Patents Represented by Attorney Stephen B. Davis

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  • Process for preparing guanine-containing antiviral agents and purinyl salts useful in such process
    Patent number: 5874578
    Abstract: A purine salt of the formula ##STR1## wherein Y.sub.1 is chloro, bromo, or iodo, and R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are independently selected from alkyl and substituted alkyl is reacted with the compound of the formulaZ.sub.1 --Xto yield the purine of the formula ##STR2## wherein x is a leaving group, and Z.sub.1 is a protected form of the carbohydrate surrogate Z.
    Type: Grant
    Filed: January 25, 1993
    Date of Patent: February 23, 1999
    Assignee: Bristol-Myers Squibb
    Inventors: Janak Singh, Gregory S. Bisacchi, Jollie D. Godfrey, Jr., Toomas Mitt, Richard H. Mueller, Robert Zahler, Thomas P. Kissick
  • Mercaptoalkanoylamino and acylmercaptoalkanoylamino benzoxazepines and benzothiazepines
    Patent number: 5859239
    Abstract: Compounds of the formula ##STR1## wherein X.sub.1 is ##STR2## are disclosed. These compounds possess inhibitory activity against angiotensin converting enzyme and neutral endopeptidase and thus useful as cardiovascular agents.
    Type: Grant
    Filed: September 30, 1997
    Date of Patent: January 12, 1999
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Donald S. Karanewsky, Jeffrey A. Robl
  • Antiviral peptides
    Patent number: 5859187
    Abstract: Inhibition of UL42 stimulation of herpesvirus DNA polymerase activity is exhibited by novel compounds of the formulasW'--A.sub.1 --A.sub.2 --A.sub.3 --A.sub.4 --A.sub.5 --A.sub.6 --A.sub.7 --A.sub.8 --A.sub.9 --A.sub.10 --A.sub.11 --X ?SEQ. ID NO: 1!andY'--A.sub.12 --A.sub.13 --A.sub.14 --A.sub.15 --A.sub.16 --A.sub.17 --Z ?SEQ. ID NO: 2!that are useful as antiviral agents.
    Type: Grant
    Filed: January 29, 1992
    Date of Patent: January 12, 1999
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: James T. Matthews, Katerina Leftheris, Robert K. Hamatake, John T. Stevens, Mary L. Haffey
  • Azepinones useful as intermediates in the preparation of inhibitors of angiotensin converting enzyme and neutralendopeptidase
    Patent number: 5856477
    Abstract: The azepine intermediates of the formula ##STR1## wherein R.sub.6 and R.sub.7 are other than hydrogen are disclosed. These intermediates can be reacted with acylmercaptocarboxylic acids of the formula ##STR2## to give the pharmaceutically active products.
    Type: Grant
    Filed: July 30, 1996
    Date of Patent: January 5, 1999
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Jeffrey A. Robl
  • Processes for preparing azepiones useful as intermediates in the preparation of inhibitors of angiotensin converting enzyme and neutral endopeptidase
    Patent number: 5856476
    Abstract: Processes are disclosed for preparing the azepine intermediates of the formula ##STR1## These intermediates can be reacted with acylmercaptocarboxylic acids of the formula ##STR2## to give the pharmaceutically active products.
    Type: Grant
    Filed: October 8, 1997
    Date of Patent: January 5, 1999
    Assignee: E. R. Squibbs & Sons, Inc.
    Inventor: Jeffrey A. Robl
  • Process for the preparation of an antiviral agent
    Patent number: 5773614
    Abstract: (1R,trans) Diprotected 3-methylene-1,2-cyclopropanedimethanol is oxidized to an optically active diol ##STR1## which is then cyclized to an orthoester ##STR2## This orthoester is then treated with a Lewis acid catalyst to give the cyclobutanone ##STR3## which is useful as an intermediate in the preparation of the antiviral agent ?1R-(1.alpha.,2.beta.,3.alpha.)!-2-amino-9-?2,3-bis(hydroxymethyl)cyclobut yl!-1,9-dihydro-6H-purin-6-one.
    Type: Grant
    Filed: September 13, 1996
    Date of Patent: June 30, 1998
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Jollie D. Godfrey, Jr., Richard H. Mueller
  • Process for preparing amino acid esters useful as intermediates for compounds containing a fused bicyclic ring
    Patent number: 5756832
    Abstract: Amino acid esters of the formula ##STR1## wherein m is zero or one and R.sub.3 is an acid protecting group are prepared. These amino acid esters are useful as intermediates in the preparation of fused bicyclic ring compounds.
    Type: Grant
    Filed: May 9, 1997
    Date of Patent: May 26, 1998
    Assignee: Bristol-Myers Squibb Co.
    Inventor: Jeffrey A. Robl
  • Acylmercaptoalkanoylamino and mercaptoalkanoylamino benzazepines
    Patent number: 5723457
    Abstract: Compounds of the formula ##STR1## wherein X.sub.1 is ##STR2## are disclosed. These compounds possess inhibitory activity against angiotensin converting enzyme and neutral endopeptidase and thus are useful as cardiovascular agents.
    Type: Grant
    Filed: July 8, 1996
    Date of Patent: March 3, 1998
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Donald S. Karanewsky, Jeffrey A. Robl
  • Dual action inhibitors containing a pyridazinodiazepine or pyrazolodiazepine lactam ring
    Patent number: 5723602
    Abstract: Compounds of the formula ##STR1## wherein X.sub.1 is ##STR2## are disclosed. These compounds possess inhibitory activity against angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP) and are thus useful as cardiovascular agents.
    Type: Grant
    Filed: April 17, 1995
    Date of Patent: March 3, 1998
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Donald S. Karanewsky, Jeffrey A. Robl
  • Bis (hydroxymethyl) cyclobutyl purines
    Patent number: 5723609
    Abstract: Antiviral activity is exhibited by compounds having the formula ##STR1## and its pharmaceutically acceptable salts wherein R.sub.1 is ##STR2## wherein R.sub.2 is hydrogen, methyl, fluoro, chloro, bromo, iodo, hydroxy or amino; or trifluoromethyl; R.sub.5 is alkyl; R.sub.6 is hydrogen, alkyl, substituted alkyl, or aryl; and R.sub.7 and R.sub.
    Type: Grant
    Filed: March 13, 1989
    Date of Patent: March 3, 1998
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: William A. Slusarchyk, Robert Zahler
  • Compounds containing a fused bicycle ring
    Patent number: 5672599
    Abstract: Compounds of the formula ##STR1## wherein X is O or S--(O).sub.t ; n is one; m is zero or one; Y is CH.sub.2, O, or S--(O).sub.t provided that Y is O or S--(O).sub.t only when m is one; and A is ##STR2## are dual inhibitors of NEP and ACE. Compounds wherein A is ##STR3## are selective ACE inhibitors. Also disclosed are methods of preparation and intermediates.
    Type: Grant
    Filed: November 22, 1995
    Date of Patent: September 30, 1997
    Assignee: Bristol-Myers Squibb Co.
    Inventor: Jeffrey A. Robl
  • Process for preparing amino acid esters useful as intermediates for compounds containing a fused bicyclic ring
    Patent number: 5670699
    Abstract: Amino acid esters of the formulas ##STR1## wherein m is zero or one and R.sub.3 is an acid protecting group are prepared. These amino acid esters are useful as intermediates in the preparation of fused bicyclic ring compounds.
    Type: Grant
    Filed: January 17, 1996
    Date of Patent: September 23, 1997
    Assignee: Bristol-Myers Squibb Co.
    Inventor: Jeffrey A. Robl
  • Spiro lactam dual action inhibitors
    Patent number: 5654294
    Abstract: Compounds of the formula ##STR1## are disclosed as possessing inhibotory activity against angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP) and thus being useful as cardiovascular agents. Processes for preparing these compounds are also disclosed.
    Type: Grant
    Filed: June 19, 1996
    Date of Patent: August 5, 1997
    Assignee: Bristol-Myers Squibb
    Inventor: Jeffrey A. Robl
  • Diazepine containing dual action inhibitors
    Patent number: 5646276
    Abstract: Compounds of the formula ##STR1## wherein X.sub.1 is ##STR2## are disclosed as possessing inhibotory activity against angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP) and thus being useful as cardiovascular agents.
    Type: Grant
    Filed: June 19, 1996
    Date of Patent: July 8, 1997
    Assignee: Bristol-Myers Squibb Co.
    Inventor: Jeffrey A. Robl
  • Fused multiple ring lactams
    Patent number: 5637698
    Abstract: Compounds of the formula ##STR1## are useful as intermediates in the preparation of compounds possessing ACE and NEP inhibition activity.
    Type: Grant
    Filed: February 26, 1996
    Date of Patent: June 10, 1997
    Assignee: Bristol-Myers Squibb Co.
    Inventor: Jeffrey A. Robl
  • Diazepine containing dual action inhibitors
    Patent number: 5635504
    Abstract: Compounds of the formula ##STR1## wherein: ##STR2## A is are dual inhibitors of NEP and ACE. Compounds wherein A is ##STR3## are selective ACE inhibitors.
    Type: Grant
    Filed: March 1, 1996
    Date of Patent: June 3, 1997
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Denis E. Ryono, Chong-Oing Sun
  • Process for preparing compounds containing a fused bicyclic ring
    Patent number: 5627278
    Abstract: A process for preparing compounds of the formula ##STR1## wherein X is O or S; n is one or two; m is zero or one; Y is CH.sub.2, O, or S provided that Y is O or S only when m is one; and A is ##STR2## is disclosed. Also disclosed are processes for preparing the corresponding amino intermediates.
    Type: Grant
    Filed: January 4, 1996
    Date of Patent: May 6, 1997
    Assignee: Bristol-Myers Squibb Co.
    Inventor: Jeffrey A. Robl
  • Process for preparing homocystein analogs useful as intermediates for compounds containing a fused bicyclic ring
    Patent number: 5616775
    Abstract: Homocysteine analogs of the formula ##STR1## wherein P.sub.1 is a nitrogen protecting group and R.sub.6 is alkyl, substituted alkyl or benzyl are prepared by esterifying N-protected L-methionine, oxidizing, treating the resulting sulfoxide with an acid anhydride, treating the resulting product with an alkali metal hydroxide followed by removal of formaldehyde and the treatment with an acid anhydride or acid halide. The L-homocysteine analogs are useful as intermediates in the preparation of compounds containing a fused bicyclic ring.
    Type: Grant
    Filed: February 5, 1996
    Date of Patent: April 1, 1997
    Assignee: Bristol-Myers Squibb Co.
    Inventors: David R. Kronenthal, Jollie D. Godfrey, Jr.
  • Purinyl salts useful for preparing guanine containing antiviral agents
    Patent number: 5608064
    Abstract: A purine salt of the formula ##STR1## wherein Y.sub.1 is chloro, bromo, or iodo, and R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are independently selected from alkyl and substituted alkyl.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: March 4, 1997
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Janak Singh, Gregory S. Bisacchi, Jollie D. Godfrey, Jr., Toomas Mitt, Richard H. Mueller, Robert Zahler, Thomas P. Kissick
  • Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
    Patent number: 5552397
    Abstract: Compounds of the formula ##STR1## are disclosed as possessing inhibitory activity against angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP) and thus being useful as cardiovascular agents. Processes for preparing these compounds are also disclosed.
    Type: Grant
    Filed: December 1, 1993
    Date of Patent: September 3, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Donald S. Karanewsky, Jeffrey A. Robl