Abstract: A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyzes. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyzes requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyzes.

Abstract: Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.

Abstract: According to the invention, an apparatus for transferring heat with a target is disclosed. The apparatus may include a body which defines a surface, inlet port, inlet manifold passages, heat transfer passages, outlet manifold passages, and outlet port. The surface may couple the target with the body. The inlet port may be configured to receive and direct a fluid into inlet manifold passages. The inlet manifold passages may be configured to receive and direct the fluid to the heat transfer passages. The heat transfer passages may be configured to receive and direct the fluid in a direction substantially parallel to the surface and substantially perpendicular the input manifold passages. The outlet manifold passages may be configured to receive and direct the fluid to an outlet port. The outlet port may be configured to receive and output the fluid.

Abstract: The present invention is directed to technology for enabling an Identity System to interact with provisioning systems. An Identity System sets a job code attribute for an entity that it manages. The job code attribute corresponds to a set of external resources associated with the entity. The resources may be supported by different provisioning systems. In response to the entity's job code attribute, a Provisioning Bridge Server provisions tasks required to make the external resources available to the entity. The tasks may be provisioned across multiple provisioning systems.

Abstract: A method for rendering a frame of animation includes retrieving scene descriptor data that specifies at least one object, wherein the object is associated with a first database query, wherein the first database query is associated with a first rendering option, receiving a selection of the first rendering option or a second rendering option, querying a database with the first database query and receiving a first representation of the object from a database when the selection is of the first rendering option, loading the first representation of the object into computer memory when the selection is of the first rendering option, and rendering the object for the frame of animation using the first representation of the object when the selection is of the first rendering option, wherein the first representation of the object is not loaded into computer memory when the selection is of the second rendering option.

Abstract: A system for providing frame rate conversion for audio data is provided. The system includes a first client configured to transmit audio data frames at a first frame rate, a second client configured to receive audio data frames at a second frame rate. The first frame rate is different from the second frame rate. The system further includes a device configured to facilitate transmission of audio data frames between the first client and the second client. The device is further configured to receive the audio data frames from the first client at the first frame rate, store the received audio data frames in an intermediate storage area and repackage the stored audio data frames into one or more frames for transmission to the second client at the second frame rate.

Abstract: An apparatus and method define a fit a set of upper and lower teeth in a masticatory system of a patient by generating a computer representation of the masticatory system of the patient; and determining an occlusion from the computer representation of the masticatory system using one or more keys.

Abstract: Systems and methods are provided for notifying a wireless communication device user regarding an account payment. One method comprises dialing a phone number of a wireless communication device, preferably a cell phone. A communication relating to an account payment that includes a balance due is then transmitted or delivered to a wireless communication device user. Optionally, at the same time or a later time, input from the wireless communication device user may be received regarding payment of the balance due. Such notification methods may be carried out by a host computer system which has a record of when the account payment is due and dials and transmits within a predetermined time frame. Generally, such methods will further comprise pre-registering or enrolling the wireless communication device user.

Abstract: Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.

Abstract: A method for making a premolded clip structure is disclosed. The method includes obtaining a first clip and a second clip, and forming a molding material around the first clip comprising a first surface and the second clip comprising a second surface. The first surface of the first clip structure and the second surface of the second clip structure are exposed through the molding material, and a premolded clip structure is then formed.

Abstract: A system and method issues a credit card or other credit instrument to a user by first obtaining authorization and authentication from the user.

Abstract: Embodiments of the present invention relate to the use of stamping to form features on a lead frame of a semiconductor device package. In one embodiment, portions of the lead frame such as pins are moved out of the horizontal plane of a diepad by stamping. In certain embodiments, indentations or a complex cross-sectional profile, such as chamfered, may be imparted to portions of the pins and/or diepad by stamping. The complexity offered by such a stamped cross-sectional profile serves to enhance mechanical interlocking of the lead frame within the plastic molding of the package body. Other techniques such as selective electroplating and/or formation of a brown oxide guard band to limit spreading of adhesive material during die attach, may be employed alone or in combination to facilitate fabrication of a package having such stamped features.

Abstract: In one embodiment, the invention provides a device for decreasing intracranial or intraocular pressures. The device comprises a housing having an inlet opening and an outlet opening that is adapted to be interfaced with a person's airway. The device further includes a valve system that is operable to regulate respiratory gas flows through the housing and into the person's lungs during spontaneous or artificial inspiration. The valve system assists in lowering intrathoracic pressures during each inspiration to repetitively lower pressures in the venous blood vessels that transport blood out of the head to thereby reduce intracranial or intraocular pressures.

Abstract: A system and device for maintaining and/or creating patency in airways is disclosed. The methods of using the system and device are also disclosed. The system includes a power source that energizes a electro-active polymer implant. The energized polymer implant provides stiffness and shape to the airway, thereby minimizing collapse or deformation of the airway. A method of making the device is also disclosed.

Abstract: A loyalty program business model includes entering into an agreement with loyalty program partners and agreeing on exchange rates between a variety of loyalty unit types. Partner accrual records (PAR's) arc accepted from the loyalty program partners related to the business activity of related loyalty program members. Loyalty units credits are calculated for a member from data obtained in the step of accepting. A partner loyalty account balance is updated according to the standardized loyalty unit debit obtained in the step of calculating. Then an invoice can be billed to a partner according to the partner loyalty account balance.

Abstract: A method for a computer system includes determining an animation variable response subspace within an animation variable response space associated with an animation variable, in response to a set of training data for the animation variable, determining a set of characteristic calculation key points configured to allow navigation within the animation variable response subspace, calculating animation variable response values for the set of characteristic calculation key points in the animation variable response subspace in response to input data for the animation variable, and predicting animation variable response values for a set of points within the animation variable response space in response to animation variable response values for the set of characteristic calculation key points in the animation variable response subspace.

Abstract: Methods, systems, and devices are described for music-based searching. Embodiments of the invention receiving music queries that specify music elements, the queries using textual, audio, and/or score data. The music queries may be used to generate search parameters based on the specified music elements, which may in some cases be weighted. The search parameters may then be directing against a database comprising data records, each data record being associated with a music piece and a set of music elements relating to the music piece. Matching data records in the database may then be identified based on music elements common between the search parameters and the associated music piece. Search output may then be ranked, displayed, and output in various ways.

Abstract: A process chamber 1 for PECVD (Plasma Enhanced Chemical Vapor Deposition) coating of a substrate includes an electrode, which is integrated in a contact frame, which is firmly connected to the recipient. A movable carrier in the process chamber carries at least one substrate. The carrier is transported by means of a driven roller positioner into the process chamber or out of the process chamber along a transport route defined by the movement. As soon as the carrier inside the recipient has reached a certain position, the lower roller positioner is uncoupled from carrier by lowering by means of a lifting device. In this regard, the carrier detaches itself from the upper roller positioner. Then, the carrier is accepted by a transfer device (not shown) and brought from the transport position laterally into a treatment position in contact with the contact frame. In this way, reliable contact is produced between the electrode and a counter-electrode provided in carrier.

Abstract: Micromodules and methods of making them are disclosed. An exemplary micromodule includes a substrate having a thin film inductor, and a bumped die mounted on the substrate and over the thin film inductor.