Abstract: Adducts of certain unsaturated halides with hexamethylenetetramine are known to be effective germicides when present in concentrations as low as 0.01 percent in water-containing organic mixtures. However, under certain conditions the compounds may undergo detrimental spontaneous exothermic decomposition. Blending with the adduct an additament which undergoes an endothermic change at a temperature below that at which exothermic decomposition of the adduct decomposition thereby providing a composition stabilized for packaging and/or storage.

Abstract: This invention is directed to rifamycin compounds which are produced by fermentation of Nocardia mediterranea ATCC 31064, ATCC 31065 or ATCC 31066 in an aqueous nutrient medium under aerobic conditions. These rifamycins are referred to as rifamycin P, rifamycin Q, rifamycin R and rifamycin U.

Abstract: 3,2-Benzoxazepines of the formula ##STR1## and their preparation. In formula (I), R respesents hydrogen or lower alkyl; R.sup.1 represents hydrogen, lower alkyl, lower alkenyl, hydroxy-lower alkyl, carbamyloxy-lower alkyl, acyl, amidino, carbamyl, mono- or di-substituted carbamyl; R.sup.2 may be in position 7 or 8 of the benzoxazepine ring and represents hydrogen, nitro, amino, acetamino or halo. The compounds are prepared by reacting 1,2,4,5-tetrahydro-3,2-benzoxazepine with a reactant which reacts with a secondary amino group to give substitution in the 2-position. The compounds have anti-inflammatory and central nervous system activity.

Abstract: The compound 5-[(1-hydroxy-1-methyl)ethyl]-1-methyl-2-nitroimidazole is valuable in combatting Trichomonas vaginalis infections in mammals.

Abstract: The new compound 1,3-dithiolo(4,5-b)pyrazin-2-ylidene-propanedinitrile 4-oxide is prepared by reacting substantially equimolar proportions of di-(sodiomercapto)methylenemalononitrile with 2,3-dichloropyrazine 1-oxide. The compound has fungicidal, algicidal and marine antifoulant utility.

Abstract: The new compound 1,3-dithiolo(4,5-b)pyrazin-2-ylidene-propanedinitrile 4-oxide is prepared by reacting substantially equimolar proportions of di-(sodiomercapto)methylenemalononitrile with 2,3-dichloropyrazine 1-oxide. The compound has fungicidal, algicidal and marine antifoulant utility.

Abstract: New heterocyclic compounds represented by the following formula: ##STR1## wherein: R and R.sub.1 are independently selected from hydrogen, hydroxy, (C.sub.1-4)alkyl, (C.sub.1-4)alkoxy, (C.sub.3-5)alkenyloxy, (C.sub.3-5)alkynyloxy, (C.sub.3-6)cycloalkyloxy, or halo or taken together represent a methylenedioxy group; the symbols W and A are defined as follows:1. W is the nitrogen atom and A is the group ##STR2## in which the carbon atom bearing the radical R.sub.2 is linked to the benzene ring and R.sub.2 is hydrogen, hydroxy, (C.sub.1-4)alkoxy or (C.sub.2-4)aliphatic acyloxy;2. W is the group =CH-- and A is --CH.sub.2 --, --CH.sub.2 --CH.sub.2 -- or --CH=CH--.The compounds have antireproductive utility.

Abstract: 4-Chlorophenyl-2-thienyliodonium chloride and similar salts are useful in the prevention of dental plaque and calculus, thereby minimizing or preventing gingivitis, caries and related periodontal disease.

Abstract: Compounds of the following formula ##STR1## wherein R is hydrogen, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec.-butyl or tert.-butyl; R.sub.1 is hydrogen, methyl, ethyl or phenyl; R.sub.2 is hydrogen, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec.-butyl or tert.-butyl; R.sub.3 is hydrogen, methoxy, trifluoromethyl, chloro, bromo or fluoro; and R.sub.4 is methyl. The new compounds are useful as CNS depressants, anticonvulsants, anti-inflammatories and inhibitors of the enzymes which promote the synthesis of prostaglandins.

Abstract: The antibiotic gardimycin and process for producing said antibiotic by fermentation of strains belonging to the genus Actinoplanes.

Abstract: A process for preparing 6-APA and 7-ACA and derivatives therefore is disclosed wherein a penicillin or cephalosporin substrate is reacted with a molar excess of an oxalyl halide of the formula halCOCOhal whereby the COOM group of the substrate, wherein M represents hydrogen, metal or ammonium cations, is transformed into the group COOCOCOhal.

Abstract: Intermediates for prostaglandins are synthesized from racemic malic acid and enantiomeric d- and l-malic acid derivatives. The novel synthesis of this invention offers the possibility of a stereoselective control of the reaction products to give optically-active derivatives.

Abstract: This invention concerns dibromo- and tribromomethanesulfonamides of the formula ##STR1## wherein ##STR2## is a heterocyclic ring which may contain oxygen as another hetero atom and may be substituted with 1 to 2 lower alkyl groups, and x is 2 or 3. The compounds have antimicrobial activity.

Abstract: Methyl dl-jasmonate and related compounds, which are useful in perfumery, are synthesized by alkylation of a 2-carbo(lower alkoxy)-3-oxocyclopentaneacetic acid lower alkyl ester. A new method for the synthesis of the intermediates, 2-carbo(lower alkoxy)-3-oxocyclopentene-1-acetic acid lower alkyl esters, is also described.

Abstract: Imidazolidinone derivatives of the formula ##STR1## where R, R.sub.1, R.sub.2 and R.sub.3 independently are hydrogen or lower alkyl, X represents one or two substituents selected from the group lower alkyl, halo, lower alkoxy, trifluoromethyl, and their pharmaceutically-acceptable acid salts.The compounds are prepared essentially by the method described by Wright in J. Med. Chem. 9, 852 (1966). The compounds have high depressant activity on the central nervous system.

Abstract: Pyrrolo[3,4-d]pyrimidines of the following formula: ##STR1## wherein: R is hydrogen, (C.sub.1-4)alkyl, benzyl or chloro-substituted benzyl;R.sub.1 is hydrogen, (C.sub.1-4)alkyl, phenyl or phenyl substituted with methyl, ethyl, methoxy, hydroxy, chloro, fluoro or bromo;R.sub.2 is hydrogen, (C.sub.1-4)alkyl, phenyl or amino;R.sub.3 is hydrogen or (C.sub.1-4)alkyl;D is a divalent radical selected from the groups ##STR2## wherein the carbon atoms are linked to the carbon atom of the pyrrole nucleus and R.sub.4 represents hydroxy, (C.sub.1-4)alkyl or phenyl; and a salt thereof with a pharmaceutically-acceptable acid. The compounds are useful as antiinflammatories and as prostaglandin synthetase inhibitors.

Abstract: High yields of phthalaldehydic acid from .alpha.,.alpha.,.alpha.,.alpha.',.alpha.'-pentachloro-o-xylene can be obtained in an excellent degree of purity if a mixture of said pentachloroxylene and phthalaldehydic acid in water is heated to a temperature between about 80.degree. and about 180.degree. C., and preferably at the boiling temperature of the reaction mixture. The mutual ratio of the reactants is not critical, and may vary within wide ranges, although it is usually preferred to have such a ratio between the said pentachloroxylene and phthalaldehydic acid that for each part by weight of the former at least 0.1 part by weight of the latter is present. Practically, there is no upper limit to the amount of phthalaldehydic acid which may be present, even to a large molecular excess.

Abstract: .[.7-.]..Iadd.3.Iaddend.-Cis- or .[.7.]..Iadd.3.Iaddend.-cis-trans-(3-Chloro-2-propenyl)-1,3,5,7-tetraazabi cyclo(3.3.1)nonane.[.-3-methanol.]. is prepared by reacting cis-, or cis-trans-.[.7.]..Iadd.1.Iaddend.-(3-chloro-2-propenyl)-3,5,7-triaza-1-azo niatricyclo(3.3.1.1.sup.3,7)decane chloride with excess aqueous strong base at room temperature to give the corresponding .[.carbinolamine, 7-.]..Iadd.3.Iaddend.-(3-chloro-2-propenyl)-1,3,5,7-tetraazabicyclo(3.3.1) nonane.[.-3-methanol.]..

Abstract: Compounds of the formula ##STR1## WHERE X represents O or S and R represents lower alkyl, cycloalkyl, phenyl or substituted phenyl wherein the substituents are selected from lower alkyl, lower alkoxy, halo and sulfonyl. The compounds are prepared by reacting the .[.carbinolamine.]. .Iadd.ring-opened intermediate,.Iaddend.obtained by reacting cis-1-(3-chloro-2-propenyl)-3,5,7-triaza-1-azoniatricyclo (3,3,1,1.sup.3,7) decane chloride with excess aqueous sodium hydroxide, with an equivalent amount of a corresponding R isocyanate or R isothiocyanate at a low temperature to give the substituted urea or thiourea product. The compounds have antimicrobial activity.

Abstract: Compounds of the .[.formulas.]. .Iadd.formula .Iaddend. ##STR1## wherein X.sup.- is a lower alkyl carboxylate .[.(I).]., a phenylcarboxylate .[.(I).]., a lower alkylsulfonate .[.(II).]. or a phenylsulfonate .[.(II).]. anion, wherein the phenyl ring may have lower alkyl, lower alkoxy, hydroxyl, amino, nitro, bromo or chloro substitution. The compounds are prepared by reacting the .[.carbinolamine.]. .Iadd.ring-opened intermediate .Iaddend.prepared by reacting cis-1-(3-chloro-2-propenyl)-3,5,7-triaza-1-azoniatricyclo(3.3.1.1.sup.3,7) decane chloride with aqueous sodium hydroxide, with a carboxylic or sulfonic acid, as indicated, to form the corresponding 1-cis-(3-chloro-2-propenyl)-3,5,7-triaza-1-azoniatricyclo(3.3.1.1.sup.3,7) decane carboxylate or sulfonate. These compounds have antimicrobial activity.