Patents Represented by Attorney Robert L. Niblack

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  • Hydroxyaminomethyl derivatives of benzoyl di-substituted .alpha.-phenoxyalkanoyl esters
    Patent number: 4323691
    Abstract: Described are compounds of the formula ##STR1## wherein ##STR2## wherein Z is hydrogen or loweralkyl, R.sub.5 and R.sub.6 may be the same or different and are hydrogen, loweralkyl or together are alkylene of 4 or 5 carbon atoms,R.sub.2 is hydrogen, halo, haloloweralkyl, loweralkyl, loweralkoxy, loweralkylthio or ##STR3## wherein R.sub.5 and R.sub.6 are previously defined, R.sub.3 is hydroxy, alkoxy, branched alkoxy, adamantyloxy, morpholino, amino or amino substituted by loweralkyl or alkylene of 4 or 5 carbon atoms,R.sub.4 is hydrogen or loweralkyl, andX.sub.1 and X.sub.2 are hydrogen, loweralkyl, halo or when substituted on adjacent carbon atoms of the benzene ring form a 1,3-butadienylene linkage, Y is oxygen or sulfur, and pharmaceutically acceptable salts thereof. The compounds are effective as diuretic agents in increasing urinary excretion.
    Type: Grant
    Filed: December 1, 1980
    Date of Patent: April 6, 1982
    Assignee: Abbott Laboratories
    Inventors: Carroll W. Ours, Cheuk M. Lee
  • Flow control device with roller orientation means
    Patent number: 4320889
    Abstract: A flow control device for regulating the flow of fluid through a flexible tubing wherein a roller is employed with a grooved surface for incrementally controlling the flow of fluid through the tubing. In order to properly orientate the groove of the roller during its path of travel through the clamp body and over the tubing, a flat segment or interrupted surface portion is provided on the roller and an interfering member is provided in the base of the clamp. In addition, and to improve the efficiency of the clamp, additional features such as a relief surface in the roller, centering lugs for the tubing to position it in the clamp body, as well as circumferential ribs on the roller are provided.
    Type: Grant
    Filed: May 16, 1980
    Date of Patent: March 23, 1982
    Assignee: Abbott Laboratories
    Inventor: Joseph N. Genese
  • Solid golf ball center with block butadiene-styrene polymers
    Patent number: 4321183
    Abstract: Radial block copolymers of the butadiene-styrene type are utilized in an uncured state to form a solid golf ball center which has high rebound characteristics as well as various durometers. The golf ball centers containing the radial block copolymers can be formulated to obtain the specific properties desired by a particular manufacturer and can be manufactured at a lower cost than those presently available.
    Type: Grant
    Filed: August 8, 1980
    Date of Patent: March 23, 1982
    Assignee: Abbott Laboratories
    Inventors: Alvon R. Cox, Thomas A. Molyneaux
  • Ovicides
    Patent number: 4318920
    Abstract: It has been found that substituted aminoacetonitriles of the structure ##STR1## wherein X and Y, independently, stand for hydrogen, halogen, loweralkyl, loweralkyloxy, nitro or CF.sub.3 ; R is hydrogen or methyl; and R' is hydrogen or loweralkyl are excellent insect ovicides.
    Type: Grant
    Filed: February 8, 1979
    Date of Patent: March 9, 1982
    Assignee: Abbott Laboratories
    Inventor: Robert G. Stein
  • 2-O-Substituted sulfonyl derivatives of fortimicin B
    Patent number: 4319022
    Abstract: A new fortimicin antibiotic, 2-deoxyfortimicin B, intermediates useful in the preparation of the compound, methods of making and using the compound and compositions containing 2-deoxyfortimicin B.
    Type: Grant
    Filed: April 27, 1980
    Date of Patent: March 9, 1982
    Assignee: Abbott Laboratories
    Inventors: Jerry R. Martin, John S. Tadanier, Paulette Collum
  • Compact filter
    Patent number: 4318812
    Abstract: A high volume filter for use in an I.V. or blood administration set. A double filter unit is formed by folding a length of filter material into two portions to form pocket members with tubular inlets placed in each. These components are then sealed into a length of plastic tubing with an additional tubular member to form a filter unit. In a preferred embodiment, the filter unit is formed integrally with a drip chamber.
    Type: Grant
    Filed: September 24, 1980
    Date of Patent: March 9, 1982
    Assignee: Abbott Laboratories
    Inventor: John L. Vcelka
  • Elastomer instrument
    Patent number: 4317363
    Abstract: An elastometer for measuring the mechanical strength of biological gels such as blood or fibrin clots. Thus this device may be used for accessing anticoagulant and fibrinolitic activities, particularly with respect to drug evaluation. The instrument can also be used to study abnormalities in the blood clotting process, i.e. for clinical diagnosis purposes.
    Type: Grant
    Filed: June 16, 1980
    Date of Patent: March 2, 1982
    Assignee: Abbott Laboratories
    Inventor: Linus L. Shen
  • 1,2-Epiminofortimicin B
    Patent number: 4317904
    Abstract: A new fortimicin antibiotic, 2-deoxyfortimicin B, intermediates useful in the preparation of the compound, methods of making and using the compound and compositions containing 2-deoxyfortimicin B.
    Type: Grant
    Filed: April 27, 1979
    Date of Patent: March 2, 1982
    Assignee: Abbott Laboratories
    Inventors: Jerry R. Martin, John S. Tadanier, Paulette Collum
  • Gravitational flow system for the sequential administration of medical liquids
    Patent number: 4316460
    Abstract: A gravitational flow system for the sequential administration of medical liquids to a patient comprises a primary container connected to a primary tube, a secondary container connected to a secondary tube, and a combined air barrier and liquid sequencing valve which connects them and is in fluid communication with a common tube extending to the patient. A primary flow control device is positioned in the primary flow path and a secondary flow control device is positioned in the secondary flow path. In operation the system dispenses primary liquid unless interrupted by a flow of secondary liquid. In that instance, primary liquid flow is cut off by an air capturing pocket. At the same time, a plurality of air barriers prevent infusion of air into the patient.
    Type: Grant
    Filed: July 14, 1980
    Date of Patent: February 23, 1982
    Assignee: Abbott Laboratories
    Inventors: Joseph N. Genese, Andrew J. Muetterties
  • Method of manufacturing a flexible container with integral ports and diaphragm
    Patent number: 4313904
    Abstract: A container for liquids, preferably sterile liquids comprises a hollow body constructed of plastic material having a plurality of tubular ports integrally formed and extending therefrom. Each port has a quantity of plastic material integrally formed as a diaphragm within the port so as to seal the container. In a preferred embodiment, at least one of the ports has a resealable septum sealed within it. The diaphragm is positioned between the septum and the liquid within the container so as to prevent deterioration of the resealable septum caused by exposure to the liquid. Both the resealable septum and the diaphragm are constructed of a material which is penetrable by a hypodermic needle for use in administering sterile solutions.
    Type: Grant
    Filed: December 26, 1979
    Date of Patent: February 2, 1982
    Assignee: Abbott Laboratories
    Inventors: Mark E. Larkin, Leonard J. Meyer
  • 2-Hydroxylaminomethyl phenols
    Patent number: 4312887
    Abstract: It has been found that certain 4-substituted 2-hydroxylaminomethyl phenols or their nontoxic pharmaceutically acceptable acid addition salts are excellent diuretic, saluretic and anti-inflammatory agents.
    Type: Grant
    Filed: October 25, 1978
    Date of Patent: January 26, 1982
    Assignee: Abbott Laboratories
    Inventor: Fortuna Haviv
  • I.V. Administration flow rate gauge
    Patent number: 4312342
    Abstract: An apparatus for measuring the flow of medical liquids within an intravenous solution administration set comprises a primary tube, a secondary tube and a tertiary tube. A constricter mechanism is postiioned in the primary tube proximate the opening to the tertiary tube in order to restrict the flow of liquid therethrough. As a result, a pressure differential is created between the secondary tube and the tertiary tube when liquid flows through the primary tube. At least a portion of the secondary or tertiary tubes are transparent in order to determine the relative position of liquid in the tube. a series of markings on the tubes represent designated rates of flow. Consequently, the relative position of the liquid is used to display the rate of flow within the system.
    Type: Grant
    Filed: June 9, 1980
    Date of Patent: January 26, 1982
    Assignee: Abbott Laboratories
    Inventor: Richard M. Chittenden
  • Antibacterial peptides
    Patent number: 4309342
    Abstract: It has been found that dipeptides containing a 3-fluoro-D-alanine N-terminus are powerful antibacterials and produce a highly useful synergistic effect with antibiotics.
    Type: Grant
    Filed: July 3, 1980
    Date of Patent: January 5, 1982
    Assignee: Abbott Laboratories
    Inventors: Daniel T. Chu, Jerry R. Martin, Alford M. Thomas
  • Biocidal chelate
    Patent number: 4307109
    Abstract: The biocidal activity of N-(2-methyl-1-naphthyl)-maleimide is vastly improved by chelating it with an amine wherein each free hydrogen on each amino group has been replaced by the groups --(CH.sub.2).sub.n COOY wherein n represents 1 or 2 and each Y represents hydrogen, ammonium or an alkali metal cation.
    Type: Grant
    Filed: May 8, 1980
    Date of Patent: December 22, 1981
    Assignee: Abbott Laboratories
    Inventors: Francis W. Arbir, William J. Rizoff, Frank C. Becker
  • 2,8-Disubstituted-10-hydroxy-5,5-dimethyl-tetrahydro-and hexahydro-5H-[1]-benzopyrano[4,3-c]pyridines, compositions and use
    Patent number: 4305938
    Abstract: The present invention provides 2,8-disubstituted-10-hydroxy-5,5-dimethyl-tetrahydro-and hexahydro-5H-[1]-benzopyrano[4,3-c]pyridines represented by Formulae I-III: ##STR1## wherein: R is selected from the group consisting of C.sub.4 -C.sub.20 straight or branched chain alkyl, C.sub.8 14 C.sub.20 straight or branched chain arylalkyl; n is an integer from 1-4 inclusive; and X is OH, NR.sub.1 R.sub.2, R.sub.1 and R.sub.2 being the same or different members of the group consisting of hydrogen and loweralkyl, and ##STR2## wherein Y is CH.sub.2, S, O or NR.sub.1 ; and the pharmaceutically acceptable salts thereof. The compounds are useful as antihypertensive agents.
    Type: Grant
    Filed: June 9, 1980
    Date of Patent: December 15, 1981
    Assignee: Abbott Laboratories
    Inventor: Harold E. Zaugg
  • Flow control device, or the like
    Patent number: D263335
    Type: Grant
    Filed: December 26, 1979
    Date of Patent: March 9, 1982
    Assignee: Abbott Laboratories
    Inventor: Albert F. Bujan
  • Flexible container for medical liquids
    Patent number: D263746
    Type: Grant
    Filed: August 30, 1979
    Date of Patent: April 6, 1982
    Assignee: Abbott Laboratories
    Inventors: Peter C. Johnson, Ralph M. Quin, Jr., John S. Ziegler
  • Flexible stylet
    Patent number: D263873
    Type: Grant
    Filed: May 3, 1979
    Date of Patent: April 13, 1982
    Assignee: Abbott Laboratories
    Inventor: Joseph N. Genese
  • Flexible stylet
    Patent number: D263874
    Type: Grant
    Filed: May 3, 1979
    Date of Patent: April 13, 1982
    Assignee: Abbott Laboratories
    Inventor: Joseph N. Genese
  • Flexible stylet
    Patent number: D263875
    Type: Grant
    Filed: May 3, 1979
    Date of Patent: April 13, 1982
    Assignee: Abbott Laboratories
    Inventor: Joseph N. Genese