Patents Represented by Attorney Thomas O. McGovern

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  • Phenyl- or cycloalkyl-benzo-oxacyclic compounds
    Patent number: 4232039
    Abstract: The invention provides compounds of formula I, ##STR1## wherein R.sub.1 is branched alkyl, cycloalkyl or phenyl,R.sub.2 is hydrogen, methyl or halogen,X--Y is --CHR.sub.3 CH.sub.2 --, --CR.sub.3 .dbd.CH-- or --(CH.sub.2).sub.4, andR.sub.3 is hydrogen or alkyl,useful, for example, in the treatment of oedemas, inflammation and arthritis.
    Type: Grant
    Filed: April 14, 1978
    Date of Patent: November 4, 1980
    Assignee: Sandoz Ltd.
    Inventors: Annemarie Closse, Walter Haefliger, Daniel Hauser
  • Ergopeptine derivatives
    Patent number: 4229451
    Abstract: This invention provides new compounds of formula I, ##STR1## wherein R is branched chain alkyl of 3 to 6 carbon atoms, useful as venoconstrictors and venotonics.
    Type: Grant
    Filed: June 29, 1978
    Date of Patent: October 21, 1980
    Assignee: Sandoz Ltd.
    Inventors: Theodor Fehr, Paul Stadler
  • 2-Keto-4,5-dihydro-3 (2H)-pyridazinones, and their use in treating muscle tension
    Patent number: 4228166
    Abstract: Ketone derivatives of 4,5-dihydro-3(2H)-pyridazinones of the formula ##STR1## where R.sub.1 is halo having an atomic weight of from 19 to 36, andR.sub.2 is a branched chain lower alkyl having 3 to 4 carbon atomsare useful as central nervous system depressants, in particular, as muscle relaxants.
    Type: Grant
    Filed: March 5, 1979
    Date of Patent: October 14, 1980
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Ergolene or ergoline compounds for treating congestive heart failure
    Patent number: 4225605
    Abstract: A method for the treatment of congestive heart failure in animals comprises administering a therapeutically effective amount of an ergolene or ergoline having dopaminergic activity to an animal in need of such treatment.
    Type: Grant
    Filed: December 18, 1978
    Date of Patent: September 30, 1980
    Assignee: Sandoz Ltd.
    Inventor: Alain Audibert
  • Treating prostate hypertrophy with 4-(4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)-1-methylpiperidines
    Patent number: 4223035
    Abstract: This invention provides new compounds of formula I, ##STR1## wherein R.sub.1 is hydrogen, chlorine or lower alkyl,R.sub.2 is lower alkyl,R.sub.3 is lower alkyl, each ofA and B is hydrogen, orA and B together form a bond,useful as luteinizing hormone secretion inhibitors, e.g. for the treatment of prostate hypertorphy.
    Type: Grant
    Filed: July 24, 1978
    Date of Patent: September 16, 1980
    Assignee: Sandoz Ltd.
    Inventor: Jean-Michel Bastian
  • Organic compounds
    Patent number: 4220641
    Abstract: The present invention relates to cyclosporin derivatives, especially compounds of formula I ##STR1## wherein A is ##STR2## useful as anti-arthritic agents.
    Type: Grant
    Filed: May 4, 1978
    Date of Patent: September 2, 1980
    Assignee: Sandoz Ltd.
    Inventors: Rene P. Traber, Max Kuhn, Hans Hofmann, Eugen Harri
  • Substituted-8-phenylamino ergolines
    Patent number: 4219556
    Abstract: Compounds of formula I ##STR1## wherein R.sub.1 is hydrogen or lower alkyl,R.sub.2, R.sub.3 and R.sub.4 are, independently, hydrogen, halogen lower alkyl, lower alkoxy or CONR.sub.5 R.sub.6 wherein R.sub.5 and R.sub.6 are, independently, hydrogen or lower alkyl, and x y is --CH.sub.2 --CH.dbd. or --CH.dbd.C.dbd..are useful as central dopaminergic agents and prolactin secretion inhibitors.
    Type: Grant
    Filed: September 1, 1978
    Date of Patent: August 26, 1980
    Assignee: Sandoz Ltd.
    Inventor: Hartmut Hauth
  • Antibiotic production
    Patent number: 4215199
    Abstract: This invention provides new antibiotics produced by cultivating a strain of the fungus species, Cylindrocarpon lucidum Booth or Tolypocladium inflatum Gams in contact with a nutrient medium, the antibiotics being useful anti-inflammatory and immunosuppressive agents.
    Type: Grant
    Filed: June 5, 1978
    Date of Patent: July 29, 1980
    Assignee: Sandoz Ltd.
    Inventors: Eugen Harri, Artur Ruegger
  • Organic compounds
    Patent number: 4210581
    Abstract: The present invention provides cyclosporin C which can be hydrogenated to produce dihydrocyclosporin C of formula, ##STR1## useful as an immunosuppressive.
    Type: Grant
    Filed: June 9, 1978
    Date of Patent: July 1, 1980
    Assignee: Sandoz Ltd.
    Inventors: Artur Ruegger, Max Kuhn
  • Pleuromutilin esters
    Patent number: 4208326
    Abstract: This invention relates to new pleuromutilins of the formula: ##STR1## wherein either R.sub.1 is ethyl or vinyl,n is an integer from 2 to 5,X is sulphur,a group ##STR2## or a group .dbd.N--R.sub.4.sup.I, whereineither Y and Z are both sulphur, orone of Y and Z is oxygen and the other is sulphur, andR.sub.4.sup.I is hydrogen or a group of the formula: ##STR3## wherein R.sub.1 is as defined above, each of R.sub.2 and R.sub.3 is alkyl of 1 to 10 carbon atoms, orR.sub.2 and R.sub.3 together with the nitrogen atom form a heterocycle of 5 to 7 ring members, and pharmaceutically acceptable acid addition salts and quaternary salts thereof.Processes for the preparation of such compounds are described.The compounds are antibiotics with an antibacterial effect.
    Type: Grant
    Filed: June 5, 1978
    Date of Patent: June 17, 1980
    Assignee: Sandoz Ltd.
    Inventors: Helmut Egger, Hellmuth Reinshagen
  • 6-Branched chain alkyl sustituted ergot alkaloids
    Patent number: 4195086
    Abstract: This invention provides new compounds of formula I, ##STR1## wherein R.sub.1 is alkyl or 2 to 5 carbon atoms, andR.sub.2 is methyl or ethyl,useful as anti-migraine agents and for the treatment of orthostatic disorders.
    Type: Grant
    Filed: July 26, 1978
    Date of Patent: March 25, 1980
    Assignee: Sandoz Ltd.
    Inventors: Theodor Fehr, Paul Stadler
  • Organic compounds
    Patent number: 4187295
    Abstract: The invention provides polypeptides useful, for example, as soporifics, a process for the preparation thereof and compositions containing these compounds.
    Type: Grant
    Filed: September 6, 1978
    Date of Patent: February 5, 1980
    Assignee: Sandoz Ltd.
    Inventors: Janos Pless, Edmond Sandrin
  • Process for producing a structurally modified interferon
    Patent number: 4184917
    Abstract: The invention provides structurally modified interferons, processes for producing such and a method of purification of interferons and structurally modified interferons. The modified interferons are useful as anti-viral agents.
    Type: Grant
    Filed: September 19, 1977
    Date of Patent: January 22, 1980
    Assignee: Sandoz Ltd.
    Inventors: Friedrich Dorner, Marianne Scriba, Rudolf Weil
  • Organic compounds
    Patent number: 4183943
    Abstract: The present invention provides compounds of formula, ##STR1## wherein n is from 0 to 4, m is from 0 to 4, whereby n+m is at least 1 and not more than 4, each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may independently be, for example, hydrogen, alkyl or alkoxy, R.sub.5 may, for example, be nitrile or carbamoyl and R.sub.6 is hydrogen and, when n is 2 and m is 0, one of R.sub.6 can be alkyl of 1 to 4 carbon atoms, which compounds possess pharmaceutical, for example antiallergic, activity.
    Type: Grant
    Filed: February 3, 1978
    Date of Patent: January 15, 1980
    Assignee: Sandoz Ltd.
    Inventor: Jean-Michel Bastian
  • 3-Hydrazino-5,6,7,8,9,10-hexahydro-cycloocta[c]pyridazines
    Patent number: 4181723
    Abstract: This invention provides new compounds of formula I, ##STR1## wherein R.sub.1 is amino, or ##STR2## wherein each of R.sub.3 and R.sub.4 is independently alkyl of 1 to 4 carbon atoms,R.sub.2 is alkyl of 1 to 4 carbon atoms or phenyl,R.sub.8 is hydrogen or alkyl of 1 to 4 carbon atoms, andA is --(CH.sub.2).sub.n --,wherein n is an integer from 1 to 3, with the proviso that when R.sub.1 is amino, R.sub.2 is methyl or phenyl and R.sub.8 is hydrogen, n is 2 or 3,or .dbd.N--CO--R.sub.5,wherein R.sub.5 is alkyl of 1 to 6 carbon atoms, alkenyl of 3 to 6 carbon atoms, a --(CH.sub.2).sub.m --R.sub.6 group, wherein m is an integer from 0 to 2, and R.sub.6 is phenyl, or phenyl monosubstituted by fluorine, chlorine, bromine, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or alkylmercapto of 1 to 4 carbon atoms,or an --OR.sub.7 group,wherein R.sub.
    Type: Grant
    Filed: November 23, 1977
    Date of Patent: January 1, 1980
    Assignee: Sandoz Ltd.
    Inventor: Erhard Schenker
  • N-9,10-dihydrolysergyl-m-aminobenzoic acid amide derivative
    Patent number: 4180581
    Abstract: The present invention provides compounds of formula I, ##STR1## wherein X is hydrogen, chlorine or bromine andY is hydrogen or bromine, with the proviso that when X is chlorine Y is hydrogen,Z is carbonyl or sulphonyl,R.sub.1 is alkyl of 1 to 4 carbon atoms, andeither (i)R.sub.2 is hydrogen or alkyl of 1 to 5 carbon atoms, andR.sub.3 is hydrogen, alkyl of 1 to 5 carbon atoms, or phenyl,or (ii)R.sub.2 together with R.sub.3 is a radical of formula ##STR2## wherein R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are, independently, hydrogen or alkyl of 1 to 4 carbon atoms,or (iii)R.sub.2 together with R.sub.4 is a radical of formula--(CH.sub.2).sub.2 --A--(CH.sub.2).sub.2 --wherein A is a bond, oxygen, sulphur or NR.sub.8 wherein R.sub.8 is hydrogen, alkyl of 1 to 4 carbon atoms, phenyl or alkoxyphenyl,useful as venotonising agents.
    Type: Grant
    Filed: January 26, 1978
    Date of Patent: December 25, 1979
    Assignee: Sandoz Ltd.
    Inventor: Paul Stadler
  • 6-(Substituted phenyl)-4,5-dihydro-pyridazin-3(2H)-ones
    Patent number: 4177273
    Abstract: The present invention provides new pyridazinones of the formula ##STR1## where R is alkyl;R.sub.1 and R.sub.2 are halo, alkyl, alkoxy, amino; nitro or trifluoromethyl;R.sub.3 is hydrogen, hydroxy, or acyloxy;R.sub.4 is hydrogen or alkyl; andR.sub.5 is hydroxy or acyl;which are useful as central nervous system depressants.
    Type: Grant
    Filed: June 14, 1978
    Date of Patent: December 4, 1979
    Assignee: Sandoz, Inc.
    Inventor: Gregory B. Bennett
  • Succinic acid esters of 2-hydroxybutyl-4,5-dihydro-3(2H)-pyridazinones and their use as muscle relaxant agents
    Patent number: 4162317
    Abstract: Succinic acid esters of -4,5-dihydro-3(2H)-pyridazinones of the formula ##STR1## where R.sub.1 is hydrogen or halo having an atomic weight of from 19 to 36, andR.sub.2 is hydrogen, chloro or lower alkyl having 1 to 4 carbon atomsAre useful as central nervous system depressants, in particular, as muscle relaxants.
    Type: Grant
    Filed: May 25, 1978
    Date of Patent: July 24, 1979
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Compositions and methods to treat hypertension comprising a pyridazine and N-amidino-2-(2,6-dichlorophenyl) acetamide
    Patent number: 4152435
    Abstract: The present invention provides a pharmaceutical composition incorporating as active agents:(a) a pyridazine anti-hypertensive agent, and(b) N-amidino-2-(2,6-dichlorophenyl)acetamide.
    Type: Grant
    Filed: November 8, 1976
    Date of Patent: May 1, 1979
    Assignee: Sandoz Ltd.
    Inventor: Roland Salzmann
  • Antibiotic compositions for treating coccidiosis
    Patent number: 4148890
    Abstract: The invention provides a synergistic composition of a polyether antibiotic and a pleuromutilin derivative, which has an enhanced effect against coccidiosis in poultry. The composition may be prepared in the form of a premix concentrate and incorporated into commercial complete poultry feed. A method of treatment or prophylaxis of coccidiosis in poultry by co-administration of the components is also claimed.
    Type: Grant
    Filed: December 20, 1977
    Date of Patent: April 10, 1979
    Assignee: Sandoz Ltd.
    Inventors: Rudolf Czok, Josef G. Meingassner, Hubert Mieth, Eberhard Schutze