, and when taken together, the substituents R.sub.1 R.sub.1 form oxygen; R.sub.2 is a C.sub.1 -C.sub.20 straight or branched chain alkyl, cycloalkyl, or ##STR4## wherein Y is a straight or branched chain alkylene group having from 1 to 10 carbon atoms, and each R.sub.5, R.sub.6 and R.sub.7 are the same or different members of the group consisting of H, halo or loweralkyl; R.sub.3 is H or ##STR5## wherein Y' is a straight or branched chain alkylene group having 1 to 8 carbon atoms, a is an integer from 1 to 4, b is an integer from 1 to 4, Z is CH.sub.2, O, S or NR.sub.9 where R.

Abstract: It has been found that N-phenylmaleimides carrying certain haloalkylsulfonyl substituents are excellent industrial biocides.

Abstract: A collapsible container for medical fluids which is blow molded in such a manner that when the container is supported at one end, the side wall portions will automatically become self-pleating and will continue to assume a pleating condition toward the bottom of the container as the medical fluid is emptied therefrom. This self-pleating aspect is accomplished by blow molding the container in such a manner that the shoulder and side wall portions are of an average smaller dimension throughout the longitudinal axis of the body section and the shoulder portions join the side wall portions at an angle so as to effect a structurally weak point when the bag is supported by a hanger tab. This self-pleating phenomenon results in a container wherein the meniscus of the fluid is readily readable and accurately ascertained.

Abstract: Radial block copolymers of the butadiene-styrene type are utilized in an uncured state to form a core wall for a liquid golf ball center which permits rapid production with better size and weight control than is currently available. The golf ball core wall containing the radial block copolymers can be formulated to obtain the specific properties desired by a particular manufacturer and can be manufactured at a lower cost than those presently available.

Abstract: A pressure activated shut-off device which will prevent the flow of liquid in an intravenous administration set when the pressure in the system reaches a predetermined point. The shut-off device is utilized in an I.V. set wherein a pumping mechanism is utilized as the force for moving the liquid through a filter. The shut-off device has a biasing element which is set with a predetermined force so as to become activated and stop fluid flow so that the filter mechanism is not ruptured by excessive fluid pressure.

Abstract: Described is a method of O-demethylating a fortimicin compound using hydriodic acid or tri-methylsilyiodide as an O-demethylating agent.

Abstract: Derivatives of O-demethylseldomycin factor 5 represented by the following formula are provided: ##STR1## wherein: R is hydrogen or loweralkyl; R.sub.1 and R.sub.2 can be either hydrogen or hydroxy with the limitation that both R.sub.1 and R.sub.2 cannot be hydroxy; R.sub.3 is selected from the group consisting of hydrogen, loweralkyl, aminoloweralkyl, diaminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, or ##STR2## with the limitation that when R.sub.1 is hydroxy, R.sub.3 cannot be hydrogen when R is hydrogen; and R.sub.4 is selected from the group consisting of loweralkyl, aminoloweralkyl, diaminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, aminohydroxyloweralkyl and N-loweralkylaminohydroxyloweralkyl; and the pharmaceutically acceptable salts thereof. The compounds are potent anti-bacterial agents.

Abstract: Equipment sets for the sequential administration of medical liquids wherein a primary liquid can be administered at a flow rate independent of the flow rate of a secondary liquid, and including a barrier substantially impervious to air to prevent the inadvertent administration of air when the secondary liquid is depleted. The sets of this invention provide parallel flow paths for the secondary liquid to insure that the flow of primary liquid is interrupted while the secondary liquid is flowing. A 3-way valve is provided in the first parallel branch to facilitate priming of the set.

Abstract: This invention provides a method for the control of mollusks by treating said mollusk or its habitat with a synergistic composition including O,O-dialkyl-O-(3-benzothienglyoxylonitrile oximino)phosphate of the structure ##STR1## wherein each R is an alkyl group of 1-4 carbon atoms and at least one other known molluscicide.

Abstract: An improved flow control device for regulating the flow of fluid through flexible tubing wherein the flow control device utilizes a rotatable member with trunnions positioned to be captively guided and rotated along guide surfaces. The rotatable member is easily inserted into the clamp body yet once it is placed therein it is difficult to remove without excessive force. The clamp body affords a rigid structure with the opposing walls being fixed at their ends yet are flexible enough to afford entry of the rotatable member into the clamp body for placement of the trunnions in the guide surfaces. In one embodiment, a ramp means is provided through an infeed section wherein the ridge portions forming the ramp merge with the guide surfaces so that when the trunnions of the roller move up the ramp and onto the guide surfaces, an outward flexing of the clamp wall is effected with a retention of the trunnions on the guide surfaces.

Abstract: Equipment sets for the sequential administration of medical liquids wherein a primary liquid can be administered at a flow rate independent of the flow rate of a secondary liquid, and including a barrier substantially impervious to air to prevent the inadvertent administration of air when the secondary liquid is depleted. The sets of this invention employ a combined air barrier and liquid sequencing valve controlled by a common flexible membrane.

Abstract: A resilient ring is fitted over a shoulder and onto the bail band indent of a bottle by an apparatus having means for supporting and locating the resilient ring, means to locate and align the bottle with the ring, and ram means for relatively displacing the ring and bottle to force the ring over the shoulder of the bottle, the ring support means engaging the shoulder of the bottle under radially inwardly directed biassing forces while supporting the ring as it is deformed to pass over the shoulder means. Preferably, the support means has a multiplicity of circumferentially spaced jaw elements displaceable under spring biassing in respective guides.

Abstract: 1-Acryloyl ureas carrying a cyano-, carbamoyl- or carbalkoxy-phenyl group on the 3-position have been found to be highly effective as fungicides when incorporated into or applied to agricultural media, plastics, paints or the like.

Abstract: Gravitational flow system and equipment sets for the sequential administration of medical liquids wherein a primary liquid can be administered at a flow rate independent of the flow rate of a secondary liquid, and including a barrier substantially impervious to air to prevent the inadvertent administration of air when the secondary liquid is depleted. The sets of this invention provide parallel flow paths for the secondary liquid to insure that the flow of primary liquid is interrupted while the secondary liquid is flowing.

Abstract: Prostaglandin type compounds of the formula ##STR1## where X is CH.sub.2 --CH.sub.2, CH.dbd.CH cis or C.tbd.C; Y is CH.sub.2 or O; Z is H, OH, CH.sub.3 or CH.sub.2 OH and R is a linear, branched or cyclo alkyl chain of 3 to 7 carbon atoms, can be prepared by essentially a one-step reaction from a new intermediate of the formula ##STR2## where R represents a linear, branched or cyclo alkyl group of 3 to 7 carbon atoms; P is a removable protective group and z is H, OP,CH.sub.3 or CH.sub.2 OP.The intermediate is useful in making known and new PGEs useful as antihypertensives, gastric acid secretion inhibitors and smooth muscle stimulants.

Abstract: Described is a method of treating hypertensive by administering to mammalian patients compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen, loweralkyl, lowercycloalkyl, aralkyl, aryl, pyridyl, isoquinolyl, phthalazinyl, or aryl substituted by one or more hydrogen, halo, loweralkyl, lowercycloalkyl, haloloweralkyl, haloloweralkyl, aminosulfonyl, nitro, hydroxy, alkoxy, carboxy, alkoxycarbonyl, cycloalkoxy carbonyl, aminocarbonyl, diloweralkylaminocarbonyl or ##STR2## wherein n is 4 or 5.R.sub.3 is hydrogen, halogen, loweralkyl or aryl, andR.sub.4 is hydrogen, acyl, amino or loweralkyl, and the pharmaceutically acceptable acid addition salts thereof.

Abstract: This invention provides 4-N-acylfortimicin B derivatives of the structure ##STR1## wherein R is acyl, aminoacyl, N-monoloweralkylminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, or substituted aminoacyl of the formula ##STR2## where R.sup.1 is an acyl radical derived from an amino acid or a short peptide, and the pharmaceutically acceptable salts thereof.The compounds are useful as intermediates for preparing 4-N-alkyl or substituted alkylfortimicin B derivatives. In addition to their utility as intermediates, some of the compounds of this invention are also useful as antimicrobial agents.