Abstract: Improved procedures and intermediates for synthesizing 11-deoxyprostaglandins wherein trans-2,3-dicarbomethoxycyclopentanone is prepared by the novel kinetically-controlled cyclization of 1,2,4-tricarbomethoxybutane using a dispersion of sodium hydride in dry p-xylene. Selective alcoholysis of the 2-position carbomethoxy group with benzyl alcohol, followed by alkylation allows for a wide range of upper side chains to be introduced at the 2-position of the cyclopentanone ring. The unwanted carbobenzyloxy group at the 2-position can then be removed easily by controlled hydrogenolysis followed by decarboxylation. This procedure allows for simultaneous epimerization of the 2-position side chain to the desired trans-configuration, relative to the carbomethoxy group in the 3-position, as well as for reduction of the 2-hexynyl moiety of the side chain to the desired cis-olefinic group of the E.sub.2 -type 11-deoxyprostaglandins, or through total reduction to the alkane upper side chain of E.sub.

Abstract: Fused isoquinoline derivatives of the general formula ##STR1## wherein: A is a divalent radical selected from the groups ##STR2## wherein R.sub.3 and R.sub.4 each independently represents hydrogen, alkyl,, alkenyl, cycloalkyl, aryl, aralkyl, aralkenyl, cycloalkyl-alkyl or, taken together with the adjacent double bond, represent a cycloalkene containing from 5 to 8 carbon atoms or an aromatic nucleus;R.sub.5 represents hydrogen, hydroxyl, alkyl, alkenyl, cycloalkyl, aryl, aralkyl, aralkenyl or cycloalkyl-alkyl;Y is .dbd.O, .dbd.S or .dbd.NH;X is --O--, --S-- or --NR.sub.6 -- wherein R.sub.6 represents hydrogen, alkyl, cycloalkyl, aryl, aralkyl or cycloalkyl-alkyl;R.sub.1 and R.sub.2 each independently represents hydrogen, alkyl, phenyl, cycloalkyl, alkoxy, alkenyloxy, methylenedioxy, cycloalkoxy, halo or di-alkylamino or, taken together with the adjacent carbon atoms of the benzene ring, form a cycloalkenyl group containing 5 or 6 carbon atoms or an aromatic nucleus fused on the benzene ring.

Abstract: 2-Nitroimidazole derivatives of the following formula: ##STR1## wherein R is benzoyl, phenylcarbamoyl or the group ##STR2## wherein R.sub.1 is C.sub.1-4 alkyl, ##STR3## in which R.sub.2 is hydrogen, halo, cyano, amino, C.sub.1-2 alkyl, or C.sub.1-3 alkoxy and X is oxygen or sulfur. These compounds have antimicrobial and amoebicidal utilities.

Abstract: The compound of this invention is prepared by reacting phenol as such or as its alkali metal phenate with dichlorodifluoroethylene to form 2,2-dichloro-1,1-difluoroethoxybenzene and reacting the latter with chlorosulfonic acid and recovering the reaction product. The compound of this invention, when reacted with acrylonitrile gives the antimicrobial compound, 2-chloro-3-(4-(2,2-dichloro-1,1-difluoroethoxy)phenyl)sulfonyl)propanenitr ile.

Abstract: Quaternary ammonium phenates containing a 3-chloro-2-propenyl substituent group attached to the nitrogen atom and having as other substitutent groups attached to the nitrogen atoms (1) a C.sub.8 -C.sub.18 alkyl group, (2) a one carbon, two carbon, C.sub.8 -C.sub.18 alkyl or a 3-chloro-2-propenyl group, (3) a one carbon or two carbon alkyl or a 3-chloro-2-propenyl group, and (4) a phenate group, wherein not more than a total of two 3-chloro-2-propenyl groups are present in the molecule. The compounds have antibacterial and antifungal utility.

Abstract: Chloral hydrate bis-ester of 2,2,3-trichloropropionic acid, CCl.sub.3 CH(OCOCCl.sub.2 CH.sub.2 Cl).sub.2, its preparation by reacting chloral hydrate with 2,2,3-trichloropropionyl chloride and herbicidal compositions containing chloral hydrate bis-ester of 2,2,3-trichloropropionic acid.

Abstract: A thiolsulfonate is reacted with an aminecarbodithioate salt to given an aminecarbotrithioate product. The products of this invention have biological activity, particularly in controlling microorganisms and other pests.

Abstract: The compounds 2-Aryl-3-amino-1-butanol derivatives of the formula ##STR1## wherein R represents hydrogen or acyl; R.sup.1 and R.sup.2 each independently represents hydrogen, phenyl lower alkyl, or lower alkoxy substituted phenyl lower alkyl, or both R.sup.1 and R.sup.2 are lower alkyl; and their pharmaceutically acceptable acid salts.The compounds are crystalline solids or liquids which, having two asymmetry centers, can be obtained in their stereoisomeric forms as racemic mixtures or in their optically active forms. The compounds have cardiovascular activity as coronary dilators.The compounds can be prepared by reacting an .alpha.-arylcrotonate with ammonia or with an amine followed by hydrogenation of the carbalkoxy group to give the corresponding butanol. The butanols are acylated in usual ways to give the compounds of formula (I) wherein R represents an acyl group.

Abstract: 3-Bromo-2,2-bis(bromomethyl)propyl bromomethanesulfonate. It is useful in the control of the athlete's foot microorganism, Trichophyton mentagrophytes.

Abstract: 3,4,5-Tris(4-pyridinylthio)-2,6-pyridinedicarbonitrile is prepared by reacting three molar proportions of 4-alkali metal mercaptopyridine with one molar proportion of 3,4,5-trihalo-2,6-pyridinedicarbonitrile. The product has antimicrobial utility.

Abstract: Oxybis(4,1-phenylene(2-oxo-2,1-ethanediyl)) thiocyanate is prepared by reacting diphenyl oxide with chloroacetyl chloride and reacting the intermediate formed thereby with potassium thiocyanate. The compound has antimicrobial utility.

Abstract: Aryl dibromonitromethyl sulfones, new compounds, wherein aryl is phenyl or lower alkyl phenyl, are effective as antimicrobials at a concentration of about 100 parts per million.

Abstract: Dibromonitromethyl methyl sulfone is effective as a slimicide at a concentration of about 100 parts per million.

Abstract: 2-(Dicyanomethylene)-1,3-dithiolo(4,5-b)pyrazine-5,6-dicarbonitrile is prepared by reacting di(sodiomercapto)methylenemalononitrile with 2,3-dichloro-5,6-dicyanopyrazine in dimethylformamide as reaction medium at a temperature between about 25.degree. and about 60.degree. C until reaction is substantially complete. The reaction product has antimicrobial utility.

Abstract: 3-((4-(2,2-Dichloro-1,1-difluoroethoxy)phenyl)sulfonyl)-2-propenenitrile is prepared by mixing together 2-chloro-3-((4-(2,2-dichloro-1,1-difluoroethoxy)phenyl)sulfonyl)propanenit rile and a slight molar excess of triethylamine in the presence of benzene as reaction medium.

Abstract: 3-((3-(Trifluoromethyl)phenyl)sulfonyl)-2-propenenitrile. The compound has antimicrobial utility.

Abstract: The compound 2-chloro-3-((4-(2,2-dichloro-1,1-difluoroethoxy)phenyl)sulfonyl)propanenit rile. The compound has antimicrobial utility.

Abstract: The title compound is prepared by reacting trichloroethenylthiophenylsulfonyl chloride with acrylonitrile in the presence of a small amount of cupric chloride, acetonitrile and triethylamine hydrochloride, recovering the product from the reaction medium.

Abstract: Compounds of the formula ##STR1## where X represents O or S and R.sub.1 and R.sub.2 each represents lower alkyl, phenyl or (lower alkyl)phenyl. The compounds are prepared by reacting the ring-opened intermediate (obtained by reacting cis-1-(3-chloro-2-propenyl)-3,5,7-triaza-1-azoniatricyclo(3.3.1.1.sup.3,7) decane chloride with excess aqueous sodium hydroxide) with an equivalent amount of a corresponding carbamoyl halide or thiocarbamoyl halide or at a low temperature to give the indicated tetrasubstituted urea or thiourea product. The compounds have antimicrobial utility.

Abstract: Compounds of the formula ##STR1## where X represents O or S and R represents C.sub.1-4 alkyl, phenyl or (C.sub.1-4 alkyl)phenyl. The compounds are prepared by reacting the ring-opened intermediate, obtained by reacting cis-1-(3-chloro-2-propenyl)-3,5,7-triaza-1-azoniatricyclo (3.3.1.1.sup.3,7) decane chloride with excess aqueous sodium hydroxide, with an equivalent amount of a corresponding halide formate or halide thioformate, ClC=X(OR), at about 0.degree. C in the presenceof a hydrogen chloride acceptor and using a non-nucleophilic organic solvent as reaction medium. The carbamate products have antimicrobial utility.