Abstract: The present invention provides a pressure sensitive skin adhesive comprising: (a) a copolymer of one or more alkyl(meth)acrylates containing 4 to 12 carbon atoms in the alkyl group and one or more hydrophilic monomers; (b) a mixture of penetration enhancers comprising: (i) an alkyl ester of an aliphatic monocarboxylic acid containing 1 to 5 carbon atoms in the alkyl group (ii) an alkyl pyrrolidone and (iii) an alkane polyol (c) a therapeutically effective amount of diclofenac or a pharmaceutically acceptable salt thereof. Further provided is a transdermal drug delivery device containing the pressure sensitive skin adhesive.

Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.

Abstract: Tool rolls and methods of using the tool rolls to manufacture articles with one or more structured surfaces are disclosed. The tool rolls include an outer surface that, when used in connection with materials of the proper viscosity or formability, can form a structured surface on an article. Because the tools are manufactured in roll-form, they can be advantageously used in continuous manufacturing processes. Alternatively, discrete articles may be processed using the tool rolls. The tool rolls are constructed of a cylindrical base roll and are wrapped with one or more continuous wires in a helical pattern. The wires are used, in essence, to form a structured surface on the tool roll that is the negative of the structured surface to be formed on the articles processed using the tool roll. One of the wires wound around the base roll may include a plurality of voids formed therein that, when wound in helical coils about the base roll, form a plurality of mold cavities on the outer surface of the tool roll.

Abstract: A diaper construction is provided with an external porous reinforcement strip at the front part of the outside of the diaper, which strip provides reinforcement against an adhesive fastening tab and provides an oil contamination tolerant adhesion surface.

Abstract: A low trauma pressure-sensitive adhesive coated substrate comprising a sheet material, tape or laminate structure designed to adhere to skin or like surfaces. The pressure-sensitive adhesive layer of this adhesive coated substrate is a fibrous adhesive layer generally having a basis weight of from 5 to 200 g/m2 applied to a conformable backing or substrate. The fibrous adhesive layer has a textured outer face and persistent porosity between discrete adhesive fibers. Generally, the fibrous adhesive layer has a MVTR (measured by ASTM E 96-80 at 40° C.) of at least 1000 g/m2/day, preferably at least 6000 g/m2/day.

Abstract: A carrier delivered dressing is disclosed which has a conformable backing with a pressure sensitive adhesive coated on a bottom face and a low adhesion coating on a top face. The backing is supported during shipping and handling by a liner attached to the adhesive and a removable heat sealed carrier attached to the top face of the backing. The method according to the present invention discloses the steps of forming and optionally removing windows in a carrier material and nonpermanently heat sealing the carrier to the backing to form the dressings of the present invention.

Abstract: There is provided an extensible elastic tab designed to be adhered to the edge of an article, formed using a coextruded elastic film comprising at least one elastic layer and at least one second layer on at least a first face of the elastic layer with at least one face of the coextruded elastic film attached to at least a partially extensible nonwoven layer. The partially expandable, or extensible nonwoven layer has at least one first portion with limited extensibility in a first direction and at least one second inextensible portion in the first direction. The extensible elastic tab when stretched to the extension limit of the first portion or portions in the first direction will elastically recover at least 1.0 cm, preferably at least 2 cm providing an elastic tab having a Useful Stretch Ratio (as defined in the Examples) of at least 30 percent.

Abstract: There is provided a vacuum cleaner filer bag including at least two sidewalls which sidewalls are joined by seams. At least one first sidewall comprises a film laminate of a heat sealable film layer and a film support layer. At least one second sidewall comprises a filter laminate comprising at least a synthetic fiber filter layer and synthetic fiber support layer where the at least one first sidewall is joined to adjacent sidewalls by thermal seams. The filter layer is preferably a high efficiency microfiber filter media which provides HEPA level performance for the vacuum cleaner bag.

Abstract: A process for preparing 1H-imidazo[4,5-c]quinolin-4-amines is disclosed. The process involves reacting a 6H-imidazo[4,5-c]tetrazolo[1,5-a]quinoline with triphenylphosphine and hydrolyzing the product thereof.

Abstract: A method for separation, identification, and quantification of radioactive species in an environmental fluid, such as surface or ground water, by passing the fluid through a sheet article. The sheet article is an essentially homogenous, fibrous or fibrillated, matrix or membrane that includes (1) ion-specific separators that sorb or react with the targeted radioactive species and (2) scintillators which emit light in response to radioactive emissions from the targeted species. The separators can be macrocyclic ligand-containing particles. The scintillators can be particles, fibers, a coating on the particles, or a coating on the fibrous matrix or membrane. The scintillator can be an organic scintillator or an inorganic crystalline scintillator. In one embodiment both the scintillator and the separator are incorporated into the same particle or fiber. A scintillation counter can be used to detect and quantify the emitted light.

Abstract: A skin abrader for a biomedical electrode is disclosed wherein the abrader has a geometrically structured surface abrasive selected to provide sufficient abrasive effect to easily remove a portion of the stratum corneum of mammalian skin with minimal skin irritation, in order to reduce skin impedance encountered during diagnosis or monitoring of a mammalian patient.

Abstract: The present invention provides a transdermal drug delivery composition comprising:(a) a copolymer of one or more (meth)acrylate monomers being selected from the group consisting of alkyl acrylates containing 4 to 12 carbon atoms in the alkyl group and alkyl methacrylates containing 4 to 12 carbon atoms in the alkyl group and one or more hydrophilic monomers being copolymerizable with said (meth)acrylate monomers, and(b) a therapeutically effective amount of lerisetron. The transdermal drug delivery composition is used to make a transdermal drug delivery device for the delivery of lerisetron.

Abstract: A multi-functional, differing electrochemical potential biomedical electrode is disclosed. Several embodiments are described based on the difference in composition of multiple conductors, the difference in composition of fields of ionically conductive media, or both on a single insulative backing of a tab/pad style electrode. A galvanic circuit can be created from electrodes of the present invention, permitting self-restoration of defibrillation recovery of monitoring electrodes and the powering of iontophoretic delivery of pharmaceuticals, among other uses.

Abstract: A dispensable nonwoven cohesive wrap that is generally dispensed from a self-wound roll. The nonwoven cohesive wrap comprises mutually entangled fibers at least some of which are pressure-sensitive adhesive fibers. The cohesive wrap also generally has a basis weight of from 40 to 200 grams/m.sup.2, a tensile strength of at least 100 grams/2.5 cm and a T-peel from itself of from 1 to 30 grams/2.5 cm. The wrap is preferably a single layer material without a separate adhesive coating or release coating where the adhesive fibers extend through the entire depth dimension of the wrap, such that a portion of the adhesive fibers are on both faces of the wrap, and preferably are uniformly distributed across the length and width dimensions of the wrap.

Abstract: There is provided a method of deforming the hook head portions of hook elements on a web backing. The hook elements on the web backing are fed into a nip formed between a support surface and an upper heated surface having a durameter hardness of less than 90 Shore A. This upper heated surface compressively engages the hook head causing it to turn down and permanently deform. This increases the uniformity of the hook head elements forming a fiber engaging crook region.

Abstract: A transdermal delivery device including an adhesive layer that contains a therapeutically effective amount of testosterone and a delivery enhancing adjuvant comprising a terpene.

Abstract: A storage/dispensing assembly, e.g., a roll or stack, of non-woven pressure sensitive adhesive tape comprising one or more multilayer sheets of pressure sensitive adhesive tape arranged such that the adhesive layer in the assembly of an overlying non-woven pressure sensitive adhesive tape is in direct contact with the underlying nonwoven backing layer of non-woven pressure sensitive adhesive tape. The non-woven backing layer is formed at least in part of fibers having a denier of greater than 15 so as to decrease the level of fibers disengagement when an overlying nonwoven pressure sensitive adhesive tape is removed from the assembly.

Abstract: An article comprising a substrate, and a textured, matte-finish, low adhesion backsize coating on one surface of the substrate, wherein the coating comprises polyvinyl carbamate having nitrogen-bonded hydrocarbon side chains which provide terminal alkyl groups more than five carbons in length.

Abstract: Methods, compounds, and medicinal formulations utilizing biocompatible polymers for delivery of a drug, particularly for solubilizing, stabilizing and/or providing sustained release of drug from topical, implantable, and inhalation systems. Many of the methods, compounds, and medicinal formulations are particularly suitable for oral and/or nasal inhalation and use polymers of the formula --[X--R.sup.1 --C(O)]-- wherein each R.sup.1 is an independently selected organic group that links the --X-- group to the carbonyl group, and each X is independently oxygen, sulfur, or catenary nitrogen.

Abstract: A high efficiency filtration medium comprised of a nonwoven filter web of electret charged fibers of a nonconductive thermoplastic resin having a resistivity greater than 10.sup.14 ohm-cm, preferably polypropylene. The nonwoven filter web has a basis weight (BW) of less than 60 grams/m.sup.2, an effective fiber diameter (EFD) of less than 5 microns and a penetration (PEN) of less than 0.03%, wherein the ratio);BW/(EFD.PEN)is greater than 200. The invention filter medium can be easily used in applications requiring HEPA performance at relatively low pressure drops.