Abstract: Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.

Abstract: An ultrasound simulator to train radiologists and technologists to locate and recognize patent and fused cranial sutures. The model is formed, for example, using specially fabricated heads or from life-sized plastic doll heads. Simulated suture lines are cut in the heads in anatomically correct positions. The typical end-to-end morphology of the sagittal and metopic sutures and the typical beveled appearance of the paired coronal and lambdoid sutures are created by angling the cutting blade. The hypoechoic appearance of patent sutures in ultrasound images is simulated by filling the gaps that were formed by cutting with a hypoechoic material. Fused echoic sutures are simulated by leaving that portion of the doll's head uncut, or by filling the openings with an echoic material. When imaged using ultrasound, the portions cut and filled with a hypoechoic material are readily distinguishable from uncut portions, and from portions cut and filled with an echoic material.

Abstract: A noninvasive technique that can be used to deny blood flow to a particular region of tissue, without the inherent risks associated with invasive procedures such as surgery and minimally-invasive procedures such as embolization. Blood flow in selected portions of the vasculature can be occluded by selectively treating specific portions of the vasculature with high intensity focused ultrasound (HIFU). The occlusion denies undesired tissue the nutrients and oxygen provided by blood flow, causing necrosis in the undesired tissue. An imaging technology (such as magnetic resonance imaging, magnetic resonance angiography, ultrasound imaging, Doppler based ultrasound imaging, or computed tomographic angiography) is used to identify the undesired tissue, and the vascular structures associated with the undesired tissue.

Abstract: A system and method for high numeric aperture imaging systems includes a splitter, a defocusing system, and a combiner. The splitter reflects a portion of collected light and transmits another portion of the collected light. The defocusing system is configured to modify optical power of either the transmitted portion or reflected portion of the collected light. The combiner is oriented with respect to a mechanical angle. The combiner recombines portions of the transmitted portion and the reflected portion such that the transmitted portion and reflected portion are subsequently transmitted being separated by an optical separation angle based upon the mechanical angle of orientation of the combiner. Various other implementations are used to maintain focus with regards to the imaging systems involved.

Abstract: A contrast enhancement (CE) agent is infused into blood flowing through a site that is to be imaged with magnetic resonance imaging (MRI). Two double inversion procedures are carried out, forming a quadruple inversion recovery (QIR) pulse sequence. Each double inversion procedure comprises a non-selective and slice-selective inversion RF pulse. The first double inversion procedure is followed by a first predefined inversion delay period, TI1, and the second procedure by a second predefined inversion delay period, TI2. A black-blood image can thus be produced in which blood appears consistently black and tissues surrounding the blood, such as a vessel wall, heart, atherosclerotic plaque, or thrombus, are clearly visible. Unlike the prior art black-blood imaging technique, the QIR method does not require a precise knowledge of the T1 of the blood carrying the CE agent in order to suppress the signal and artifacts caused by the blood flowing through the site.

Abstract: A deep-pipeline system substantially reduces the overhead of setup delays and pipeline delays by dynamically controlling access of a plurality of configuration register sets by both a host central processing unit (CPU) and the stages of the pipelines. A master configuration register set is loaded with configuration parameters by the host CPU in response to an index count provided by a setup-index counter. A plurality of other counters are employed to track timing events in the system. In one embodiment, a run-index counter provides a run-index count to the first stage of the pipeline that is propagated along the stages, enabling configuration register sets to transfer configuration parameters to the stages of the pipeline when required to enable processing of a task. In an alternative embodiment, a plurality of D flip-flops sequentially propagates a state for successive registers, so that the setup-index counter is not required.

Abstract: Linear actuators (also known as an inchworm actuator) including a magnetically actuatable shape memory alloy (SMA) are described. The linear actuators include a bar and an actuator assembly, configured to achieve a linear displacement of the actuator assembly relative to the bar. A hybrid magnetic trigger including an electromagnet and a permanent magnet is used to selectively attract the magnetically actuatable SMA toward the magnetic trigger. The motion of the magnetically actuatable SMA can be converted to a linear displacement. The magnetically actuatable SMA can be implemented using a SMA exhibiting both ferromagnetic and SMA properties, or by a ferromagnetic mass coupled with an SMA (i.e., a ferromagnetic SMA composite). Linear actuators including bars incorporating a ratchet mechanism, and featureless bars are described. A hydraulic system incorporating actuators including magnetically actuatable SMA membranes is also disclosed.

Abstract: Ultrasound contrast agents are used to enhance imaging and facilitate HIFU therapy in four different ways. A contrast agent is used: (1) before therapy to locate specific vascular structures for treatment; (2) to determine the focal point of a HIFU therapy transducer while the HIFU therapy transducer is operated at a relatively low power level, so that non-target tissue is not damaged as the HIFU is transducer is properly focused at the target location; (3) to provide a positive feedback mechanism by causing cavitation that generates heat, reducing the level of HIFU energy administered for therapy compared to that required when a contrast agent is not used; and, (4) to shield non-target tissue from damage, by blocking the HIFU energy. Various combinations of these techniques can also be employed in a single therapeutic implementation.

Abstract: Reprocessable medical devices that have been disposed of in a sharps container are recovered, disinfected or sterilized, sorted, and packed for reprocessing in a generally continuous process. In one embodiment, either a sharps container or at least a portion of its contents is successively and controllably conveyed, either manually or automatically, through a plurality of processing stations that are configured to perform different operations. The operations performed by the processing stations can include, for example, detecting and identifying contents, cleaning and disinfecting, opening the sharps containers, separating and sorting their contents, and disposal of contents that are non-reprocessable. Reprocessable medical devices can be sorted by type as they move along on a conveyor.

Abstract: A vehicle with a positional tracking unit traverses a specific route while collecting actual route data that includes position data indicative of the actual route followed. The actual route data (including the position data) is stored as optimal route data for that specific route. Once the optimal route is defined and stored, future positional data (i.e., actual route data) collected during subsequent vehicle traversal of that specific route can be compared to the optimal route data. Whenever subsequently collected actual route data represents an improvement, as determined by one or more predefined criteria, the actual route data replaces the previously obtained optimal route data. Exception reports can be automatically generated by comparing the optimal route data to subsequently collected actual route data to determine when a deviation has occurred.

Abstract: Devices including EC monomers polymerized using chronoamperometry to deposit a very thin homogeneous layer followed by cyclic voltammetry to increase the density of the EC polymer film. Another aspect of the present invention is directed to specific web like configurations for a grid of conductive material deposited onto a transparent substrate. The web like configuration is based either on concentric circles, or on concentric ellipses. Yet another aspect of the present invention is directed to an imaging system including a digital window that is disposed between a prism and a patterned analytic layer.

Abstract: A method and system for combining the process variations in circuits and distributed interconnect-based electromagnetic (EM) objects in order to capture a statistical behavior of overall circuit performance parameters. In an exemplary approach, a coupled circuit-EM system is decoupled at the points where the EM objects connect to the circuit portion, and circuit ports are defined at those points. The sources of variation are identified and used to determine Y-parameters for the ports with EM elements and for all EM elements based on the SPICE-like and EM full-wave simulations. A response surface is generated for each variable and is used to extract circuit and EM parameters by generating many random vectors representing combinations of the random variables. These Y-parameters are merged to produce a probability density function (PDF) of one or more performance metrics for the electronic device or system.

Abstract: A solution to the problem of maintaining application integrity when device drivers fail. This solution employs a new mechanism, the shadow driver, which is an operating system (OS) kernel agent that monitors communication between the OS kernel and the device driver it “shadows.” When a device driver error occurs, the shadow driver acts in place of the failed device driver, intercepting and responding to calls from the OS kernel and the device driver during cleanup, unloading, reloading, and re-initialization of the failed device driver. Applications and the OS kernel are thus isolated from the failure. An initial embodiment was developed for use with the Linux™ OS and was tested with a dozen device drivers. Results demonstrate that shadow drivers successfully mask device driver failures from applications, impose minimal performance overhead, require no changes to existing applications and device drivers, and can be implemented with relatively little code.

Abstract: Disclosed herein is a method for obtaining a composite interference-free ultrasound image when non-imaging ultrasound waves would otherwise interfere with ultrasound imaging. A conventional ultrasound imaging system is used to collect frames of ultrasound image data in the presence of non-imaging ultrasound waves, such as high-intensity focused ultrasound (HIFU). The frames are directed to a processor that analyzes the frames to identify portions of the frame that are interference-free. Interference-free portions of a plurality of different ultrasound image frames are combined to generate a single composite interference-free ultrasound image that is displayed to a user. In this approach, a frequency of the non-imaging ultrasound waves is offset relative to a frequency of the ultrasound imaging waves, such that the interference introduced by the non-imaging ultrasound waves appears in a different portion of the frames.

Abstract: High-power inductively coupled plasma technology is used for thermal cracking and vaporization of continuously fed carbonaceous materials into elemental carbon, for reaction with separate and continuously fed metal catalysts inside a gas-phase high-temperature reactor system operating at or slightly below atmospheric pressures. In one particularly preferred embodiment, in-flight growth of carbon nanomaterials is initiated, continued, and controlled at high flow rates, enabling continuous collection and product removal via gas/solid filtration and separation methods, and/or liquid spray filtration and solid collection methods suitable for producing industrial-scale production quantities. In another embodiment, the reaction chamber and/or filtration/separation media include non-catalytic or catalytic metals to simultaneously or separately induce on-substrate synthesis and growth of carbon nanomaterials.

Abstract: A membrane actuator includes a magnetically actuatable membrane and a magnetic trigger. The membrane includes a shape memory alloy (SMA), and the magnetic trigger is configured to induce a martensitic transformation in the SMA, to produce a larger force than would be achievable with non-SMA-based materials. Such a membrane actuator can be beneficially incorporated into a wide variety of devices, including fluid pumps, shock absorbing systems, and synthetic jet producing devices for use in an aircraft. The membrane/diaphragm can be formed from a ferromagnetic SMA, or a ferromagnetic material can be coupled with an SMA such that the SMA and the ferromagnetic material move together. A hybrid magnetic trigger, including a permanent magnet and an electromagnet, is preferably used for the magnetic trigger, as hybrid magnetic triggers are easy to control, and produce larger magnetic gradients than permanent magnets or electromagnets alone.

Abstract: A medical training simulator includes contact-less sensors and corresponding detection objects, configured to enable sensor data collected during a training exercise to be used to evaluate the performance of the training exercise. The simulator includes a simulated anatomical structure, at least one contact-less sensor, and at least one detection object. During a training exercise, a spatial relationship between the contact-less sensor and the detection object produces data for evaluating performance of the training exercise. Either the contact-less sensor or the detection object is embedded in the simulated physiological structure, while the other is included in either a support for the simulated physiological structure, or as part of a tool used during the training exercise. Many types of contact-less sensors can be employed, including capacitance sensors, impedance sensors, inductive sensors, and magnetic sensors.

Abstract: A dataflow instruction set architecture and execution model, referred to as WaveScalar, which is designed for scalable, low-complexity/high-performance processors, while efficiently providing traditional memory semantics through a mechanism called wave-ordered memory. Wave-ordered memory enables “real-world” programs, written in any language, to be run on the WaveScalar architecture, as well as any out-of-order execution unit. Because it is software-controlled, wave-ordered memory can be disabled to obtain greater parallelism. Wavescalar also includes a software-controlled tag management system.

Abstract: A method for making a ductile and porous shape memory alloy (SMA) using spark plasma sintering, and an energy absorbing structure including a ductile and porous SMA are disclosed. In an exemplary structure, an SMA spring encompasses a generally cylindrical energy absorbing material. The function of the SMA spring is to resist the bulging of the cylinder under large compressive loading, thereby increasing a buckling load that the cylindrical energy absorbing material can accommodate. The SMA spring also contributes to the resistance of the energy absorbing structure to an initial compressive loading. Preferably, the cylinder is formed of ductile, porous and super elastic SMA. A working prototype includes a NiTi spring, and a porous NiTi cylinder or rod.

Abstract: A method and system to efficiently create electromagnetic coupled basis functions for an electronic circuit that is defined by geometry data and topology data. The geometry data for the circuit are read, and a three-dimensional mesh of polygons for the circuit is created. External port geometry and internal port geometry (internal ports occur where vias are attached to conductive layers) are determined from the geometry data. Circuit electromagnetic basis functions are then created as are loop-tree formations that are coupled to the basis functions. The loops include local loops, via loops, and hole loops. The three-dimensional mesh is efficiently created by extruding a two-dimensional mesh for each layer and via in the circuit.