Abstract: This invention relates to aryloxy-, alkoxy-, arylthio-, and alkylthio-11,12-seco-prostaglandins and to processes for their manufacture. These compounds have prostaglandin-like activity and are particularly useful in fertility control such as for estrus synchronization in animals and postcoital contraceptive agents in humans.
Abstract: Novel substituted (3-loweralkylamino-2-R.sub.1 O-propoxy)pyridines, their pharmaceutically acceptable salts and their preparation are disclosed. These pyridines have pharmaceutical properties such as anti-hypertensive activity of rapid onset.
Abstract: This invention relates to 11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators, for the treatment of hypertension, and for the prevention of thrombus formation.
Abstract: This invention relates to 11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators, for the treatment of hypertension, and for the prevention of thrombus formation.
Abstract: This invention relates to novel 8-aza-9-oxo-11-thia-, -11-oxothia-, and -11-dioxothia-prostanoic acid compounds, salts, and derivatives thereof and also to processes for the preparation of such compounds. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators, for the treatment of certain autoimmune diseases, and in preventing thrombus formation.
Type:
Grant
Filed:
May 24, 1976
Date of Patent:
November 22, 1977
Assignee:
Merck & Co., Inc.
Inventors:
Robert L. Smith, Ta-Jyh Lee, Edward J. Cragoe, Jr.
Abstract: This invention relates to 10-aza-11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators.
Abstract: Phenylthioaralkylamines and 2-phenylthiobenzylamines are prepared by reaction of the corresponding phenylthiobenzoyl chloride or homologs thereof with ammonia or an amine to produce the corresponding phenylthiobenzamide or N-substituted or N,N-disubstituted derivative thereof followed by reduction with lithium aluminum hydride to produce the corresponding phenylthiobenzylamine or the N-substituted or N,N-disubstituted derivative thereof. The compounds are also prepared by reaction of the corresponding phenylthiobenzyl halide with ammonia or a selected amine. The compounds are active as antiarrhythmics.
Abstract: The invention is concerned with novel 16-aryloxy-, 16-alkoxy-, 16-arylthio- and 16-alkylthio-8-aza-9-dioxothia-11,12-seco-prostaglandins and processes for their preparation. These novel compounds are useful as pharmaceuticals since they can be used in animals for estrus synchronization and treatment of infertility due to persistence of luteal function.
Abstract: Methods of using aqueous hydraulic cement compositions containing polyamido-sulfonic compounds as flow-property-improving and turbulence-inducing additives are disclosed.
Type:
Grant
Filed:
March 4, 1977
Date of Patent:
October 11, 1977
Assignee:
Calgon Corporation
Inventors:
Sally Lee Adams, Michael M. Cook, Fred David Martin
Abstract: Novel cyano substituted (3-loweralkylamino-2-acyl-O-propoxy)pyridines, their pharmaceutically acceptable salts and their preparation are disclosed. The pyridines are vasodilators having antihypertensive activity of rapid onset and extended duration and reduced tendency to cause undesirable tachychardia; they are also .beta.-adrenergic blocking agents.
Abstract: Novel pharmaceutical compositions comprising hydrazino-phenylpropionic acid decarboxylase inhibitors and certain benzimidazole and benzoxazole alanines are disclosed. The compositions have enhanced hypotensive activity.
Abstract: (2-oxo-3-butenyl)dimethylamine monomers which may be used in the preparation of high molecular weight water-soluble cationic polymers which may be used as flocculants, drainage and retention aids, or conductive polymers.
Abstract: Cationic, electrically conductive polymers are mixed with multifunctional anionic compounds and/or anionic polymers to form a polysalt complex which exhibits markedly improved properties. Specifically, solvent holdout to parafinic solvents and to toluene are considerably improved, and the tackiness of the resulting film is notably decreased. The polysalt products also exhibit very good filmability on plastic substrates whereas the cationic polymer alone normally forms very poor films on such substrates.
Type:
Grant
Filed:
October 27, 1976
Date of Patent:
August 9, 1977
Assignee:
Calgon Corporation
Inventors:
Andrew Jackson Sharpe, Jr., Robert H. Windhager, Kathleen Seese Hearp
Abstract: Methods of using aqueous hydraulic cement compositions containing phosphonobutane tricarboxylic acid as a flow-property-improving and turbulence-inducing additive are disclosed.
Type:
Grant
Filed:
April 14, 1976
Date of Patent:
August 9, 1977
Assignee:
Calgon Corporation
Inventors:
Leonard J. Persinski, Fred David Martin, Sally Lee Adams
Abstract: Use of oil soluble cationic polymers as flocculants for the purification of used motor oil. Polymers useful in the process of the instant invention include oil soluble polymers such as fatty acid salts of cationic polymers.
Abstract: Methods of using aqueous hydraulic cement compositions containing sulfonated copolymers of styrene-maleic anhydride as flow-property-improving and turbulence-inducing additives are disclosed.
Type:
Grant
Filed:
April 14, 1976
Date of Patent:
July 19, 1977
Assignee:
Calgon Corporation
Inventors:
Leonard J. Persinski, Fred David Martin, Sally Lee Adams
Abstract: This invention relates to 8-aza-9-oxo(and dioxo)-thia-11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators, for the prevention of thrombus formation, to induce growth hormone release, and as regulators of the immune response.
Abstract: This invention relates to novel 9-thia-, 9-oxothia-, and 9-dioxothia-11-oxo-12-azaprostanoic acid compounds, salts, and derivatives thereof and also to processes for the preparation of such compounds. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators, as platelet aggregation inhibitors, and for the treatment of certain autoimmune diseases.
Type:
Grant
Filed:
May 24, 1976
Date of Patent:
May 10, 1977
Assignee:
Merck & Co., Inc.
Inventors:
Robert L. Smith, Ta-Jyh Lee, Edward J. Cragoe, Jr.
Abstract: This invention relates to aryloxy-, and alkoxy-, arylthio-, and alkylthio-11,12-seco-prostaglandins and to processes for their manufacture. These compounds have prostaglandin-like activity and are particularly useful in fertility control such as for estrus synchronization in animals and postcoital contraceptive agents in humans.