Patents Represented by Attorney, Agent or Law Firm Steve T. Zelson
  • Patent number: 5912262
    Abstract: The present invention relates to novel N-substituted amino alcohols, amino acids and acid derivatives thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
    Type: Grant
    Filed: October 24, 1997
    Date of Patent: June 15, 1999
    Assignee: Novo Nordish A/S
    Inventors: Rolf Hohlweg, Tine Krogh J.o slashed.rgensen, Knud Erik Andersen, Uffe Bang Olsen, Peter Madsen, Zdenek Polivka, Otylie Konigova, Frantisek Miksik, Martina Kovandova, Alexandra Silhankova, Karel Sindelar
  • Patent number: 5912405
    Abstract: The invention is directed to a method of bleaching dye or colorant in solution which comprises a phenol oxidizing enzyme (e.g. A peroxidase or a laccase) and an enhancing agent (e.g. acetosyringone).
    Type: Grant
    Filed: February 20, 1997
    Date of Patent: June 15, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Palle Schneider, Ture Damhus
  • Patent number: 5912407
    Abstract: The invention relates to a process for treatment of cellulosic material, as for example, knitted or woven cotton fabric, comprising the steps of preparing an aqueous enzyme solution comprising pectinase, treating the cellulosic material with an effective amount of the aqueous enzyme solution under alkaline scouring conditions; e.g., pH of 9 or above and a temperature of 50.degree. C. or above, in a low calcium or calcium-free environment, yielding a modification of the cellulosic material such that exhibits an enhanced respond to a subsequent chemical treatment.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: June 15, 1999
    Assignee: Novo Nordisk Biochem North America, Inc.
    Inventors: Carl Andrew Miller, Steen Skjold Jorgensen, Eric W. Otto, Niels K. Lange, Brian Condon, Jiyin Liu
  • Patent number: 5912229
    Abstract: The present invention relates to appetite-suppressing peptides or an appetite-suppressing peptide-containing fraction for the treatment of obesity or type II diabetes.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: June 15, 1999
    Assignee: Novo Nordisk Als
    Inventors: Lars Thim, Birgitte Schjellerup Wulff, Martin Edward Judge, Ole Dragsbaek Madsen, Jens Juul Holst
  • Patent number: 5912157
    Abstract: The present invention relates to cellulases derived from the strain Myceliophthora thermophila and variants thereof comprising a core and optionally a C-terminal link consisting of 10 amino acids at the most, especially cellulases having a substrate binding cleft of a depth of at least 12 .ANG., exhibit enhanced enzyme activity in the alkaline pH range while exerting a moderate cellulolytic action on the cellulosic substrate and are, for example, useful in detergent compositions, especially for soil removal or color clarification or preventing backstaining; in fabric softeners; for bio-polishing of textiles; for drainage improvement of paper pulp; for deinking of old paper; for plant degradation.
    Type: Grant
    Filed: September 9, 1996
    Date of Patent: June 15, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Claus von der Osten, Martin Schulein
  • Patent number: 5908472
    Abstract: The present invention relates to a process for providing an abraded look with a reduced strength loss in dyed fabric comprising (a) contacting, in an aqueous medium, a dyed fabric with a cellulase in a concentration corresponding to 0.01-250 .mu.g of enzyme protein per g of fabric; and (b) simultaneously or subsequently treating the fabric with a phenol oxidizing enzyme and an enhancing agent.
    Type: Grant
    Filed: May 14, 1998
    Date of Patent: June 1, 1999
    Assignee: Novo Nordisk A/S
    Inventor: Thomas Vollmond
  • Patent number: 5906398
    Abstract: In a joint for joining a first and a second part so that these first and second parts maintain a predefined rotational position in relation to each other, where the joint comprises an internal thread (33) in the firs part (34), which internal thread has an inner end and an outer free end receiving an outer free end of a corresponding external thread (22) on the second part (21) which external thread has an inner end adjacent to the second part, the free end of the ridge and the inner end of the groove forming the threads are bounded by surfaces (27, 39) lying in a plane through the axis of the threads, and the length of the threads are so adapted that a plane end surface of the ridge of one thread engages the plane end surface of the groove of the other thread when the two parts are screwed together and occupy the predefined mutual rotational position.
    Type: Grant
    Filed: June 23, 1997
    Date of Patent: May 25, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Andre Larsen, S.o slashed.ren Mikkelsen
  • Patent number: 5905140
    Abstract: A method of selectively acylating an insulin, an insulin analogue or a precursor thereof having a free .epsilon.-amino group of a Lys residue contained therein and at least one free .alpha.-amino group which method comprises reacting the .epsilon.-amino group with an activated amide in a polar solvent in the presence of a base.
    Type: Grant
    Filed: July 8, 1997
    Date of Patent: May 18, 1999
    Assignee: Novo Nordisk A/S, Novo Alle
    Inventor: Louis Brammer Hansen
  • Patent number: 5899212
    Abstract: The present invention relates to a method for re-forming keratinous fibre cross links comprising contacting at least one oxidoreductase with the keratinous fibres for a sufficient period of time and under conditions sufficient to permit re-formation of keratinous fibre cross links. The method may be performed simultaneously with dyeing of said keratinous fibres. The invention also relates to the use at least one oxidoreductase for re-formation of keratinous fibre cross links.
    Type: Grant
    Filed: May 7, 1998
    Date of Patent: May 4, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Niels Henrik S.o slashed.rensen, Jason Patrick McDevitt
  • Patent number: 5898067
    Abstract: A method of providing zinc containing crystals of a protein derivative which has a lysine residue which carries a lipophilic substituent on the .epsilon.-amino group, said method comprising providing a solution of the protein derivative in an alkaline buffer, which further contains a zinc salt, adjusting the pH value of the solution to a value between 7 and 10, and isolating the crystals formed.
    Type: Grant
    Filed: February 2, 1998
    Date of Patent: April 27, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Per Balschmidt, Jean Lesley Whittingham
  • Patent number: 5898028
    Abstract: A therapeutic powder formulation suitable for pulmonary administration comprising particles composed of human insulin or any analogue or derivative thereof and an enhancer which enhances the absorption of insulin in the lower respiratory tract, wherein at least 50% by weight of the particles are crystalline.
    Type: Grant
    Filed: March 20, 1998
    Date of Patent: April 27, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Steen Jensen, Philip Hansen
  • Patent number: 5892013
    Abstract: The present invention relates to lipase variants which exhibit improved properties, detergent compositions comprising said lipase variants, DNA constructs coding for said lipase variants, and methods of making said lipase variants.
    Type: Grant
    Filed: September 5, 1995
    Date of Patent: April 6, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Allan Svendsen, Shamkant Anant Patkar, Erik Gormsen, Ib Groth Clausen, Jens Sigurd Okkels, Marianne Thellersen
  • Patent number: 5891669
    Abstract: The present invention relates to methods of producing a polypeptide, comprising: (a) introducing into a respiratory-defective mutant of a cell (i) one or more first nucleic acid sequences which complement the respiratory defect and (ii) a second nucleic acid sequence which encodes the polypeptide; (b) cultivating the cell containing the first and second nucleic acid sequences in a culture medium under aerobic conditions suitable for expression of the first and second nucleic acid sequences; and (c) isolating the polypeptide from the cultivation medium of the cell. The present invention also relates to methods for disrupting a gene in a respiratory-deficient mutant cell. The present invention further relates to respiratory-deficient mutant cells and methods for obtaining such mutant cells.
    Type: Grant
    Filed: March 17, 1997
    Date of Patent: April 6, 1999
    Assignees: Novo Nordisk A/S, Novoalle,, Novo Nordisk Biotech
    Inventors: Ejner Bech Jensen, Joel R. Cherry, Susan L. Elrod
  • Patent number: 5891701
    Abstract: The present invention relates to isolated nucleic acid sequences encoding polypeptides having protease activity, in which the polypeptides are obtainable from an alkalophilic Bacillus species having enhanced stability towards bleaching agents of the peroxy type. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as recombinant methods for producing the polypeptides.
    Type: Grant
    Filed: June 12, 1997
    Date of Patent: April 6, 1999
    Assignee: Novo Nordisk BioTech Inc.
    Inventors: Alan Sloma, Lynne Christianson
  • Patent number: 5889002
    Abstract: 1,2,4-Thiadiazine and 1,4-thiazine derivatives represented by the formula ##STR1## wherein A, B, D, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are defined in the description, compositions thereof and methods for preparing the compounds are described. The compounds are useful in the treatment of diseases of the central nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinologic system.
    Type: Grant
    Filed: January 17, 1997
    Date of Patent: March 30, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Flemming Elmelund Nielsen, Holger Claus Hansen, John Bondo Hansen, Tina M.o slashed.ller Tagmose
  • Patent number: 5888797
    Abstract: This invention is in the field of detergent proteases obtainable from a strain of a new Bacillus sp. ZI 315. Moreover, the invention is directed towards a process for the preparation of the protease, the use of the protease as detergent enzyme, and detergent compositions comprising the protease of the invention.
    Type: Grant
    Filed: July 7, 1997
    Date of Patent: March 30, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Helle Outtrup, Lars Sparre Conrad
  • Patent number: 5885304
    Abstract: The present invention relates to a detergent composition, detergent additive as well as a method of oxidizing a substrate which comprises contacting the substrate with a composition which includes an enzyme selected from the group consisting of laccase, catechl oxidase, monophenol monooxygenase, and bilirubin oxidase and an enhancing agent.
    Type: Grant
    Filed: April 16, 1997
    Date of Patent: March 23, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Palle Schneider, Anders Hjelholt Pedersen
  • Patent number: 5885618
    Abstract: This invention relates to a directly compressible enzyme powder produced by mixing a liquid enzyme preparation with a suitable carrier, using the principle of wet granulation, whereby the step of freeze drying and spray-drying is avoided. The resulting enzyme powder has extraordinary good compression qualities and may directly be tabletted.
    Type: Grant
    Filed: November 28, 1995
    Date of Patent: March 23, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Inge Helmer Knap, Breian Knudsen
  • Patent number: 5885819
    Abstract: An enzyme exhibiting xylanase activity, which enzyme is immunologically reactive with an antibody raised against a purified xylanase derived from Aspergillus aculeatus, CBS 101.43. The enzyme may be used for degrading plant cell wall components e.g. in the preparation of feed, in baking, in the paper and pulp industry and in connection with separation of wheat into starch and gluten.
    Type: Grant
    Filed: July 30, 1997
    Date of Patent: March 23, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Lene Venke Kofod, Markus Sakari Kauppinen, Stephan Christgau, Hans Peter Heldt-Hansen, Henrik Dalb.o slashed.ge, Lene Nonboe Andersen, Joan Qi Si, Tina Sejersg.ang.rd Jacobsen, Niels Munk, Anette Mullertz
  • Patent number: 5886021
    Abstract: The present invention provides novel uses of compounds of general formula I ##STR1## wherein R.sup.1, R.sup.4 and R.sup.5 are individually hydrogen, hydroxy, halogen, trifluoromethyl, lower alkyl, lower alkoxy or (tertiary amino)(lower alkoxy); and R.sup.2 and R.sup.3 are individually hydrogen or lower alkyl, or as a pharmaceutically acceptable salt thereof in combination with a pharmaceutically acceptable carrier for the manufacture of a pharmaceutical composition for vasodilatory treatment or prophylaxis.
    Type: Grant
    Filed: August 18, 1997
    Date of Patent: March 23, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Niels Korsgaard, Michael Shalmi, Jan Ulrik Weis, Birgitte Hjort Guldhammer