Patents Represented by Attorney Stephen B. Coan

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  • Steroid ointment
    Patent number: 4070462
    Abstract: An improved ointment for the topical administration of steroids is comprised of a therapeutically effective amount of a 17-mono or 17,21-diester of betamethasone in a non-aqueous base comprised of 5-15% of a glycol solvent, 1-3% of a principle emulsifying agent; 0-7% of a secondary emulsifying agent; and 70-90% of a petrolatum base.
    Type: Grant
    Filed: October 26, 1976
    Date of Patent: January 24, 1978
    Assignee: Schering Corporation
    Inventor: Varda Ecker
  • 2-Aminomethyl-5-chloro-3-(2,4-dichlorophenyl)indole
    Patent number: 4070369
    Abstract: Disclosed herein is the novel compound, 2-aminomethyl-5-chloro-3-(2,4-dichlorophenyl)indole, useful by virtue of its antimicrobial, sanitizing, disinfectant, preservative, viricidal and herbicidal properties.
    Type: Grant
    Filed: August 18, 1976
    Date of Patent: January 24, 1978
    Assignee: Schering Corporation
    Inventor: Martin Steinman
  • 1-Desamino-1-hydroxy and 1-desamino-1-epi-hydroxy-4,6-di-o-(aminoglycosyl)-1,3-diaminocyclitols; 1-desamino-1-oxo-4,6-di-o-(aminoglycosyl)-1,3-diaminocyclitols, intermediates and use as antibacterial agents
    Patent number: 4066752
    Abstract: This invention relates to the preparation of novel 1-desamino-1-oxo-aminoglycosides and their use as intermediates in the preparation of novel 1-desamino-1-hydroxy and 1-desamino-1-epi-hydroxyaminoglycoside antibacterial agents.
    Type: Grant
    Filed: June 21, 1976
    Date of Patent: January 3, 1978
    Assignee: Schering Corporation
    Inventors: Alan K. Mallams, David Huw Davies
  • Use of 2-imidazolines as hypoglycemic agents
    Patent number: 4065569
    Abstract: The present 2-substituted imidazolines possess valuable hypoglycemic activity. The compounds are prepared by the condensation of an appropriately substituted aryl nitrile with a diamine.
    Type: Grant
    Filed: August 25, 1976
    Date of Patent: December 27, 1977
    Assignee: Schering Corporation
    Inventor: Heide Roebke
  • Garamine and derivatives thereof
    Patent number: 4063015
    Abstract: This disclosure relates to the preparation of garamine, its use as an antibacterial, and its use as an intermediate in the novel processes for preparing novel pseudotrisaccharides containing a garamine moiety, and to the use of the novel pseudotrisaccharides as antimicrobial, anthelmintic, antiprotozoal and antiviral agents.
    Type: Grant
    Filed: July 17, 1975
    Date of Patent: December 13, 1977
    Assignee: Schering Corporation
    Inventor: Alan K. Mallams
  • 6-(Polyhaloisopropyl)quinazoline-2,4-diones
    Patent number: 4058612
    Abstract: Novel 6-(polyhaloisopropyl)quinazoline-2,4-diones, preparable from polyhaloisopropylarylureas, are disclosed herein. These compounds display potent hypotensive activity and are thus useful in the treatment of mammalian hypertension.
    Type: Grant
    Filed: May 20, 1976
    Date of Patent: November 15, 1977
    Assignee: Schering Corporation
    Inventor: Bernard R. Neustadt
  • Rosamicin derivatives and method of using same
    Patent number: 4056616
    Abstract: Rosamicin is an antibiotic elaborated by Micromonospora rosaria. The compounds described herein are antibacterial derivatives of rosamicin. Also described are processes for the preparation of these antibacterial derivatives from rosamicin.
    Type: Grant
    Filed: March 5, 1976
    Date of Patent: November 1, 1977
    Assignee: Schering Corporation
    Inventors: Hans Reimann, Robert S. Jaret, Mohammad Mehdi Nafissi-Varchei
  • Substituted aryl and aralkyl amides
    Patent number: 4053509
    Abstract: Amides having aromatic substituents of the formula: ##STR1## wherein R is an acyl radical derived from a carboxylic acid having from 3 to 20 carbon atoms, X and Y are members selected from the group consisting of hydrogen, fluoro, trifluoromethyl and hydroxy, and n is an integer selected from the group consisting of 0, 1 and 2, exhibit an effect upon the central nervous system.
    Type: Grant
    Filed: March 15, 1973
    Date of Patent: October 11, 1977
    Assignee: Schering Corporation
    Inventors: Hans-Peter Faro, Samson Symchowicz
  • N-diphenylalkyl-2-benzyl azacyclic compounds
    Patent number: 4052383
    Abstract: Novel N-diphenylalkyl-2-benzyl azacyclic compounds are disclosed which can be used as antiobesity agents. Some of these compounds also exhibit useful antimicrobial properties. Additionally, novel chemical intermediates for the synthesis of this series are provided.
    Type: Grant
    Filed: March 8, 1976
    Date of Patent: October 4, 1977
    Assignee: Schering Corporation
    Inventors: Elijah H. Gold, Daniel M. Solomon
  • Stable topical anesthetic compositions
    Patent number: 4052513
    Abstract: A cosmetically elegant and stable oil in water emulsion for use as a topical anesthetic containing 0.5-15% benzocaine solubilized in water with a dialkyl ester of an alkanedioic acid having the formula ROOC--C.sub.n H.sub.2n --C00R' where R and R' are alkyl groups of from 1 to 4 carbon atoms and n is an integer from 1 to 8.
    Type: Grant
    Filed: April 2, 1976
    Date of Patent: October 4, 1977
    Assignee: Plough, Inc.
    Inventor: Carl Kaplan
  • Serologic test for systemic candidiasis
    Patent number: 4051232
    Abstract: An in vitro test method for the diagnosis of systemic candidiasis in mammals is carried out with an antigen solution containing a specified concentration and ratio of protein antigen and mannan antigen whereby false readings are reduced.
    Type: Grant
    Filed: August 12, 1975
    Date of Patent: September 27, 1977
    Assignee: Schering Corporation
    Inventors: Walter P. Protzman, George L. Evans
  • Methods for the preparation of semi-synthetic aminocyclitol aminoglycoside antibiotics
    Patent number: 4049498
    Abstract: Micromonospora inyoensis strain 155OF-1G NRRL 5742 is incapable of producing antibiotics unless an aminocyclitol is added to the fermentation medium. When such a compound is added, antibiotics are produced, said antibiotics being analogs of known aminoglycoside antibiotics differing therefrom with respect to the aminocyclitol subunit.
    Type: Grant
    Filed: December 15, 1976
    Date of Patent: September 20, 1977
    Assignee: Schering Corporation
    Inventors: Marvin Joseph Weinstein, Peter John Lovell Daniels, Gerald Howard Wagman, Raymond Thomas Testa
  • Amino glycoside antibiotics having antibacterial activity
    Patent number: 4049796
    Abstract: In the fermentation production of gentamicin C a plurality of additional antibiotic compounds are obtained. Four of these compounds, gentamicin A, gentamicin B, gentamicin B.sub.1 and gentamicin X exhibit significant anti-protozoal and anthelmintic activity while gentamicin B and B.sub.1 have significant antibacterial properties with markedly reduced side effects.
    Type: Grant
    Filed: October 1, 1975
    Date of Patent: September 20, 1977
    Assignee: Schering Corporation
    Inventors: David J. Cooper, Jay Allan Waitz, Mae Counelis, Jay Weinstein
  • Method for treatment of canine seborrhea
    Patent number: 4039684
    Abstract: A method for the treatment of canine seborrhea comprising oral administration of a daily dosage of 5-25 mg/kg of either 4-nitro-3-trifluoromethylisobutyranilide or its metabolite 4'-nitro-3'-trifluoromethyl-2-hydroxyisobutyranilide.
    Type: Grant
    Filed: March 25, 1976
    Date of Patent: August 2, 1977
    Assignee: Schering Corporation
    Inventors: Robert N. Berkman, Jesse W. Houdeshell
  • Anti-diarrheal anthranilic acids
    Patent number: 4029815
    Abstract: This invention relates to compositions of matter useful as anti-diarrheal agents and to the method of controlling and treating diarrhea in warm blooded animals. The active anti-diarrheal agents are substituted N-aryl-anthranilic acids, and salts thereof and ester and hydrazine derivatives of said acids.
    Type: Grant
    Filed: April 30, 1975
    Date of Patent: June 14, 1977
    Assignee: Schering Corporation
    Inventors: Margaret H. Sherlock, James F. Long
  • Everninomicin antibacterial derivatives, electrochemical method for their manufacture, method for their use as antibacterial agents, and pharmaceutical compositions useful therefor
    Patent number: 4027016
    Abstract: Everninomicin derivatives devoid of a nitro group and having antibacterial activity are prepared by electrochemically reducing the corresponding everninomicin having a nitro function or salts thereof in an aprotic anhydrous solvent in the absence of carbon dioxide. A preferred starting compound is everninomicin D whereby is produced a product mixture of antibacterial agents identified as desevernitrose everninomicin D, everninomicin D-3, and everninomicin D-7, respectively.
    Type: Grant
    Filed: January 19, 1976
    Date of Patent: May 31, 1977
    Assignee: Schering Corporation
    Inventors: Peter Kabasakalian, Sami Y. Kalliney, Ashit K. Ganguly, Anita Westcott
  • Treatment of oxyuriasis
    Patent number: 4021570
    Abstract: A novel compound, N-carbomethoxy-N'-methyl-N'-(2-nitro-4-N-propyloxyphenyl)thiourea, is highly effective in the treatment of pinworm infections.
    Type: Grant
    Filed: April 20, 1976
    Date of Patent: May 3, 1977
    Assignee: Schering Corporation
    Inventor: Mohammad Mehdi Nafissi-Varchei
  • Process for the preparation of 21-halogeno-21-desoxy-17.alpha.-acyloxy 20-keto-pregnenes
    Patent number: 4021459
    Abstract: 21-Halogeno-17.alpha.-acyloxy-20-keto-4-pregnenes having physiological properties are prepared by the reaction of a 17.alpha.,21-dihydroxy-20-keto-4-pregnene 17.alpha.,21-orthoester with a triphenylmethyl halide in an organic solvent, said halide being chloride or bromide.
    Type: Grant
    Filed: August 14, 1975
    Date of Patent: May 3, 1977
    Assignee: Schering Corporation
    Inventor: Michael J. Green
  • Methods for treating microbial infections
    Patent number: 4018893
    Abstract: Disclosed herein are 2-aminoalkyl-3-aryl-benzothiophenes and benzofurans useful as antimicrobial agents.
    Type: Grant
    Filed: December 12, 1975
    Date of Patent: April 19, 1977
    Assignee: Schering Corporation
    Inventor: Martin Steinman
  • Self-adherent shelf sign blank
    Patent number: D245290
    Type: Grant
    Filed: June 30, 1976
    Date of Patent: August 2, 1977
    Assignee: Plough, Inc.
    Inventor: Ted I. Kingsford