Abstract: The invention is directed to agents used in the retention of color values on fabrics formed from cellulose fibers (color clarification agents) and to a method for treatment of such fabrics. The method comprises treating a colored fabric with a cellulase and a polymer selected from the group consisting of a polyalkylene oxide graft polymer, a polyamino acid polymer, and a carboxylated polysaccharide polymer in an amount effective to preserve the color of the fabric after at least one wash cycle.
Type:
Grant
Filed:
October 18, 1996
Date of Patent:
July 6, 1999
Assignees:
Novo Nordisk A/S, Novo Nordisk Biochem North America, Inc.
Inventors:
Sonja I. Salmon, Anita R. Mishra, Jack B. Nielsen
Abstract: The present invention provides novel uses of compounds of general formula I ##STR1## wherein R1, R4 and R5 are individually hydrogen, hydroxy, halogen, trifluoromethyl, lower alkyl, lower alkoxy or (tertiary amino)(lower alkoxy); and R2 and R3 are individually hydrogen or lower alkyl, or as a pharmaceutically acceptable salt thereof in combination with a pharmaceutically acceptable carrier for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of idiopathic or physiologic gynaecomastia.
Type:
Grant
Filed:
March 4, 1997
Date of Patent:
July 6, 1999
Assignee:
Novo Nordisk A/S
Inventors:
Niels Korsgaard, Michael Shalmi, Birgitte Hjort Guldhammer
Abstract: The present invention relates to a one-step method for disinfection and cleaning of contact lenses of the type using hydrogen peroxide as the disinfecting agent and a protease as the cleaning agent, comprising the following steps: a) disinfection of the contact lenses in an aqueous disinfecting solution comprising from 1 wt. % to 5 wt. % hydrogen peroxide at a pH not acceptable to the eyes, b) cleaning the contact lenses by subjecting the contact lenses to a protease being inactivated within a period of time at a pH level not acceptable to the eyes, c) neutralization of the hydrogen peroxide in the aqueous disinfecting solution with a microbial catalase being substantially active at pH 3.0 to 7.0, d) adjusting the pH in the aqueous disinfecting solution to a pH level acceptable to the eyes.
Type:
Grant
Filed:
February 11, 1998
Date of Patent:
July 6, 1999
Assignee:
Novo Nordisk A/S
Inventors:
Thomas Lykke Sorensen, Flemming Mark Christensen
Abstract: The present invention relates to an alkaline lipolytic enzyme derivable from a strain of Botryosphaeria or Guignardia, to a lipolytic enzyme-producing microbial strain, to methods for the production of lipolytic enzyme and to a detergent composition comprising the lipolytic enzyme.
Abstract: DNA sequences are disclosed encoding an enzyme exhibiting endoglucanase activity. The endoglucanase is useful in a variety of industrial processes requiring an alkaline cellulase.
Type:
Grant
Filed:
March 20, 1997
Date of Patent:
July 6, 1999
Assignee:
Novo Nordisk A/S
Inventors:
Martin Schulein, Karen Margrethe Oxenb.o slashed.ll, Lene Nonboe Andersen, S.o slashed.ren Flensted Lassen, Markus Sakari Kauppinen, Jack Bech Nielsen
Abstract: The present invention relates to therapeutically active compounds of formula I ##STR1## a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in the prevention or treatment of estrogen related diseases or syndromes.
Type:
Grant
Filed:
October 27, 1997
Date of Patent:
July 6, 1999
Assignee:
Novo Nordisk A/S
Inventors:
Poul Jacobsen, Svend Treppendahl, Paul Stanley Bury, Anders Kanstrup, Lise Brown Christiansen
Abstract: The present invention relates to novel compounds of the general formula I ##STR1## which can be used for treating medical disorders resulting from a deficiency in growth hormone.
Type:
Grant
Filed:
April 23, 1997
Date of Patent:
July 6, 1999
Assignee:
Novo Nordisk A/S
Inventors:
Thomas Kruse Hansen, Bernd Pesche, Knud Erik Andersen
Abstract: A process for providing improved localised variation in the color density of the surface of dyed fabrics by reducing backstaining, the process including treating a dyed fabric with a cellulytic enzyme in an aqueous liquor and adding a sufficient amount of chelating agent to the liquor to reduce the concentration of di- or trivalent cation to less than 20 mg/l.
Abstract: The present invention relates to therapeutically active azacyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.
Type:
Grant
Filed:
June 12, 1997
Date of Patent:
July 6, 1999
Assignee:
Novo Nordisk A/S
Inventors:
Per Sauerberg, Preben H. Olesen, Charles H. Mitch
Abstract: A DNA construct comprising a DNA sequence encoding a polypeptide having .alpha.-galactosidase activity, having the amino acid sequence of SEQ ID NO:3.
Abstract: This invention relates to an enzyme which exhibits cellulase activity and is producible by a strain of Bacillus sp., NCIMB 40250, or a related Bacillus sp. strain, or a derivative of said cellulase. This invention also relates to an enzyme which comprises a core region derived from an endoglucanase combined with a cellulose-binding domain derived from another cellulase, or which comprises a core region derived from another cellulase combined with a cellulose-binding domain derived from an endoglucanase.
Type:
Grant
Filed:
July 27, 1992
Date of Patent:
June 29, 1999
Assignee:
Novo Nordisk A/S
Inventors:
Per Lin.ang. J.o slashed.rgensen, Martin Schulein, Christian Hansen
Abstract: The present invention relates to novel N-substituted amino alcohols, amino acids and acid derivatives thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
Type:
Grant
Filed:
October 24, 1997
Date of Patent:
June 29, 1999
Assignee:
Novo Nordisk A/S
Inventors:
Rolf Hohlweg, Tine Krogh J.o slashed.rgensen, Knud Erik Andersen, Uffe Bang Olsen, Peter Madsen, Zdenek Polivka, Otylie Konigova, Frantisek Miksik, Martina Kovandova, Alexandra Silhankova, Karel Sindelar
Abstract: The present invention relates to 1,4-disubstituted piperazines of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.2 and r are as defined in the detailed part of the present description or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for the treatment of indications caused by or related to the secretion and circulation of insulin antagonizing peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.
Type:
Grant
Filed:
October 3, 1997
Date of Patent:
June 29, 1999
Assignee:
Novo Nordisk A/S
Inventors:
Rolf Hohlweg, Peter Madsen, Tine Krogh J.o slashed.rgensen, Knud Erik Andersen, Brett Watson, Zdenek Polivka, Otylie Konigova, Martina Kovandova, Alexandra Silhankova, Vladimir Valenta
Abstract: The present invention relates to novel N-substituted amino alcohols, amino acids and acid derivatives thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
Type:
Grant
Filed:
May 15, 1998
Date of Patent:
June 29, 1999
Assignee:
Novo Nordisk A/S
Inventors:
Rolf Hohlweg, Tine Krogh J.o slashed.rgensen, Knud Erik Andersen, Uffe Bang Olsen, Peter Madsen, Zdenek Polivka, Otylie Konigova, Frantisek Miksik, Martina Kovandova, Alexandra Silhankova, Karel Sindelar
Abstract: A method for obtaining a cellulosic textile fabric having a strongly reduced tendency to pilling formation, preferably corresponding to a pilling note of at least 4, more preferably of at least 4.5, which method comprises treating the fabric with a cellulase capable of performing a partial hydrolysis of the fibre surface corresponding to a <2% weight loss based on the untreated cellulosic textile fabric. The cellulase is preferably a 43 kD endoglucanase derived from or producible by Humicola insolens, DSM 1800, SEQ ID NO:1, or a functional analogue of said cellulase such as a variant which is modified by substitution of one or more amino acid residues in one or more of the positions 8, 55, 58, 62, 67, 132, 147, 162, 221, 222, 223, 280; or modified by truncation, preferably genetically truncation, at any position from position 213.
Type:
Grant
Filed:
May 8, 1997
Date of Patent:
June 29, 1999
Assignee:
Novo Nordisk A/S
Inventors:
Henrik Lund, Hanne H.o slashed.st Pedersen
Abstract: This invention relates to novel stabilized enzymes. More specifically the invention relates to novel stabilized enzymes, in which a naturally occurring amino acid residue (other than proline) has been substituted with a proline residue at one or more positions; at which position(s) the dihedral angles .phi. (phi) constitute values within the interval ?-90.degree.<.phi.<-40.degree.!; preferably the dihedral angles .phi. (phi) and .psi. (psi) constitute values within the intervals ?-90.degree.<.psi.<-40.degree.! and ?-180.degree.<.psi.<-150.degree. or -80<$g c)<10 or 100<.psi.<180!; and which positions(s) is/are not located in regions in which the enzyme is characterized by possessing .alpha.-helical or .beta.-sheet structure. The invention also relates to nucleotide sequences encoding the novel stabilized enzymes, and expression vectors and host organisms containing the nucleotide sequences. This invention also relates to detergent compositions comprising the stabilized enzymes.
Type:
Grant
Filed:
October 22, 1993
Date of Patent:
June 22, 1999
Assignee:
Novo Nordisk A/S
Inventors:
Allan Svendsen, Claus von der Osten, Ib Groth Clausen, Shamkant Anant Patkar, Kim Borch
Abstract: The present invention relates to therapeutically active azatricyclic compounds of formula I ##STR1## a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating a disease in the central nervous system caused by malfunctioning of the muscarinic cholinergic system.
Type:
Grant
Filed:
April 1, 1997
Date of Patent:
June 22, 1999
Assignee:
Novo Nordisk
Inventors:
Lone Jeppesen, Preben H. Olesen, Per Sauerberg
Abstract: A new method of manufacturing a fabric or a garment with a stone-washed or worn look, the method comprising coating the yarn or fabric or garment with a polymer, e.g. a xyloglucan, prior to dyeing and afterwards creating the abraded or worn look by enzymatic degradation of said polymer, e.g. by using a xyloglucanase.
Abstract: The present invention relates to an amylase from the genus Pyrodictium, specifically to an amylase from Pyrodictium abyssi and more specifically to an amylase from Pyrodictium abyssi, DSM 6158, which has amylase activity optimum at temperatures in the range 110-120.degree. C., determined at pH 5.5 with starch as a substrate.