Patents Represented by Attorney, Agent or Law Firm Sandra M. Nolan
  • Piperazinyl-and piperidinyl-cyclohexanols
    Patent number: 5478828
    Abstract: Novel piperazinyl- and piperidinyl-cyclohexanols are useful as anxiolytic agents and have other psychotropic properties.
    Type: Grant
    Filed: January 24, 1995
    Date of Patent: December 26, 1995
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ronald J. Mattson, John D. Catt
  • Gepirone dosage form
    Patent number: 5478572
    Abstract: Gepirone compositions having extended release properties contain a gepirone salt, a cellulosic polymer matrix and suitable quantities of pharmaceutical excipients. Dosage forms based thereon require 18 to 24 hours for release of 90 to 95% of gepirone.
    Type: Grant
    Filed: September 6, 1994
    Date of Patent: December 26, 1995
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Stephen T. David, Claude E. Gallian, Joseph C. H. Chou
  • Stabilized solutions of platinum(II) antitumor agents
    Patent number: 5455270
    Abstract: Solutions of carboplatin and other malonato platinum(II) antitumor agents are prepared containing stabilizing amounts of 1,1-cyclobutanedicarboxylic acid or salt at pH 4-8. The stabilizers inhibit unacceptable discoloration and precipitation. The solutions may also be stabilized by purging the carrier with air or oxygen and, optionally, blanketing the headspace with air or oxygen.
    Type: Grant
    Filed: August 11, 1993
    Date of Patent: October 3, 1995
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Murray A. Kaplan, Lawan Phusanti, Robert K. Perrone, Scott R. Stenberg, Sheeram Agharkar, Joseph B. Bogardus
  • Alicyclic phospholipase A.sub.2 inhibitors
    Patent number: 5436369
    Abstract: Certain novel alicyclic compounds are effective phospholipase A.sub.2 (PLA.sub.2) inhibitors.
    Type: Grant
    Filed: February 23, 1994
    Date of Patent: July 25, 1995
    Assignee: Bristol-Myers Squibb Company
    Inventors: Joanne J. Bronson, Katharine M. Greene, Muzammil M. Mansuri, Stanley V. D'Andrea, F. Ivy Carroll, Anita Lewin
  • N-substituted 2-azetidinones
    Patent number: 5412092
    Abstract: Novel cis compound having the formula: ##STR1## wherein R.sup.1 is alkyl, haloalkyl, cycloalkyl, aryl or a carbohydrate derivative; X is O, N, S, C(O)O or a direct bond; and R.sup.2 is aryl, substituted aryl or heteroaryl are useful in the synthesis of taxol and taxol derivatives.
    Type: Grant
    Filed: December 13, 1993
    Date of Patent: May 2, 1995
    Assignee: Bristol-Myers Squibb Company
    Inventors: Allan W. Rey, Purushotham Vemishetti, Roberto Droghini
  • Aminomethyl-benzodioxane and benzopyran serotonergic agents
    Patent number: 5391570
    Abstract: Certain aminomethyl-benzodioxanes and benzopyrans are useful serotonergic agents. They possess anxiolytic properties with few of the side effects often associated with dopaminergic agents.
    Type: Grant
    Filed: October 14, 1993
    Date of Patent: February 21, 1995
    Assignee: Bristol-Myers Squibb
    Inventors: John D. Catt, Ronald J. Mattson
  • Biaryl phospholipase A.sub.2 inhibitors
    Patent number: 5391817
    Abstract: Certain novel biaryl compounds are effective phospholipase A.sub.2 (PLA.sub.2) inhibitors.
    Type: Grant
    Filed: December 21, 1993
    Date of Patent: February 21, 1995
    Assignee: Bristol-Myers Squibb
    Inventors: Dane Springer, Bing-Yu Luh, Katharine M. Greene, Joanne J. Bronson, Muzammil M. Mansuri
  • Piperazinyl-and piperidinyl-cyclohexanols
    Patent number: 5387593
    Abstract: Novel piperazinyl- and piperidinyl-cyclohexanols of the following formula are useful as anxiolytic agents and have other psychotropic properties ##STR1##
    Type: Grant
    Filed: February 17, 1994
    Date of Patent: February 7, 1995
    Assignee: Briston-Myers Squibb
    Inventors: Ronald J. Mattson, John D. Catt
  • Antitumor antibiotic
    Patent number: 5378463
    Abstract: A certain fermentation product of Actinomadura strain Q473-8 yield, when suitably treated, a novel compound having both antibiotic and antitumor activities.
    Type: Grant
    Filed: October 25, 1993
    Date of Patent: January 3, 1995
    Assignee: Bristol Myers Squibb Co.
    Inventors: Daniel R. Schroeder, Kin S. Lam, Jacqueline M. Veitch
  • Production of pradimicin antibiotics
    Patent number: 5374552
    Abstract: The present invention relates to a fermentation process for producing BMY-28960 and desxylosyl BMY-28960, and to a novel BMY-28960-producing organism belonging to the genus Actinomadura and designated as strain AB 1236 (ATCC 55208).
    Type: Grant
    Filed: December 1, 1992
    Date of Patent: December 20, 1994
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Tamotsu Furumai, Masami Hatori, Masatoshi Kakushima, Chiharu Ikeda, Yoichiro Saitoh, Seikichi Kobaru
  • Antiischemic piperazinyl- and piperidinyl-cyclohexanes
    Patent number: 5352678
    Abstract: Certain piperazinyl- and piperidinyl-substituted cyclohexanes have anti-ischemic properties.
    Type: Grant
    Filed: June 25, 1993
    Date of Patent: October 4, 1994
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Ronald J. Mattson, John D. Catt
  • Antitumor antibiotic BMY-41219
    Patent number: 5326754
    Abstract: An antitumor antibiotic designated BMY-41219 is produced by fermentation of Saccharothrix aerocolonigenes ATCC 39243. The BMY-41219 antibiotic exhibits antitumor activity.
    Type: Grant
    Filed: May 18, 1993
    Date of Patent: July 5, 1994
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Kin S. Lam, Leonard A. McDonald, Jacqueline Mattei, Salvatore Forenza, James A. Matson
  • Antiviral antibiotic BU-3889V
    Patent number: 5286649
    Abstract: Production of an antiviral antibiotic complex, BU-3889V and its bioactive components A.sub.1, A.sub.2, A.sub.3, D.sub.1, D.sub.2 and D.sub.3, by fermentation of a BU-3889V producing strain of the new microorganism Amycolatopsis orientalis ATCC-53884 is disclosed. Complex BU-3889V is recovered and the components separated by the use of ion exchange chromatography techniques. The bioactive components are characterized by their physico-chemical characterizing properties. The products have been found to be effective to inhibit viruses including herpes simplex virus, human immunodeficiency virus (HIV) and influenza virus.
    Type: Grant
    Filed: January 10, 1992
    Date of Patent: February 15, 1994
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Masataka Konishi, Mitsuaki Tsunakawa, Osamu Tenmyo, Takeo Miyaki, Toshikazu Oki
  • 1H-cycloundeca[1,2-b:5,6-b']biscyclohepta(b)pyrans useful as antitumor agents
    Patent number: 5284866
    Abstract: A compound isolated from Eupricillium brefeldionum having the structure: ##STR1## is a useful antitumor agent.
    Type: Grant
    Filed: October 5, 1992
    Date of Patent: February 8, 1994
    Assignee: Bristol-Myers Squibb Company
    Inventors: Friedrich Mayerl, Xiaohua Huang, Qi Gao
  • Antitumor process employing novel fermentate of an Actinomadura strain
    Patent number: 5281417
    Abstract: A certain fermentation product of Actinomadura strain Q473-8 yields, when suitably treated, a novel compound having both antibiotic and antitumor activities.
    Type: Grant
    Filed: February 12, 1993
    Date of Patent: January 25, 1994
    Assignee: Bristol-Myers Squibb Company
    Inventors: Daniel R. Schroeder, Kin S. Lam, Jacqueline M. Veitch
  • Lauryl alcohol as skin penetration enhancer for topical imidazole agents
    Patent number: 5219877
    Abstract: A gel formulation for topical administration with enhanced skin penetration properties comprising a therapeutically effective amount of an imidazole antifungal agent, either by itself or in combination with a steroid anti-inflammatory agent, in a vehicle system that includes lauryl alcohol is disclosed.
    Type: Grant
    Filed: September 25, 1989
    Date of Patent: June 15, 1993
    Assignee: Bristol-Myers Squibb Company
    Inventors: Hemanshu S. Shah, Susan Genier, Cheng D. Yu, Bhiku Patel
  • Stable solutions of mitomycin C
    Patent number: 5216011
    Abstract: A stable solution of mitomycin C in propylene glycol or propylene glycol/water is disclosed. The solutions have an acceptable shelf-life of greater than 24 months at 4.degree. C. and can be injected directly or diluted with water or other aqueous parenteral vehicle for parenteral administration.
    Type: Grant
    Filed: September 1, 1989
    Date of Patent: June 1, 1993
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Mehdi Paborji, Joseph B. Bogardus, Shreeram N. Agharkar, William P. Coppola
  • Production of 2',3'-dideoxy-2',3'-didehydronucleosides
    Patent number: 5212294
    Abstract: There are disclosed novel processes for producing 2',3'-dideoxy-2'3'-didehydronucleosides, for example, 2',3'-dideoxy-2',3'-didehydrothymidine in high yields and on a large scale. The compounds so-produced are useful as antiviral agents, especially as agents effective against the human immunodeficiency viruses (HIV).
    Type: Grant
    Filed: March 31, 1992
    Date of Patent: May 18, 1993
    Assignee: Bristol-Myers Squibb Company
    Inventors: John E. Starrett, Jr., Muzammil M. Mansuri, John C. Martin, Carl E. Fuller, Henry G. Howell
  • Topical anti-fungal agents having anti-inflammatory activity
    Patent number: 5208015
    Abstract: The certain imidazoles have been found to exhibit anti-inflammatory as well as antifungal activity.
    Type: Grant
    Filed: July 23, 1991
    Date of Patent: May 4, 1993
    Assignee: Bristol-Myers Squibb Company
    Inventors: Hemanshu S. Shah, Cheng-Der Yu, John Gibson
  • Antibiotic 5-lipoxygenase inhibitors
    Patent number: 5208364
    Abstract: Novel compounds derived from cultures of Streptomyces sp. AA2807 are useful as 5-lipoxygenase inhibitors.
    Type: Grant
    Filed: June 25, 1992
    Date of Patent: May 4, 1993
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Hiroaki Ohkuma, Yutaka Hoshino, Yosuke Sawada, Derek Hook