Abstract: A dosage form that coadministers a drug and two percutaneous absorption enhancers to a defined area of the skin is described. The dosage form comprises a body that contains supplies of drug and enhancers and has a basal surface that contacts the area of skin and transmits the drug and enhancers to the area for absorption thereby.

Abstract: A transdermal delivery system for the administering of ethinyl estradiol and levonorgestrel, in combination, utilizing a polymer matrix having the drug formulation along with a permeation enhancer dispersed throughout.

Abstract: An osmotic device is disclosed comprising a first composition, and a second composition with the beneficial drug isradipine in the first composition.

Abstract: A dosage form is disclosed comprising a wall that surrounds a compartment with an exit means in the wall. The compartment comprises a first or fast releasing lamina and a second or short releasing lamina that are delivered through the exit means over two different periods of time.

Abstract: A dispenser is disclosed for delivering a beneficial agent to an environment of use. The dispenser comprises a semipermeable wall surrounding a compartment containing a heat responsive composition, and an expandable composition. A passageway in the wall connects the compartment with the exterior of the dispenser.

Abstract: A medical bandage is disclosed comprising a reservoir containing a gelled fluid, rheological agent and a drug. A method of using the bandage for producing a beneficial effect is disclosed also.

Abstract: A dosage form is disclosed for delivering the beneficial drugs pseudoephedrine and brompheniramine to a biological environment of use.

Abstract: A dosage form is disclosed for delivering the beneficial drug pseudoephedrine to a biological environment of use.

Abstract: A method of forming a dispenser for delivering a beneficial agent to a biological environment. A beneficial agent and an expandable composition are placed in a capsule made of fluid dissolvable material. The capsule is closed and surrounded by a semipermeable wall which is permeable to fluid but not to the beneficial agent. Then a passageway is drilled in the capsule between the exterior and the interior which contains the beneficial agent.

Abstract: A parenteral delivery system and a formulation chamber are disclosed for administering a beneficial agent. The parenteral delivery system comprises a drip chamber and a formulation chamber. The formulation chamber comprises a wall surrounding an internal space and it has an inlet for admitting a liquid into the formulation chamber and an outlet for letting an agent formulation leave the formulation chamber. The chamber houses an agent delivery system for releasing a beneficial agent into a liquid that enters the chamber.

Abstract: A transdermal delivery system for the administering of progesterone and an estradiol ester alone or in combination utilizing a polymer matrix having the drug(s) along with a permeation enhancer dispersed throughout.

Abstract: A bilaminated dosage form is disclosed comprising at least 30 weight percent cellulose ether, a first lamina and a second lamina with each lamina comprising a different cellulose ether formulation, and a drug in at least one of the lamina.

Abstract: This invention pertains to a programmable delivery system.

Abstract: An osmotic system is disclosed comprising a wall comprising in at least a part of a semipermeable material that surrounds a compartment. The compartment contains a first osmotic composition comprising a beneficial drug selected from the group consisting of a calcium antagonist, angiotensin enzyme inhibitor and nonsteroidal antiinflammatory drugs, and a second and different osmotic composition. A passageway in the wall connects the first composition with the exterior of the system.

Abstract: A diffusional drug delivery device is described which can provide for stability of the adhesive and system components, elimination of the initial burst of drug and hence irritation, and to provide for delayed onset of therapeutic effect along with delivery of a therapeutic agent at an optimum rate. The therapeutic agent in a first form which is suitable for storage, and the anhydrous activating means are inert when in an anhydrous environment. Moisture activates the system whereby the activating means provides an acidic or basic solution and the first form of the therapeutic agent is converted to a second form which is suitable for absorption through the skin or mucosa.

Abstract: A dispenser is disclosed for delivering a beneficial agent formulation to a warm, fluid environment of use. The dispenser comprises an outer semipermeable wall surrounding and laminating an inner hydrophilic, swellable wall. The walls define an interior space for containing a thermo-responsive beneficial agent formulation. A passageway through the semipermeable wall connects the exterior of the dispenser through an opening in the inside wall with the interior of the dispenser.

Abstract: The package of the present invention comprises a sheath formed from a folded, relatively rigid strip having structure for receiving and releasably holding the ends of the fiber to be packaged. In a preferred embodiment, the fiber is between the two folded over parts of the strip with the ends of the fiber anchored in place in a pair of slits. The sheath is in a pouch formed by a pair of foil members on opposite sides of the sheath. When ready for use, the package is opened by peeling the foil members apart, thereby exposing the sheath and permitting access to the fiber carried by the sheath. An improved apparatus and method are provided to form the package. In the first instance, the sheath is prepared by first folding a strip of relatively rigid material, such as siliconized polyester, then moving the folded strip along a path of travel and feeding the fiber into the region between the parts of the strip as the strip moves.

Abstract: A delivery system is disclosed comprising a wall surrounding a lumen containing a plurality of dosage delivery devices. The wall is formed of an environment sensitive material that releases the dosage forms into the environment. The dosage forms comprise a semipermeable wall surrounding a compartment containing drug. A passageway through the semipermeable wall releases drug from the dosage form to the environment.

Abstract: A dispensing system is disclosed comprising a wall surrounding a lumen. The lumen comprises (1) a thermo responsive composition comprising a beneficial agent, (2) means for occupying space in the lumen for pushing the thermo responsive composition from the dispensing system, and (3) means for enhancing the amount of the beneficial agent dispensed from the system positioned between the thermo responsive composition and the means for occupying space.

Abstract: An osmotic system is disclosed comprising a wall comprising in at least a part of a semipermeable material that surrounds a compartment. The compartment contains an osmotic composition comprising a beneficial drug selected from the group consisting of nifedipine, prazosin and doxazosin, and a second and different osmotic composition. A passageway in the wall connects the first composition with the exterior of the system.