Patents Represented by Attorney Thomas O. McGovern

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  • 6-Methyl-8-thiomethyl-ergolene derivatives
    Patent number: 4147789
    Abstract: This invention provides new compounds of formula I, ##STR1## wherein X Y IS THE GROUP ##STR2## and R is hydrogen, cyano, a 5- or 6-membered unsaturated heterocyclic radical attached through a ring carbon atom and having 1, 2 or 3 hetero ring atoms, the first hetero atom being nitrogen, oxygen or sulphur, and the second and third hetero atoms, if present, being nitrogen, or 2- or 4-pyridyl monosubstituted by lower alkyl, lower alkoxy or halogen,Useful as anti-Parkinson agents.
    Type: Grant
    Filed: September 27, 1976
    Date of Patent: April 3, 1979
    Assignee: Sandoz Ltd.
    Inventors: Peter Stutz, Paul Stadler
  • 8-Adamantylaminomethyl ergolene derivatives
    Patent number: 4146626
    Abstract: The present invention provides compounds of the formula, ##STR1## wherein R.sub.1 is alkyl (C.sub.1-5),R.sub.2 is alkyl (C.sub.1-5),R.sub.3 is hydrogen or halogen, and either each of R.sub.4 and R.sub.5 is hydrogen, orR.sub.4 and R.sub.5, together, are a bond,Which are useful as sleep-inducing and sleep-prolonging agents.
    Type: Grant
    Filed: December 14, 1977
    Date of Patent: March 27, 1979
    Assignee: Sandoz Ltd.
    Inventors: Peter Stutz, Paul Stadler
  • Increasing vigilance or treating cerebral insufficiency with substituted vincamines
    Patent number: 4146643
    Abstract: Halo-, hydroxy-, alkyl- and alkoxy-vincamine derivatives are useful vigilance increasing agents.
    Type: Grant
    Filed: December 2, 1977
    Date of Patent: March 27, 1979
    Assignee: Sandoz Ltd.
    Inventor: Paul Pfaffli
  • Process for preparing oxazolo?3,2-a!pyrrolo?2,1-c!pyrazine derivatives
    Patent number: 4145549
    Abstract: The present invention provides a novel cyclization process useful for the production of the peptide moiety of an ergotalkaloid.
    Type: Grant
    Filed: January 7, 1977
    Date of Patent: March 20, 1979
    Assignee: Sandoz Ltd.
    Inventor: Paul Stadler
  • 1,4-Substituted piperazinyl derivatives useful as psychostimulants
    Patent number: 4144337
    Abstract: The invention provides compounds of formula I, ##STR1## wherein each of R.sub.1 and R.sub.4, which may be the same or different, is hydrogen, halogen, alkyl or alkoxy; each of R.sub.2 and R.sub.3 is hydrogen, or together, oxygen; B and D together with the carbon atoms to which they are bound may be a benzene ring or a substituted or unsubstituted thiophene ring and A may, for example, be oxygen, sulpur, --CH.sub.2 --O--, --CH.sub.2 --S, ethylene or vinylene, useful as psychostimulants and vigilance-increasing agents.
    Type: Grant
    Filed: February 14, 1977
    Date of Patent: March 13, 1979
    Assignee: Sandoz Ltd.
    Inventor: Jean-Michel Bastian
  • Influenza sub-unit vaccine
    Patent number: 4140762
    Abstract: This invention provides a novel sub-unit vaccine comprising a mixture of the hemagglutinin and neuraminidase components of the virus in the substantial absence of non-essential viral particles.
    Type: Grant
    Filed: September 23, 1977
    Date of Patent: February 20, 1979
    Assignee: Sandoz Ltd.
    Inventors: Helmut Bachmayer, Gerhard Schmidt
  • Stable solutions and processes for their preparation
    Patent number: 4138565
    Abstract: Solutions of certain hydrogenated ergopeptide alkaloids in mixtures of pharmacologically acceptable alcohols and water have improved stability. Preferred solvents are mixtures of ethanol, propylene glycol and glycerol containing from 15-40% wt. of water and having dielectric constants between 34 and 46. With these solutions it is not essential to carry out the filing operation under an inert atmosphere.
    Type: Grant
    Filed: September 15, 1977
    Date of Patent: February 6, 1979
    Assignee: Sandoz Ltd.
    Inventors: Lothar Ehrhardt, Ludwig Patt, Volker Hartmann
  • 3-Piperidino-2-hydroxypropoxy substituted-2-indolinones
    Patent number: 4137331
    Abstract: This invention provides new compounds of formula I, ##STR1## wherein Het is a radical formed by removing one of the hydrogens from the phenyl ring of 2-indolinone or fluorenone, andR is the group A, B, C or D, ##STR2## wherein N IS THE NUMBER 2 OR 3,n' is the number 1, 2, 3 or 4, andX-x' is ethylene or vinylene,Wherein in group D each of the two C atoms adjacent to the N atom are identically substituted by hydrogen or by one or two alkyl groups of 1 to 4 carbon atoms useful as antiarrhythmic agents.
    Type: Grant
    Filed: December 16, 1976
    Date of Patent: January 30, 1979
    Assignee: Sandoz Ltd.
    Inventors: Richard Berthold, Franz Troxler
  • Organic compounds
    Patent number: 4137323
    Abstract: This invention provides new compounds of formula I, ##STR1## wherein R.sub.1 is hydrogen, halogen of atomic number from 9 to 35 or lower alkyl,R.sub.2 is hydrogen or lower alkyl, each ofR.sub.3 and R.sub.4 is hydrogen, orR.sub.3 and R.sub.4 together are oxygen,N is 2, 3 or 4, andA is ethylene or vinylene,Useful as antiphlogistics and anti-arthritics.
    Type: Grant
    Filed: June 24, 1977
    Date of Patent: January 30, 1979
    Assignee: Sandoz Ltd.
    Inventor: Jean-Michel Bastian
  • Hydroxyalkyl substituted-4,5-dihydropyridazin(2H)-3-ones and diazabicyclo-ene-ones
    Patent number: 4136184
    Abstract: Hydroxyalkyl and aryl or heterocyclic substituted-4,5-dihydropyridazin(2H)-3-ones and diazabicyclo-ene-ones e.g., 6-(p-chlorophenyl)-2-(2-hydroxybutyl)-4,5-dihydropyridazin(2H)-3-one are prepared by condensing 1-hydrazino-2-alkanols with aryl or heterocyclic-.gamma.-keto acids and are useful as central nervous system depressants.
    Type: Grant
    Filed: July 22, 1977
    Date of Patent: January 23, 1979
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • -4-Phenylhexahydro-4-indolinol derivatives
    Patent number: 4124719
    Abstract: The invention provides new (3aRS,4SR,7aRS)-4-phenyl-hexahydro-4-indolinol derivatives useful as anti-depressants and anti-arrhythmics.
    Type: Grant
    Filed: April 25, 1977
    Date of Patent: November 7, 1978
    Assignee: Sandoz Ltd.
    Inventors: Richard Berthold, Franz Troxler
  • Ergot peptide alkaloid derivatives
    Patent number: 4124712
    Abstract: Compounds of formula I, ##STR1## wherein R.sub.1 is alkyl of 1 to 4 carbon atoms,R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms or benzyl,R.sub.3 and R.sub.5 are, independently, hydrogen or methyl,R.sub.4 is hydrogen or alkyl of 1 to 4 carbon atoms, andR.sub.6 and R.sub.7 together form a single bond, orR.sub.6 and R.sub.7 are each hydrogen,R.sub.6 is methoxy, andR.sub.7 is hydrogen,Are useful in the treatment of hypertension, angina pectoris, depressions, neuroses and psychoses.
    Type: Grant
    Filed: August 30, 1977
    Date of Patent: November 7, 1978
    Assignee: Sandoz Ltd.
    Inventors: Peter Stutz, Paul Stadler
  • Psychostimulating 14-amino-14,15-dihydroeburnamenines
    Patent number: 4123535
    Abstract: This invention provides new compounds of formula I, ##STR1## wherein X is hydrogen or halogen having an atomic number from 9 to 35 in the 10- or 11-position, andR is a radical of the series OR.sub.1, SR.sub.2, NR.sub.3 R.sub.4,whereinR.sub.1 and R.sub.2 are alkyl of 1 to 4 carbon atoms, hydroxyalkyl or aminoalkyl of 2 to 4 carbon atoms, phenyl or phenylalkyl of 7 to 10 carbon atoms in the aggregate thereof, andR.sub.3 and R.sub.4 are, independently, hydrogen, alkyl of 1 to 4 carbon atoms, phenyl or phenylalkyl of 7 to 10 carbon atoms in the aggregate thereof.Useful as psycho-stimulants or vigilance increasing agents.
    Type: Grant
    Filed: April 18, 1977
    Date of Patent: October 31, 1978
    Assignee: Sandoz Ltd.
    Inventor: Paul Pfaffli
  • Treating acromegaly
    Patent number: 4122190
    Abstract: .alpha.-Adrenoceptor agonists are useful in the treatment of acromegaly.
    Type: Grant
    Filed: October 3, 1977
    Date of Patent: October 24, 1978
    Assignee: Sandoz Ltd.
    Inventor: Ioana Lancranjan
  • Method of treating oligospermia and asthenospermia
    Patent number: 4122177
    Abstract: The present invention relates to a new use of an active agent selected from compounds of formula I, ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 5 carbon atoms,R.sub.2 is hydrogen, alkyl of 1 to 5 carbon atoms or benzyl, andR.sub.3 is hydrogen or alkyl of 1 to 4 carbon atoms,In the treatment of oligosphermia and asthenospermia.
    Type: Grant
    Filed: September 1, 1977
    Date of Patent: October 24, 1978
    Assignee: Sandoz Ltd.
    Inventor: Hans Ulrich Fehr
  • Organic compounds
    Patent number: 4117118
    Abstract: This invention provides new antibiotics produced by cultivating a strain of the fungus species, Cylindrocarpon lucidum Booth or Tolypocladium inflatum Gams in contact with a nutrient medium, the antibiotics being useful anti-inflammatory and immunosuppressive agents.
    Type: Grant
    Filed: March 28, 1977
    Date of Patent: September 26, 1978
    Assignee: Sandoz Ltd.
    Inventors: Eugen Harri, Artur Ruegger
  • Indolinylguanidines
    Patent number: 4112111
    Abstract: This invention provides new compounds of formula I, ##STR1## wherein R.sub.1 to R.sub.3 are hydrogen or optionally substituted hydrocarbyl substituents, andR.sub.5 and R.sub.6 are hydrogen, halogen, alkoxy or alkylthio,Useful as anti-hypertensive agents.
    Type: Grant
    Filed: July 27, 1977
    Date of Patent: September 5, 1978
    Assignee: Sandoz Ltd.
    Inventors: Gerhard Bormann, Richard Berthold
  • Polyhalo alkyl or alkenyl alcohol esters of piperazino acids
    Patent number: 4112091
    Abstract: Inhibiting methanogenesis by adding polyhaloalkyl or alkenyl alcohol esters of piperazino acids of the formula ##STR1## wherein X and Z are oxygen or sulphur.
    Type: Grant
    Filed: April 4, 1977
    Date of Patent: September 5, 1978
    Assignee: Sandoz Ltd.
    Inventors: Hans Nesvadba, Hellmuth Reinshagen
  • Dihydrocyclosporin C
    Patent number: 4108985
    Abstract: The present invention provides dihydrocyclosporin C of formula, ##STR1## useful as an immunosuppressive.
    Type: Grant
    Filed: October 27, 1976
    Date of Patent: August 22, 1978
    Assignee: Sandoz Ltd.
    Inventors: Artur Ruegger, Max Kuhn
  • Process for making pleuromutilins
    Patent number: 4107434
    Abstract: Novel process for the production of antibacterially active pleuromutilin derivatives.
    Type: Grant
    Filed: January 10, 1977
    Date of Patent: August 15, 1978
    Assignee: Sandoz Ltd.
    Inventor: Erwin Waldvogel