Abstract: Multimodal/multispectral images of a population of cells are simultaneously collected. Photometric and/or morphometric features identifiable in the images are used to separate the population of cells into a plurality of subpopulations. Where the population of cells includes diseased cells and healthy cells, the images can be separated into a healthy subpopulation, and a diseased subpopulation. Where the population of cells does not include diseased cells, one or more ratios of different cell types in patients not having a disease condition can be compared to the corresponding ratios in patients having the disease condition, enabling the disease condition to be detected. For example, blood cells can be separated into different types based on their images, and an increase in the number of lymphocytes, a phenomenon associated with chronic lymphocytic leukemia, can readily be detected.

Abstract: Multimodal/multispectral images of a population of cells are simultaneously collected. Photometric and/or morphometric features identifiable in the images are used to separate the population of cells into a plurality of subpopulations. Where the population of cells includes diseased cells and healthy cells, the images can be separated into a healthy subpopulation, and a diseased subpopulation. Where the population of cells does not include diseased cells, one or more ratios of different cell types in patients not having a disease condition can be compared to the corresponding ratios in patients having the disease condition, enabling the disease condition to be detected. For example, blood cells can be separated into different types based on their images, and an increase in the number of lymphocytes, a phenomenon associated with chronic lymphocytic leukemia, can readily be detected.

Abstract: A reduced field-of-view (FOV) imaging technique combines suppression of signals from outer volume and inflowing blood. Both outer volume and blood suppression are achieved using an SFQIR (Small-FOV Quadruple-inversion-Recovery) preparative pulse sequence including two double-inversion pulse pairs separated by appropriate delays. Within each pair, inversion pulses are successively applied to the imaged slice and the slab orthogonal to the imaging plane, with the thickness equal to the FOV size in the phase-encoding direction. Each double-inversion results in a reinversion of the magnetization in a central part of the FOV, while outer areas of the FOV and inflowing blood remain inverted. The SFQIR module was implemented for single-slice and multislice acquisition with a fast spin-echo readout sequence. Timing parameters of the sequence corresponding to the maximal suppression efficiency can be found by minimizing variation of the normalized signal over the entire range of T1 occurring in tissues.

Abstract: Interference in ultrasound imaging when used in connection with high intensity focused ultrasound (HIFU) is avoided by employing a synchronization signal to control the HIFU signal. Unless the timing of the HIFU transducer is controlled, its output will substantially overwhelm the signal produced by ultrasound imaging system and obscure the image it produces. The synchronization signal employed to control the HIFU transducer is obtained without requiring modification of the ultrasound imaging system. Signals corresponding to scattered ultrasound imaging waves are collected using either the HIFU transducer or a dedicated receiver. A synchronization processor manipulates the scattered ultrasound imaging signals to achieve the synchronization signal, which is then used to control the HIFU bursts so as to substantially reduce or eliminate HIFU interference in the ultrasound image. The synchronization processor can alternatively be implemented using a computing device or an application-specific circuit.

Abstract: An optical fiber scanner is used for multiphoton excitation imaging, optical coherence tomography, or for confocal imaging in which transverse scans are carried out at a plurality of successively different depths within tissue. The optical fiber scanner is implemented as a scanning endoscope using a cantilevered optical fiber that is driven into resonance or near resonance by an actuator. The actuator is energized with drive signals that cause the optical fiber to scan in a desired pattern at successively different depths as the depth of the focal point is changed. Various techniques can be employed for depth focus tracking at a rate that is much slower than the transverse scanning carried out by the vibrating optical fiber. The optical fiber scanner can be used for confocal imaging, multiphoton fluorescence imaging, nonlinear harmonic generation imaging, or in an OCT system that includes a phase or frequency modulator and delay line.

Abstract: A low pulsatility syringe pump including a duplex bearing set rotatingly supporting a lead screw, and a transmission having a first drive train configured to increase a number of motor rotations required for a single rotation of the lead screw, and a second drive train configured to reduce the number of motor rotations required for a single rotation of the lead screw as compared to the first drive train. Another embodiment also includes a motor configured to rotate the syringe about its own axis, independent of the motion of the lead screw. In this other embodiment, the fluid in the syringe barrel includes objects (such as cells, latex beads, etc.) entrained in the fluid. The rate of rotation (e.g., about three revolutions per second) is chosen such that each object traces a substantially circular pathway in the syringe barrel and remains in suspension.

Abstract: Potable water is produced by extraction of water vapor from air. Water absorbed inside a desiccant bed is forced into vapor phase by using input heat energy, for example, waste heat from the exhaust of an internal combustion engine. Pre-heating a portion of the desiccant material prior to desorption enhances efficiency. Energy for the pre-heating may be obtained by recovering heat from the desiccant material prior to adsorption.

Abstract: A fabrication technique called “component and polymorphic network,” in which semiconductor chips are made from small prefabricated bare electronic component dies, e.g., application specific integrated circuits (ASICs), that are assembled according to designer specifications, and bonded to a semiconductor substrate comprising the polymorphic network. The component and polymorphic network assembly has a low overhead for producing custom chips. In another exemplary embodiment, the polymorphic network can be combined with functional components in a single die. The interconnect scheme for ports on the polymorphic network can be configured or reconfigured with configuration data prior to the runtime of an application, to achieve different interconnect schemes.

Abstract: A videoendoscopic surgery training system includes a housing defining a practice volume in which a simulated anatomical structure is disposed. Openings in the housing enable surgical instruments inserted into the practice volume to access the anatomical structure. A digital video camera is disposed within the housing to image the anatomical structure on a display. The position of the digital video camera can be fixed within the housing, or the digital video camera can be positionable within the housing to capture images of different portions of the practice volume. In one embodiment the digital video camera is coupled to a boom, a proximal end of which extends outside the housing to enable positioning the digital video camera. The housing preferably includes a light source configured to illuminate the anatomical structure. One or more reflectors can be used to direct an image of the anatomical structure to the digital video camera.

Abstract: A recovery device and method of use ensure that any reprocessable medical device that has been disposed of in a sharps container is recovered, cleaned, sterilized, and repackaged for reuse. In one embodiment, a sharps container and sorting surface are manipulated to rotate together and independently, so that the content of the sharps container are emptied onto the sorting surface, enabling an operator to manually, safely, efficiently, and timely retrieve reprocessable medical devices from the sorting surface and place these medical devices into a receptacle bin. The non-reprocessable contents are subsequently dumped into a waste bin, whose contents will subsequently be incinerated or otherwise destroyed. The operator of the recovery device is protected by a shield and an exhaust system that minimize the operator's exposure to airborne biohazardous toxins and enable the sorting to be done without injury to the operator from sharp medical devices.

Abstract: Selective occlusion of a blood vessel is achieved by selectively damaging endothelial cells at a target location in the blood vessel, resulting in the formation of a fibrin clot proximate to the damaged endothelial cells. Additional fibrinogen can then be introduced into the blood vessel if occlusion is not achieved, as the fibrinogen is converted to fibrin by enzymes released by the exposed thrombogenic tissue and activated platelets. Endothelial cells are selectively damaged using thermal effects induced by ultrasound, by mechanical effects induced by ultrasound, or by mechanical effects produced by a tool introduced into the blood vessel (such as a catheter-based tool). A particularly preferred technique for selectively damaging endothelial cells involves introducing an ultrasound activatable agent into the blood vessel, and causing cavitation in that agent using pulses of high-intensity focused ultrasound having a duration insufficient to induce thermal damage in adjacent perivascular tissue.

Abstract: Airborne particles are impacted on a collection surface, analyzed, and then the collection surface is regenerated. Thus, the same collection surface can be used in numerous cycles. The analysis can be focused on one or more properties of interest, such as the concentration of airborne biologicals. Sensors based on regenerative collection surfaces may be incorporated in many networks for applications such as building automation.

Abstract: Airborne particles are impacted on a collection surface, analyzed, and then the collection surface is regenerated. Thus, the same collection surface can be used in numerous cycles. The analysis can be focused on one or more properties of interest, such as the concentration of airborne biologicals. Sensors based on regenerative collection surfaces may be incorporated in many networks for applications such as building automation.

Abstract: Combinatorially-synthesized deoxyribonucleic acid (DNA) oligonucleotides attached to encoded beads that are hybridized to amplified and labeled genomic DNA or ribonucleic acid (RNA) are analyzed using a flow imaging system. Oligonucleotides and corresponding reporters are bound to the surfaces of a plurality of small beads such that different beads bear different oligo sequences. Each bead bears a unique optical signature comprising a predefined number of unique reporters, where each reporter comprises a predefined combination of different fluorochromes. The composite spectral signature in turn identifies the unique nucleotide sequence of its attached oligo chains. This optical signature is rapidly decoded using an imaging system to discriminate the different reporters attached to each bead in a flow in regard to color and spatial position on the bead.

Abstract: Data collected in connection with operation of a vehicle can be used to automatically determine upon which one of a plurality of predefined routes a vehicle has been operating. In one exemplary embodiment, an operator inputs identification data into a data set that also includes other types of data. The route identification data uniquely identifies the specific one of the plurality of predefined routes, enabling the route the vehicle was operating on during that time period corresponding to the data set to be determined. In a second exemplary embodiment, rather than requiring the operator to provide the route identification data, geographical position data collected during operation of a vehicle are compared with geographical position data corresponding to each one of the plurality of predefined routes until a match is found, thereby identifying the route the vehicle was operating on during collection of the geographical position data.

Abstract: An accessory (502) removably attached to a portable computing device (504) and handheld, portable readers (578, 141, 143, and 632) are used to generate and store data that indicate an operator was sufficiently close to each of a plurality of components during an inspection to actually inspect the components. The portable device includes a sensor that detects tokens such as radio frequency identification tags, which are affixed adjacent to the components. Messages appearing on a display and/or audible instructions from the portable reader prompt the operator to proceed to each checkpoint where the state of the component at that location is determined. The date, time and coordinates of each component's inspection (and optionally, the component's state) are included in the data produced by the portable reader. The data are temporarily stored in the portable reader and subsequently transferred to a remote data storage site.

Abstract: An apparatus and method for providing image acquisition and/or image display in a limited region of interest (ROI). The apparatus comprises a micro electro-mechanical system (MEMS), preferably integrating a light source, a cantilever, a lens, an actuator, a light detector, and a position sensor. The light source provides light for illuminating the ROI, displaying an image, providing a therapy, and/or performing other functions. The cantilever comprises a resin waveguide with a fixed end attached to a substrate that supports many or all other components. A free end of the cantilever is released from the substrate during fabrication and includes the lens. The actuator scans the free end in orthogonal directions to illuminate the ROI or display an image. The position sensors detect the position of the free end for control. The light detector receives light backscattered from the ROI separate from, or at the fixed end the cantilever.

Abstract: Syntheses of a new blue EC monomer (ProDOT-MePro), and a new red EC monomer (ProDOP-Et2) are described. Two additional new types of EC monomers based on 3,4-alkylenedioxythiophene include fluorinated EC monomers and an EC monomer including silicon. EC polymer devices having more than one different color EC polymer to enable additional colors to be provided using subtractive color mixing are also described, as well as EC polymer devices incorporating a logo, image, or text, are generally obscured when the device is colored, but become visible when the device is not colored. Also described are EC polymer devices that include a cathodic EC polymer layer, a gel electrolyte, a counter electrode, and a reference electrode. Working prototypes of such devices exhibit significant increases in the speed of transition of the EC device from a colored state to a transparent state.

Abstract: A sleeved hose assembly for lateral jet drilling through an ultra-short radius curve. The sleeved hose assembly includes a wire-wound high-pressure hose inserted inside a reinforcing sleeve. In general, wire-wound high-pressure hoses exhibit transverse moduli that are insufficient to resist buckling forces encountered during lateral drilling. A sleeve is selected to encompass a wire-wound high-pressure hose and to exhibit a transverse stiffness sufficient to prevent the combination of the wire-wound high-pressure hose and the sleeve (i.e., a “sleeved hose assembly”) from buckling during lateral drilling. Also disclosed are a method for drilling a lateral borehole using such a sleeved hose assembly, and a method for drilling an ultra-short radius curve using such a sleeved hose assembly. In a particularly preferred exemplary embodiment, the sleeve includes a fiber reinforced epoxy composite having a transverse modulus of about 10 GPa.

Abstract: Paper pulp is added to a stain solution. The stain solution and pulp fibers are mixed to form a slurry. Samples are removed from the slurry and are admixed with dilution water and a bleach. Then, the fibers are moved into a flow cell where they are subjected to a light source adapted to stimulate fluorescence from the stained pulp fiber. Before the fiber slurry enters the flow cell it is mixed with a dilution water of bleach to reduce background fluorescence. The fluorescent light is collimated and directed through a dichroic filter onto a fluorescence splitting dichroic filter.