Patents Represented by Attorney Steven F. Stone
  • Patent number: 4863738
    Abstract: A method for enhancing the flux of transdermally deliverable drugs through intact skin is described in which the drug is delivered simultaneously with glycerol monooleate. Preferred embodiments of therapeutic systems for delivering drug and glycerol monooleate employ matrix containing drug at a concentration above saturation.
    Type: Grant
    Filed: November 23, 1987
    Date of Patent: September 5, 1989
    Assignee: ALZA Corporation
    Inventor: Lina T. Taskovich
  • Patent number: 4863456
    Abstract: A dosage form is disclosed comprising a wall surrounding a compartment housing a first layer comprising a drug formulation, a middle layer comprising a hydrophobic composition, and a third layer comprising a hydrophilic composition.
    Type: Grant
    Filed: February 8, 1988
    Date of Patent: September 5, 1989
    Assignee: ALZA Corporation
    Inventors: Sally I. Stephens, Patrick S. L. Wong
  • Patent number: 4859470
    Abstract: A device is disclosed for delivering diltiazem at a controlled and substantially zero order rate over a prolonged period of time.
    Type: Grant
    Filed: June 2, 1988
    Date of Patent: August 22, 1989
    Assignee: Alza Corporation
    Inventors: George V. Guittard, Patrick S. L. Wong, Felix Theeuwes, Richard Cortese
  • Patent number: 4857330
    Abstract: An osmotic dosage form is disclosed for delivering chlorpheniramine.
    Type: Grant
    Filed: April 1, 1988
    Date of Patent: August 15, 1989
    Assignee: Alza Corporation
    Inventors: Sally I. Stephens, Lawrence G. Hamel, Glen E. Barclay, Patrick S. L. Wong
  • Patent number: 4857052
    Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.
    Type: Grant
    Filed: May 4, 1987
    Date of Patent: August 15, 1989
    Assignee: Alza Corporation
    Inventor: Felix Theeuwes
  • Patent number: 4855141
    Abstract: A delivery device is disclosed for delivering a beneficial agent to an animal. The device comprises a wall housing an internal space, a beneficial agent in the space, expandable means in the space for causing the beneficial agent to be delivered from the device and means in the space for shielding the beneficial agent from fluid.
    Type: Grant
    Filed: March 25, 1988
    Date of Patent: August 8, 1989
    Assignee: ALZA Corporation
    Inventors: James B. Eckenhoff, Judy A. Magruder, Richard Cortese, John R. Peery, Jeremy C. Wright
  • Patent number: 4851232
    Abstract: A delivery device is disclosed for delivering a beneficial drug to a biological environment of use. The device comprises a hydrogel reservoir containing tiny pills. The tiny pills comprise a wall surrounding a drug core.
    Type: Grant
    Filed: June 8, 1987
    Date of Patent: July 25, 1989
    Assignee: Alza Corporation
    Inventors: John Urquhart, Felix Theeuwes
  • Patent number: 4851229
    Abstract: An osmotic delivery system is disclosed for delivering a useful agent at a controlled and constant rate modulated by a pulsed delivery of the useful agent to an environment of use.
    Type: Grant
    Filed: January 29, 1988
    Date of Patent: July 25, 1989
    Assignee: ALZA Corporation
    Inventors: Paul R. Magruder, Brian Barclay, Patrick S. L. Wong, Felix Theeuwes
  • Patent number: 4851231
    Abstract: A delivery system is disclosed for delivering an agent to a selected environment of use having a pH of greater than 3.5.
    Type: Grant
    Filed: March 16, 1987
    Date of Patent: July 25, 1989
    Assignee: ALZA Corporation
    Inventors: John Urquhart, Felix Theeuwes
  • Patent number: 4849226
    Abstract: A medical bandage is disclosed comprising a reservoir containing a gelled fluid, rheological agent and a drug. A method of using the bandage for producing a beneficial effect is disclosed also.
    Type: Grant
    Filed: December 14, 1987
    Date of Patent: July 18, 1989
    Assignee: Alza Corporation
    Inventor: Robert M. Gale
  • Patent number: 4847093
    Abstract: An osmotic device is disclosed comprising a release rate controlling wall that surrounds a carbon dioxide generating compound.
    Type: Grant
    Filed: June 19, 1986
    Date of Patent: July 11, 1989
    Assignee: ALZA Corporation
    Inventors: Atul D. Ayer, Patrick S. L. Wong
  • Patent number: 4846826
    Abstract: A method is disclosed for treating an ischemic condition. The method comprises coadministering topically and internally a vasodilator to a patient having the condition for treating the condition.
    Type: Grant
    Filed: November 21, 1986
    Date of Patent: July 11, 1989
    Assignee: Alza Corporation
    Inventors: Jane Shaw, Robert M. Gale
  • Patent number: 4844984
    Abstract: A dispensing system is disclosed comprising a wall surrounding a lumen. The lumen comprises (1) a thermo responsive composition comprising a beneficial agent, (2) means for occupying space in the lumen for pushing the thermo responsive composition from the dispensing system, and (3) means for enhancing the amount of the beneficial agent dispensed from the system positioned between the thermo responsive composition and the means for occupying space.
    Type: Grant
    Filed: March 24, 1988
    Date of Patent: July 4, 1989
    Assignee: ALZA Corporation
    Inventors: James B. Eckenhoff, Richard Cortese, Felix A. Landrau
  • Patent number: 4842867
    Abstract: A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.
    Type: Grant
    Filed: May 9, 1986
    Date of Patent: June 27, 1989
    Assignee: Alza Corporation
    Inventors: Atul D. Ayer, Felix Theeuwes, Patrick S. Wong
  • Patent number: 4837111
    Abstract: An osmotic dosage system is disclosed for delivering the therapeutically beneficial drug doxazosin to an environment of use over time.
    Type: Grant
    Filed: March 21, 1988
    Date of Patent: June 6, 1989
    Assignee: ALZA Corporation
    Inventors: Joseph C. Deters, Patrick S. L. Wong, Brian L. Barclay, Felix Theeuwes, David R. Swanson
  • Patent number: 4837027
    Abstract: A diffusional drug delivery device is described which can provide for stability of the adhesive and system components, elimination of the initial burst of drug and hence irritation, and to provide for delayed onset of therapeutic effect along with delivery of a therapeutic agent at an optimum rate. The therapeutic agent in a first form which is suitable for storage, and the anhydrous activating means are inert when in an anhydrous environment. Moisture activates the system whereby the activating means provides an acidic or basic solution and the first form of the therapeutic agent is converted to a second form which is suitable for absorption through the skin or mucosa.
    Type: Grant
    Filed: August 9, 1988
    Date of Patent: June 6, 1989
    Assignee: ALZA Corporation
    Inventors: Eun S. Lee, Su I. Yum
  • Patent number: 4834979
    Abstract: A medical bandage is disclosed comprising a reservoir containing a gelled fluid, rheological agent and a drug. A method of using the bandage for producing a beneficial effect is disclosed also.
    Type: Grant
    Filed: December 14, 1987
    Date of Patent: May 30, 1989
    Assignee: ALZA Corporation
    Inventor: Robert M. Gale
  • Patent number: 4832953
    Abstract: A method for preventing the formation of crystalline hydrates in a dispersion of a hydratable liquid in a nonaqueous matrix is disclosed. The method is particularly useful in the manufacture of laminated items formed from such dispersions and comprises forming individual subunits from such dispersions, heating the subunits, preferably after they have been packed in sealed containers, to a temperature high enough to melt the crystalline hydrate, maintaining said subunits at such temperature for a time sufficient to melt all the crystalline hydrate present and to prevent the occurrence of crystals for an extended period of time after cooling and cooling subunits to ambient conditions. The use of the method in the manufacture of transdermal delivery devices for the delivery of scopolamine base is described.
    Type: Grant
    Filed: August 13, 1987
    Date of Patent: May 23, 1989
    Assignee: Alza Corporation
    Inventors: Patricia S. Campbell, David J. Enscore, Robert M. Gale, Arnold Kaufman
  • Patent number: 4824675
    Abstract: A dispenser is disclosed for delivering tiny pills to an environment of use. The dispenser comprising a wall that surrounds an internal space comprising a first mean in the dispenser for changing from a dispenser state to an environment of use state on leaving the dispenser, tiny pills in the first means, and a second means in the dispenser for aiding in displacing the first means for the dispenser.
    Type: Grant
    Filed: July 13, 1987
    Date of Patent: April 25, 1989
    Assignee: ALZA Corporation
    Inventors: Patrick S. L. Wong, Felix Theeuwes, Richard Cortese, James B. Eckenhoff
  • Patent number: 4822802
    Abstract: A method of postoperative pain relief using transdermal delivery of fentanyl or its analgetically effective derivatives preceded by a dose of said material to increase the serum drug levels to steady state more quickly.
    Type: Grant
    Filed: February 24, 1987
    Date of Patent: April 18, 1989
    Assignee: ALZA Corporation
    Inventors: Gerhard Levy, Mary Southam, Marilou S. Powers Cramer