Abstract: Trypsin (trypsinogen) may be produced in a filamentous fungus by transforming a filamentous fungus with a vector comprising a DNA sequence encoding protrypsin or a derivative thereof N-terminally fused to a DNA sequence encoding a signal peptide, culturing the transformed filamentous fungus in a suitable culture medium to produce trypsinogen and recovering trypsinogen and/or trypsin from the medium.

Abstract: The present invention relates to a method of treating a disease in the central nervous system via the metabotropic glutamate receptor system, the use of the known as well as novel pyridino(2,3-b) indoles (formula Ib) for the preparation of a medicament for treating said diseases, novel therapeutic active pyridino(2,3-b) indoles, a method for preparing the same and pharmaceutical compositions comprising these compounds.

Abstract: DNA sequences encoding lipases and method for producing the lipases. The disclosed lipases are industrially useful in, for example, detergents, food processing, paper making, oil manufacturing.

Abstract: The present invention relates to a gene encoding an ascomycete or deuteromycete carboxypeptidase Y gene, and host cells modified so as to produce reduced amounts of carboxypeptidase.

Abstract: The present invention relates to a pharmaceutical composition for the prevention or treatment of diseases or conditions involving stress injury to cells, the composition comprising(a) a lipid-containing substance having a lipid portion which is structurally identical with or analogous to a ceramide, conjugated to(b) a protein capable of binding said lipid-containing substance in such a way that, when the conjugate is contacted with living cells, the lipid-containing substance activates a ceramide-activated protein phosphatase resulting in down-regulation of cellular metabolism, and(c) a pharmaceutically acceptable diluent or carrier.

Abstract: The present invention relates to therapeutically active azacyclic and azabicyclic compounds, to methods for their preparation and to pharmaceutical compositions comprising the compounds. These compounds are useful in treating diseases in the central nervous system related to malfunctioning of the nicotinic cholinergic system.

Abstract: The present invention relates xylose isomerases obtainable from strains of Thermotoga. More specifically the invention provides DNA sequences encoding xylose isomerases, expression vectors and host cells comprising the DNA sequences of the invention, and methods of producing xylose isomerases. The invention also provides isolated xylose isomerases free from homologous impurities and obtained by the method of the invention.

Abstract: Therapeutically effective amounts of a 3,4-diarylchroman can be administered transdermally by incorporation of the 3,4-diarylchroman in a matrix or liquid reservoir patch suitable for transdermal delivery, which matrix or liquid reservoir patch optionally contains hydrophobic and/or hydrophilic vehicle(s).

Abstract: A lipolytic enzyme with high activity at alkaline pH in the absence of Ca.sup.++ can be obtained from strains of filamentous fungi belonging to the genus Absidia. The lipolytic enzymes are effective for improving the effect of detergents towards fatty soiling.

Abstract: A process for simultaneously desizing and bleaching of a sized fabric containing starch or starch derivatives, which process comprises treating the fabric with a bleaching composition and an oxidation stable .alpha.-amylase.

Abstract: The present invention relates to a drug delivery device wherein a dose to be apportioned from a cartridge is set by changing the relative position of co-operating dose setting elements (3, 5) and is injected by pressing a button (5) until this button abuts a stop (6). By operation of count up (7) or count down (8) buttons the dose is set and read into an electronic circuit (9) comprising a microprocessor and the dose setting movement of the dose setting elements relative to each other is performed by a motor (11) controlled by the circuit in accordance with the read in dose. The set dose is shown on a display (10). The motor (11) is further controlled to perform certain movements of the piston rod (3) so as retraction of this rod when a cartridge (1) is going to be changed an advancing of the piston rod to abutment with the piston (2) after the cartridge has been changed and further to advance this piston to expel air from the cartridge.

Abstract: This invention is in the field of detergent proteases obtainable from strains of a new Bacillus sp. I 612. Moreover, the invention is directed towards a process for the preparation of the protease, the use of the protease as a detergent enzyme, and detergent compositions comprising the protease of the invention.

Abstract: A method of treating fabrics, garments, or yarns comprising treating undyed fabric, garment, or yarn in an aqueous medium with an effective amount of a haloperoxidase, a halide source, and a hydrogen peroxide source. The treated fabric, garment, or yarn exhibits improved characteristics relative to untreated fabric, garment, or yarn, such as improved shrink-resistance.

Abstract: The present invention relates to methods of overdyeing a warp dyed denim textile, comprising treating the textile in an aqueous dye liquor with a dye system which comprises an effective amount of (a) one or more mono-, di- or polycyclic aromatic or heteroaromatic compounds and (b) (i) a hydrogen peroxide source and at least one enzyme exhibiting peroxidase activity and/or (ii) at least one enzyme exhibiting oxidase activity on the one or more aromatic or heteroaromatic compounds.

Abstract: Disclosed is a process for preparing (-)-3,4-trans-diarylchromans of formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined in the specification. This process involves reacting a (+,-)-3,4-cis-diarylchroman with a chiral acid in an inert organic solvent to obtain the chiral acid salt of the (-)-3,4-cis enantiomer in crystalline form, subjecting the crystalline salt to hydrolysis, and rearranging the (-)-3,4-cis enantiomer to the (-)-3,4-trans enantiomer with a strong base in an inert aprotic solvent.

Abstract: The present invention relates to laccase mutants with improved stability properties, in particular to Myceliophthora and Scytalidium laccase variants.

Abstract: A method of amplifying in vivo a DNA sequence B present in a genome of a parent cell, comprising (a) integrating in a genome of said cell a DNA construct comprising the structure C-M-A-D, in which both A and C denote a DNA sequence which is homologous with a genomic DNA fragment either flanking or overlapping the DNA sequence B, the sequence C being located in the opposite end the sequence B as compared to A, D denotes a DNA sequence which is homologous with a genomic DNA fragment located distal for C as compared to B, and M denotes a DNA sequence encoding a selection marker, (b) selecting for cells in which the DNA sequence M has been integrated in the genome, which cells comprise, in any orientation, the structure A-B-C-M-A-D and (c) propagating the cells selected in step (b) under increasing selection pressure to obtain a cell which has obtained an increased number of genomically integrated copies of the DNA sequences B and M.

Abstract: An isolated nucleic acid constructs encoding cellulytic enzymes derived from a strain of Bacillus agaradherens, recombinant vectors and host cells comprising such constructs, and methods for obtaining cellulytic enzymes.

Abstract: The present invention relates to a nucleic acid construct containing a nucleic acid sequence encoding an element of a filamentous fungal signal recognition particle.

Abstract: Novel peptide derivatives, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone are disclosed. The peptides have the formula (I): ##STR1## wherein a, b, A, R.sup.1, L.sup.1, D, R.sup.3, R.sup.4, R.sup.2, L.sup.2, E and G are as defined in the specification. These peptides exhibit improved resistance to proteolytic degradation, and hence, improved bioavailability.