Patents Represented by Attorney, Agent or Law Firm Steve T. Zelson
  • Fervidobacterium amylase and pullulanase
    Patent number: 5714369
    Abstract: The present invention relates to Fervidobacterium amylase and pullulanase preparations and their use in producing sweeteners and ethanol from starch. In particular the enzymes are derived from Fervidobacterium pennavorans.
    Type: Grant
    Filed: September 9, 1996
    Date of Patent: February 3, 1998
    Assignee: Novo Nordisk A/S
    Inventors: Carsten Sj.o slashed.holm, Garabed Antranikian
  • Method of treating urinary bladder dysfunctions
    Patent number: 5712271
    Abstract: The present invention relates to a novel method for treating a mammal suffering from urinary bladder dysfunctions.
    Type: Grant
    Filed: October 3, 1996
    Date of Patent: January 27, 1998
    Inventors: Mark A. Muhlhauser, Harlan E. Shannon, Karl B. Thor
  • N-substituted azaheterocyclic carboxylic acids and esters thereof
    Patent number: 5712292
    Abstract: The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
    Type: Grant
    Filed: October 18, 1995
    Date of Patent: January 27, 1998
    Assignee: Novo Nordisk A/S
    Inventors: Knud Erik Andersen, Uffe Bang Olsen, Hans Petersen, Frederik Christian Gr.o slashed.nvald, Ursula Sonnewald, Tine Krogh J.o slashed.rgensen, Henrik Sune Andersen
  • Dye transfer inhibition
    Patent number: 5712153
    Abstract: The transfer of a textile dye from a dyed fabric to another fabric during washing or rinsing is inhibited by adding an enzyme exhibiting peroxidase activity or an enzyme exhibiting a suitable oxidase activity to the wash liquor in which said fabrics are washed and/or rinsed. Peroxidase is produced extracellularly by some strains of Bacillus pumilus. The novel peroxidase preparation from B. pumilus is a microperoxidase, i.e. it contains hemopeptide as an active component. The preparation has improved stability at high temperature, at high pH and at high concentrations of hydrogen peroxide. It can be produced without undesired catalase activity.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: January 27, 1998
    Assignee: Novo Nordisk A/S
    Inventors: Ture Damhus, Ole Kirk, Gitte Pedersen, Manuel Garcia Venegas, Bj.o slashed.rn Eggert Christensen, Palle Schneider
  • Method of treating urinary bladder dysfunctions
    Patent number: 5712287
    Abstract: The present invention relates to a novel method for treating a mammal suffering from urinary bladder dysfunctions.
    Type: Grant
    Filed: October 3, 1996
    Date of Patent: January 27, 1998
    Inventors: Mark A. Muhlhauser, Harlan E. Shannon, Karl B. Thor
  • Piperdine compounds and their preparation and use
    Patent number: 5712297
    Abstract: The present invention relates to therapeutically active piperidine compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.
    Type: Grant
    Filed: September 23, 1996
    Date of Patent: January 27, 1998
    Assignee: Novo Nordisk A/S
    Inventors: Per Sauerberg, Preben H. Olesen
  • Method of treating urinary bladder dysfunctions
    Patent number: 5710151
    Abstract: The present invention relates to a novel method for treating a mammal suffering from urinary bladder dysfunctions.
    Type: Grant
    Filed: October 3, 1996
    Date of Patent: January 20, 1998
    Inventors: Mark A. Muhlhauser, Harlan E. Shannon, Karl B. Thor
  • Process for the treatment of cellulosic fabrics with cellulases
    Patent number: 5707858
    Abstract: This invention relates to an improved cellulase treatment of cellulosic fabrics to improve fabric quality with respect to handle and appearance without loss of fabric wettability. Cellulosic fabrics are subjected to two treatments with cellulase. The resulting fabric has a soft and smooth feel and reduced pilling.
    Type: Grant
    Filed: June 15, 1995
    Date of Patent: January 13, 1998
    Assignee: Novo Nordisk A/S
    Inventors: Garrett A. Screws, Gitte Pedersen
  • Human AlaGlu-IGF-1
    Patent number: 5708134
    Abstract: This invention is directed to isolated human AlaGlu-IGF-1, a novel compound which exerts IGF-1 activity and is a valuable precursor in the preparation of IGF-1 itself.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: January 13, 1998
    Assignee: Novo Nordisk A/S
    Inventors: Lars Skriver, Kim Ry Hejn.ae butted.s, Henrik Dalb.o slashed.ge
  • Identification of ligands by selective amplification of cells transfected with receptors
    Patent number: 5707798
    Abstract: The invention is directed to a method for identifying substances acting as ligands for transfected receptors by using transfected markers to measure receptor/ligand interactions.
    Type: Grant
    Filed: July 12, 1994
    Date of Patent: January 13, 1998
    Assignee: Novo Nordisk A/S
    Inventor: Mark Robert Brann
  • Process of preparing a spread
    Patent number: 5707668
    Abstract: The present invention relates to a process of preparing a spread and the use of an enzyme in the production of a spread. The process of preparing a spread includes the following steps: a) the aqueous phase, which includes protein, is treated with an enzyme capable of enhancing the viscosity of the aqueous phase, b) the pH-value is adjusted to 4.8 to 6.0, c) the aqueous phase or emulsion is heated to between 60.degree. C. and 100.degree. C. for a period of time, d) the aqueous phase or the emulsion is tempered to a temperature between 30.degree. C. and 50.degree. C., e) the tempered aqueous phase is mixed with the fat phase and tempered to between 30.degree. C. and 50.degree. C. until an emulsion is formed, f) the emulsion is crystallized to form a spread. The steps in the process may be performed in the sequence steps a), b), c), d) e), f) or a), b), d), e), c), d), f).
    Type: Grant
    Filed: February 12, 1997
    Date of Patent: January 13, 1998
    Assignee: Novo Nordisk A/S
    Inventor: Lars Peter Andersen
  • Enzyme exhibiting pectin methylesterase activity
    Patent number: 5707847
    Abstract: An enzyme exhibiting pectin methyl esterase activity, wherein the enzyme a) is derived from Aspergillus aculeatus; b) is encoded by Seq ID No:1; or c) has the amino acid sequence of Seq ID No:2 or a sequence which is at least 95% homologous thereto. An enzyme can be used for the modification of plant cell wall components.
    Type: Grant
    Filed: November 2, 1995
    Date of Patent: January 13, 1998
    Assignee: Novo Nordisk A/S
    Inventors: Stephan Christgau, Lene Venke Kofod, Lene Nonboe Andersen, Sakari Kauppinen, Hans Peter Heldt-Hansen, Gitte Budolfsen, Henrik Dalb.o slashed.ge
  • Pharmaceutical formulation
    Patent number: 5705482
    Abstract: A pharmaceutical formulation comprising a growth hormone and Leu-His-Leu as additive or buffering substance shows a very high stability against deamidation, oxidation and cleavage of peptide bonds. The stability of the product allows for the storing and shipment thereof in a lyophilized state or in the form of a dissolved or re-dissolved formulation at ambient temperature.
    Type: Grant
    Filed: January 13, 1995
    Date of Patent: January 6, 1998
    Assignee: Novo Nordisk A/S
    Inventors: Thorkild Christensen, Per Balschmidt, Hans Holmegaard S.o slashed.rensen, Ole Hvilsted Olsen, Lars Thim
  • Gene encoding carboxypeptidase of Aspergillus niger
    Patent number: 5705376
    Abstract: The present invention relates to a gene encoding an ascomycete or deuteromycete carboxypeptidase Y gene, and host cells modified so as to produce reduced amounts of carboxypeptidase.
    Type: Grant
    Filed: February 28, 1996
    Date of Patent: January 6, 1998
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: Debbie Sue Yaver, Sheryl Ann Thompson
  • Processes for producing an enzyme
    Patent number: 5702934
    Abstract: The present invention is related to a process for producing an active enzyme comprising fermenting the proform of the active enzyme in the present of a proteolytic enzyme different from the active enzyme and capable of converting the proenzyme into an active enzyme as well as to host cells, recombinant expression vectors and host cells suitable for use in the process.
    Type: Grant
    Filed: May 4, 1994
    Date of Patent: December 30, 1997
    Assignees: Novo Nordisk A/S, Novo Nordisk Biotech, Inc.
    Inventors: Sven Hastrup, Sven Branner, Birthe Ravn J.o slashed.rgensen, Tove Christensen, Birgitte Bojer J.o slashed.rgensen, Jeffrey R. Shuster, Mark Madden, Donna L. Moyer, Claus Fuglsang
  • Purification of Factor VII
    Patent number: 5700914
    Abstract: The present invention describes a method for controlled activation and degradation of FVII during purification whereby a solution of Factor VII is subjected to a number of chromatographic purification steps wherein Zn.sup.++ is present in at least one of the purification steps.The present invention also describes a method for controlled activation and degradation of FVII wherein a solution of FVII is applied to a number of anion exchange and immunoaffinity columns.
    Type: Grant
    Filed: May 28, 1995
    Date of Patent: December 23, 1997
    Assignee: Novo Nordisk A/S
    Inventors: Tony J.o slashed.rgensen, Anders Hjelholt Pedersen
  • Enhancement of enzyme reactions
    Patent number: 5700769
    Abstract: This invention relates to activation of enzymes. More specifically, the invention relates to peroxidase enhancing agents. The invention also relates to methods of oxidizing a substrate with a source of hydrogen peroxide in the presence of a peroxidase enzyme and a peroxidase enhancing agent More specifically, the invention relates to a method of bleaching of dye in solutions, to a method of inhibiting the transfer of a textile dye from a dyed fabric to another fabric when said fabrics are washed together in a wash liquor, to a method of bleaching of lignin-containing material in particular bleaching of pulp for paper production, to a method of treatment of waste water from pulp manufacturing, and to a method of enzymatic polymerization and/or modification of lignin or lignin containing material.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: December 23, 1997
    Assignee: Novo Nordisk A/S
    Inventors: Palle Schneider, Lars Sparre Conrad, S.o slashed.ren Ebdrup, Birgitte Yde
  • Dye transfer inhibition and novel peroxidase
    Patent number: 5700770
    Abstract: The transfer of a textile dye from a dyed fabric to another fabric during washing or rinsing is inhibited by adding an enzyme exhibiting peroxidase activity or an enzyme exhibiting a suitable oxidase activity to the wash liquor in which said fabrics are washed and/or rinsed. Peroxidase is produced extracellularly by some strains of Bacillus pumilus. The novel peroxidase preparation from B. pumilus is a microperoxidase, i.e. it contains hemopeptide as an active component. The preparation has improved stability at high temperature, at high pH and at high concentrations of hydrogen peroxide. It can be produced without undesired catalase activity.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: December 23, 1997
    Assignee: Novo Nordisk A/S
    Inventors: Ture Damhus, Ole Kirk, Gitte Pedersen, Manuel Garcia Venegas
  • Bacillus promoter derived from a variant of a bacillus licheniformis X-amylase promoter
    Patent number: 5698415
    Abstract: A Bacillus promoter included in DNA sequence (SEQ ID#1), wherein each of N.sup.1 -N.sup.9 is A, T, C or G with the exception that N.sup.2 -N.sup.9 do not together form the sequence ATGTTTCA or GTGTTTCA, or a functional homologue of said sequence.
    Type: Grant
    Filed: May 10, 1994
    Date of Patent: December 16, 1997
    Assignee: Novo Nordisk Als
    Inventors: Steen Troels J.o slashed.rgensen, B.o slashed.rge Krag Diderichsen
  • Alkalophilic Bacillus sp. AC13 and protease, xylanase, cellulase obtainable therefrom
    Patent number: 5696068
    Abstract: The present invention relates to novel microorganisms, novel enzymes obtainable herefrom, and to a method of producing the novel enzymes. More specifically, the invention relates to novel enzymes obtainable from strains of the novel alkalophilic species Bacillus sp. AC13. Moreover, the invention relates to a method for producing the enzymes of the invention, and to the use of the enzymes in detergents or in the paper pulp industry.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 9, 1997
    Assignee: Novo Nordisk A/S
    Inventors: Helle Outtrup, Claus Dambmann, Arne Agerlin Olsen, Henrik Bisg.ang.rd-Frantzen, Martin Schulein