Abstract: The present invention relates to therapeutically active azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.
Abstract: Removal of hydrophobic esters from fabric comprises the sequential steps of: 1) impregnating the fabric with an aqueous solution of lipase to a liquor pick-up ratio of 50-200%; 2) incubating the impregnated fabric at 15.degree.-70.degree. C. for 1-24 hours; and 3) washing and rinsing to remove fatty acids.
Abstract: This application relates to methods of treating myocardial or cerebral ischemia, comprising administering a compound of formula I: ##STR1## wherein X is halogen, perhalomethyl, cyano, C.sub.1-6 -alkoxy, C.sub.1-6 -alkylthio or C.sub.1-6 -alkylamino; andR.sup.1 is selected from N-bonded heterocycles.The compound with the greatest ability to discriminate between the A1 and A2 adenosine receptors is 2-chloro-N-[4-phenoxy-1-piperidinyl]adenosine.
Abstract: Variant of human Kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI), the variant comprising the following amino acid sequence ##STR1## wherein Xaa at position 1 is H or a naturally occurring amino acid residue except Cys, each Xaa at positions 2-5 is independently a naturally occurring amino acid residue except Cys or is absent, each Xaa at positions 14, 16, 18, 19, 20, 21, 22, 23, 37, 42, 43, 44, and 49 independently a naturally occurring amino acid except Cys, each Xaa at positions 61, 62, 63, and 64 is independently a naturally occurring amino acid except Cys or is absent, and Xaa at position 65 is OH or a naturally occurring amino acid except Cys, with the proviso that at least one of the amino acid residues designated Xaa is different from the amino acid residue of the native sequence.
Type:
Grant
Filed:
October 12, 1994
Date of Patent:
November 19, 1996
Assignee:
Novo Nordisk A/S
Inventors:
Fanny Norris, Kjeld Norris, S.o slashed.ren E. Bj.o slashed.rn, Lars C. Petersen, Ole H. Olsen
Abstract: The method for processing of potatoes is characterized by the fact that the method is carried out in a potato processing plant, which comprises an oil separator, heating equipment and at least one enzyme reactor and which is modified in such a manner that it can also be used for processing of rape. It is not obvious that such modification is sufficiently small for achieving an economically sound method for processing of rape outside the potato season.
Abstract: In the method for treatment of potato fruit water the potato fruit water is subjected to a heat treatment to at least 125.degree. C. for at least 3 minutes, whereafter the heat treated potato fruit water is cooled to a temperature, at which enzymes are relatively stable, then enzymatically treated with a proteinase, and finally concentrated to microbial stability. Hereby a method for treatment of potato fruit water, which will enable a commercially sound utilization of potato fruit water, is provided.
Abstract: The present invention relates to therapeutically active azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.
Abstract: The present invention relates to therapeutically active azacyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.
Type:
Grant
Filed:
December 22, 1994
Date of Patent:
November 5, 1996
Assignee:
Novo Nordisk A/S
Inventors:
Per Sauerberg, Preben H. Olesen, Charles H. Mitch
Abstract: The present invention relates to catalases obtained from a strain of Scytalidium thermophilum or Humicola insolens which retains at least 75% residual activity after 20 minutes at 70.degree. C. and a pH in the range of 9.0-10.5 in the presence of 40 mM polyvinyl pyrrolidone and methods for producing and using same.
Type:
Grant
Filed:
September 15, 1993
Date of Patent:
November 5, 1996
Assignee:
Novo Nordisk A/S
Inventors:
Bj.o slashed.rn E. Christensen, Niels K. Lange, Kosaku Daimon
Abstract: Novel compounds of formula I ##STR1## wherein R.sup.1 is independently hydrogen, hydroxy, alkyl with 1 to 6 carbon atoms, acyloxy groups with 1 to 6 carbon atoms, alkyloxy with 1 to 6 carbon atoms or from 1 to 5 sugar moieties; and R.sup.2 is independently hydrogen, or alkyl with 1 to 6 carbon atoms.The compounds are producible by aerobic cultivation on suitable nutrient media under suitable conditions of a strain of the fungus Ascochyta sp., subsequent recovery of the active component from the fermentation medium, and optionally modifying the active compound to obtain a compound of the desired formula I.Disclosed is also microorganisms capable of producing said compounds, compositions containing said compounds, and the use of such compositions for controlling fungi in valuable crops, animals, including birds and mammals, and in the preservation of wood, paints and edible products.
Abstract: A method for quantitation of blood parameters comprises the steps: provision of a sample of plasma, serum or blood, entering the sample into a cuvette with an internal dimension less than 1 mm, illuminating the sample by a light source, measuring and recording the changes of light properties caused by the sample as a function of time, calculating parameters of the recorded light signal/time curve such as slopes, extreme values, and the time distance between such extreme values, and interpreting the parameters as blood parameters. For the measurements, an apparatus is used comprising a cuvette (16, 17) with an internal dimension less than 1 mm, a light source (7, 9), means (8, 10) for measuring currently a light signal from the sample, means for recording the measured light signal values, and means for calculating parameters of the thereby defined light signal versus time graph.
Type:
Grant
Filed:
August 3, 1994
Date of Patent:
October 22, 1996
Assignee:
Novo Nordisk A/S
Inventors:
Ole Hauch, Jens B. Knudsen, Thomas M. Plum
Abstract: The present invention relates to the treatment of dyed fabric comprising contacting, in an aqueous medium, the fabric with a cellulolytic enzyme and heat expanded perlite in an amount effective for providing localized variation in the color density of the surface of the dyed fabric. The present invention also relates to compositions comprising a cellulase, heat expanded perlite and a buffer and optionally a dispersing agent and/or a chelating agent.
Type:
Grant
Filed:
October 24, 1993
Date of Patent:
October 15, 1996
Assignee:
Novo Nordisk A/S
Inventors:
Thomas Videb.ae butted.k, Walter H. Westendorp
Abstract: Haemoglobin is crosslinked by means of transglutaminase, whereafter the transglutaminase is inactivated. The crosslinked haemoglobin can be used as a molecular agent for oxygen transportation, as an oxygen scavenger, and as a constituent of a food composition.
Abstract: Quinoxaline compounds of the general formula ##STR1## wherein R.sup.1 is COX', POX'X" or alkyl substituted with COX' or POX'X", and X' and X" independently are hydroxy or alkoxy, and R.sup.6, R.sup.7, R.sup.8 and R.sup.9 independently are hydrogen, alkyl, halogen, NH.sub.2, NO.sub.2, CN, CF.sub.3, SO.sub.2 NY'Y" or COZ' wherein Z' is NY'Y" or alkyl and Y' and Y" independently are hydrogen or alkyl, triazolyl, imidazolyl, imidazolyl substituted with phenyl or alkyl, or R.sup.6 and R.sup.7, or R.sup.8 and R.sup.9, together form a further fused ring, are useful in the treatment of indications caused by hyperactivity of the excitatory neurotransmitters.
Type:
Grant
Filed:
December 7, 1994
Date of Patent:
September 24, 1996
Assignee:
Novo Nordisk A/S
Inventors:
Poul Jacobsen, Flemming E. Nielsen, Lone Jeppesen
Abstract: This invention relates to the treatment of glaucoma by topically administering a compound selected among ##STR1## wherein Z, R, and R.sup.1 are defined in the specification, and a pharmaceutically acceptable salt thereof.
Abstract: The present invention relates to therapeutically active azacyclic compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.
Type:
Grant
Filed:
May 30, 1995
Date of Patent:
September 24, 1996
Assignee:
Novo Nordisk A/S
Inventors:
Per Sauerberg, Preben H. Olesen, Charles H. Mitch
Abstract: The invention relates to a Bacillus thuringiensis strain(s) which solely produces a CryIA(a) crystal delta-endotoxin having a molecular weight of 130,000 daltons and is active against lepidopteran pests. The invention is also related to a spore(s), mutant(s), or crystal delta-endotoxin obtainable therefrom. Furthermore, the invention relates to insecticidal compositions comprising the B.t. strain, spore, mutant or crystal delta-endotoxin of the present invention. The invention further relates to methods of using the insecticidal compositions to control an insect pest(s) of the order Lepidoptera.
Abstract: The present invention relates to a dispenser for tablets, comprising a drawer element having a through going opening for the accommodation of just one tablet, which drawer element may be displaced along a narrow sidewall of a box shaped housing. A partition parallel with said sidewall bars the inlet of the opening when the dispenser is operated, and an opening serves as a dispensing opening when the drawer is displaced to align its through-going opening with the dispensing opening. The ends of the drawer are closed by trough shaped shells, the shell at the one end being at its end opposite the drawer hinged to the housing, and being at its end adjacent to the drawer hinged to the drawer, and the end of the housing adjacent to the hinged shell being obliquely cut, so that the narrow side of the housing adjacent to the hinge hinging the shell to the housing is longer than the narrow sidewall forming the sliding surface for the drawer.
Type:
Grant
Filed:
June 9, 1994
Date of Patent:
September 10, 1996
Assignee:
Novo Nordisk A/S
Inventors:
Thomas Munk Plum, Kim Steengaard, Jens M.o slashed.ller-Jensen
Abstract: A closure for the outlet end of an ampoule having a neck with an outwardly extending annular projection (30), said closure comprising a holding cap (18;61) with a skirt (35;62) with interior protrusions (38) for engagement behind the annular projection (30) of the neck, which holding cap engages a disc shape part (31) to press it sealingly against the annular projection (30). A locking ring (20;64) on the outer side of the skirt (35;62) locks projections (38) in their engagement position behind the annular projection (30). Resilient fingers (37;65) and recesses (36;66) are provided on either the skirt or the locking ring, the recesses being positioned below the fingers so that the fingers may be pushed into the recesses when the locking ring is passed over the skirt. Either the skirt (35) or the locking ring (64), which part is not provided with the fingers and recesses, is provided with an edge over which the fingers may grip irreversibly when the locking ring is mounted in position on the skirt.