Abstract: Compound of the formula
are inhibitors of the enzyme Factor Xa. These compounds are useful as anticoagulants in the treatment of cardiovascular diseases associated with thromboses.
Type:
Grant
Filed:
July 27, 2001
Date of Patent:
January 28, 2003
Assignee:
Bristol-Myers Squibb Co.
Inventors:
Philip D. Stein, Yan Shi, Stephen P. O'Connor, Chi Li
Abstract: Mercaptoalkanoylamino lactam acids are recrystallized by treatment with an agent that minimizes the formation of disulfides. Suitable agents are bismercaptans, phosphine or phosphite reducing agents, zinc metal powder, and sodium hydrosulfite.
Type:
Grant
Filed:
November 16, 2001
Date of Patent:
November 26, 2002
Assignee:
Bristol-Myers Squibb Co.
Inventors:
David R. Kronenthal, Rajendra P. Deshpande, James Simpson
Abstract: Substituted alkylketo compounds of the formula
can be converted to the corresponding amino acid by a stereoselective enzymatic process. The resulting amino acid compounds can be employed as starting materials for pharmaceutically active compounds. This invention is directed to the substituted alkylketo compounds and their method of preparation.
Type:
Grant
Filed:
May 3, 2001
Date of Patent:
November 26, 2002
Assignee:
Bristol-Myers Squibb Co.
Inventors:
Ronald L. Hanson, Paul A. Jass, Wen-Sen Li, Ramesh Patel, Keith Ramig, John J. Venit
Abstract: A biphasic controlled release delivery system for pharmaceuticals which have high water solubility, such as the antidiabetic metformin HCl salt, is provided which provides a dosage form that has prolonged gastric residence so that a dosing regimen of at least one gram metformin, once daily, may be achieved while providing effective control of plasma glucose.
Type:
Grant
Filed:
September 16, 1999
Date of Patent:
November 5, 2002
Assignee:
Bristol-Myers Squibb Co.
Inventors:
Peter Timmins, Andrew B. Dennis, Kiren A. Vyas
Abstract: Acylmercaptoalkanoylamino lactam esters or acids are converted to the corresponding mercaptoalkanoylamino lactam ester or acid under basic conditions by including an agent which minimizes the amount of disulfides. Suitable agents are bismercaptans, phosphine or phosphate reducing agents, zinc metal powder, and sodium hydrosulfite.
Type:
Grant
Filed:
November 16, 2001
Date of Patent:
September 3, 2002
Assignee:
Bristol-Myers Squibb Co.
Inventors:
David R. Kronenthal, Rajendra P. Deshpande
Abstract: Acylmercaptoalkanoylamino lactam esters or acids are converted to the corresponding mercaptoalkanoylamino lactam ester or acid under basic conditions by including an agent which minimizes the amount of disulfides. Suitable agents are bismercaptans, phosphine or phosphite reducing agents, zinc metal powder, and sodium hydrosulfite. Such agents are also employed in the recrystallization and reprocessing of the mercaptoalkanoylamino lactam acids.
Type:
Grant
Filed:
December 9, 1998
Date of Patent:
January 22, 2002
Assignee:
Bristol-Myers Squibb Co.
Inventors:
David R. Kronenthal, Theodor Denzel, Bang-Chi Chen, James H. Simpson, Rajendra P. Deshpande
Abstract: Compounds of the formulas:
are disclosed. These compounds inhibit tryptase as well as other enzyme systems or are selective tryptase inhibitors and are useful as antiinflammatory agents particularly in the treatment of chronic asthma.
Type:
Grant
Filed:
December 13, 1999
Date of Patent:
January 1, 2002
Assignee:
Bristol-Myers Squibb Co.
Inventors:
Gregory S. Bisacchi, William A. Slusarchyk, Uwe Treuner, James C. Sutton, Robert Zahler, Steven Seiler, David R. Kronenthal, Michael E. Randazzo, Mark D. Schwinden, Zhongmin Xu, Zhongping Shi
Abstract: The glycinamide of the formula
is reacted with the dioxolane of the formula
wherein L is a leaving group such as iodo, bromo, alkylsulfonyloxy, or arylsulfonyloxy to give the dioxolane of the formula
Treating the dioxolane of formula III under aqueous refluxing conditions followed by exchanging the dioxolane acetal with a dimethoxy acetal and introduction of the methyl ester gives (S)-2-amino-6,6-dimethoxyhexanoic acid, methyl ester which is an intermediate in the preparation of the dual inhibitor [4S-[4&agr;(R*),7&agr;,10a&bgr;]]-octahydro-4-[(2-mercapto-1-oxo-3-phenylpropyl)-amino]-5-oxo-7H-pyrido[2,1-b][1,3]thiazepine-7-carboxylic acid. Also disclosed are storage stable salts of (S)-2-amino-6, 6-dimethoxyhexanoic acid, methyl ester.
Type:
Grant
Filed:
October 12, 2000
Date of Patent:
December 11, 2001
Assignee:
Bristol-Myers Squibb Co.
Inventors:
Jollie D. Godfrey, Jr., David R. Kronenthal, Mark D. Schwinden, Sushil K. Srivastava, Keith Ramig, John J. Venit, Paul A. Jass, Saibaba Racha, John L. Dillon, Jr., Nachimuthu Soundararajan, Gerald L. Powers, Atul S. Kotnis
Abstract: The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin converting enzyme inhibition activity.
Type:
Grant
Filed:
August 31, 1999
Date of Patent:
July 17, 2001
Assignee:
Bristol-Myers Squibb Company
Inventors:
Ramesh N. Patel, Amit Banerjee, Venkata B. Nanduri, Laszlo J. Szarka, Shankar Swaminathan, John J. Venit, Jerome L. Moniot, David A. Lust, Sushil K. Srivastava
Abstract: A method is provided for preventing a cerebral infarction by administering to a patient a combination of an ADP-receptor blocking antiplatelet drug, such as clopidogrel, in combination with an antihypertensive agent such as an angiotensin AII antagonist (for example, irbesartan), an ACE inhibitor (for example, fosinopril) or a NEP/ACE inhibitor such as omapatrilat.
Abstract: The glycinamide of the formula
is reacted with the dioxolane of the formula
wherein L is a leaving group such as iodo, bromo, alkylsulfonyloxy, or arylsulfonyloxy to give the dioxolane of the formula
Treating the dioxolane of formula III under aqueous refluxing conditions followed by exchanging the dioxolane acetal with a dimethoxy acetal and introduction of the methyl ester gives (S)-2-amino-6,6-dimethoxyhexanoic acid, methyl ester which is an intermediate in the preparation of the dual inhibitor [4S-[4&agr;(R*),7&agr;, 10a&bgr;]]-)octahydro-4-[(2-mercapto-1-oxo-3-phenylpropy)-amino]-5-oxo-7H-pyrido[2,1-b][1,3]thiazepine-7-carboxylic acid. Also disclosed are storage stable salts of (S)-2-amino-6,6-dimethoxyhexanoic acid, methyl ester.
Type:
Grant
Filed:
October 12, 2000
Date of Patent:
June 19, 2001
Assignee:
Bristol-Myers Squibb Co.
Inventors:
Jollie D. Godfrey, Jr., David R. Kronenthal, Mark D. Schwinden, Sushil K. Srivastava, Keith Ramig, John J. Venit, Paul A. Jass, Saibaba Racha, John L. Dillon, Jr., Nachimuthu Soundararajan, Gerald L. Powers, Atul S. Kotnis
Abstract: Compounds having the following formula I, and pharmaceutically acceptable salts thereof, including dual inhibitors of ACE and NEP and selective ACE inhibitors:
wherein:
Y1 and Y2 are each independently hydrogen, alkyl, aryl, halogen, or alkoxy;
X is O or S(O)t;
A is
t is zero, one or two;
m and n are independently zero or one;
and wherein R, R5, R5a, R5b, R6, R7, R11, q and r are defined herein.
Abstract: The glycinamide of the formula (I) ##STR1## is reacted with the dioxolane of the formula (II) ##STR2## wherein L is a leaving group such as iodo, bromo, alkylsulfonyloxy, or arylsulfonyloxy to give the dioxolane of the formula (III) ##STR3## Treatment of (III) gives the dioxolane pentanoic acid IV ##STR4## which can be converted to (S)-2-amino-6,6-dimethoxyhexanoic acid, methyl ester.
Type:
Grant
Filed:
July 8, 1999
Date of Patent:
December 26, 2000
Assignee:
Bristol-Myers Squibb Co.
Inventors:
Jollie D. Godfrey, Jr., David R. Kronenthal, Mark D. Schwinden
Abstract: N-protected-L-homocysteine disulfide of the formula ##STR1## or an activated form thereof is reacted with (S)-2-amino-6,6-dimethoxyhexanoic acid, methyl ester to give the disulfide intermediate of the formula ##STR2## Cleavage of the disulfide bond followed by acid catalyzed cyclization produces the N-protected lactam of formula III which is useful for preparing the pharmaceutically active compound omapatrilat.
Type:
Grant
Filed:
July 8, 1999
Date of Patent:
December 19, 2000
Assignee:
Bristol-Myers Squibb Co.
Inventors:
Jerome L. Moniot, Sushil K. Srivastava, William J. Winter, John J. Venit, Shankar Swaminathan, Keith Ramig, Paul A. Jass, Mark D. Schwinden, John L. Dillon, Jr., Saibaba Racha, James Simpson, Chien-Kuang Chen, Shawn K. Pack
Abstract: Vasopeptidaes inhibitors, especially omapatrilat, are useful in treating and/or relieving the symptoms of angina pectoris. The vasopeptidase inhibitor may be used in combination with other pharmaceutically active agents.
Abstract: Novel quinazolinone compounds, methods of using such compounds in the treatment of cGMP-associated conditions such as erectile dysfunction, and pharmaceutical compositions containing such compounds.
Type:
Grant
Filed:
May 28, 1999
Date of Patent:
July 11, 2000
Assignee:
Bristol-Myers Squibb Company
Inventors:
John E. Macor, David P. Rotella, Harold N. Weller, III, David W. Cushman, Joseph P. Yevich