Abstract: A gravitational flow system for the sequential administration of medical liquids to a patient comprises a primary container connected to a primary tube, a secondary container connected to a secondary tube, and a combined air barrier and liquid sequencing valve which connects them and is in fluid communication with a common tube extending to the patient. A primary flow control device is positioned in the primary flow path and a secondary flow control device is positioned in the secondary flow path. In operation, the system dispenses primary liquid unless interrupted by a flow of secondary liquid. In that instance, primary liquid flow is cut off by an air capturing pocket. At the same time, a plurality of air barriers prevent infusion of air into the patient.

Abstract: An improved tamperproof closure system for molded plastic containers has a threaded neck portion sealed at its distal end, and a screw-cap designed for attachment to the container neck. A flange extends radially from the container neck and a frangible annular groove is circumferentially disposed within the flange. A shoulder on the screw-cap is designed to press against the flange when the screw-cap is rotated downwardly on the neck. The force of the shoulder pressing against the flange ruptures the frangible annular groove, thereby severing the end portion of the container neck from the remainder of the neck, and retaining it within the screw-cap. A stop mechanism positioned in the threading of the container neck allows the screw-cap to be rotated downward to a point short of that necessary to rupture the frangible annular groove and yet far enough to securely attach the cap to the container. The stop mechanism also indicates when a container has been opened.

Abstract: A connecting device for medical liquid administration sets, particularly for use in continuous ambulatory peritoneal dialysis comprises a tubular port extending from a medical liquid container. The tubular port has a pierceable diaphragm positioned within and sealing the same. A hollow tubular piercing pin having a sharpened tip is used for penetrating the pierceable diaphragm. A length of flexible tubing extends from the piercing pin and is connected to a catheter positioned in the peritoneum of the patient once the piercing pin and port are connected. A locking mechanism is utilized for selectively retaining the piercing pin within the tubular port following insertion, and for asepticizing the connection.

Abstract: An improved in-line sleeve valve comprises a modular tubular port having a stationary plug concentrically supported therein and a reciprocating tubular sleeve arranged for sealing against the stationary plug. A resilient, flexible flange connects the tubular sleeve and the tubular port. The flange is sufficiently elastic to allow easy manual displacement of the sleeve from the tubular stationary plug in order to allow the flow of liquid, but is biased in a first direction so as to return the tubular sleeve to a position abutting the stationary plug upon release thereof.

Abstract: A sterile container for a medicinal material which is to be intermixed in an I.V. solution wherein the container serves as a mixing device as well as a portion of an I.V. administration apparatus. The device of this invention includes a container which is closed at opposing ends by pierceable diaphragm portions. Extending from one end is a piercing pin having a diaphragm piercing portion which can pierce the diaphragm when it is moved inwardly into the container and also provide a fluid passageway for the container contents. At the opposing end a diaphragm is housed in a closure with a flexible end wall and a tubular guide section for the piercing pin of an I.V. administration set. The container therefore serves a dual function of holding a fluid material such as a powder in a sterile condition yet serving as a component of an I.V. set to thereby afford a quick and simple procedure for mixing additive components into an I.V. administration set.

Abstract: A sterile container for a medicinal material which is to be intermixed in an I.V. solution wherein the container serves as a mixing device as well as a portion of an I.V. administration apparatus. The device of this invention includes a container which is closed at opposing ends by pierceable diaphragm portions. Extending from one end is a piercing pin having a diaphragm piercing portion which can pierce the diaphragm when it is moved inwardly into the container and also provide a fluid passageway for the container contents. At the opposing end a diaphragm is housed in a closure with a tubular guide section for the piercing pin of an I.V. administration set. The container therefore serves a dual function of holding a fluid material such as a powder in a sterile condition yet serving as a component of an I.V. set to thereby afford a quick and simple procedure for mixing additive components into an I.V. administration set.

Abstract: An apparatus for facilitating assembling a length of flexible tubing on a component part which avoids the use of sealing solvents yet affords a secure placement of the tubing thereon. The apparatus and method assures a secure fitment by stretching the tubing to a predetermined dimension which is larger than the outside dimension of the portion on which the tubing is to be placed on the component part, and while in such a position the tubing is temporarily frozen by means of a coolant. An important feature in stretching the tubing to the enlarged dimension is in assuring that it is done in a uniform manner and that the stretched walls are substantially parallel to each other. This is effected by utilizing a parallel motion of jaw members which are placed within the tubing to stretch it to its expanded state.

Abstract: Described are compounds of the formula ##STR1## wherein R is hydrogen, loweralkyl, aminomethyl or halo; R.sub.1 is carboxy, carboxyloweralkyl, aminocarbonyl, hydroxymethyl, anilinomethyl, or aminomethyl; A is oxygen, CH.sub.2, Sulfur or a single bond; X is oxygen, CH.sub.2, sulfur or sulfoxide; and Y is hydrogen, loweralkyl or halo and may be the same or different, and pharmaceutically acceptable salts thereof.The compounds are effective as diuretic agents.

Abstract: A needle-inside, catheter placement assembly including a spliced, two-part needle and a catheter unit comprising a catheter, winged catheter insertion means, flexible tubing and tube hub, wherein axial and rotational alignment of the needle and catheter unit are maintained by mechanically interlocked complementary portions of the needle and lumen of the winged catheter insertion means.

Abstract: A needle-inside, catheter placement assembly including needle and catheter units. The needle unit comprises a needle joined by a flexible line to a needle hub. The catheter unit comprises a catheter, winged catheter insertion means, flexible tubing and tube hub, wherein an area of reduced thickness on each wing of the insertion means provides improved flexibility for the wing. The needle is captured within the winged catheter insertion means when the wings are simultaneously held in a vertical position and axial and rotational alignment of the needle and catheter units are maintained by mechanically interlocked complementary means associated with the needle and lumen of the winged catheter insertion means.

Abstract: A flow control device which will limit the maximum flow rate of liquid through a length of flexible tubing such as utilized in a parenteral administration set so as to prevent a runaway condition. A base and a cover member are provided which are hingedly attached to each other and have a groove for the placement of the tubing therein. The groove or grooves are of a dimension such that when the tubing is seated therein and the cover and base members brought together, the tubing is prevented from expanding beyond a predetermined dimension. Frictional engaging means are provided on the base and the cover member so as to provide a temporary closing of the cover and base members over the tubing.

Abstract: A continuous low flow rate dispenser of the syringe type wherein a fluid medicament can be administered at a slow and controlled rate to a patient over a long period of time. A syringe carrier having biasing means in the form of spiral coiled springs will be placed under tension as an abutment member is moved away from an opposing slidable driver member. A standard syringe has the plunger moved to an activated position and placed in the syringe carrier with the abutment member in contact with the engagement surface at the end of the plunger rod and the opposing slidable driver member in contact with the engagement surfaces (finger flanges) on the barrel member. A control means is placed in a closed position which will hold the fluid medicament in the syringe barrel but under the biased tension of the biasing means.

Abstract: A disposable intravenous pump chamber cassette for an intravenous administration set which is specifically fabricated for use with the administration of blood. The pump chamber is specifically constructed to be utilized in conjunction with an intravenous pump having a driver to activate a diaphragm member and includes an improved outlet valve member having an outwardly extending lateral wall surface to direct the blood away from the biasing mechanism for the outlet valve member to thereby substantially reduce hemolysis.

Abstract: Described are compounds of the formula ##STR1## wherein Y and Z independently of one another denote hydrogen, halo or trihalomethyl, with the proviso that Y and Z cannot both be hydrogen, R is hydrogen or loweralkyl, n is 5 to 19, and pharmaceutically acceptable salts thereof.The compounds are active hypocholesterolemic agents.