Patents Represented by Attorney, Agent or Law Firm Sandra M. Nolan
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Patent number: 6207650Abstract: Provided are very highly water soluble, stable, crystalline salts of 2′,3′-dideoxy-2′,3′-didehydrothymidine (“d4T”), 2′,3′-dideoxyinosine (“ddI”), and 2′,3′-dideoxy-2′-fluoroinosine (“F-ddI”). Such salts are useful as intermediates or as antiviral agents.Type: GrantFiled: December 6, 1991Date of Patent: March 27, 2001Assignee: Bristol-Myers Squibb CompanyInventors: Joseph B. Bogardus, Murray A. Kaplan, Robert K. Perrone
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Patent number: 6090830Abstract: Lipid lowering dosage units, to be used once a day, produce minimal side effects. They contain a combination of microspheres formulated to co-deliver a HMG-CoA reductase inhibitor component and a niacin component.Type: GrantFiled: July 20, 1998Date of Patent: July 18, 2000Assignee: Fuisz International Ltd.Inventors: Michael Myers, Pradeepkumar P. Sanghvi
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Patent number: 6020002Abstract: The present invention is a method and a dosage unit for delivery of a controlled-release system. The dosage unit is a quick dissolve unit which can be prepared by mixing uncured shearform matrix and a controlled-release system, either molding or compacting a unit dosage form and curing the shearform matrix. The controlled-release systems used in the present invention include instantaneous release components, delayed release components, sustained release components, and combinations thereof.Type: GrantFiled: November 5, 1997Date of Patent: February 1, 2000Assignee: Fuisz Technologies Ltd.Inventors: Garry L. Myers, Gerald E. Battist, Richard C. Fuisz
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Patent number: 6008347Abstract: The present invention provides novel cis-N-iminomethyl-3,4-disubstituted-2-azetidinones, and their use in the preparation of N-acyl-2-azetidinones, intermediates in the semi-synthesis of taxol and taxol derivatives.Type: GrantFiled: January 10, 1995Date of Patent: December 28, 1999Assignee: Bristol-Myers Squibb CompanyInventors: Allan W. Rey, Purushotham Vemishetti, Roberto Droghini
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Patent number: 5980941Abstract: A self-binding, glycerine-free tablettable composition has a saccharide carrier and the sugar alcohols sorbitol and xylitol.Type: GrantFiled: June 19, 1998Date of Patent: November 9, 1999Assignee: Fuisz Technologies Ltd.Inventors: Michael G. Raiden, Pradeepkumar P. Sanghvi, Tushar K. Misra, Jeffrey W. Currington, Satish V. Kamath
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Patent number: 5965164Abstract: A recipient-dosage delivery system including shearlite particles of a bio-affecting agent for delivery to a recipient. The particles are provided in a metered dose and are packaged in a bi-functional vessel. The particles are produced under liquiflash conditions and exhibit sufficient flowability so as to allow administration of the metered dose to the recipient under the force of gravity.Type: GrantFiled: April 29, 1996Date of Patent: October 12, 1999Assignee: Fuisz Technologies Ltd.Inventors: Richard C. Fuisz, Robert K. Yang, Whitney S. Cavanagh, Garry L. Myers, Mark R. Herman
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Patent number: 5935600Abstract: The present invention deals with compositions and methods for preparing comestible units which disperse quickly in the mouth, especially when chewed. The present invention also includes the product made therefrom. The method includes initiating crystallization of shearform matrix with crystallization/bindig promoter and combining it with an additive to form flowable, compactible micro-particulates. The combination is then shaped to form a comestible unit having high structural integrity, good appearance, and excellent release characteristics.Type: GrantFiled: June 16, 1998Date of Patent: August 10, 1999Assignee: Fuisz Technologies Ltd.Inventors: Subraman R. Cherukuri, Richard C. Fuisz, Pradeepkumar P. Sanghvi, Tushar K. Misra, John R. Sisak
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Patent number: 5895664Abstract: The present invention is a method of preparing a comestible unit which disperses quickly in the mouth. The present invention also includes the product resulting from the method. The method includes initiating crystallization of shearform matrix and combining with an additive, either before or after initiating crystallization, to form flowable, compactible micro-particulates. The combination is then subjected to compacting to form a comestible unit having high structural integrity, good appearance, and excellent release characteristics.Type: GrantFiled: June 14, 1994Date of Patent: April 20, 1999Assignee: Fuisz Technologies Ltd.Inventors: Subraman R. Cherukuri, Garry L. Myers, Gerald E. Battist, Richard C. Fuisz
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Patent number: 5874110Abstract: The present invention is a method of entrapping an additive within carbohydrate bodies. The additive is drawn into the internal structure as a fluid during transformation of the bodies from a substantially amorphous state to a crystalline state. The present invention is also a delivery system including a carbohydrate body having an internal free volume space defined by an at least partially crystalline structure at equilibrium conditions, and an additive loaded within the carbohydrate body.Type: GrantFiled: July 22, 1997Date of Patent: February 23, 1999Assignee: Fuisz Technologies Ltd.Inventors: Andrea S. Blake, Robert K. Yang, Richard C. Fuisz
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Patent number: 5871781Abstract: The present invention involves an apparatus for making comestible units. The comestible units made in accordance with the present invention can include active ingredients and are capable of dissolving in the mouth of the consumer within several seconds. They are particularly useful as antacids and as delivery vehicles for biologically active ingredients, especially those which are ideally combined with antacid ingredients.Type: GrantFiled: December 19, 1996Date of Patent: February 16, 1999Assignee: Fuisz Technologies Ltd.Inventors: Garry L. Myers, Gerald E. Battist, Richard C. Fuisz
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Patent number: 5869098Abstract: The invention relates to compositions useful for making tablets which can be formed using conventional tableting machines and which disintegrate rapidly when placed in the mouth. The compositions typically include partially hygroscopic shearform matrices which may be recrystallized using crystallization promoters.Type: GrantFiled: August 20, 1997Date of Patent: February 9, 1999Assignee: Fuisz Technologies LTD.Inventors: Tushar K. Misra, Jeffery W. Currington, Satish V. Kamath, Pradeep P. Sanghvi, John R. Sisak, Michael G. Raiden
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Patent number: 5866163Abstract: The present invention is a method of preparing rapidly dissolving comestible units such as tablets. The present invention also includes an apparatus for making the comestible units and the units themselves. The product prepared in accordance with the present invention can include active ingredients and is capable of dissolving in the mouth of the consumer within several seconds. The unit dosage forms prepared in accordance with the present invention are particularly useful as antacids and as a delivery vehicle for biologically active ingredients, especially those which are ideally combined with antacid ingredients in order to ameliorate the effects of antacid environment.Type: GrantFiled: December 19, 1996Date of Patent: February 2, 1999Assignee: Fuisz Technologies Ltd.Inventors: Garry L. Myers, Gerald E. Battist, Richard C. Fuisz
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Patent number: 5862998Abstract: An apparatus and method for continuously making chopped amorphous fibers that uses an air transport system. The apparatus includes a source of floss, a duct for transporting the floss while it is entrained in a stream of gaseous carrier medium, a chopper for chopping the floss, and a separator. In a preferred embodiment, the floss is chopped while it is entrained in the stream of gaseous carrier medium using a rotating ring chopper, and the chopped floss is subsequently separated using a cyclone separator.Type: GrantFiled: April 11, 1997Date of Patent: January 26, 1999Assignee: Fuisz Technologies Ltd.Inventors: Beuford A. Bogue, Claude Bayard, William F. Rutkowski
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Patent number: 5853762Abstract: The present invention is a method and a dosage unit for delivery of a controlled-release system. The dosage unit is a quick dissolve unit which can be prepared by mixing uncured shearform matrix and a controlled-release system, either molding or compacting a unit dosage form and curing the shearform matrix. The controlled-release systems used in the present invention include instantaneous release components, delayed release components, sustained release components, and combinations thereof.Type: GrantFiled: August 16, 1996Date of Patent: December 29, 1998Assignee: Fuisz Technologies LtdInventors: Garry L. Myers, Gerald E. Battist, Richard C. Fuisz
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Patent number: 5851552Abstract: The present invention is a method and a dosage unit for delivery of a controlled-release system. The dosage unit is a quick dissolve unit which can be prepared by mixing uncured shearform matrix and a controlled-release system, either molding or compacting a unit dosage form and curing the shearform matrix. The controlled-release systems used in the present invention include instantaneous release components, delayed release components, sustained release components, and combinations thereof.Type: GrantFiled: August 16, 1996Date of Patent: December 22, 1998Assignee: Fuisz Technologies, Ltd.Inventors: Garry L. Myers, Gerald E. Battist, Richard C. Fuisz
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Patent number: 5851553Abstract: The present invention is a method of preparing rapidly dissolving comestible units such as tablets. The present invention also includes an apparatus for making the comestible units and the units themselves. The product prepared in accordance with the present invention can include active ingredients and is capable of dissolving in the mouth of the consumer within several seconds. The unit dosage forms prepared in accordance with the present invention are particularly useful as antacids and as a delivery vehicle for biologically active ingredients, especially those which are ideally combined with antacid ingredients in order to ameliorate the effects of antacid environment.Type: GrantFiled: December 19, 1996Date of Patent: December 22, 1998Assignee: Fuisz Technologies, Ltd.Inventors: Garry L. Myers, Gerald E. Battist, Richard C. Fuisz
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Patent number: 5851555Abstract: Controlled release dosage units containing water soluble active agents can be made using an active agent, an optional inert carrier, a cellulosic polymer and a lipophilic ingredient.Type: GrantFiled: August 15, 1997Date of Patent: December 22, 1998Assignee: Fuisz Technologies Ltd.Inventors: Pradeepkumar P. Sanghvi, Tushar K. Misra, David V. Prior
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Patent number: 5849223Abstract: The present invention is a method of making discrete particles by subjecting an organic feedstock to liquiflash conditions whereby the feedstock is transformed instantaneously from solid to liquiform to solid. Liquiform is a transient condition wherein the feedstock has substantially unimpeded internal flow. Shear force is imparted to the liquiform feedstock in an amount sufficient to separate tiny masses of feedstock. The tiny masses solidify as discretized particles. The present invention also includes unique products resulting from the process, e.g., a monodispersed microsphere product and coated particles prepared therefrom.Type: GrantFiled: May 26, 1995Date of Patent: December 15, 1998Assignee: Fuisz Technologies Ltd.Inventors: Garry L. Myers, Robert K. Yang, Mark R. Herman
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Patent number: 5840334Abstract: Shearform compositions made without added glycerine are disclosed. The compositions are self-binding and exhibit excellent cohesivity when used in tableting compositions. Typically, xylitol is incorporated into a feedstock which is flash-flow processed to form a self-binding shearform matrix.Type: GrantFiled: August 20, 1997Date of Patent: November 24, 1998Assignee: Fuisz Technologies Ltd.Inventors: Michael G. Raiden, Pradeepkumar P. Sanghvi, Tushar K. Misra, Jeffery W. Currington, Satish V. Kamath, Mahendra Govind Pankhania
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Patent number: 5811123Abstract: Anti-ulcer compositions are disclosed having therapeutic agents dispersed in a soluble matrix formed by melt spinning the therapeutic agent with a carrier and hydrogel. Methods of treating mucosal ulcer-bearing tissue and preparing the matrix are also disclosed. One embodiment includes use of gastric irritating bio-affecting agents in which case the composition is preventative as well as therapeutic.Type: GrantFiled: June 6, 1995Date of Patent: September 22, 1998Assignee: Fuisz Technologies Ltd.Inventor: Richard C. Fuisz