Patents Represented by Attorney Steven F. Stone

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  • Fluid imbibing pump activated by capillary action of a fabric or polymeric sleeve
    Patent number: 4946456
    Abstract: An agent dispenser of the fluid imbibing type having a flexible bag within a membrane and in which a wicking or wetting device is in contact with the outer surface of the membrane to keep such outer surface wet at all times for all attitudes of a containment vessel housing the bag and the membrane. The wicking device is in the form of a fabric tube, such as a stretch knit fabric, or a preformed hydrophilic polymeric sleeve, which can be mounted on the outer surface of the membrane and remain in contact with it so long as there is any liquid in the containment vessel. Since the amount of water drawn by the wicking device is controlled by the membrane porosity and the amount of a solute composition in an intermediate layer between the bag and the membrane, the wicking device provides for a continuous controlled delivery of agent from the inner bag of the dispenser.
    Type: Grant
    Filed: August 26, 1988
    Date of Patent: August 7, 1990
    Assignee: Alza Corp.
    Inventors: Nathan Roth, Su I. Yum, Felix Theeuwes
  • Dosage form for treating cardiovascular diseases
    Patent number: 4946687
    Abstract: An osmotic device is disclosed comprising a first composition, and a second composition with the beneficial drug isradipine in the first composition.
    Type: Grant
    Filed: November 7, 1988
    Date of Patent: August 7, 1990
    Assignee: Alza Corporation
    Inventors: Atul D. Ayer, David R. Swanson, Anthony L. Kuczynski
  • Cellulosic dosage form
    Patent number: 4946685
    Abstract: A bilaminate dosage form is disclosed comprising a first lamina and a second lamina with each lamina comprising a cellulose ether composition, and wherein a drug is present in at least one of the lamina. An optional coat is disclosed that surrounds the bilaminate form.
    Type: Grant
    Filed: September 1, 1988
    Date of Patent: August 7, 1990
    Assignee: Alza Corporation
    Inventors: David E. Edgren, Judy A. Magruder, Gurdish K. Bhatti
  • Skin permeation enhancer compositions using sucrose esters
    Patent number: 4940586
    Abstract: A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with sucrose monolaurate or a mixture of sucrose esters of coconut fatty acids, which is predominantly sucrose monolaurate. Preferred embodiments of therapeutic systems for delivering the drug and the sucrose ester employ a matrix containing drug at a concentration above saturation.
    Type: Grant
    Filed: October 13, 1988
    Date of Patent: July 10, 1990
    Assignee: Alza Corporation
    Inventors: Yu-Ling Cheng, Robert M. Gale, Edna Sugihara, Harold F. Sanders
  • Dispenser comprising displaceable matrix with solid state properties
    Patent number: 4940465
    Abstract: A dispenser is enclosed for delivering a beneficial agent to an environment of use. The dispenser comprising a wall that surrounds an internal space comprising a first means in the dispenser for changing from a dispenser state to an environment of use state on leaving the dispenser, a beneficial agent in the first means, and a second means in the dispenser for aiding in displacing the first means from the dispenser.
    Type: Grant
    Filed: November 7, 1988
    Date of Patent: July 10, 1990
    Inventors: Felix Theeuwes, Patrick S.-L. Wong, Richard Cortese, James B. Eckenhoff
  • Elastomeric bladders for medical infusers
    Patent number: 4938751
    Abstract: Elastomeric bladders having improved resistance to spontaneous rupture when inflated are made by vulcanizing a homogeneous mixture of synthetic polyisoprene having 90% to 98% cis-1,4 linkages, 3 to 10 phr fumed silicon dioxide, and vulcanizing agent while simultaneously forming the mixture into hollow cylindrical bodies. After being formed the bodies are solvent extracted to remove unreacted vulcanizing agent and the degradation products of the vulcanizing agent. Following the solvent extraction about 0.2 to 2 phr of a nontoxic, nonleachable antioxidant are imbibed into the bodies by contacting the bodies with a liquid solution of the antioxidant.
    Type: Grant
    Filed: July 21, 1988
    Date of Patent: July 3, 1990
    Assignee: Alza Corporation
    Inventors: Harold M. Leeper, George V. Guittard
  • Transdermal delivery device having a rate controlling adhesive
    Patent number: 4938759
    Abstract: A transdermal delivery device having a release-rate controlling-adhesive is disclosed having improved delivery characteristics. The device employs a polyisobutylene/mineral oil adhesive formulation and an ethylene/viny acetate (EVA) drug reservoir formulation. The device is useful in delivering a wide variety of transdermally administrable drugs, particularly those which are moderately soluble in mineral oil. Preferred embodiments deliver timolol base and atropine base from an EVA (40% VA) reservoir formulation.
    Type: Grant
    Filed: September 2, 1986
    Date of Patent: July 3, 1990
    Assignee: Alza Corporation
    Inventors: David J. Enscore, Eun S. Lee, Su I. Yum
  • Urinary drainage container comprising external source of biocide
    Patent number: 4938748
    Abstract: A patient-care apparatus comprising a container for receiving a biological fluid, and a delivery device on the outside of the container, which device comprises a biocide that is released to the container for preventing the multiplication of and/or eliminating the presence of unwanted pathogens in the container.
    Type: Grant
    Filed: September 1, 1988
    Date of Patent: July 3, 1990
    Inventors: Su I. Yum, Felix Theeuwes
  • Aqueous based pharmaceutical coating composition for dosage forms
    Patent number: 4931285
    Abstract: A dosage form is disclosed comprising a coat that surrounds a drug. The coat comprises a subcoat and an overcoat thermally annealed to provide a single unit coat around the drug.
    Type: Grant
    Filed: April 28, 1988
    Date of Patent: June 5, 1990
    Assignee: ALZA Corporation
    Inventors: David E. Edgren, Felix Theeuwes
  • Implantable fluid imbibing pump with improved closure
    Patent number: 4929233
    Abstract: An improved imbibing agent dispenser having a snap-on closure which is highly reliable, is simple to assemble on one end of the agent dispenser, and can be made at minimum expense without requiring heat or an adhesive to bond the closure to the dispenser. The closure is held in place on the dispenser by a locking feature formed by a shoulder on the end of the dispenser and a ledge on an outer, annular wall of the closure, the ledge being removably hooked beneath and biased toward the shoulder to releasably lock the closure to the dispenser. An important aspect of this closure is that the design provides for the complete containment of a solute component within the dispenser.
    Type: Grant
    Filed: August 26, 1988
    Date of Patent: May 29, 1990
    Assignee: ALZA Corporation
    Inventors: Nathan Roth, Su I. Yum
  • Dispenser for delivering drug to livestock
    Patent number: 4927633
    Abstract: A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a housing defining an internal space, (2) heat responsive means containing a beneficial agent in the spece, (3) means for increasing the amount of beneficial agent delivered from the device in the space, (4) expandable means in the space, (5) an optional dense means in the space, and (6) means in the housing for delivering the beneficial agent from the dispensing device.
    Type: Grant
    Filed: June 24, 1987
    Date of Patent: May 22, 1990
    Assignee: Alza Corporation
    Inventors: James B. Eckenhoff, Richard Cortese, Felix A. Landrau
  • Electrotransport transdermal system
    Patent number: 4927408
    Abstract: A transdermal therapeutic system which utilizes electrical current to facilitate agent delivery and which isolates the electrochemical reactants and products from the agent containing reservoir.
    Type: Grant
    Filed: October 3, 1988
    Date of Patent: May 22, 1990
    Assignee: Alza Corporation
    Inventors: Ronald P. Haak, Felix Theeuwes, J. Richard Gyory
  • Selective pulsed drug delivery system
    Patent number: 4927632
    Abstract: This invention pertains to a programmable delivery system.
    Type: Grant
    Filed: June 29, 1988
    Date of Patent: May 22, 1990
    Assignee: Alza Corporation
    Inventor: Patrick S.-L. Wong
  • Transdermal drug delivery device
    Patent number: 4917895
    Abstract: A diffusional drug delivery device is described which can provide shelf life stability of the system components, elimination of the initial burst of drug and hence irritation, delayed onset of therapeutic effect and delivery of a therapeutic agent at an optimum rate. A metal layer and an activating means are inert when dry. Moisture activates the system whereby the activating means provides release of an eroding agent which erodes the metal layer through which the therapeutic agent diffuses and is subsequently delivered.
    Type: Grant
    Filed: July 14, 1988
    Date of Patent: April 17, 1990
    Assignee: ALZA Corporation
    Inventors: Eun S. Lee, David Edgren, Su I. Yum
  • Composition comprising drug, HPC, HPMC and PEO
    Patent number: 4915952
    Abstract: A dosage form is disclosed for delivering the beneficial drugs pseudoephedrine and brompheniramine to a biological environment of use.
    Type: Grant
    Filed: February 15, 1989
    Date of Patent: April 10, 1990
    Assignee: Alza Corporation
    Inventors: Atul D. Ayer, Lawrence G. Hamel
  • Dosage form for delivering a drug at two different rates
    Patent number: 4915954
    Abstract: A dosage form is disclosed comprising a wall that surrounds a compartment with an exit means in the wall. The compartment comprises a first or fast releasing lamina and a second or short releasing lamina that are delivered through the exit means over two different periods of time.
    Type: Grant
    Filed: February 21, 1989
    Date of Patent: April 10, 1990
    Assignee: Alza Corporation
    Inventors: Atul D. Ayer, Maureen L. Jordan, Paul R. Magruder, David E. Edgren
  • Dispenser with movable matrix comprising a plurality of tiny pills
    Patent number: 4915949
    Abstract: A dispenser is disclosed for delivering tiny pills to an environment of use. The dispenser comprising a wall that surrounds an internal space comprising a first mean in the dispenser for changing from a dispenser state to an environment of use state on leaving the dispenser, tiny pills in the first means, and a second means in the dispenser for aiding in displacing the first means for the dispenser.
    Type: Grant
    Filed: February 21, 1989
    Date of Patent: April 10, 1990
    Assignee: Alza Corporation
    Inventors: Patrick S.-L. Wong, Felix Theeuwes, Richard Cortese, James B. Eckenhoff
  • Dosage form for delivering acetaminophen or phenylpropanolamine
    Patent number: 4915953
    Abstract: A dosage form is disclosed comprising a wall that surrounds a compartment with an exit means in the wall. The compartment comprises a first or fast releasing lamina and a second or short releasing lamina that are delivered through the exit means over two different periods of time.
    Type: Grant
    Filed: February 21, 1989
    Date of Patent: April 10, 1990
    Assignee: ALZA Corporation
    Inventors: Maureen L. Jordan, Atul D. Ayer, Paul R. Magruder, David E. Edgren
  • Parenteral delivery system comprising a vial containing a beneficial agent
    Patent number: 4915689
    Abstract: A parenteral delivery system for delivering a beneficial agent is disclosed. The delivery system comprises a reservoir containing a medical fluid, a vial containing a beneficial solid agent, and a manifold for establishing fluid communication between the reservoir and the vial.
    Type: Grant
    Filed: February 24, 1986
    Date of Patent: April 10, 1990
    Assignee: ALZA Corporation
    Inventor: Felix Theeuwes
  • Post-surgical applications for bioerodible polymers
    Patent number: 4913903
    Abstract: Applications of bioerodible polymers as surgical "leave behind" products in the areas of orthopedic, thoracic, abdominal, ocular and liver/spleen surgery.
    Type: Grant
    Filed: April 10, 1989
    Date of Patent: April 3, 1990
    Assignee: ALZA Corporation
    Inventors: Einar Sudmann, Pieter Bonsen, Eun S. Lee