Patents Represented by Attorney Saliwanchik, Lloyd & Eisenschenk
  • Patent number: 8268963
    Abstract: The present invention concerns a process for the purification of macrolide antibiotics. More specifically it concerns a process for the purification of macrolide antibiotics that result in a white powder. The powder remains white also after some time of storage. The process of the present invention is performed by dissolving the macrolide antibiotics, e.g. commercial vancomycin hydrochloride, in water and subjecting the solution to ultrafiltration with a membrane having nominal retention lower than 30,000 Da, preferably of 10,000 Da. The purified solution is preferably concentrated by reversed osmosis and then lyophilized at the optimized conditions of pressure and temperature to obtain a white powder.
    Type: Grant
    Filed: December 7, 2006
    Date of Patent: September 18, 2012
    Assignee: Xellia Pharmaceuticals ApS
    Inventor: Vincenzo De Tommaso
  • Patent number: 8263595
    Abstract: The present invention relates to triazolopyridine compounds according to Formula (I), their use as medicament, for treating autoimmune disorders, inflammatory diseases, cardiovascular diseases and/or neurodegenerative diseases and a process for their preparation.
    Type: Grant
    Filed: August 20, 2008
    Date of Patent: September 11, 2012
    Assignee: Merck Serono SA
    Inventors: Dominique Swinnen, Catherine Jorand-Lebrun, Tania Grippi-Vallotton, Mathilde Muzerelle, Amanda Royle, Jacqueline MacRitchie, Richard Hill, Jeffrey P. Shaw
  • Patent number: 8263344
    Abstract: The present invention relates to a method for determining the susceptibility of a patient tumor cell to a cancer treatment, which method comprises the detection or measure of CRT, KDEL receptor and/or ERp57 on the surface of a tumor cell.
    Type: Grant
    Filed: September 7, 2007
    Date of Patent: September 11, 2012
    Assignees: Institut Gustave Roussy, INSERM (Institut National de la Sante et de la Recherche Medicale)
    Inventors: Guido Kroemer, Laurence Zitvogel, Theocharis Panaretakis
  • Patent number: 8264030
    Abstract: A flash memory device and a method for manufacturing the same are provided. The flash memory device can include first and second memory gates on a substrate, an oxide layer on sides of and on the substrate outside of the first and second memory gates, a source poly contact between the first and second memory gates, first and second select gates outside the first and second memory gates, a drain region outside the first and second select gates, and a metal contact on the drain region and the source poly contact.
    Type: Grant
    Filed: December 21, 2009
    Date of Patent: September 11, 2012
    Assignee: Dongbu Hitek Co., Ltd.
    Inventor: Young Jun Kwon
  • Patent number: 8258558
    Abstract: Provided are image sensors and methods of manufacturing the same. An image sensor includes a metal line and an interlayer insulation layer on a semiconductor substrate including a readout circuit; an image detection unit on the interlayer insulation layer and including stacked first and second doping layers; a pixel separation unit penetrating the image detection unit, separating the image detection unit by pixel; a first metal contact penetrating the image detection unit and the interlayer insulation layer to contact the metal line; a first barrier pattern protecting the first metal contact from contacting the second doping layer, while exposing the first metal contact to the first doping layer; and a second metal contact in a trench above the first metal contact, wherein the second metal contact is electrically connected to the second doping layer while being isolated from the first metal contact by a second barrier pattern.
    Type: Grant
    Filed: September 3, 2009
    Date of Patent: September 4, 2012
    Assignee: Dongbu Hitek Co., Ltd.
    Inventor: Tae Gyu Kim
  • Patent number: 8258113
    Abstract: The invention relates to a method for influencing the miR-92 expression in a cell, comprising the following steps: (a) providing a cell; and (b1) reducing the miR-92 expression in the cell in order to promote the vascularization or vessel repair by introducing an antisense molecule against miR-92 into the cell, or (b2) increasing the miR-92 expression in the cell for an inhibition of the tumor angiogenesis by introducing a construct into the cell, wherein the construct includes an expressible miR-92 sequence. Furthermore, the invention relates to a pharmaceutical composition, comprising an agent for reducing the miR-92 activity or expression in a cell in the form of an antisense molecule against miR-92, or an agent for increasing the miR-92 expression in a cell in the form of a construct for expressing miR-92.
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: September 4, 2012
    Assignee: t2cure GmbH
    Inventors: Stefanie Dimmeler, Andreas M. Zeiher, Angelika Bonauer, Carmen Urbich
  • Patent number: 8257686
    Abstract: The present invention relates to a method for protecting a human patient or a mammalian animal to be subjected to chemotherapy treatment of a tumor not residing in the scalp of the patient or the skin of the animal against chemotherapy-induced alopecia, comprising administering to the scalp of the patient or the skin of the animal an effective amount of a composition comprising a chemical inducer of the stress protein response sufficiently prior to the administration of a chemotherapeutic drug. It also relates to pharmaceutical compositions for the prevention of chemotherapy-induced alopecia. It further relates to a method for protecting a human patient or a mammalian animal to be subjected to chemotherapy treatment of a tumor not residing in the scalp of the patient or the skin of the animal against chemotherapy-induced alopecia, comprising administering to the scalp of the patient or the skin of the animal an effective heat dose sufficiently prior to the administration of a chemotherapeutic drug.
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: September 4, 2012
    Assignee: HSF Pharmaceuticals S.A.
    Inventor: Richard W. Voellmy
  • Patent number: 8258595
    Abstract: Provided are an image sensor and a method for manufacturing the same. The image sensor comprises a substrate, a bonding silicon, an interlayer dielectric, a first contact plug, a second contact plug, a second metal interconnection, and a color filter layer and a microlens. The substrate comprises a first metal interconnection. The bonding silicon is formed on the substrate, and comprises a plurality of impurity regions. The interlayer dielectric is formed on the bonding silicon. The first contact plug penetrates the bonding silicon and is electrically connected to the first metal interconnection. The second contact plug penetrates the interlayer dielectric and is connected to a surface of the bonding silicon. The second metal interconnection is formed on the interlayer dielectric, and is connected to the second contact plug. The color filter layer and a microlens are formed over the second metal interconnection.
    Type: Grant
    Filed: November 9, 2009
    Date of Patent: September 4, 2012
    Assignee: Dongbu Hitek Co., Ltd.
    Inventor: Seoung Hyun Kim
  • Patent number: 8258187
    Abstract: The subject invention provides materials and methods for improving alcohol metabolism in animals. In a preferred embodiment, the invention provides methods for increasing the ability of people to consume alcohol while reducing hangovers or other effects of intoxication. Specifically exemplified herein is the use of a cysteamine compound to reduce the adverse effects of alcohol consumption. For example, the undesirable and unpleasant symptoms association with hangovers can be reduced through consumption, according to the subject invention, of cysteamine hydrochloride.
    Type: Grant
    Filed: September 27, 2010
    Date of Patent: September 4, 2012
    Assignee: Omega Bio-Pharma (I.P.1) Ltd.
    Inventors: Wen Qin Tang, Francis Chi
  • Patent number: 8251065
    Abstract: The present invention relates to a four-sided dustproof mask including: an upper filter adapted to surround a wearer's nose area; a lower filter adapted to surround the wearer's chin area; and a protruded center filter adapted to attach the upper filter and the lower filter thereto in such a manner as to make the both ends of the upper filter and the lower filter correspond to center points formed at the both ends of a curved folding line dividing the protruded center filter into two sides, the curved folding line having a straight line portion having a predetermined length protrudedly extended from the center points thereof, whereby while the upper filter and the lower filter are being developed, the protruded center filter is protruded to a dome-like shape.
    Type: Grant
    Filed: July 28, 2009
    Date of Patent: August 28, 2012
    Assignee: Jangjung Industrial Corp.
    Inventor: Tae Gyu Kim
  • Patent number: 8255937
    Abstract: A spindle motor is disclosed which is configured such a manner that a rotor is press-fitted into a portion of a rotor fastener corresponding to a radially thicker portion out of outer portions of the rotor fastener of a clamping device, and a portion of the rotor fastener corresponding to a relatively thinner radial portion is filled up with an adhesive to adhesively couple a case with the rotation shaft side. Consequently, even if the rotation shaft side is coupled with the case, the case is not damaged to therefore enhance the reliability of the product.
    Type: Grant
    Filed: December 28, 2009
    Date of Patent: August 28, 2012
    Assignee: LG Innotek Co., Ltd.
    Inventor: Jin Seung Yoo
  • Patent number: 8251006
    Abstract: A trim tab apparatus capable of causing the stern of a vessel to be raised or lowered relative to the surface of the water in which it rests. A trim tab plane can be pivotally attached to one or more arms that can be attached to a vessel by one or more brackets. When the trim tab plane is rotated in an aft direction as a vessel is moving, the force of water passing under the trim tab plane causes the vessel stern to be raised. If the trim tab planes are rotated in a fore direction as the vessel is moving, water is forced across the top of the trim tab planes causing stern-drag, so that the vessel stern is lowered in the water.
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: August 28, 2012
    Assignee: Anthony Kalil
    Inventor: Anthony Kalil
  • Patent number: 8252279
    Abstract: The subject invention pertains to materials and methods for inhibiting process formation and extension by cells in culture. The subject invention further includes cultures of process-forming cells wherein formation and extension of processes have been inhibited. In another aspect, the subject invention concerns methods of transplantation using process-forming cells that have been cultured by the process-inhibiting methods of the invention.
    Type: Grant
    Filed: December 6, 2007
    Date of Patent: August 28, 2012
    Assignee: University of South Florida
    Inventors: Pablo Caviedes, Raul Caviedes, Thomas B. Freeman, Juan A. Asenjo, Barbara A. Andrews, Dario SepĂșlveda, Christian Arriagada, Julio Salazar Rivera
  • Patent number: 8253282
    Abstract: Disclosed is a linear vibrator, the linear vibrator including a substrate supplying electric power, a case including a base supporting the substrate and a cover wrapping the base, a stator fixed to either the base or the cover, a vibrator including magnets each arranged to face both sides of the stator and a weight to which the magnets are fixed, an inner spring coupled to both sides of the weight to wrap the weight, and an external spring, both end portions of which are coupled to an inner lateral surface of the case to wrap the inner spring, and a part of which is coupled to the inner spring.
    Type: Grant
    Filed: November 24, 2010
    Date of Patent: August 28, 2012
    Assignee: LG Innotek Co., Ltd.
    Inventor: Youngil Park
  • Patent number: 8255042
    Abstract: A system and method for monitoring an individual's physiological condition and detecting abnormalities therein, comprising concurrently receiving an electrocardiograph signal and a ballistocardiograph signal. The electrocardiograph and ballistocardiograph signals are conditioned to minimize background extraneous noise after which, each signal is concurrently processed and analyzed to detect repeating cyclical patterns and further characterized to identify individual components of the repeating cycles. At least one individual component in one signal is selected as a reference marker or a selected component in the other signal. The two signals are then synchronized, outputs produced therefrom and stored in a database.
    Type: Grant
    Filed: November 30, 2010
    Date of Patent: August 28, 2012
    Assignee: Heart Force Medical Inc.
    Inventors: David MacQuarrie, Bozena Kaminska
  • Patent number: 8251911
    Abstract: A system and method for monitoring an individual's physiological condition and detecting abnormalities therein, comprising concurrently receiving an electrocardiograph signal and a ballistocardiograph signal. The electrocardiograph and ballistocardiograph signals are conditioned to minimize background extraneous noise after which, each signal is concurrently processed and analyzed to detect repeating cyclical patterns and further characterized to identify individual components of the repeating cycles. At least one individual component in one signal is selected as a reference marker or a selected component in the other signal. The two signals are then synchronized, outputs produced therefrom and stored in a database.
    Type: Grant
    Filed: November 30, 2010
    Date of Patent: August 28, 2012
    Assignee: Heart Force Medical Inc.
    Inventors: David MacQuarrie, Bozena Kaminska
  • Patent number: 8247372
    Abstract: Compounds which are Spiruchostatin analogues of the general formula (I) or (I?), isosteres thereof and pharmaceutically acceptable salts thereof are found to inhibit HDAC wherein R1, R2, R3 and R4 are the same or different and represent an amino acid side chain moiety and each R6 is the same or different and represents hydrogen or C1-C4 alkyl.
    Type: Grant
    Filed: November 23, 2007
    Date of Patent: August 21, 2012
    Assignee: University of Southampton
    Inventors: Graham Keith Packham, Arasu Ganesan, Alexander Richard Liam Cecil
  • Patent number: 8246993
    Abstract: New hydrogel, including a hydrogel containing cationic BSA is included in a vaccine to stimulate the immune system to increase the potency of the vaccine.
    Type: Grant
    Filed: June 9, 2005
    Date of Patent: August 21, 2012
    Assignee: Cytogel Pharma, LLC
    Inventors: Daqing Wu, Chih-Chang Chu, Joseph Carozza
  • Patent number: 8247445
    Abstract: The subject invention concerns platinum complexes that exhibit antitumor cell and/or antiparasitic activity. The subject invention also concerns the use of platinum complexes of the invention to treat oncological and inflammatory disorders. The platinum complexes of the invention can also be used to treat or prevent infection by a virus or a bacterial or parasitic organism in vivo or in vitro.
    Type: Grant
    Filed: July 13, 2010
    Date of Patent: August 21, 2012
    Assignee: University of South Florida
    Inventors: Heidi Kay, Jay W. Palmer, Joseph A. Stanko
  • Patent number: D665913
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: August 21, 2012
    Inventor: Ann Marcile Ross