Abstract: This invention relates to new pleuromutilins of the formula: ##STR1## wherein EITHERR.sub.1 is ethyl or vinyl,N is an integer from 2 to 5,X is sulphur, a group ##STR2## or a group =N--R.sub.4 .sup.I, whereinWhereinEither Y and Z are both sulphur, orOne of Y and Z is oxygen and the other is sulphur, andR.sub.4.sup.i is hydrogen or a group of the formula: ##STR3## wherein R.sub.1 is as defined above,Each ofR.sub.2 and R.sub.3 is alkyl of 1 to 10 carbon atoms, orR.sub.2 and R.sub.3 together with the nitrogen atom form a heterocycle of 5 to 7 ring members,And pharmaceutically acceptable acid addition salts and quaternary salts thereof.Processes for the preparation of such compounds are described.The compounds are antibiotics with an antibacterial effect.

Abstract: Free flowing, rapid dissolving, effervescent granules in particular, potassium chloride granules, are prepared by granulating an alkali metal carbonate and/or bicarbonate and active ingredient with water containing a surfactant, such as polyethylene glycol 1540, and after drying mixing with a pharmaceutically acceptable organic acid plus additives.

Abstract: This invention provides new compounds of formula I, ##STR1## wherein R.sub.1 is hydrogen, alkyl of 2 to 8 carbon atoms, or phenylalkyl of 7 to 9 carbon atoms, andR.sub.2 is branched alkyl of 3 or 4 carbon atoms or benzyl,Useful as agents for the treatment of migraine, hypotonia and orthostatic disorders.

Abstract: The invention provides novel pleuromutilin solvates and a method of purifying pleuromutilin via such solvates.

Abstract: This invention provides new compounds of formula I, ##STR1## wherein the indicated radical in the 8 or 9 position of the benzonaphthyridine structure (R.sub.1) is hydrogen, alkoxy of 1 to 4 carbon atoms or hydroxy, andR.sub.2, r.sub.3 and R.sub.4 are selected in certain combinations from hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, benzyloxy, hydroxy, halogen, nitro, amino, dimethylamino, or --NHCOR.sub.5wherein R.sub.5 is hydrogen or alkyl of 1 to 4 carbon atoms,Useful as bronchospasmolytics.

Abstract: 6-(1-Piperazinyl)morphanthridine is a useful sleep promoting agent.

Abstract: The present invention provides compounds of formula I, ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 4 carbon atoms in position 1 or 2 of the indazole nucleus,R.sub.2 is hydrogen, halogen, trifluoromethyl, hydroxy or alkyl, alkylthio or alkoxy of 1 to 4 carbon atoms, or a group of formula II, ##STR2## wherein X is oxygen or sulphur,R.sub.3 is hydrogen, halogen, trifluoromethyl, hydroxy or alkyl, alkylthio or alkoxy of 1 to 4 carbon atoms, andR.sub.4 is hydrogen or a group of formula II, as defined above, with the proviso that one of R.sub.2 and R.sub.4 is a group of formula II and the other is other than a group of formula II,useful as myotonolytics and anti-hypertensives.

Abstract: The present invention relates to the use of the known compounds of formula ##STR1## wherein R is lower alkyl, as mood elevating agents for geriatric patients.

Abstract: The present invention relates to a pharmaceutical composition comprising aggregates of diameter of at most 20,000 A, comprising:Component (a) comprising at least one pharmaceutically acceptable active agent, andComponent (b) comprising at least one pharmaceutically acceptable emulsifier,Component (b) having a mean HLB value of 10 to 30 and present in an amount greater than 10 times by weight of component (a).The composition has enhanced resorption properties.

Abstract: The present invention concerns novel 13-bromo-lysergic acid compounds of formula I: ##STR1## wherein R.sub.2 is isopropyl, 1 or 2-methylpropyl or benzyl, useful as agents for the treatment of cerebral insufficiency.

Abstract: The present invention relates to the use of the known compound 4-(1-methyl-4-piperidylidene)-4H-benzo 4,5!cyclohepta 1,2-b!thiophen-10(9H )-one for the prevention and treatment of allergic conditions such as allergic asthma.

Abstract: The invention concerns novel compounds of the formula: ##STR1## wherein n is 1, 2 or 3 R.sub.1 is lower alkylR.sub.2 is hydrogen or lower alkyl andA is a tricyclic moiety,Useful as sedative-neuroleptic, muscle-relaxant and sleep-promoting agents.

Abstract: The immunogenic components from influenze viruses are isolated by selectively solubilizing the component in an aqueous media with a cationic detergent.

Abstract: This invention provides new compounds of formula I, ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 4 carbon atoms,Or hydroxyalkyl of 1 to 4 carbon atoms, andR.sub.2 is hydrogen or halogen,Useful as anti-psychotics and sleep-inducing agents.

Abstract: The invention provides structurally modified interferons, processes for producing such and a method of purification of interferons and structurally modified interferons. The modified interferons are useful as anti-viral agents.

Abstract: The present invention concerns novel compounds of formula I, ##STR1## wherein R.sub.1 is hydroxy, or ##STR2## wherein N IS AN INTEGER FROM 1 TO 5, ANDR.sub.3 and R.sub.4 are independently alkyl of 1 to 4 carbon atoms, orR.sub.3 and R.sub.4 together form an alkylene chain of 2 or 3 carbon atoms,R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms, phenylalkyl of 7 to 9 carbon atoms, or phenylalkyl of 7 to 9 carbon atoms mono- or disubstituted on the phenyl radical by halogen, alkyl of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms, andEitherX is hydrogen, andY is methyl,OrX is methylthio or dialkylamino, wherein the alkyl chains are independently of 1 to 4 carbon atoms, andY is hydrogen,OrX is chlorine or bromine, andY is chlorine,Or, when R.sub.1 is the above acetal group, X also signifies hydrogen, chlorine, bromine or methyl, and Y signifies hydrogen,Useful as salidiuretics.

Abstract: The invention provides novel 5-nitrothiazolylimidazoline derivatives, useful as chemotherapeutic agents.

Abstract: This invention provides novel 5-nitrothiazolo-2-imidazoles which are useful as chemotherapeutical agents.

Abstract: Hydroxyalkyl and aryl or heterocyclic substituted-4,5-dihydropyridazin(2H)-3-ones and diazobicyclo-ene-ones, e.g., 6-(p-chlorophenyl)-2-(2-hydroxybutyl)-4,5-dihydropyridazin(2H)-3-one are prepared by condensing 1-hydrazino-2-alkanols with aryl or heterocyclic-.gamma.-keto acids and are useful as central nervous system depressants.

Abstract: Basically substituted imidazolyl-2-quinazolines of the formula ##STR1## where R.sub.1 is hydrogen, lower alkyl or halogen;R.sub.2 is lower alkyl, lower alkenyl or lower hydroxalkyl; andR.sub.3 is a basic organic substituent,Are useful as anti-parasitic agents and as mycoplasma growth inhibiting agents.