Patents Represented by Attorney Stephen B. Davis

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  • Diol sulfonamide and sulfinyl renin inhibitors
    Patent number: 5545838
    Abstract: Compounds of the formula ##STR1## wherein Z is SO or SO.sub.2 possess renin inhibition activity and are useful in treating hypertension and other diseases where the reduction of the levels of circulating angiotensin II are beneficial.
    Type: Grant
    Filed: January 27, 1992
    Date of Patent: August 13, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Michael A. Poss
  • Process for the preparation of an antiviral agent
    Patent number: 5525726
    Abstract: Racemic Feist's acid is treated with (R)-(+) -.alpha.-methylbenzylamine to yield (1R-trans)-3-methylene -cyclopropane-1,2-dicarboxylic acid, (R)-.alpha.-methylbenzyl-amine (1:1) salt. This salt can then be converted to (1R-trans)-3-methylene-1,2-cyclopropanedicarboxylic acid, dimethyl ester which is an intermediate in the preparation of the antiviral agent [1R-(1.alpha.,2.beta.,3.alpha.)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobut yl]-1,9-dihydro-6H-purin-6-one. The improved process also enables the recovery of racemic Feist's acid from the resolution.
    Type: Grant
    Filed: November 12, 1993
    Date of Patent: June 11, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jollie D. Godfrey, Jr., Richard H. Mueller, Thomas P. Kissick, Janak Singh
  • Compounds containing a fused multiple ring lactam
    Patent number: 5525723
    Abstract: Compounds of the formula ##STR1## wherein A is ##STR2## are useful as ACE and NEP inhibitors and those wherein A is ##STR3## are useful as ACE inhibitors. Methods of preparation and intermediates are also disclosed.
    Type: Grant
    Filed: November 18, 1993
    Date of Patent: June 11, 1996
    Assignee: Bristol-Myers Squibb Co.
    Inventor: Jeffrey A. Robl
  • Process for preparing [IR-(1.alpha.,2.beta.-3.alpha.)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclob utyl]-1,9-dihydro-6H-purin-6-one
    Patent number: 5516903
    Abstract: The protected cyclobutanone of the formula ##STR1## is treated with a dialkylaluminum chloride, an alkylaluminum dichloride, a trialkylaluminum compound, hydrogen in the presence of the catalysts ruthenium black or ruthenium on alumina, diphenyl-silane in the presence of tris(triphenylphosphine) rhodium (I) chloride, or iridium tetrachloride to yield the corresponding diprotected cyclobutanol. This compound is useful as an intermediate in the preparation of antiviral agents.
    Type: Grant
    Filed: November 4, 1994
    Date of Patent: May 14, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Janak Singh, Gregory S. Bisacchi, Richard H. Mueller
  • Compounds containing a fused bicycle ring and processes therefor
    Patent number: 5508272
    Abstract: Compounds of the formula ##STR1## wherein X is O or S--(O).sub.t ; n is one or two; m is zero or one; Y is CH.sub.2, O, or S--(O).sub.t provided that Y is O or S--(O).sub.t only when m is one; and A is ##STR2## are dual inhibitors of NEP and ACE. Compounds wherein A is ##STR3## are selective ACE inhibitors. Also disclosed are methods of preparation and intermediates.
    Type: Grant
    Filed: May 5, 1994
    Date of Patent: April 16, 1996
    Assignee: Bristol-Myers Squibb Company
    Inventor: Jeffrey A. Robl
  • Benzo-fused lactams
    Patent number: 5504080
    Abstract: Compounds of the formula ##STR1## wherein A is ##STR2## are useful as ACE and NEP inhibitors and those wherein A is ##STR3## are useful as ACE inhibitors. Methods of preparation and intermediates are also disclosed.
    Type: Grant
    Filed: September 22, 1993
    Date of Patent: April 2, 1996
    Assignee: Bristol-Myers Squibb Co.
    Inventor: Donald S. Karanewsky
  • Inhibitors of neutral endopeptidase
    Patent number: 5496805
    Abstract: Diuresis, natriuresis, and the lowering of blood pressure are produced in a host by administering one or more neutral endopeptidase inhibitors. An additional blood pressure lowering agent such as an angiotensin converting enzyme inhibitor can be administered along with the neutral endopeptidase inhibitor.
    Type: Grant
    Filed: July 12, 1990
    Date of Patent: March 5, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Norma G. Delaney, Eric M. Gordon, Jack M. DeForrest, David W. Cushman
  • Retrocarbamate protease inhibitors
    Patent number: 5492910
    Abstract: The invention discloses compounds of the formula ##STR1## are disclosed as HIV protease inhibitors.
    Type: Grant
    Filed: November 17, 1994
    Date of Patent: February 20, 1996
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Joel C. Barrish, Steven H. Spergel
  • Trifluoromethyl mercaptan and mercaptoacyl derivatives and method of using same
    Patent number: 5414017
    Abstract: Compounds of the formula ##STR1## wherein m is zero or 1; n is zero, 1 or 2; p is zero or 1 to 6 provided that m and p are not both zero; R.sub.3 is hydrogen, acyl, or benzyl; and R.sub.1 is hydrogen, alkyl, phenyl, substituted phenyl, phenyl-alkylene, heterocyclic-alkylene, etc. These compounds are useful as cardiovascular agents.
    Type: Grant
    Filed: March 26, 1993
    Date of Patent: May 9, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Norma G. Delaney, George C. Rovnyak, Melanie J. Loots
  • Antiviral tetrahydropyrans
    Patent number: 5414096
    Type: Grant
    Filed: February 22, 1994
    Date of Patent: May 9, 1995
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Joseph A. Tino, Gregory S. Bisacchi, Saleem Ahmad
  • Trifluoromethyl mercaptan and mercaptoacyl derivatives and method of using same
    Patent number: 5414013
    Abstract: Compounds of the formula ##STR1## wherein Z is ##STR2## proline, pipecolic acid, an indolecarboxylic acid or an isoquinolinecarboxylic acid. These compounds are useful as cardiovascular agents.
    Type: Grant
    Filed: March 26, 1993
    Date of Patent: May 9, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Norma G. Delaney, George C. Rovnyak, Melanie J. Loots
  • Antiviral pyrinyl substituted tetrahydropyrans
    Patent number: 5414000
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is a substituted purinyl group including pharmaceutically acceptable salts are useful as antiviral agents.
    Type: Grant
    Filed: February 22, 1994
    Date of Patent: May 9, 1995
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Joseph A. Tino, Gregory S. Bisacchi, Saleem Ahmad
  • Process for preparing diprotected 2,3-hydroxymethyl cyclobutanol
    Patent number: 5412134
    Abstract: The protected cyclobutanone of the formula ##STR1## is treated with a dialkylaluminum chloride, an alkylaluminum dichloride, a trialkylaluminum compound, diphenylsilane in the presence of tris(triphenylphosphine) rhodium (I) chloride, or iridium tetrachloride to yield the corresponding diprotected cyclobutanol. This compound is useful as an intermediate in the preparation of antiviral agents.
    Type: Grant
    Filed: May 26, 1992
    Date of Patent: May 2, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Janak Singh, Gregory S. Bisacchi, Richard H. Mueller
  • Process for preparing substituted cyclobutanes
    Patent number: 5399775
    Abstract: The present invention relates to a process for the preparation of substituted cyclobutanes and their use as intermediates for the preparation of anti-viral nucleoside analogs.
    Type: Grant
    Filed: June 14, 1993
    Date of Patent: March 21, 1995
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Richard J. Pariza, Steven M. Hannick, Thomas J. Sowin, Elizabeth M. Doherty
  • Hydroxymethyl cyclobutyl purines
    Patent number: 5369098
    Abstract: Antiviral activity is exhibited by compounds having the formula ##STR1## and their pharmaceutically acceptable salts. R.sub.1 is ##STR2## R.sub.2 is hydrogen, --PO.sub.3 H.sub.2, ##STR3## wherein R.sub.3 is hydrogen, alkyl, substituted alkyl, or aryl, and R.sub.4 is alkyl.
    Type: Grant
    Filed: June 16, 1989
    Date of Patent: November 29, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: William A. Slusarchyk
  • Substituted azepino[2,1-a]isoquinoline compounds
    Patent number: 5362727
    Abstract: Compounds of the formula ##STR1## wherein A is ##STR2## are dual inhibitors of NEP and ACE. Compounds wherein A is ##STR3## are selective as ACE inhibitors. Methods of preparation and intermediates are also disclosed.
    Type: Grant
    Filed: July 26, 1993
    Date of Patent: November 8, 1994
    Assignee: Bristol-Myers Squibb
    Inventor: Jeffrey A. Robl
  • Intermediates in the synthesis of an optically active cyclobutane nucleoside
    Patent number: 5344962
    Abstract: Cyclobutane intermediates wherein the absolute stereochemistry is (1S,2R) of the formula ##STR1## are disclosed. These intermediates are useful in the preparation of compounds having anti-viral activity.
    Type: Grant
    Filed: May 10, 1993
    Date of Patent: September 6, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Saleem Ahmad
  • Hydroxymethyl(methylenecyclopentyl) purines and pyrimidines
    Patent number: 5340816
    Abstract: Antiviral activity is exhibited by compounds having the formula ##STR1## and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: January 15, 1993
    Date of Patent: August 23, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Robert Zahler, William A. Slusarchyk
  • Antiviral tetrahydropyrans
    Patent number: 5314893
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is an amino substituted pyrimidinone or a pyrimidinedione including pharmaceutically acceptable salts are useful as antiviral agents.
    Type: Grant
    Filed: January 25, 1993
    Date of Patent: May 24, 1994
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Joseph A. Tino, Gregory S. Bisacchi, Saleem Ahmad
  • Process for preparing substituted cyclobutanes
    Patent number: 5312963
    Abstract: The present invention relates to a process for the preparation of substituted cyclobutanes and their use as intermediates for the preparation of anti-viral nucleoside analogs.
    Type: Grant
    Filed: June 14, 1993
    Date of Patent: May 17, 1994
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Richard J. Pariza, Steven M. Hannick, Thomas J. Sowin, Elizabeth M. Doherty