Abstract: The present invention is directed to double prodrugs containing polymeric-based transport forms.

Abstract: A mounting system comprises base structural supports and connecting structural supports which are fastened horizontally to vertical structural supports. The vertical structural supports are connected to a building wall. Each base structural support has a U-like cross section, in which the upwardly directed leg that is further away from the building wall is shorter than the leg fastened to the vertical structural supports. Each connecting structural support has a short, upwardly and downwardly directed leg that is further away from the building wall than a vertical leg that is connected to the vertical structural supports. A horizontal leg which has a flexible elastic insert at its open end, adjoins the lower end of the vertical leg.

Abstract: Substantially non-antigenic polymers containing pI and/or pH optimum modulating moieties are disclosed. The polymers are useful as intermediates for synthesis of amine-based polymers and in the formation of activated polymers for conjugation with nucleophiles. Conjugates and methods of preparation and treatment with the conjugates are also disclosed.

Abstract: An apparatus for inspecting the print quality of a series of barcodes positioned on at least one side of a high speed moving web. The apparatus includes a synchronization element having a light source and a photocell; a laser scanning element; a microprocessor, and means for generating decoded barcode data. Also included is a means for comparing the contrast value of the print on either side of the web material, whether black or multicolored. The apparatus includes an objective means of inspecting print quality which is more efficient than subjective means of visual inspection. If erroneous scanned data is found, the web is stopped until the problem is corrected.

Abstract: The present invention is directed to polymeric- prodrug transport forms of the formula: ##STR1## wherein: B is a leaving group, OH, a residue of a hydroxyl-containing moiety or ##STR2## wherein B.sub.1 is a leaving group, OH or a residue of a hydroxyl-containing moiety;Y.sub.1-2 are independently O or S;M is selected from either X or Q; wherein X is an electron withdrawing group and Q is a moiety containing a free electron pair positioned three to six atoms from C(.dbd.Y.sub.2); R.sub.2-5 are independently selected from the group consisting of hydrogen, C.sub.1-6 alkyls, C.sub.3-12 branched alkyls, C.sub.3-8 cycloalkyls, C.sub.1-6 substituted alkyls, C.sub.3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C.sub.1-6 heteroalkyls and substituted C.sub.1-6 heteroalkyls;(m) is zero or one;(n) is a positive integer;(p) is zero or a positive integer;Z is an electron withdrawing group; andR.sub.

Abstract: The present invention relates to a method for negative a positive image, using a negative acting color proofing element comprising, sequentially, a strippable cover sheet; a crosslinked layer containing a polymer having phenolic groups; a color layer, containing a colorant, a polymeric binder, a polymerizable monomer and, optionally, a photoinitiator; a photoadhering layer containing polymerizable groups, and, optionally, a free radical photoinitiator; and a optional thermoplastic adhesive layer. At least one of the color layer and the photoadhering layer containing the photoinitiator. The element is first exposed to actinic radiation and then laminated to a receiver sheet. The composite peeled apart to thereby form a colored negative image on the receiver sheet.

Abstract: The invention relates to a peel-apart, single sheet color proofing system capable of producing a negative image on a receiver sheet upon exposure to infrared laser radiation and peel development. The invention provides a negative working thermal imageable element for infrared laser imaging having a substantially transparent substrate, an infrared radiation sensitive, crosslinked thermal transfer layer on a surface of the substrate having a substantially uniform admixture of carbon black and a crosslinked polymer, a color layer on the crosslinked thermal transfer layer having a substantially uniform admixture of an organic binder and a colorant, and a thermoplastic adhesive layer on the color layer. The invention also provides a method for producing a negative image and a method for producing a negative working thermal imageable element.

Abstract: A purified arginine deiminase (ADI) obtained from Mycoplasma arthritidis having the amino acid sequence of SEQ ID NO:2 as well as an isolated nucleic acid molecule containing a nucleotide sequence encoding the amino acid sequence set forth in SEQ ID NO:1 are disclosed. Other aspects of the invention include an expression vector, a cloned gene for expressing the Mycoplasma arthritidis derived ADI, (recombinant) host cells useful in expressing the ADI of the present invention and substantially non-antigenic polymer conjugates containing the ADI of the present invention as well as methods of treating arginine deiminase susceptible conditions in mammals. The arginine deiminase-polymer conjugates have high levels of retained enzyme activity and relatively long circulating lives.

Abstract: The present invention is directed compositions of the formula: ##STR1## wherein: D is a residue of a biologically active moiety;X is an electron withdrawing group;Y and Y' are independently O or S;(n) is zero (0) or a positive integer, preferably from 1 to about 12;R.sub.1 and R.sub.2 are independently selected from the group consisting of H, C.sub.1-6 alkyls, aryls, substituted aryls, aralkyls, heteroalkyls, substituted heteroalkyls and substituted C.sub.1-6 alkyls;R.sub.3 is a substantially non-antigenic polymer, C.sub.1-12 straight or branched alkyl or substituted alkyl, C.sub.5-8 cycloalkyl or substituted cycloalkyl, carboxyalkyl, carboalkoxy alkyl, dialkylaminoalkyl, phenylalkyl, phenylaryl or ##STR2## R.sub.4 and R.sub.5 are independently selected from the group consisting of H, C.sub.1-6 alkyls, aryls, substituted aryls, aralkyls, heteroalkyls, substituted heteroalkyls, and substituted C.sub.1-6 alkyls or jointly form a cyclic C.sub.5 -C.sub.7 ring.

Abstract: Branched, substantially non-antigenic polymers are disclosed. Conjugates prepared with the polymers and biologically active molecules such as proteins and peptides demonstrate extended circulating life in vivo. Substantially fewer sites on the biologically active material are used as attachment sites. Methods of forming the polymer, conjugating the polymers with biologically active moieties and methods of using the conjugates are also disclosed.

Abstract: The present invention is directed to methods of forming esters of tertiary alcohols. The methods include reacting a compound containing a tertiary alcohol with an acyl heteroaromatic ion-based compound of the formula: ##STR1## wherein R.sub.1 is an aromatic or aliphatic acid residue;Y is O or S;Z is R.sub.2 N;X is selected from the group consisting of ##STR2## wherein R.sub.2 and R.sub.3 are independently selected from the group consisting ofH, C.sub.1-6 alkyls, C.sub.1-6 substituted alkyls, C.sub.1-6 heteroalkyls, C.sub.3-8, branched alkyls, C.sub.3-8 cycloalkyls, C.sub.1-6 substituted heteroalkyls, aryls, substituted aryls, except that R.sub.2 is not H when X is ##STR3## C.sub.1-6 alkyl aralkyls, C.sub.1-6 heteroalkyl aralkyls, C.sub.3-8, branched alkyl aralkyls and C.sub.3-8 cycloalkyl aralkyls; and R.sub.2 ' is the same as R.sub.2 except that R.sub.2 ' is not H;in the presence of a lanthanide.sup.III metal-based catalyst and a base.

Abstract: A towed body yaw angle sensor arrangement used to sense the angle between the axis of a tow fish and the flow of water. The water flow vector is used as the reference for correcting towed body yaw so that a magnetic compass in the towed body is aligned with the towed arrays streaming in the water flow. A yaw angle in the towed body with respect to the flow will cause errors for target bearing and skew the arrays relative to each other which will also cause errors. The flow sensor must be in the free flow off the towed body and ideally the sensing part is aligned with water current flow. Also provided is a method for sensing and correcting a yaw angle.

Abstract: A two part, polymerizable, skin sealant or shield which cures in situ to form a custom made, solid, shaped, skin friendly barrier which absorbs aqueous fluids without disintegrating.

Abstract: Compositions containing alpha interferon conjugated to a substantially non-antigenic polymer are disclosed in which at least about 30% of the conjugates include covalent attachment of the alpha interferon to the substantially non-antigenic polymer at a histidine. Also disclosed is a process for preparing the conjugates. The process includes contacting an alpha interferon with a succinimidyl carbonate-activated substantially non-antigenic polymer at a pH which is sufficient to facilitate covalent attachment of the polymer on a histidine of the alpha interferon.

Abstract: The invention relates to machines for cleaning the inner surfaces of all kinds of tanks. The cleaning is processed by means of a nozzle (14) spraying a jet of cleaning fluid against the surface to be cleaned. Each nozzle (14) is rotatable around two axes, that enclose an angle. In order to be able to customize the working procedures of the machine to the geometry and size of the tank and to the kind of pollution, the machine comprises an electronic control and two independently operating drives (4) by means of which the rotational movement of the nozzle (14) around the two axes can be controlled.

Abstract: A method for rendering water-insoluble materials water-soluble is provided. The method is useful for solubilizing substantially water-insoluble bioactive materials such as drugs. This is accomplished by forming a non-covalently bonded complex between the drug and a polymer which is soluble in both water and an organic solvent. This is carried out by combining the desired medicinal agent with the polymer is an organic solvent, removing the solvent and dissolving the complex in water or aqueous buffer. When the organic solvent is evaporated, a solid complex is recovered which is water-soluble. Methods of treatment with the complexes are also provided.

Abstract: Substantially pure histidine-linked protein-polymer conjugates and processes for their preparation are disclosed. The processes include contacting a protein with an activated polymer under conditions sufficient to facilitate covalent attachment of at least a portion of the polymer strands on histidine residues of the protein and thereafter substantially separating the histidine-linked conjugates from the remaining reactants.