Patents Represented by Attorney Stephen B. Coan

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  • Certain 8-amino-1,7-naphthyridines
    Patent number: 4017500
    Abstract: This invention relates to 1-amino naphthyridines prepared by a base-catalyzed condensation while in an aprotic solvent. In this condensation an o-alkyl aryl nitrile may be reacted either with the same or different o-alkyl aryl nitrile or with another nitrile. The 1-amino naphthyridines are useful as antifungal and antibacterial agents.
    Type: Grant
    Filed: November 12, 1975
    Date of Patent: April 12, 1977
    Assignee: Schering Corporation
    Inventors: Joseph Mayer, Margaret H. Sherlock
  • Benzenesulfonyl urea compounds and their therapeutic use
    Patent number: 4016291
    Abstract: This application is directed to novel sulfonyl urea compounds, their non-toxic pharmaceutically acceptable salts, and to processes for making and using said compound. Exemplary of the sulfonyl ureas of this invention is N-(aralkyl)-N'-(p-benzenesulfonyl)urea.
    Type: Grant
    Filed: March 15, 1976
    Date of Patent: April 5, 1977
    Assignee: Schering Corporation
    Inventors: Lester Zitowitz, Lewis A. Walter, Arnold J. Wohl
  • Semi-synthetic aminocyclitol aminoglycoside antibiotics and methods for the preparation thereof
    Patent number: 4011390
    Abstract: Micromonospora inyoensis strain 1550F-1G NRRL 5742 is incapable of producing antibiotics unless an aminocyclitol is added to the fermentation medium. When such a compound is added, mutamicins are produced, said mutamicins being analogs of known aminoglycoside antibiotics differing therefrom with respect to the aminocyclitol subunit.
    Type: Grant
    Filed: June 5, 1974
    Date of Patent: March 8, 1977
    Assignee: Schering-Plough Corporation
    Inventors: Marvin J. Weinstein, Peter J. L. Daniels, Gerald H. Wagman, Raymond Testa
  • Aminoglycoside 66-40C, method for its manufacture, method for its use as an intermediate in the preparation of known antibiotics and novel antibacterials
    Patent number: 4009328
    Abstract: Aminoglycoside 66-40C, a minor product produced by the fermentation of Micromonospora inyoensis, is separated from said fermentation mixture, and is used as an intermediate in preparing the known antibiotic, sisomicin, as well as 6' -N-alkylsisomicins having antibacterial activity. Claimed are Aminoglycoside 66-40C as well as 6' -N-t-alkylsisomicins having a tertiary carbon bonded to the 6' -nitrogen.
    Type: Grant
    Filed: May 2, 1975
    Date of Patent: February 22, 1977
    Assignee: Schering Corporation
    Inventors: Alan K. Mallams, Richard W. Tkach, David Huw Davies
  • Antibiotic compositions and methods from micromonospora purpurea JI-20
    Patent number: 4009269
    Abstract: A mutant strain of Micromonospora purpurea herein designated M. purpurea JI-20 elaborates an antibiotic complex comprising gentamicin and at least two novel antibiotic substances namely Antibiotic JI-20A and Antibiotic JI-20B. The so-produced antibiotics have an adverse effect upon the growth of gram-positive and gram-negative bacteria.
    Type: Grant
    Filed: June 9, 1975
    Date of Patent: February 22, 1977
    Assignee: Schering Corporation
    Inventors: Jan Ilavsky, Aris P. Bayan, William Charney, Hans Reimann
  • Certain benzothiazoles used in the treatment of helminthiasis
    Patent number: 4006242
    Abstract: A novel treatment of helminthiasis is provided by means of the administration of specified benzothiazoles.
    Type: Grant
    Filed: April 25, 1975
    Date of Patent: February 1, 1977
    Assignee: Schering Corporation
    Inventor: Mohammad Mehdi Nafissi-Varchei
  • Antibiotic G-52 and method for the production thereof
    Patent number: 4001209
    Abstract: A novel actinomycete herein designated Micromonospora zionensis elaborates a product having substantial antibacterial activity, said activity being due to sisomicin and the novel antibiotic substance coproduced therewith. The disclosure sets forth methods for producing, isolating and using the antibiotics.
    Type: Grant
    Filed: February 28, 1975
    Date of Patent: January 4, 1977
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez
  • Means for depositing aerosol sprays in buttery form
    Patent number: 4001391
    Abstract: Disclosed herein is an aerosol package and method using this package for dispensing substances in spray form and depositing them on a desired limited surface area in the form of a buttery, liquescent solid. The aerosol packaging contains an anhydrous, oleaginous base containing specified fats or waxes and a propellant miscible therewith.
    Type: Grant
    Filed: September 16, 1971
    Date of Patent: January 4, 1977
    Assignee: Plough, Inc.
    Inventors: Wolffe Harry Feinstone, Fred J. Bandelin
  • Adjustable mascara applicator
    Patent number: 3998235
    Abstract: An applicator for applying a predetermined metered amount of a cosmetic material characterized by a plurality of axially spaced coating surfaces in which the axial distance between each coating surface is adjustable.
    Type: Grant
    Filed: November 24, 1975
    Date of Patent: December 21, 1976
    Assignee: Plough, Inc.
    Inventor: Ted I. Kingsford
  • Antibiotic G-418 and the production thereof
    Patent number: 3997403
    Abstract: A novel actinomycete herein designated Micromonospora rhodorangea elaborates a product having substantial antibacterial activity, said activity being due primarily to a novel antibiotic herein designated Antibiotic G-418. The disclosure sets forth methods for producing, isolating and using said antibiotic.
    Type: Grant
    Filed: October 10, 1975
    Date of Patent: December 14, 1976
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Raymond T. Testa, Joseph A. Marquez
  • Antimicrobial compositions
    Patent number: 3996159
    Abstract: Disclosed herein are 2-aminoalkyl-3-aryl-hetero-indenes useful as antimicrobial agents.
    Type: Grant
    Filed: December 1, 1975
    Date of Patent: December 7, 1976
    Assignee: Schering Corporation
    Inventor: Martin Steinman
  • Antiandrogenic agents and method for the treatment of androgen dependent disease states
    Patent number: 3995060
    Abstract: This application relates to certain 4'-substituted and to 3',4'-disubstituted anilides, to methods for their preparation and to methods for their use as antiandrogens. These substituted anilides are useful in the treatment of androgen dependent disease states, such as benign prostatic hypertrophy, hirsutism, acne and the like.
    Type: Grant
    Filed: September 11, 1974
    Date of Patent: November 30, 1976
    Assignee: Schering Corporation
    Inventors: Rudolph O. Neri, John G. Topliss
  • 2-Imidazolines and their use as hypoglycemic agents
    Patent number: 3992403
    Abstract: The present 2-substituted imidazolines possess valuable hypoglycemic activity. The compounds are prepared by the condensation of an appropriately substituted aryl nitrile with a diamine.
    Type: Grant
    Filed: May 30, 1975
    Date of Patent: November 16, 1976
    Assignee: Schering Corporation
    Inventor: Heide Roebke
  • Antibiotics sisomicin and verdamicin I and complex containing same
    Patent number: 3988316
    Abstract: A novel composition having antibiotic activity is produced by fermentation of the new species of microorganism, Micromonospora grisea. The antibiotic complex is composed of four components, Verdamicin I, sisomicin, Antibiotic G-418, and gentamicin A, of which Verdamicin I is a novel basic antibiotic possessing a broad antibacterial spectrum. The other components have been produced previously.
    Type: Grant
    Filed: February 18, 1975
    Date of Patent: October 26, 1976
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez
  • Antibiotic from micromonospora purpurea JI-20
    Patent number: 3986929
    Abstract: A mutant strain of Micromonospora purpurea herein designated M. purpurea JI-20 elaborates an antibiotic complex comprising gentamicin and at least two novel antibiotic substances namely Antibiotic JI-20A and Antibiotic JI-20B. The so-produced antibiotics have an adverse effect upon the growth of gram-positive and gram-negative bacteria.
    Type: Grant
    Filed: June 9, 1975
    Date of Patent: October 19, 1976
    Assignee: Schering Corporation
    Inventors: Jan Ilavsky, Aris P. Bayan, William Charney, Hans Reimann
  • Novel benzimidazoles useful as anti-androgens
    Patent number: 3987182
    Abstract: Disclosed herein are chemical compounds identifiable as substituted 2-alkylbenzimidazoles particularly useful as anti-androgens.
    Type: Grant
    Filed: June 9, 1975
    Date of Patent: October 19, 1976
    Assignee: Schering Corporation
    Inventor: Elijah H. Gold
  • Aminoglycoside antibiotics
    Patent number: 3985727
    Abstract: This disclosure relates to the preparation of certain gentamine derivatives, to their use as intermediates in the preparation of certain novel pseudotrisaccharides containing a gentamine moiety, and to the use of these pseudotrisaccharides as antibacterial agents.
    Type: Grant
    Filed: March 28, 1975
    Date of Patent: October 12, 1976
    Assignee: Schering Corporation
    Inventor: Peter J. L. Daniels
  • Method of isolating gentamicin C.sub.2a
    Patent number: 3984395
    Abstract: Fermentation of Micromono spora purpurea NRRL 2953 under controlled aerobic conditions produces a plurality of antibiotic substances including gentamicin C.sub.2a which has been heretofore unknown and unrecognized. A method of isolating said antibiotic is described as are the chemical and biological properties of the same.
    Type: Grant
    Filed: August 19, 1974
    Date of Patent: October 5, 1976
    Assignee: Schering Corporation
    Inventors: Peter J. L. Daniels, Joseph A. Marquez
  • Antimicrobial halo-substituted-2-cyanoethylaminoalkyl-3-phenyl-indoles
    Patent number: 3978224
    Abstract: Disclosed are 2-cyanoethyl amino alkyl-3-phenyl indoles of the formula ##SPC1##Wherein n 1, X.sub.2, Y.sub.1 and Y.sub.2 are hydrogen or halogen, at least one of X.sub.1 and X.sub.2 being halogen; n is an integer selected from 1,2 and 3; and the acid addition salts thereof which are useful as antimicrobials.
    Type: Grant
    Filed: July 1, 1975
    Date of Patent: August 31, 1976
    Assignee: Schering Corporation
    Inventors: Martin Steinman, Pirouz Tahbaz
  • Preparation of 12,13-desepoxy-12,13-dehydrorosamicin
    Patent number: 3975372
    Abstract: Described is a novel process for the preparation of 12,13-desepoxy-12,13-dehydrorosamicin by reducing rosamicin in a mineral acid solution containing Cr.sup.+.sup.+ cations. Rosamicin is an antibiotic elaborated by Micromonospora rosaria.
    Type: Grant
    Filed: February 28, 1975
    Date of Patent: August 17, 1976
    Assignee: Schering Corporation
    Inventors: Ashit K. Ganguly, Olga Sarre