Abstract: The present invention provides methods and devices for distributing sample material to a plurality of process chambers in a sample processing device by rotating the device about an axis of rotation. The process chambers are located along conduits extending from a loading chamber and, together, the loading chamber, conduits, and process chambers form process arrays that are aligned along a length of the sample processing devices. The process arrays are unvented, i.e., access to the interior volume of the process arrays is available only through the loading chamber. Also disclosed are methods of centrifugally loading sample material into the process chambers, as well as an assembly including a sample processing device and a carrier.

Abstract: Compositions containing a near-IR dye and greater than about 0.5 wt-% of a surfactant selected from the group of a nonionic surfactant, a zwitterionic surfactant, and a mixture thereof, and methods for processing sample materials.

Abstract: The present invention provides high-density arrays including mask layers and methods of manufacturing the same. The arrays are formed on a polymeric substrate and include a mask layer. Various linking agents, linking agent coatings, and/or reactants may be provided on the mask layer. Where present, the linking agents and reactants preferably operate together to capture a desired analyte which can then be detected based on an electromagnetic signal, e.g., fluorescence, that is emitted by the analyte in response to excitation energy incident on the array. With the mask layer in place, the signal-to-background ratio provided by the arrays can be increased.

Abstract: An electrostaticly charged filtration media is provided including a plurality of polymeric structured polymeric film layers having a structured surface defined on at least one face of each structured film layer forming at least in part flow channels. The plurality of structured film layers are configured as a stack with the structured surfaces defining a plurality of ordered inlets open through a face of the stack that are in fluid communication with ordered fluid pathways. Each fluid pathway is defined at least in part by at least one discrete flow channel such that fluid can flow substantially unimpeded from one of the inlets to an outlet opening at another face of the stack. A layer of fluid pathways is defined by two opposing charged film layers at least one of which is a structured film layer. The flow channels have an average height of from 0.1 mm to 5 mm and an average width of from 0.05 mm to 50 mm and an average aspect ratio of from 0.5 to 10.

Abstract: A cover slip material and a method of making and using the same are provided. The material comprises (a) a light transmissible polymeric backing having first and second surfaces; (b) a tack free bonding layer disposed on the first surface of the backing, the bonding layer comprising polymers selected from the group consisting of acrylate, methacrylate, and combinations thereof; and (c) a protective coating disposed on the second surface of the backing. Upon exposure to an environmentally friendly activating solvent such as terpene, d-limonene, esters of coconut oil and aliphatic hydrocarbon blends, the bonding layer acquires tacky properties causing the cover slip to adhere to a specimen previously mounted on a microscope slide.

Abstract: High-density, miniaturized arrays including high surface areas. Arrays described include substrate with a coating of linking agents, as well as arrays with reactants affixed to the substrates. Methods of manufacturing high-density arrays of reactants. The methods include the use of oriented, heat shrink films and elastomeric materials. Methods of functionalizing a substrate with linking agents for subsequent affixation of reactants are also disclosed herein.

Abstract: A mushroom-type hook strip for a hook-and-loop fastener has a flexible backing of thermoplastic resin and, integral with backing, an array of upstanding stems distributed across at least one face of the backing, each having a mushroom head. The stems have a molecular orientation as evidenced by a birefringence value of at least 0.001. The mushroom-type hook strip can be produced continuously by injecting resin into cavities of a cylindrical mold while evacuating and cooling the cavities so that the cooled resin becomes molecularly oriented, thus affording to the stems excellent stiffness, durability, and tensile and flexural strength.

Abstract: High-density, miniaturized arrays including high surface areas. Arrays described include substrate with a coating of linking agents, as well as arrays with reactants affixed to the substrates. Methods of manufacturing high-density arrays of reactants. The methods include the use of oriented, heat shrink films and elastomeric materials. Methods of functionalizing a substrate with linking agents for subsequent affixation of reactants are also disclosed herein.

Abstract: A nonwoven fabric sheet comprising a multiplicity of generally parallel elongate strands of inelastic thermoplastic material extending in a first direction in spaced relationship, each of said strands having opposite elongate side surface portions that are spaced from and are adjacent elongate side surface portions of adjacent strands, and each of said strands also having corresponding opposite first and second elongate surface portions extending between said opposite elongate side surface portions, and a first sheet of flexible nonwoven material having spaced anchor portions bonded at first bond sites of the strands along said first elongate surface portions wherein the elongate strands thermoplastic material is oriented at least between adjacent bond sites along the length of the strands.

Abstract: Sample processing devices with electrophoresis channels and methods of loading the electrophoresis channels with electrophoresis sieving polymer while rotating the sample processing device are disclosed. In some instances, the electrophoresis channels may be arranged radially relative to the axis of rotation of the sample processing device. In other sample processing devices, the electrophoresis channels may be arranged in curved arcs that are concentric about the center of the sample processing device (which preferably corresponds to the axis of rotation).

Abstract: There is provided a three-dimensional adsorbent particle filter having a width, depth and at least one exposed outer face. The filter comprises darkly colored adsorbent particles having an L-value of 60 or less, preferably 20 or less providing a dark contrasting background. Reflective particles are present at the outer face of the filter at levels that allow a user to visually differentiate the filter based on the contrast between the reflective particles and the dark adsorbent particles. Different reflective particle or combinations of reflective particles are used with different filters to differentiate the filters each from the other.

Abstract: There is provided a dispensable package of oil absorbing wipes in the form of a plurality of discrete sheets comprising a consolidated melt-blown web of thermoplastic fibers. The web has an opacity value of about 65 or less when oil free, and changes transparency by at least 30 when loaded with about 6 grams or less of oil per square centimeter. The wipes are contained in a package having at least one access opening allowing a user to grasp a single discrete sheet of wipe material.

Abstract: There is provided an extensible elastic tab designed to be adhered to the edge of an article, formed using a coextruded elastic film comprising at least one elastic layer and at least one second layer on at least a first face of the elastic layer with at least one face of the coextruded elastic film attached to at least a partially extensible nonwoven layer. The partially expandable, or extensible nonwoven layer has at least one first portion with limited extensibility in a first direction and at least one second inextensible portion in the first direction. The extensible elastic tab when stretched to the extension limit of the first portion or portions in the first direction will elastically recover at least 1.0 cm, preferably at least 2 cm providing an elastic tab having a Useful Stretch Ratio (as defined in the Examples) of at least 30 percent.

Abstract: There is provided a mechanical fastener tape tab laminate capable of remaining closed until needed for use on a disposable garment. A tape tab backing had at least a first distal end portion, an inner tab portion and second distal end portion. The second distal end portion is provided with a mechanical fastener material. The first distal end portion is provided with an adhesive layer for permanent attachment to the disposable absorbent article. The tape tab backing laminate further has a folded tape portion comprising a backing having an adhesive layer on an outer face and at least an inner leg portion and an outer leg portion. The outer leg portion has an exposed adhesive provided for permanent attachment to the disposable absorbent article. The inner leg portion is attached to the tape tab backing so that the folded tape portion keeps the second distal end folded onto the first distal end. The inner and outer leg portions are separated by at least one fold.

Abstract: A filtration media is formed from at least one structured polymeric layer, wherein a structured surface is defined within the layer. Layers may be configured as a stack that has the structured surfaces defining a plurality of ordered inlets open through a face of the stack and corresponding ordered fluid pathways, thereby forming an ordered, porous volume. The ordered fluid pathways may be defined by a plurality of flow channels formed within the structured surfaces of the structured layers, or may be defined by a plurality of protuberances formed in an ordered pattern within the structured surfaces of the structured layers.

Abstract: An active fluid separation device for removing a constituent of a fluid mixture. The separation device formed from a first polymeric structured layer having a plurality of flow channels defined in one surface, and a selectively permeable fluid separation media covering at least some of the flow channels. An external source is also included to provide a potential over the flow channels to promote movement of the fluid through the separation media, thereby removing a constituent component of the fluid mixture. A manifold in fluid contact with the flow channels of the structured layer may also be used to operatively permit the source to provide the potential over the flow channels.

Abstract: This invention provides a one-piece multilayer article for use in solid phase extraction that includes at least two porous support layers and a solid phase extraction medium, wherein the porous support layers are thermo-mechanically attached at at least one thermo-mechanical attachment site. At least one of the porous support layers can be a prefilter layer.

Abstract: Articles, such as high density arrays, on heat-relaxable substrates that can be relaxed by exposure to thermal energy are disclosed, along with methods of manufacturing the arrays, and systems/apparatus for relaxing arrays using electromagnetic energy. The arrays may themselves include electromagnetic energy sensitive material in their construction, in which case exposure of the arrays to suitable electromagnetic energy can provide the thermal energy required to cause the arrays to relax. In other embodiments, the arrays may not include an electromagnetic energy sensitive material in their construction, in which case the arrays may be heated indirectly, i.e., by locating the arrays within a system or apparatus that includes an electromagnetic energy sensitive material and transferring the thermal energy from the electromagnetic energy sensitive material to the array by, e.g., conduction.

Abstract: A wet-laid, porous solid phase extraction sheet material that contains both active particles and binder and that possesses excellent wet strength is described. The binder is present in a relatively small amount while the particles are present in a relatively large amount. The sheet material is sufficiently strong and flexible so as to be pleatable so that, for example, it can be used in a cartridge device.

Abstract: A diffusion channel assembly for use with a device enclosure with two or more nested cups forming at least one diffusion channel. The nested cups are formed of a thermoplastic film material. Each of the cups has a perimeter seal portion substantially around the entire outer perimeter of the cups and surrounding a cup portion having a vent hole. The perimeter seal portions form a sealing surface and are generally integral with the cup portions. The cup portions have vent holes and at least one gap between adjacent cup portions that connect the vent holes of the adjacent cup portions. The gaps coupled with the vent holes of adjacent cup portions form at least one diffusion channel of a length of at least 5 mm. The perimeter seal portions are sealed to form an airtight seal around the cup portion forming an integral diffusion channel assembly.