Abstract: An apparatus and method for placing component parts on the ends of flexible tubing which is employed in an I.V. administration set. Flexible tubing is continuously supplied in a rectilinear manner and cut into predetermined lengths. These lengths have the ends thereof moved in a substantially transverse manner with respect to the original direction. Each end is then placed in a solvent-type solution and subsequently into a cavity of a component part. All of the foregoing functions are accomplished continuously and automatically in a device which employs a conveyor system for the cut tubing and a separate conveyor system for the component parts. The conveyors travel over a substantial elliptical pathway and along a horizontal axis. The upper conveyor is positioned with respect to the lower conveyor such that their pathways overlap a substantial distance. The upper conveyor provides a multiplicity of carrier members to which are fed and positioned predetermined cut lengths of flexible tubing.

Abstract: A closure is provided for a container such as a flexible bag for I.V. liquids which is easily removed therefrom with a minimum amount of force. The easily-removable cap structure affords a sterile closure system, yet at the same time is susceptible of different geometric configurations which concentrate pulling forces in a confined area and in conjunction with a pre-weakened tear line so that a force not exceeding more than about 12 pounds will initiate a tearing away of the cap structure so as to expose the port and the contents of the container.

Abstract: The invention relates generally to an improved catheter insertion device of the type having a drum-like receptacle which advances the catheter when it is rotated relative to the base, causing the catheter to move through a tubular outlet. The improvement comprises a removable needle which extends coaxially through a tubular housing tangentially affixed to the dispenser. A flexible cannula telescopically surrounds the distal portion of the needle. The cannula is connected to a catheter outlet from the receptacle and is adapted to be inserted into the vein of a patient during venipuncture. Once venipuncture is performed, the needle is slidably removed from the cannula and catheter outlet, and the catheter is telescopically inserted into and through the cannula and thereby into the vein of the patient. The base and receptacle may then be easily separated and removed from the catheter.

Abstract: An enteric coated erythromycin tablet is provided that produces essentially the same blood levels in fasting and nonfasting subjects. The tablet contains erythromycin base dihydrate and a highly water-soluble nontoxic salt in the core and the coating polymer is a hydroxypropyl methylcellulose phthalate.

Abstract: A combination quick disconnect coupling and liquid cutoff valve comprises a first tubular member, and a second tubular member having a cylindrical sheath slidably disposed about and extending therefrom, sized for telescopic insertion into the first tubular member. The first and second tubular members may be coupled together and retained in that position as required. Two fluid passageways extend through the second tubular member. A third tubular member is concentrically positioned within the second tubular member and has a resilient, releasable, penetrable diaphragm at one end. A piercing pin is disposed within the movable cylindrical sheath so that when the piercing pin is exterior to the diaphragm, a first liquid passes through the connector, but when the piercing pin is inserted through the penetrable diaphragm, a second liquid passes through the connector and the flow of the first liquid is shut off.

Abstract: An improved clamp for regulating the flow of fluid through a length of flexible tubing comprising a clamp body for supporting the tubing, having opposing walls extending from the surface of the clamp body so as to present a passage for the flexible tubing. A platen is mounted between the walls for contacting the tubing. Guide surfaces are arranged in the walls with a roller positioned within the guide surfaces. The platen is movably positioned between the roller and the flexible tubing so as to present a compression surface against the tubing along the path of travel of the roller. The combination of the platen and the roller exerts a compressive force against the tubing and distributes the force over a wide area of the tubing so as to prevent permanent deformation of the tubing. This compressive force constricts the tubing and thereby regulates flow of liquid therethrough.

Abstract: An I.V. administration set is provided with a flexible expansion section so as to accommodate an additional volume of liquid without the use of excessive lengths of tubing. The expansion section is in the form of pleated or corrugated tubing which, upon the introduction of liquid into an I.V. set such as by means of a hypodermic syringe, will accommodate an additional portion of liquid which is known in the I.V. administration art as a retrograde volume.

Abstract: 1-Acryloyl-3-(substituted)phenyl ureas have been found to be highly effective as fungicides when incorporated into or applied to agricultural media, plastics, paints or the like.

Abstract: Described is a method of obtaining complete copying of the entire length of single stranded ribonucleic acid (RNA) into its complementary deoxyribonucleic acid (cDNA) by reverse transcription using binding protein. The method can be used in recombinant DNA research to copy total messenger RNA into DNA.

Abstract: What is described is 2-epi-fortimicin A, 2-epi-fortimicin B or a 2-epi-fortimicin B derivative represented by the formula: ##STR1## wherein R.sub.1 is hydrogen or loweralkyl; R.sub.2 is hydrogen or hydroxy; R.sub.3 is methyl or hydrogen; and R.sub.4 is selected from the group consisting of hydrogen, loweralkyl, aminoloweralkyl, diaminoloweralkyl, N-loweralkylaminoalkyl, N,N-diloweralkylaminoloweralkyl, hydroxyloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkylaminohydroxyloweralkyl, acyl of the formula ##STR2## wherein R.sub.5 is loweralkyl, aminoacyl, diaminoacyl, hydroxyacyl, N-loweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl or an amino acid residue other than those defined above and the pharmaceutically acceptable salts thereof useful in the treatment of infections.

Abstract: An improved process for producing 3-O-demethylfortimicins and other O-methyl-containing aminoglycoside antibiotics comprising the steps of reacting the fortimicin to be 3-O-demethylated with a borontrihalide and recovering the 3-O-demethylfortimicin from the reaction mixture. 3-O-Demethylfortimicin derivatives which can be prepared by this process include compounds represented by the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are hydrogen or methyl with the limitation that one of either R.sub.1 or R.sub.2 must be hydrogen; R.sub.3 is hydrogen or methyl; R.sub.4 and R.sub.11 are the same or different members of the group consisting of hydrogen, acyl, aminoacyl, diaminoacyl, N-loweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, loweralkyl, aminoloweralkyl, diaminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, N-loweralkylaminohydroxyloweralkyl and N,N-diloweralkylaminohydroxyloweralkyl; R.sub.5 and R.sub.

Abstract: An improved venipuncture device comprises a catheter having a catheter hub at one end, with a needle having a needle hub at one end and a sharpened tip at the second end extending through the catheter and catheter hub. The needle is adapted for insertion and removal from the catheter. A fin extends substantially vertically from the needle hub and is constructed and arranged for gripping the device in a manner which facilitates venipuncture.

Abstract: Described is a structurally modified urokinase which is biologically active over an extended time period in comparison to native urokinase. The extended activity permits the administration of lower doses of urokinase when it is used in the treatment of thromboembolic diseases. Methods of appropriately modifying the structure of urokinase are described.

Abstract: A two-step release valve unit for a feminine syringe wherein a valve member and nozzle serve to open and close a dispensing port for an expandable syringe bag. The valve unit includes a slidable nozzle member which in one position will open a valve element. A two-step frictional engagement is provided between the nozzle member and the valve member housing so that the nozzle is retentively held out of contact with the valve element in a first position yet can be released therefrom to engage and open the valve element in the second position. When the nozzle member is removed, the bag is easily filled through a filling orifice in the valve member.

Abstract: Equipment sets for the sequential administration of medical liquids allow primary liquid to be administered at a flow rate independent of the flow rate of a secondary liquid. The sets include a combined air barrier and liquid sequencing device to prevent the inadvertent administration of air when secondary liquid is depleted. The device also prevents the flow of primary liquid when secondary liquid is being dispensed.