Abstract: A plastein material is made by reversing the normal hydrolytic activity of a serine protease. The protease produces a plastein material by acting on a proteinaceous substrate. The substrate is preferably whey, casein or soy protein.

Abstract: The present invention relates to a method and apparatus for inspecting entities comprising liquid-filled containers for one or more test parameters of the liquid, the container, or both, by rotating and axially line scanning said entities and comparing said scans electronically, after which entities exhibiting one or more unacceptable test parameters are identified and separated from entities exhibiting acceptable test parameters.

Abstract: The present invention relates to a pea protein hydrolyzate with very high purity and with organoleptic properties. The present invention also relates to a method for producing said pea protein hydrolyzate.

Abstract: Novel compounds of the general composition I, Lactate (1), Glycine (1), Valine (4), Isoleucine (1), pipecolic acid (1), Aspartic acid (1), Tyrosine (1), wherein each amino acid residue independently may occur in L- or D- form, and wherein the number in parenthesis indicates the number of occurrences of each moiety, and derivatives thereof are disclosed. The compounds are producible by aerobic cultivation on suitable nutrient media under suitable conditions of a strain of the fungus Curvularia sp., subsequent recovery of the active component from the fermentation medium, and optionally modifying the active compound to obtain a compound of the desired general composition. Disclosed are also microorganisms capable of producing said compounds, compositions containing said compounds, and the use of such compositions for controlling fungi in crops, and in the preservation of wood, paints, cosmetics, and edible products.

Abstract: A polypeptide for production in yeast comprises a fusion of a signal peptide, a leader peptide and a heterologous protein or polypeptide. The polypeptide is modified in its amino acid sequence adjacent to a yeast processing site positioned between the C-terminal end of the leader peptide and the N-terminal end of the heterologous protein so as to provide a presentation of the processing site which makes it accessible to proteolytic cleavage. Such a presentation is provided by adding one or more amino acids (at least one of which is negatively charged) to either the C-terminal end of the leader or the N-terminal end of the protein, or both. The heterologous protein may, for instance, be aprotinin or insulin precursor or an analogue thereof.

Abstract: A method for measuring the presence of traces of substance in air by providing in a cuvette a substrate reacting with the substance by changing its opacity, passing at a defined flow rate air from the air body to be checked through the substrate, measuring the development of opacity. A portable apparatus comprises a housing (1, 101) holding a cuvette (131) containing a substrate (3, 103), an inlet tube (28) leading to the bottom of the cuvette, a pump (13) sucking air from the cuvette through a flow monitor (138) controlling the pump, a spectrophotometer lamp (19, 119) and a photo-diode (20) on opposite sides of the cuvette (131), a monitor monitoring the level (4, 104) of the substrate in the cuvette, and a monitor (23, 123) monitoring the temperature of the substrate, a computer (24) receiving signals from the photodiode (20), the level monitor, and the temperature monitor to calculate a temperature and level compensated indication of the substrate opacity.

Abstract: A polypeptide for production in yeast comprises a fusion of a signal peptide, a leader peptide and a heterologous protein or polypeptide. The polypeptide is modified in its amino acid sequence adjacent to a yeast processing site positioned between the C-terminal end of the leader peptide and the N-terminal end of the heterologous protein so as to provide a presentation of the processing site which makes it accessible to proteolytic cleavage. Such a presentation is provided by adding one or more amino acids (at least one of which is negatively charged) to either the C-terminal end of the leader or the N-terminal end of the protein, or both. The heterologous protein may, for instance, be aprotinin or insulin precursor or an analogue thereof.

Abstract: A blood sampler comprises a small chamber having a stiletto mounted air-tightly through a flexible top wall with a pointed end of the stiletto positioned inside the chamber opposite an opening in the bottom part of the chamber. The sampler is designed to be mounted in a tool which compresses the chamber by pressing the flexible top wall against the bottom of the chamber. Further, the tool has means for imparting an impact on a blunt outer end of the stiletto to drive the stiletto further through the top wall to make its sharp end protrude through the opening in the bottom part into the skin to which the sampler may be attached by an adhesive. When the sampler is ejected from the tool, it regains its original shape, providing in the chamber a vacuum for sucking blood from the perforated skin into this chamber.

Abstract: Quinoxaline compounds represented by formulas I or II, ##STR1## wherein R.sup.1 and R.sup.2 are independently hydrogen, C.sub.1-6 -alkyl, halogen, NO.sub.2, NH.sub.2, CN, CF.sub.3, SO.sub.2 NR.sup.4 R.sup.5 wherein R.sup.4 and R.sup.5 are independently hydrogen or C.sub.1-6 -alkyl, or COR.sup.6 wherein R.sup.6 is C.sub.1-6 -alkyl; and R.sup.3 is hydrogen, C.sub.1-6 -alkyl or CF.sub.3, compositions thereof and methods of preparing the compounds are described.The compounds are useful in the treatment of indications caused by hyperactivity of the excitatory neurotransmitters.

Abstract: Novel cyclodextrin glycosyl transferases (CGTase) can be produced by anaerobic cultivation of strains of Thermoanaerobacter or Thermoanaerobium. They are more thermostable than known CGTases and have temperature optimum about 95.degree. C.The novel CGTases can be used for starch liquefaction at pH 4.5 and temperature exceeding 100.degree. C. in the production of dextrose or ethanol. They can also be used for conversion of liquefied starch to cyclodextrin at a temperature of 80.degree.-90.degree. C.A method for enzymatically converting solid and liquefied starch into cyclodextrin using cyclodextrin glycosyl transferases (CGTase) elaborated by thermophilic obligate anaerobic strains belonging to the genus Clostridium. These CGTases are characterized by thermostability and a capability to liquefy starch and/or to convert liquefied starch to cyclodextrin at pH 5.0-5.5 and 60.degree.-90.degree. C.

Abstract: Patients with chronic liver disease and consequently very low concentrations of IGF-1 in the blood, in spite of increased GH concentrations, are treated with periodically injections of hGH for a period both parameters being individually adjusted for the patients.

Abstract: The present invention provides fungicidal and insecticidal active compounds and derivatives thereof, fungicidal and insecticidal compositions comprising said compounds, processes for producing said compounds and the use of said compounds for controlling fungi and/or insects.

Abstract: An isolated arabinofuranosidase from Bacillus stearothermophilus NRRL B-18659, Bacillus stearothermophilus NRRL B-18660 and Bacillus stearothermophilus NRRL B-18661 is disclosed. The arabinofuranosidase has a maximum activity at about pH 6.0 and at about 65.degree. C., maintains at least about 50% of its maximum activity at 70.degree. C. and pH 7.0 after 80 minutes, and has an isoelectric point of about 4.4. The arabinfuranosidase can be used in a method of hydrolyzing xylan present in wood pulp at temperatures of at least about 60.degree. C. and a pH of at least about 7.0. The arabinofuranosidase is used along with at least two xylanases and a xylosidase isolated from the above Bacillus stearothermophilus strains.

Abstract: An isolated xylosidase from Bacillus stearothermophilus NRRL B-18659, Bacillus stearothermophilus NRRL B-18660 and Bacillus stearothermophilus NRRL B-18661 is disclosed. The xylosidase has a maximum activity at about pH 6.0 and at about 75.degree. C., maintains at least about 60% of its maximum activity at about 65.degree. C. and pH 7 after 4 hours, is resistant to end-product inhibition maintaining over 75% of maximum activity in the presence of 1 molar xylose and has an isoelectric point of about 5.0. The xylosidase can be used in a method of hydrolyzing xylan present in wood pulp at temperatures of at least about 60.degree. C. and a pH of at least about 7.0. The xylosidase is used along with at least two xylanases and an arabinofuranosidase isolated from the above Bacillus stearothermophilus strains.

Abstract: The new casein hydrolyzate does not contain any unhydrolyzed casein and is characterized by a defined molecular weight distribution. The method is characterized by being performed by means of three defined proteolytic enzymes and a non-pH star method. The casein hydrolyzate exhibits an optimal balance between DH, free amino acids, bitterness and yield.

Abstract: The invention relates to thermostable pullulanases endogenous to the strain Fervidobacterium sp. Ven 5, DSM 6204, or a mutant thereof which is capable of producing the pullulanase having (a) a temperature optimum in the range 80-90.degree. C.; (b) a pH optimum in the range of 5-7; and (c) at least 60% residual activity after 24 hours of incubation at pH 6.0. The invention also relates to the use of the pullulanases in starch converting processes, and to saccharification processes.

Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof: ##STR1## wherein X is halogen, trifluoromethyl, cyano, C.sub.1-6 -alkoxy, C.sub.1-6 -alkylthio, C.sub.1-6 -alkylamino or C.sub.1-6 -dialkylamino;R.sup.1 and R.sup.4 are H or straight or branched C.sub.1-6 -alkyl or trifluoromethyl or R.sup.1 and R.sup.4 together form a cycloalkyl ring;Y is O, S, SO.sub.2, NH or N-alkyl;R.sup.5 is selected from optionally substituted heterocycles.R.sup.6 and R.sup.7 are hydrogen, benzoyl or C.sub.1-6 -alkanoyl.The compounds have been found useful for treating central nervous system and cardiovascular ailments.

Abstract: This invention relates to enzymes, to rDNA techniques applicable for example to their production, to mutated genes, vectors and mutant and transformed microorganisms useful in their production, and to their uses including for example enzymatic detergent and cleaning compositions containing them.

Abstract: The present invention relates to isolated nucleic acid fragments containing a sequence encoding a Rhizoctonia solani laccase having optimum activity at a neutral or basic pH. and the laccase proteins encoded thereby.

Abstract: Piperidine derivatives of formula ##STR1## wherein A is straight or branched alkyl, alkoxy-alkyl, or alkenyl; X is O or NH; Y is O, S, NH, NCN, or N-alkyl; R.sup.1 is 6-fluoro-1,2-benzisoxazol-3-yl, 6-fluoro-1H-indazol-3-yl, or 6-fluoro-1-methyl-1H-indazol-3-yl; R.sup.2 is alkyl or phenyl; and R.sup.3 is phenyl optionally substituted, or R.sup.3 is ##STR2## wherein Z represents a 5- or 6-membered heterocyclic ring; or R.sup.2 and R.sup.3 together with the nitrogen atom form a fused heterocyclic ring system; or pharmaceutically acceptable salts thereof are useful in the treatment of indications related to the CNS-system, cardiovascular system or to gastrointestinal disorders.