Patents Represented by Attorney, Agent or Law Firm Robert L. Starnes
  • Methods for increasing homologous recombination of a nucleic acid sequences
    Patent number: 8343767
    Abstract: The present invention relates to methods for increasing homologous recombination of a nucleic acid sequence introduced into a host cell, comprising: (a) introducing into a population of filamentous fungal host cells a first nucleic acid sequence encoding a recombination protein and a second nucleic acid sequence comprising one or more regions which are homologous with the genome of the filamentous fungal host cell, wherein (i) the recombination protein promotes the recombination of the one or more regions with the corresponding homologous region in the host's genome to incorporate the second nucleic acid sequence by homologous recombination, and (ii) the number of host cells comprising the incorporated second nucleic acid sequence in the population is increased at least 20% compared to the same population without the first nucleic acid sequence; (b) and isolating from the population a filamentous fungal cell comprising the incorporated second nucleic acid sequence.
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: January 1, 2013
    Assignee: Novozymes, Inc.
    Inventors: Paul Harris, Howard Brody
  • Methods for determining cellulolytic enhancing activity of a polypeptide
    Patent number: 8338121
    Abstract: The present invention relates to methods for determining cellulolytic enhancing activity of a polypeptide, comprising: (a) incubating a cellulosic material with an enzyme composition comprising a cellobiose dehydrogenase and one or more cellulolytic enzymes in the presence and absence of the polypeptide; and (b) measuring the release of sugar from the cellulosic material in the presence and absence of the polypeptide.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: December 25, 2012
    Assignee: Novozymes, Inc.
    Inventors: Matthew David Sweeney, Elena Vlasenko
  • Polypeptides having acetylxylan esterase activity and polynucleotides encoding same
    Patent number: 8338666
    Abstract: The present invention relates to isolated polypeptides having acetylxylan esterase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: December 25, 2012
    Assignee: Novozymes A/S
    Inventors: Michelle Maranta, Kimberly Brown
  • Methods for increasing hydrolysis of cellulosic material
    Patent number: 8337663
    Abstract: The present invention relates to methods for pretreating a cellulosic material, methods for degrading or converting a cellulosic material, methods for producing a fermentation product, and methods of fermenting a cellulosic material under anaerobic conditions.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: December 25, 2012
    Assignee: Novozymes, Inc.
    Inventors: Feng Xu, Jason Quinlan, Ani Tejirian
  • Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
    Patent number: 8323944
    Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: December 4, 2012
    Assignee: Novozymes A/S
    Inventors: Paul Harris, Suchindra Maiyuran, Kimberly Brown
  • Polypeptides having beta-glucosidase activity and polynucleotides encoding same
    Patent number: 8318458
    Abstract: The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: November 27, 2012
    Assignee: Novozymes, Inc.
    Inventors: Paul Harris, Elizabeth Golightly
  • Polypeptides having arabinofuranosidase activity and polynucleotides encoding same
    Patent number: 8298803
    Abstract: The present invention relates to isolated polypeptides having alpha-L-arabinofuranosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: October 10, 2011
    Date of Patent: October 30, 2012
    Assignee: Novozymes A/S
    Inventors: Michelle Maranta, Kimberly Brown, James Langston
  • Polypeptides having xylanase activity and polynucleotides encoding same
    Patent number: 8299322
    Abstract: The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: May 23, 2012
    Date of Patent: October 30, 2012
    Assignee: Novozymes, A/S
    Inventors: Lan Tang, Ye Liu, Junxin Duan, Hanshu Ding
  • Polypeptides having cellulolytic enhancing activity and nucleic acids encoding same
    Patent number: 8288140
    Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: April 14, 2010
    Date of Patent: October 16, 2012
    Assignee: Novozymes, Inc.
    Inventors: Kimberly Brown, Paul Harris, Elizabeth Zaretsky, Edward Re, Elena Vlasenko, Keith McFarland, Alfredo Lopez de Leon
  • Polypeptides having endoglucanase activity and polynucleotides encoding same
    Patent number: 8268589
    Abstract: The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: April 5, 2012
    Date of Patent: September 18, 2012
    Assignees: Novozymes, Inc., Novozymes A/S
    Inventors: Paul Harris, Elena Vlasenko, Marcus Sakari Kauppinnen, Elizabeth Zaretsky
  • Polypeptides having endoglucanase activity and polynucleotides encoding same
    Patent number: 8268606
    Abstract: The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: April 20, 2010
    Date of Patent: September 18, 2012
    Assignee: Novozymes A/S
    Inventors: Alfredo Lopez de Leon, Michael Rey
  • Polypeptides having lipase activity and polynucleotides encoding same
    Patent number: 8263824
    Abstract: The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: April 5, 2012
    Date of Patent: September 11, 2012
    Assignees: Novozymes A/S, Novozymes, Inc.
    Inventors: Debbie Yaver, Suzanne Otani, Janine Lin, Christopher Amolo, Kim Borch, Shamkant Anant Patkar, Michael Lamsa, Barbara Cherry
  • Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
    Patent number: 8242329
    Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: August 14, 2012
    Assignees: Novozymes, Inc., Novozymes A/S
    Inventors: Lan Tang, Ye Liu, Junxin Duan, Yu Zhang, Christian Isak Jorgensen, Randall Kramer
  • Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
    Patent number: 8242328
    Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: August 14, 2012
    Assignees: Novozymes, Inc., Novozymes A/S
    Inventors: Junxin Duan, Lan Tang, Ye Liu, Wenping Wu, Jason Quinlan, Randall Kramer
  • Methods of improving the introduction of DNA into bacterial cells
    Patent number: 8236544
    Abstract: The present invention relates to methods of improving the introduction of DNA into bacterial host cells.
    Type: Grant
    Filed: October 1, 2010
    Date of Patent: August 7, 2012
    Assignee: Novozymes, Inc.
    Inventors: Michael Thomas, Michael Rey
  • Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
    Patent number: 8227667
    Abstract: The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: February 27, 2012
    Date of Patent: July 24, 2012
    Assignee: Novozymes A/S
    Inventors: Suchindra Maiyuran, Paul Harris, Hanshu Ding, Kimberly Brown
  • Polypeptides having xylanase activity and polynucleotides encoding same
    Patent number: 8211665
    Abstract: The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: July 3, 2012
    Assignees: Novozymes, Inc., Novozymes A/S
    Inventors: Lan Tang, Ye Liu, Junxin Duan, Hanshu Ding
  • Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
    Patent number: 8207400
    Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: September 21, 2011
    Date of Patent: June 26, 2012
    Assignee: Novozymes, Inc.
    Inventors: Alfredo Lopez de Leon, Hanshu Ding, Kimberly Brown
  • Polypeptides having endoglucanase activity and polynucleotides encoding same
    Patent number: 8168865
    Abstract: The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: May 1, 2012
    Assignees: Novozymes, Inc., Novozymes A/S
    Inventors: Paul Harris, Elena Vlasenko, Marcus Sakari Kauppinnen, Elizabeth Zaretsky
  • Methods for monitoring multiple gene expression
    Patent number: 8168768
    Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing Trichoderma reesei ESTs or SSH clones, or a combination thereof. The present invention also relates to computer readable media and substrates containing such array features for monitoring expression of a plurality of genes in filamentous fungal cells.
    Type: Grant
    Filed: June 5, 2008
    Date of Patent: May 1, 2012
    Assignee: Novozymes, Inc.
    Inventors: Randy Berka, Elena Bachkirova, Michael Rey