Abstract: A method for enhancing the flux of transdermally deliverable drugs through intact skin is described in which the drug is delivered simultaneously with glycerol monooleate. Preferred embodiments of therapeutic systems for delivering drug and glycerol monooleate employ matrix containing drug at a concentration above saturation.
Abstract: A dosage form is disclosed comprising a wall surrounding a compartment housing a first layer comprising a drug formulation, a middle layer comprising a hydrophobic composition, and a third layer comprising a hydrophilic composition.
Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.
Abstract: A delivery device is disclosed for delivering a beneficial agent to an animal. The device comprises a wall housing an internal space, a beneficial agent in the space, expandable means in the space for causing the beneficial agent to be delivered from the device and means in the space for shielding the beneficial agent from fluid.
Type:
Grant
Filed:
March 25, 1988
Date of Patent:
August 8, 1989
Assignee:
ALZA Corporation
Inventors:
James B. Eckenhoff, Judy A. Magruder, Richard Cortese, John R. Peery, Jeremy C. Wright
Abstract: A delivery device is disclosed for delivering a beneficial drug to a biological environment of use. The device comprises a hydrogel reservoir containing tiny pills. The tiny pills comprise a wall surrounding a drug core.
Abstract: An osmotic delivery system is disclosed for delivering a useful agent at a controlled and constant rate modulated by a pulsed delivery of the useful agent to an environment of use.
Type:
Grant
Filed:
January 29, 1988
Date of Patent:
July 25, 1989
Assignee:
ALZA Corporation
Inventors:
Paul R. Magruder, Brian Barclay, Patrick S. L. Wong, Felix Theeuwes
Abstract: A medical bandage is disclosed comprising a reservoir containing a gelled fluid, rheological agent and a drug. A method of using the bandage for producing a beneficial effect is disclosed also.
Abstract: A method is disclosed for treating an ischemic condition. The method comprises coadministering topically and internally a vasodilator to a patient having the condition for treating the condition.
Abstract: A dispensing system is disclosed comprising a wall surrounding a lumen. The lumen comprises (1) a thermo responsive composition comprising a beneficial agent, (2) means for occupying space in the lumen for pushing the thermo responsive composition from the dispensing system, and (3) means for enhancing the amount of the beneficial agent dispensed from the system positioned between the thermo responsive composition and the means for occupying space.
Type:
Grant
Filed:
March 24, 1988
Date of Patent:
July 4, 1989
Assignee:
ALZA Corporation
Inventors:
James B. Eckenhoff, Richard Cortese, Felix A. Landrau
Abstract: A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.
Type:
Grant
Filed:
May 9, 1986
Date of Patent:
June 27, 1989
Assignee:
Alza Corporation
Inventors:
Atul D. Ayer, Felix Theeuwes, Patrick S. Wong
Abstract: A diffusional drug delivery device is described which can provide for stability of the adhesive and system components, elimination of the initial burst of drug and hence irritation, and to provide for delayed onset of therapeutic effect along with delivery of a therapeutic agent at an optimum rate. The therapeutic agent in a first form which is suitable for storage, and the anhydrous activating means are inert when in an anhydrous environment. Moisture activates the system whereby the activating means provides an acidic or basic solution and the first form of the therapeutic agent is converted to a second form which is suitable for absorption through the skin or mucosa.
Abstract: A medical bandage is disclosed comprising a reservoir containing a gelled fluid, rheological agent and a drug. A method of using the bandage for producing a beneficial effect is disclosed also.
Abstract: A method for preventing the formation of crystalline hydrates in a dispersion of a hydratable liquid in a nonaqueous matrix is disclosed. The method is particularly useful in the manufacture of laminated items formed from such dispersions and comprises forming individual subunits from such dispersions, heating the subunits, preferably after they have been packed in sealed containers, to a temperature high enough to melt the crystalline hydrate, maintaining said subunits at such temperature for a time sufficient to melt all the crystalline hydrate present and to prevent the occurrence of crystals for an extended period of time after cooling and cooling subunits to ambient conditions. The use of the method in the manufacture of transdermal delivery devices for the delivery of scopolamine base is described.
Type:
Grant
Filed:
August 13, 1987
Date of Patent:
May 23, 1989
Assignee:
Alza Corporation
Inventors:
Patricia S. Campbell, David J. Enscore, Robert M. Gale, Arnold Kaufman
Abstract: A dispenser is disclosed for delivering tiny pills to an environment of use. The dispenser comprising a wall that surrounds an internal space comprising a first mean in the dispenser for changing from a dispenser state to an environment of use state on leaving the dispenser, tiny pills in the first means, and a second means in the dispenser for aiding in displacing the first means for the dispenser.
Type:
Grant
Filed:
July 13, 1987
Date of Patent:
April 25, 1989
Assignee:
ALZA Corporation
Inventors:
Patrick S. L. Wong, Felix Theeuwes, Richard Cortese, James B. Eckenhoff
Abstract: A method of postoperative pain relief using transdermal delivery of fentanyl or its analgetically effective derivatives preceded by a dose of said material to increase the serum drug levels to steady state more quickly.
Type:
Grant
Filed:
February 24, 1987
Date of Patent:
April 18, 1989
Assignee:
ALZA Corporation
Inventors:
Gerhard Levy, Mary Southam, Marilou S. Powers Cramer