Patents Represented by Attorney, Agent or Law Firm Sandra M. Nolan
  • Patent number: 6207650
    Abstract: Provided are very highly water soluble, stable, crystalline salts of 2′,3′-dideoxy-2′,3′-didehydrothymidine (“d4T”), 2′,3′-dideoxyinosine (“ddI”), and 2′,3′-dideoxy-2′-fluoroinosine (“F-ddI”). Such salts are useful as intermediates or as antiviral agents.
    Type: Grant
    Filed: December 6, 1991
    Date of Patent: March 27, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Joseph B. Bogardus, Murray A. Kaplan, Robert K. Perrone
  • Patent number: 6090830
    Abstract: Lipid lowering dosage units, to be used once a day, produce minimal side effects. They contain a combination of microspheres formulated to co-deliver a HMG-CoA reductase inhibitor component and a niacin component.
    Type: Grant
    Filed: July 20, 1998
    Date of Patent: July 18, 2000
    Assignee: Fuisz International Ltd.
    Inventors: Michael Myers, Pradeepkumar P. Sanghvi
  • Patent number: 6020002
    Abstract: The present invention is a method and a dosage unit for delivery of a controlled-release system. The dosage unit is a quick dissolve unit which can be prepared by mixing uncured shearform matrix and a controlled-release system, either molding or compacting a unit dosage form and curing the shearform matrix. The controlled-release systems used in the present invention include instantaneous release components, delayed release components, sustained release components, and combinations thereof.
    Type: Grant
    Filed: November 5, 1997
    Date of Patent: February 1, 2000
    Assignee: Fuisz Technologies Ltd.
    Inventors: Garry L. Myers, Gerald E. Battist, Richard C. Fuisz
  • Patent number: 6008347
    Abstract: The present invention provides novel cis-N-iminomethyl-3,4-disubstituted-2-azetidinones, and their use in the preparation of N-acyl-2-azetidinones, intermediates in the semi-synthesis of taxol and taxol derivatives.
    Type: Grant
    Filed: January 10, 1995
    Date of Patent: December 28, 1999
    Assignee: Bristol-Myers Squibb Company
    Inventors: Allan W. Rey, Purushotham Vemishetti, Roberto Droghini
  • Patent number: 5980941
    Abstract: A self-binding, glycerine-free tablettable composition has a saccharide carrier and the sugar alcohols sorbitol and xylitol.
    Type: Grant
    Filed: June 19, 1998
    Date of Patent: November 9, 1999
    Assignee: Fuisz Technologies Ltd.
    Inventors: Michael G. Raiden, Pradeepkumar P. Sanghvi, Tushar K. Misra, Jeffrey W. Currington, Satish V. Kamath
  • Patent number: 5965164
    Abstract: A recipient-dosage delivery system including shearlite particles of a bio-affecting agent for delivery to a recipient. The particles are provided in a metered dose and are packaged in a bi-functional vessel. The particles are produced under liquiflash conditions and exhibit sufficient flowability so as to allow administration of the metered dose to the recipient under the force of gravity.
    Type: Grant
    Filed: April 29, 1996
    Date of Patent: October 12, 1999
    Assignee: Fuisz Technologies Ltd.
    Inventors: Richard C. Fuisz, Robert K. Yang, Whitney S. Cavanagh, Garry L. Myers, Mark R. Herman
  • Patent number: 5935600
    Abstract: The present invention deals with compositions and methods for preparing comestible units which disperse quickly in the mouth, especially when chewed. The present invention also includes the product made therefrom. The method includes initiating crystallization of shearform matrix with crystallization/bindig promoter and combining it with an additive to form flowable, compactible micro-particulates. The combination is then shaped to form a comestible unit having high structural integrity, good appearance, and excellent release characteristics.
    Type: Grant
    Filed: June 16, 1998
    Date of Patent: August 10, 1999
    Assignee: Fuisz Technologies Ltd.
    Inventors: Subraman R. Cherukuri, Richard C. Fuisz, Pradeepkumar P. Sanghvi, Tushar K. Misra, John R. Sisak
  • Patent number: 5895664
    Abstract: The present invention is a method of preparing a comestible unit which disperses quickly in the mouth. The present invention also includes the product resulting from the method. The method includes initiating crystallization of shearform matrix and combining with an additive, either before or after initiating crystallization, to form flowable, compactible micro-particulates. The combination is then subjected to compacting to form a comestible unit having high structural integrity, good appearance, and excellent release characteristics.
    Type: Grant
    Filed: June 14, 1994
    Date of Patent: April 20, 1999
    Assignee: Fuisz Technologies Ltd.
    Inventors: Subraman R. Cherukuri, Garry L. Myers, Gerald E. Battist, Richard C. Fuisz
  • Patent number: 5874110
    Abstract: The present invention is a method of entrapping an additive within carbohydrate bodies. The additive is drawn into the internal structure as a fluid during transformation of the bodies from a substantially amorphous state to a crystalline state. The present invention is also a delivery system including a carbohydrate body having an internal free volume space defined by an at least partially crystalline structure at equilibrium conditions, and an additive loaded within the carbohydrate body.
    Type: Grant
    Filed: July 22, 1997
    Date of Patent: February 23, 1999
    Assignee: Fuisz Technologies Ltd.
    Inventors: Andrea S. Blake, Robert K. Yang, Richard C. Fuisz
  • Patent number: 5871781
    Abstract: The present invention involves an apparatus for making comestible units. The comestible units made in accordance with the present invention can include active ingredients and are capable of dissolving in the mouth of the consumer within several seconds. They are particularly useful as antacids and as delivery vehicles for biologically active ingredients, especially those which are ideally combined with antacid ingredients.
    Type: Grant
    Filed: December 19, 1996
    Date of Patent: February 16, 1999
    Assignee: Fuisz Technologies Ltd.
    Inventors: Garry L. Myers, Gerald E. Battist, Richard C. Fuisz
  • Patent number: 5869098
    Abstract: The invention relates to compositions useful for making tablets which can be formed using conventional tableting machines and which disintegrate rapidly when placed in the mouth. The compositions typically include partially hygroscopic shearform matrices which may be recrystallized using crystallization promoters.
    Type: Grant
    Filed: August 20, 1997
    Date of Patent: February 9, 1999
    Assignee: Fuisz Technologies LTD.
    Inventors: Tushar K. Misra, Jeffery W. Currington, Satish V. Kamath, Pradeep P. Sanghvi, John R. Sisak, Michael G. Raiden
  • Patent number: 5866163
    Abstract: The present invention is a method of preparing rapidly dissolving comestible units such as tablets. The present invention also includes an apparatus for making the comestible units and the units themselves. The product prepared in accordance with the present invention can include active ingredients and is capable of dissolving in the mouth of the consumer within several seconds. The unit dosage forms prepared in accordance with the present invention are particularly useful as antacids and as a delivery vehicle for biologically active ingredients, especially those which are ideally combined with antacid ingredients in order to ameliorate the effects of antacid environment.
    Type: Grant
    Filed: December 19, 1996
    Date of Patent: February 2, 1999
    Assignee: Fuisz Technologies Ltd.
    Inventors: Garry L. Myers, Gerald E. Battist, Richard C. Fuisz
  • Patent number: 5862998
    Abstract: An apparatus and method for continuously making chopped amorphous fibers that uses an air transport system. The apparatus includes a source of floss, a duct for transporting the floss while it is entrained in a stream of gaseous carrier medium, a chopper for chopping the floss, and a separator. In a preferred embodiment, the floss is chopped while it is entrained in the stream of gaseous carrier medium using a rotating ring chopper, and the chopped floss is subsequently separated using a cyclone separator.
    Type: Grant
    Filed: April 11, 1997
    Date of Patent: January 26, 1999
    Assignee: Fuisz Technologies Ltd.
    Inventors: Beuford A. Bogue, Claude Bayard, William F. Rutkowski
  • Patent number: 5853762
    Abstract: The present invention is a method and a dosage unit for delivery of a controlled-release system. The dosage unit is a quick dissolve unit which can be prepared by mixing uncured shearform matrix and a controlled-release system, either molding or compacting a unit dosage form and curing the shearform matrix. The controlled-release systems used in the present invention include instantaneous release components, delayed release components, sustained release components, and combinations thereof.
    Type: Grant
    Filed: August 16, 1996
    Date of Patent: December 29, 1998
    Assignee: Fuisz Technologies Ltd
    Inventors: Garry L. Myers, Gerald E. Battist, Richard C. Fuisz
  • Patent number: 5851555
    Abstract: Controlled release dosage units containing water soluble active agents can be made using an active agent, an optional inert carrier, a cellulosic polymer and a lipophilic ingredient.
    Type: Grant
    Filed: August 15, 1997
    Date of Patent: December 22, 1998
    Assignee: Fuisz Technologies Ltd.
    Inventors: Pradeepkumar P. Sanghvi, Tushar K. Misra, David V. Prior
  • Patent number: 5851553
    Abstract: The present invention is a method of preparing rapidly dissolving comestible units such as tablets. The present invention also includes an apparatus for making the comestible units and the units themselves. The product prepared in accordance with the present invention can include active ingredients and is capable of dissolving in the mouth of the consumer within several seconds. The unit dosage forms prepared in accordance with the present invention are particularly useful as antacids and as a delivery vehicle for biologically active ingredients, especially those which are ideally combined with antacid ingredients in order to ameliorate the effects of antacid environment.
    Type: Grant
    Filed: December 19, 1996
    Date of Patent: December 22, 1998
    Assignee: Fuisz Technologies, Ltd.
    Inventors: Garry L. Myers, Gerald E. Battist, Richard C. Fuisz
  • Patent number: 5851552
    Abstract: The present invention is a method and a dosage unit for delivery of a controlled-release system. The dosage unit is a quick dissolve unit which can be prepared by mixing uncured shearform matrix and a controlled-release system, either molding or compacting a unit dosage form and curing the shearform matrix. The controlled-release systems used in the present invention include instantaneous release components, delayed release components, sustained release components, and combinations thereof.
    Type: Grant
    Filed: August 16, 1996
    Date of Patent: December 22, 1998
    Assignee: Fuisz Technologies, Ltd.
    Inventors: Garry L. Myers, Gerald E. Battist, Richard C. Fuisz
  • Patent number: 5849223
    Abstract: The present invention is a method of making discrete particles by subjecting an organic feedstock to liquiflash conditions whereby the feedstock is transformed instantaneously from solid to liquiform to solid. Liquiform is a transient condition wherein the feedstock has substantially unimpeded internal flow. Shear force is imparted to the liquiform feedstock in an amount sufficient to separate tiny masses of feedstock. The tiny masses solidify as discretized particles. The present invention also includes unique products resulting from the process, e.g., a monodispersed microsphere product and coated particles prepared therefrom.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: December 15, 1998
    Assignee: Fuisz Technologies Ltd.
    Inventors: Garry L. Myers, Robert K. Yang, Mark R. Herman
  • Patent number: 5840334
    Abstract: Shearform compositions made without added glycerine are disclosed. The compositions are self-binding and exhibit excellent cohesivity when used in tableting compositions. Typically, xylitol is incorporated into a feedstock which is flash-flow processed to form a self-binding shearform matrix.
    Type: Grant
    Filed: August 20, 1997
    Date of Patent: November 24, 1998
    Assignee: Fuisz Technologies Ltd.
    Inventors: Michael G. Raiden, Pradeepkumar P. Sanghvi, Tushar K. Misra, Jeffery W. Currington, Satish V. Kamath, Mahendra Govind Pankhania
  • Patent number: 5811123
    Abstract: Anti-ulcer compositions are disclosed having therapeutic agents dispersed in a soluble matrix formed by melt spinning the therapeutic agent with a carrier and hydrogel. Methods of treating mucosal ulcer-bearing tissue and preparing the matrix are also disclosed. One embodiment includes use of gastric irritating bio-affecting agents in which case the composition is preventative as well as therapeutic.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: September 22, 1998
    Assignee: Fuisz Technologies Ltd.
    Inventor: Richard C. Fuisz