Abstract: An ultrasonic transducer that operates in flexure mode provides a highly efficient and compact sonophoresis device. Such a device is particularly useful for efficiently enhancing permeation of a substance through a membrane, such as dermal and mucosal membranes for purposes of transdermal/transmucosal drug delivery and/or body fluid monitoring.

Abstract: Thiazolo-, oxazolo- and selenazolo[4,5-c]quinolin-4-amines and analogs thereof are described including methods of manufacture and the use of novel intermediates. The compounds are immunomodulators and induce cytokine biosynthesis, including interferon and/or tumor biosynthesis, necrosis factor, and inhibit the T-helper-type 2 immune response. The compounds are further useful in the treatment of viral and neoplastic diseases.

Abstract: A medicinal aerosol steroid solution formulation product with enhanced chemical stability. The steroid is a 20-ketosteroid having an OH group at the C-17 or C-21 position and the aerosol container has a non-metal interior surface which has been found to reduce chemical degradation of such steroids.

Abstract: Transdermal drug delivery compositions comprising pressure sensitive adhesive microspheres that contain a softening agent and/or a drug. Typically the microspheres contain at least 10 wt-% of a softening agent. The drug and/or softening agent can be incorporated into the microspheres during or after their formation.

Abstract: An assay device for detection and enumeration of microorganisms. The device includes absorbent discs on a substrate, an inoculation vehicle to inoculate the discs with sample and an optional coversheet. Methods of use are also disclosed.

Abstract: A filtration media array is provided having at least one contoured polymeric film layer having surface structures. The film layers may be configured as a stack that has the contoured film layer defining a plurality of ordered inlet openings through a face of the stack and corresponding air pathways, thereby forming an open, porous volume. The air pathways may be defined by a plurality of flow channels formed by the contours of the structured contoured film layers.

Abstract: There is provided an air delivery device and method of moving and filtering air. The air delivery device comprises a housing having an air inlet and an air outlet. Between the air inlet and the air outlet is located an air delivery fan having at least two rotating air moving elements, the rotating air moving elements intersects the flow of air between the air inlet and the air outlet and establishes a higher pressure zone at the air outlet relative to the air inlet. The air delivery fan further comprises at lest one filter element, having at least one upstream filter face and at least one downstream filter face, defining at least one primary flow channel, and rotating along the same axis of rotation as the air moving elements and preferably forming the air moving elements at least in part.

Abstract: There is provided a method of forming a shaped sorbent filter preferably having a three dimensional shape. The method generally entails: a) providing porous flexible tubular web structure having two open ends; b) sealing a first end of the tubular web structure; c) filling the sealed tubular web structure with flowable filter material of sorbent material and binder; d) sealing the opposite open end of the tubular web material; and e) heating the tubular web structure to active the binder and form a shaped sorbent filter. The tubular web structure preferably is deformed while it is heated so that there is provided at least one permanently deformed bending portion. The invention method provides a simple effective process for forming complex overwrapped shaped small sorbent filters for use in the electronics industry.

Abstract: Described are anisotropic films comprising a continuous elastic phase comprising a polyolefin elastomer; and a discontinuous phase oriented within the continuous phase such that the film exhibits anisotropic properties.

Abstract: A wound dressing and delivery system comprising carrier frame that overlaps a heavy absorbent pad on a thin backing of the wound dressing (with the backing sandwiched between the pad and carrier frame) so that the carrier frame and absorbent pad support (e.g., rigidify) the backing to facilitate handling. The carrier frame also has a window over the absorbent pad. Adhesive is provided one major surface of the backing, and the absorbent pad is provided on this major surface. The carrier frame is provided on the opposite major surface to the absorbent pad. The backing is preferably a very thin transparent or translucent elastic polymeric film, and the absorbent pad is relative thick, heavy and stiff and preferably includes hydrocolloid or hydrogel materials. Slits may be provided in the carrier frame to permit one of more portions of the frame to be removed from the backing without removing the entire frame from the backing.

Abstract: A pharmaceutical aerosol formulation suitable for oral and/or nasal inhalation including an anti-inflammatory steroid of the formula in which: R1 is 1-butyl, 2-butyl, cyclohexyl or phenyl and R2 is acetyl or isobutanoyl, in particular ciclesonide. The formulations also include hydrofluorocarbon propellants such as HFC 134a and/or 227, and cosolvent such as ethanol in an amount sufficient to solubilize the ciclesonide or related steroid (and various optional ingredients, such as surfactant). The formulations exhibit very desirable physical and chemical stability, as well as excellent delivery characteristics.

Abstract: A dust bag comprises a filter bag consisting of a filter material. In a first wall portion of the filter bag, an inlet opening is provided through which the air flow to be cleaned gets into the filter bag. On the inner surface of the wall portion opposite the inlet opening, there lies a protective layer of a resistant material of great tensile strength. This protective layer extends as a strip through the filter bag and prevents damage to the inner surface of the filter bag caused by particles striking the same.

Abstract: Immune response modifier (IRM) compounds—imidazoquinoline amines, imidazopyridine amines, 6,7-fused cycloalkylimidazopyridine amines, 1,2-bridged imidazoquinoline amines, thiazolo- and oxazolo-quinolinamines and pyridinamines, imidazonaphthyridine and tetrahydroimidazonaphthyridine amines—are useful for the treatment of conditions at and below the mucosal surfaces by administering a therapeutically effective amount of such compounds to the mucosal surface. Novel pharmaceutical formulations are provided. In one embodiment, the pharmaceutical formulations are advantageous for treatment of cervical conditions such as cervical dysplasias including cervical intraepithelial neoplasias.

Abstract: A sheet material comprising i) a pressure-sensitive adhesive film comprising an acrylic pressure-sensitive adhesive polymer, and ii) a release film comprising a polyolefin polymer having a density of no greater than 0.90 g/cc, the pressure-sensitive adhesive film being in contact with the polyolefin polymer.

Abstract: A method and apparatus for coating a moving web with a coating fluid. The coating die has at least one feed slot for supplying the coating fluid to the moving web and a front face demarked from the at least one feed slot by a die edge. A guide mechanism guides the moving web in a first direction past the coating die such that a coating bead is formed in a gap between the moving web and the die edge. The spraying system sprays a cleaning fluid on at least a portion of the front face of the slide coating die such that the coating bead forms a substantially linear static wetting line on the front face of the coating die.

Abstract: A method for reducing coating defects caused by strikethrough when simultaneously slide coating a first fluid layer, a second fluid layer, and a third fluid layer. The method includes preparing the first, second, and third fluids such that the first solute is incompatible with the second and third solutes and such that the first fluid minimizes strikethrough of at least one of the second and third fluids to a slide surface when the first fluid is positioned between the slide surface and the second and third fluids. The present invention is useful in preparing imaging, data storage, and other media.

Abstract: Immune response modifier compounds—imidazoquinoline amines, imidazopyridine amines, 6,7-fused cycloalkylimidazopyridine amines, and 1,2-bridged imidazoquinoline amines—are useful for the treatment of TH2 mediated diseases by administering a therapeutically effective amount of such compounds in order to inhibit TH2 immune response, suppress IL-4/IL-5 cytokine induction and eosinophilia, as well as enhance TH1 immune response.

Abstract: The present invention provides an adhesive article that includes a backing substrate and a discontinuous adhesive layer disposed thereon, wherein the backing substrate comprises a fibrous web and absorbent particulate material, and further wherein the article has an initial wet skin adhesion of at least 20 g/2.5 cm (0.08 N/cm).

Abstract: A closure system and method of making a closure system for a disposable article. A substantially continuous closure system web is provided. One face of the web is provided with first fastening region at terminal end portion(s) of the web. A second fastening region, engagable with the first fastening region, is provided on a second face of the web in a region adjacent the terminal end portion(s). The closure system tab elements are cut from the web and attached to a second web, used in producing the disposable article, at longitudinally spaced locations. This second web is then cut at transverse cut lines separating the closure system tab element into two functional elements. A first functional element has a fastening tab portion and the second functional element has an attachment portion, The attachment portion of one closure system tab element interacts with a fastening tab portion of an adjacent closure system tab element to form a functional closure system on a disposable article made using the second web.

Abstract: An air filter device to filter fresh air for occupants of a vehicle is disclosed. The device includes a generally circular bottom base unit including a perimeter mounting portion to retain said device in an air conduit. The perimeter mounting portion includes a pair of mounting lips separated by an outwardly extending mounting groove. The lips resiliently flex over a rim formed in the vehicle to position the device in place. Extending from the base unit is an air filter which is sized and shaped to fit into a cavity located within a blower motor assembly. In this manner the device can be retrofit into a standard vehicle to provide air filtration without requiring extensive modification of the ducting and the like.