Abstract: The hedgehog pathway in cerebellar cancer cells was modulated with siRNA specifically targeted to the shh and gli-I genes. Silencing of the two genes in a medullablastoma cell line transfected with the siRNAs caused significant reduction of mRNA specific for the targeted shh and gli-I genes and a loss of protein expression. The disclosed methods and compositions may be useful for treatment of a range of primitive neuroectodermal tumors (PNET) by shutting down or modulating the expression of gene products associated with the hedgehog pathway.

Abstract: A method of forming a device isolation film of a semiconductor device is provided. The method of forming a device isolation film of a semiconductor device according to an embodiment includes forming the device isolation film by ion-implanting insulation materials inside of a trench formed on a semiconductor substrate.

Abstract: The present invention provides novel fluorescent compounds and covalent attachment chemistries which facilitate the use of these compounds as labels for ultrasensitive and quantitative fluorescent detection of low levels of biomolecules. In a preferred embodiment, the fluorescent labels of this invention are novel derivatives of the hydroxy-pyrene trisulphonic and disulphonic acids which may be used in any assay in which radioisotopes, colored dyes or other fluorescent molecules are currently used. Thus, for example, any assay using labeled antibodies, proteins, oligonucleotides or lipids, including fluorescent cell sorting, fluorescence microscopy (including dark-field microscopy), fluorescence polarization assays, ligand, receptor binding assays, receptor activation assays and diagnostic assays can benefit from use of the compounds disclosed herein.

Abstract: The present invention relates to cells obtainable from cell lines having the ECACC Accession Nos 04091601, 04110301 and 04092302.

Abstract: A camera module, including a printed circuit board, an image sensor chip, and a housing, is provided. A plating line can be formed in an inner layer of the printed circuit board. A method of manufacturing the camera module can include connecting the plating line of the inner layer of the printed circuit board to a pattern of an outer layer using a via hole, performing a plating process, and forming an image sensor, the housing, and a lens part on the printed circuit board.

Abstract: Provided is an image sensor and method of manufacturing the same. The image sensor can include a semiconductor substrate, a metal interconnection layer, an inorganic layer, lens seed patterns, and microlenses. The semiconductor substrate can include unit pixels. The metal interconnection layer can be disposed on the semiconductor substrate to provide signal and poser connections to the unit pixels. The inorganic layer can be disposed on the metal interconnection layer. The lens seed patterns are selectively disposed on the inorganic layer and are formed of an organic material. The microlenses are formed on the lens seed patterns.

Abstract: Compounds of Formula I, stereoisomers, and pharmaceutically acceptable salts or prodrugs thereof, their preparation, and their uses for the treatment of hepatitis C viral infection are described:

Abstract: A method for fabricating a semiconductor device is provided. A nickel layer is deposited on a semiconductor substrate and plasma-processed. Rapid thermal processing is performed on the plasma-processed nickel layer to form a nickel silicide layer. The portion of the nickel layer that has not reacted with silicon is then removed.

Abstract: The subject invention provides novel, inexpensive, and highly effective methods and devices for convenient and effective wound irrigation. In one embodiment the subject invention provides a discharge means for a reservoir housing containing irrigation solution wherein the discharge means has one or more specifically designed nozzles through which a sufficient volume of the irrigation solution can pass at an appropriate pressure.

Abstract: The subject invention pertains to methods and compositions for protecting feline animals from infection by FIV using immunogens derived from primate immunodeficiency viruses, including HIV and SIV. Methods for vaccinating feline animals with the subject vaccine compositions are described. Feline animals vaccinated according to the methods and compositions of the subject invention exhibit protective humoral and cellular immune responses to FIV when challenged with FIV. The subject invention further concerns methods and compositions for protecting humans and other animals against infection by immunodeficiency viruses, such as HIV and FIV.

Abstract: The present invention pertains to a method for treatment of allergic diseases by administering a natriuretic hormone peptide (NHP), or a nucleic acid sequence encoding NHP, to a patient in need thereof. In another aspect, the present invention concerns an expression vector comprising a nucleic acid sequence encoding NHP. In another aspect, the present invention concerns a host cell genetically modified with a nucleic acid sequence encoding NHP. In another aspect, the present invention concerns a pharmaceutical composition comprising NHP or a nucleic acid sequence encoding NHP and a pharmaceutically acceptable carrier. In another aspect, the present invention pertains to novel fragments of atrial natriuretic peptide (ANP) exhibiting bronchodilatory and anti-inflammatory activity, and isolated nucleic acid sequences encoding the fragments.

Abstract: The subject invention pertains to a method and apparatus for high heat flux heat transfer. The subject invention can be utilized to transfer heat from a heat source to a coolant such that the transferred heat can be effectively transported to another location. Examples of heat sources from which heat can be transferred from include, for example, fluids and surfaces. The coolant to which the heat is transferred can be sprayed onto a surface which is in thermal contact with the heat source, such that the coolant sprayed onto the surface in thermal contact with the heat absorbs heat from the surface and carries the absorbed heat away as the coolant leaves the surface. The surface can be, for example, the surface of an interface plate in thermal contact with the heat source or a surface integral with the heat source. The coolant sprayed onto the surface can initially be a liquid and remain a liquid after absorbing the heat, or can in part or in whole be converted to a gas or vapor after absorbing the heat.

Abstract: The subject invention provides materials and methods for soft tissue augmentation. The materials and methods of the subject invention can, advantageously, be used to correct defects such as velopharyngeal insufficiency after cleft palate repair. Other uses include treatments for gastroesophageal acid-reflux, urinary incontinence, wrinkles and contains abnormalities.

Abstract: Embodiments of a linear vibrator are provided that are capable of reducing the manufacturing cost, increasing the product reliability and increasing the vibrating quantity. An embodiment of a linear vibrator can include a case formed of an upper case portion and a lower case portion coupled to each other to provide a predetermined inner space; a substrate disposed on an upper surface of the lower case portion; a first coil and a second coil installed at both end parts inside of the case and connected to the substrate; a spring having one side fixed on at least one of the inside faces of the case; and a magnet fixed at another side of the spring and located between the first and second coils inside of the case, where the magnet can vertically vibrate through an interaction with the first and second coils.

Abstract: Embodiments pertain to methods of improving the performance of a frequency modulation continuous wave (FMCW) radar system and improving the value of the information provided the FMCW system. In an embodiment, the IF level is monitored while sweeping the frequency of the system through at least a portion of the frequency range of the system and the frequency is set to produce the minimum IF level. Embodiments expedite the adaptation of the comb filter to the signal when the system is turned on. In an embodiment, a method of quickly determining the largest peaks in the RDM is implemented. Embodiments relate to a method for processing a radar signal that classifies two or more targets. An embodiment classifies a human target or other target(s) using amplitude values in time-consecutive range-Doppler maps. An embodiment processes a radar signal for improving the performance of FMCW detection, tracking, and classification algorithms.

Abstract: A flat vibration motor is provided. The flat vibration motor includes a rotor portion, a stator portion, a fixing mount, a pair of terminals, and a base portion. The rotor portion generates vibrating force when rotating. The stator portion houses and couples with the rotor portion to allow the rotor portion to rotate. The fixing mount extends from a side of a lower case of the stator portion. Each terminal includes a contacting portion, an elastic portion, and a joining portion. The base portion forms a plurality of supporting holes through which each of the terminals respectively passes. The joining portion of the terminal connects electrically to the circuit board through a peripheral lower surface around the supporting hole, when the base portion and the fixing mount are coupled.

Abstract: A semiconductor device having a variable capacitance capacitor and a method of manufacturing the same are disclosed. An example semiconductor device includes a capacitor having a bottom electrode, a dielectric layer and an upper electrode, formed on a semiconductor substrate. The example semiconductor also includes a first insulating layer formed on the semiconductor substrate to cover the capacitor, a plurality of first contact plugs formed in a plurality of first via holes of the first insulating layer, each of which is electrically connected to either the bottom electrode or the upper electrode, a first metal wiring formed on the first insulating layer and connected to the bottom electrode through the first contact plug, a second contact plug formed on the first insulating layer and connected to the upper electrode through the first contact plug, and a second insulating layer formed on the first insulating layer to cover the first metal wiring and the second contact plug.

Abstract: A method to prepare halogen end-capped polypyrroles, polyfurans or copolymeric pyrroles and furans is presented that readily occurs in a liquid state as well as a solid state without the need of a catalyst from a dihalopyrrole monomer, dihalofuran monomer, or a mixture of monomers. The polymerization mixture can be modified to include a monohalo-monomer for the introduction of a specific end-group or a polyhalo-monomer to form a branched polymer or network. An initiating species can be included in the polymerization mixture to avoid an induction period or to commence the polymerization process on demand. The electroactive polymers can be formed as a bulk material, a coating, or as a film.

Abstract: The subject invention pertains to a method and apparatus for providing a trailer jack mount. The subject invention also pertains to a method and apparatus for providing a trailer jack mount for use with towable trailers. The subject invention is advantageous for use with trailers, such as utility trailers, which are frequently moved between various locations. The subject apparatus can also enable the mounting of a trailer jack to a trailer such that the trailer jack can quickly transition up or down relative to the trailer. In a specific embodiment, the subject invention includes a first piece mountable to a trailer and a second piece to which a trailer jack can be secured. In this embodiment, the subject apparatus also includes means for securely attaching the second piece to the first piece and allowing the second piece to pivot relative to the first piece. Advantageously, the subject invention can either be retrofitted to an existing trailer with jack, or installed at original manufacture.

Abstract: An image sensor and a method of manufacturing the same are provided. The image sensor includes a semiconductor substrate, a metal line layer, a first conduction type conducting layer, a first pixel isolation layer, an intrinsic layer, and second conduction type conducting layer. The semiconductor substrate includes a circuit region. The metal line layer including a plurality of metal lines and an interlayer insulating layer is formed on the semiconductor substrate. The first conductive layer having patterns separated from each other by the pixel isolation layer is formed on the metal lines. The first pixel isolation layer is formed between the separated patterns of the first conduction type conducting layer. The intrinsic layer is formed on the first conductive layer and the first pixel isolation layer. The second conduction type conducting layer is formed on the intrinsic layer.