Abstract: This invention relates to 9-thia-, 9-oxothia, and 9-dioxothia-11,12-seco-prostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful for the treatment of skin diseases such as psoriasis, for the prevention of Thrombus formation, in stimulating the production of growth hormone in intact animals, and as regulators of the immune response.
Type:
Grant
Filed:
March 22, 1976
Date of Patent:
April 19, 1977
Assignee:
Merck & Co., Inc.
Inventors:
Edward J. Cragoe, Jr., John B. Bicking, Robert L. Smith
Abstract: A method of inhibiting corrosion and scale formation in an aqueous system is disclosed which comprises the step of treating the said system with 0.1 to 500 parts per million by weight of the total aqueous content of the said system, of a composition which comprises amine adducts of maleic anhydride polymers and which may additionally include zinc.
Type:
Grant
Filed:
February 12, 1976
Date of Patent:
April 19, 1977
Assignee:
Calgon Corporation
Inventors:
Bennett P. Boffardi, Michael M. Cook, Paul H. Ralston
Abstract: Improved cementing compositions and their use in cementing operations is disclosed, wherein copolymers of hydrolyzed acrylamide and 2-acrylamido-2-methylpropane sulfonic acid derivatives are used as fluid loss additives for aqueous hydraulic cement slurries.
Type:
Grant
Filed:
May 10, 1976
Date of Patent:
April 5, 1977
Assignee:
Calgon Corporation
Inventors:
Leonard J. Persinski, Michael M. Cook, Sally Lee Adams
Abstract: Methods of using aqueous hydraulic cement compositions containing polyamido-sulfonic compounds as flow-property-improving and turbulence-inducing additives are disclosed.
Type:
Grant
Filed:
January 29, 1976
Date of Patent:
March 15, 1977
Assignee:
Calgon Corporation
Inventors:
Sally Lee Adams, Fred David Martin, Michael M. Cook
Abstract: Alcohols, particularly anhydrous alcohols, thickened with aminomethylated polyacrylamide, used as fracturing fluids for stimulating well production.
Abstract: Novel di-bicyclo[3.1.1] and [2.2.1]heptyl and dibicyclo[3.1.1] and [2.2.1]heptenyl ketones are useful as intermediates for preparing novel polyamines useful as antimicrobial agents, as well as algae inhibitors.
Abstract: Water-soluble segmented polymers of the ##STR1## A--B--A, and (A--B).sub.n types wherein the A-segments are grafted homopolymer, copolymer and/or terpolymer segments of water-soluble vinyl monomers, and the B-segments are homopolymer segments of poly(vinyl pyrrolidone) or poly(vinyl alcohol), are prepared by a process employing inverse emulsion techniques and cerium (IV) salt initiators.
Abstract: In the flocculation and removal of suspended matter from water, combinations of cationic and nonionic water-soluble polymers are found to be more effective than equivalent concentrations of cationics alone, and significantly lower concentrations of the combination are found to be equivalent in effect to higher concentrations of cationic polymers alone.
Type:
Grant
Filed:
March 8, 1972
Date of Patent:
November 30, 1976
Assignee:
Calgon Corporation
Inventors:
Emerson George Rausch, Ramon Anthony Muia
Abstract: Block polymers of the A-B-A type wherein the A block is derived from a water-soluble monomer and the B block is derived from N-vinyl pyrrolidone. The polymers are water soluble and are useful as flocculants.
Abstract: The invention relates to a new and novel synthesis of prostaglandin E.sub.2, and it particularly relates to a novel process starting with relatively inexpensive starting materials. The invention further relates to a synthesis which is readily adaptable for large scale processing because of the high yields in the individual reaction steps.The invention further relates to novel compounds formed as intermediates in the synthesis of prostaglandin E.sub.2. The invention still further relates to synthetic analogs and known metabolites of prostaglandin E.sub.2 and prostaglandin E.sub.1, useful as standards in certain biological assays for determining prostaglandin-like activity.
Abstract: The invention is concerned with novel 16-aryloxy-, 16-alkoxy-, 16-arylthio- and 16-alkylthio-8-aza-9-dioxothia-11,12-seco-prostaglandins and processes for their preparation. These novel compounds are useful as pharmaceuticals since they can be used in animals for estrus synchronization and treatment of infertility due to persistence of luteal function.
Abstract: This invention relates to 11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators, for the treatment of hypertension, and for the prevention of thrombus formation.
Abstract: This invention relates to 8,10-diaza-9-oxo(and thioxo)-11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators, and for the prevention of thrombus formation.
Abstract: This invention relates to 8-aza-11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators.