Abstract: A variety of zinc finger proteins (ZFPs) and methods utilizing such proteins are provided for use in treating neuropathic pain. ZFPs that bind to a target site in genes that are aberrantly expressed in subjects having neuropathic pain are described. In addition, ZFPs that bind to a target site in genes expressed at normal levels in subjects experiencing neuropathic pain, modulation of whose expression results in decreased pain perception, are also provided. For example, genes that are over-expressed in the dorsal root ganglia (DRG) of pain patients (e.g., VR1, TRKA and/or Nav1.8) can be repressed, whereas genes that are under-expressed in the same populations can be activated.

Abstract: A method of respectively reading and writing data to and from a plurality of physical disk units in response to I/O requests from a host computing system includes establishing a logical disk group having a number of logical disk elements, mapping each of the logical disk elements to corresponding physical disk units, receiving from the host computing system an I/O request for data to select a one of the number of logical disk elements, accessing the physical disk unit corresponding to the selected one logical disk to access for the data, and transferring the accessed data to the host computing system.

Abstract: An apparatus and method for encoding and decoding a voice signal. The apparatus includes an encoder configured to generate an output bitstream signal from an input voice signal. The output bitstream signal is associated with at least a first standard of a first plurality of CELP voice compression standards. Additionally, the apparatus includes a decoder configured to generate an output voice signal from an input bitstream signal. The input bitstream signal is associated with at least a first standard of a second plurality of CELP voice compression standards. The CELP encoder includes a plurality of codec-specific encoder modules. Additionally, the CELP encoder includes a plurality of generic encoder modules. The CELP decoder includes a plurality of codec-specific decoder modules. Additionally, the CELP decoder includes a plurality of generic decoder modules.

Abstract: The present invention provides a novel method for detection and/or genotyping of nucleic acids that utilizes the specificity of an AP endonuclease. In addition, the present invention provides a novel method for nucleic acid amplification.

Abstract: A system for monitoring information real-time through a network. The system has a plurality of network elements Each of the network elements comprises an interface device. The plurality of network elements are configured to route a call from a source to a destination through the network elements. A mediator is coupled to each of the network elements. The mediator is adapted to receive events from any one of the network elements as the call as being routed through the elements from the source to the destination. A message bus is coupled to the mediator for receiving the events. The system also has an application process coupled to the messaging bus. The application process is adapted to use the events. The system is fault tolerant and information under process is not lost even when one of the system components fails.

Abstract: In accordance with the invention a thread carrying apparatus is proposed with a thread (2) lying in contact with or passing along the thread carrying apparatus with friction in the operating state. The thread carrying apparatus includes excitation means (3) for producing oscillations which reduce the frictional force between the thread (2) and the thread carrying apparatus. In this arrangement a resonator body (4) is provided with the thread (2) lying in contact with or passing along the resonator body with friction in the operating state. The resonator body (4) is designed in such a manner that the excitation means (3) produce resonant structural sound oscillations in the resonator body (4).

Abstract: This invention provides a method for treating or preventing arrhythmias in a human subject comprising the administration of an effective amount of a calcium/calmodulin-dependent protein kinase inhibitor. Also provided are pharmaceutical compositions comprising a calcium/calmodulin-dependent protein kinase inhibitor and a pharmaceutically acceptable carrier and methods for identifying agents useful for the treatment of arrhythmias.

Abstract: An integrated circuit device structure (and methods). The structure includes a semiconductor substrate comprising a surface. A first doped polysilicon liner is defined within a first trench region formed on a first plug coupled to the surface of the substrate and a second doped polysilicon liner is defined within a second trench region on a second plug coupled to the surface of the substrate. The first trench region is separated from the second trench region by a predetermined dimension. The structure also has a first rugged polysilicon material overlying surfaces of the first doped polysilicon material within the first trench region and a second rugged polysilicon material overlying surfaces of the second doped polysilicon material in the second trench region. The first rugged polysilicon material is free from a possibility of electrical contact with the second rugged polysilicon material.

Abstract: The invention provides systems and methods for ergonomic dental instruments for dental professionals with small hands. In one embodiment, a dental instrument includes an elongated metal handle having a length in the range of about 3- 7/16 inches to about 3- 15/16 inches and a diameter in the range of about ¼ inches to about ¾ inches. A working end may be operably coupled to one or both ends of the handle via a sweated fit. The length and knurling of the elongated metal shaft and terminal shaft facilitate optimum performance for the user.

Abstract: Provided are nucleic acid sequences from Brassica oleracea plants that encode enzymes involved in the synthesis of a glucosinolate molecule, including BoGSL-ALK, and BoGSL-ELONG, and methods of their use. The sequences find particular use in modifying the glucosinolate content of a plant. Also provided are primers for these two genes and a third key gene in the glucosinolate pathway, BoGSL-PRO, that can be used for developing molecular markers for assisted selection of plants with specific glucosinolate compositions. Additionally, compositions and methods for a simple, reliable and efficient PCR-based marker system, named sequence-related amplification polymorphism (SRAP), that finds use in the identification of coding sequences in the genome of a plant are provided.

Abstract: Processes, techniques, and compositions used to fabricate high performance solid acid fuel cell membrane electrode assemblies are disclosed. The techniques include preparing the solid acid electrolyte material, depositing the electrolyte membrane, depositing the electrocatalyst layer, preparing the electrodes, fabricating the gas seals, and constructing the membrane electrode assembly.

Abstract: The invention relates to the internal exhaust-gas recirculation in an internal combustion engine with gas exchange valves periodically controlled by a camshaft (22) in accordance with the four-stroke principle, in which, during the gas exchange exhausting of exhaust gas from the respective cylinder (1) into the exhaust duct (5), an intake valve (2) associated with the respective cylinder (1) is open in a crank angle range after top dead center of the ignition of the gas mixture present in the cylinder (1), in order to exhaust part of the exhaust gas into an intake duct (3), so that during the next gas exchange intake both fresh gas and exhaust gas are taken in from the intake duct (3), the respective intake valve (2) being actuated during the gas exchange exhausting independently of the periodic gas exchange intake, and the additional opening of the respective intake valve (2) being carried out in the range from 110 to 150% of the opening angle of the start of opening of the exhaust duct (5) by the exhaust va

Abstract: Apparatuses and methods are provided directed at teaching writing, such as printing, cursive, and calligraphy, to users of all ages. Typically, the embodiments are directed toward teaching children the basic skills of writing. However, it may be appreciated that the embodiments may be utilized by users of all ages. In particular, embodiments of the invention can be used to teach the skill of writing and learning letters of the English alphabet to foreigners. Or, embodiments of the invention can be used to teach English speakers various foreign alphabets. For example, embodiments may provide instruction in writing Arabic letters, Greek letters, or Chinese or Japanese characters, to name a few. Additionally, embodiments of the invention may be used to teach artistic forms of writing, such as calligraphy, script, or various fonts.

Abstract: A non-volatile memory device includes a substrate having a first active region and a second active region. A first floating gate is provided over the first active region and having an edge, the first floating gate being made of a conductive material. A first spacer is connected to the edge of the first floating gate and being made of the same conductive material as that of the first floating gate. A control gate is provided proximate to the floating gate.

Abstract: A material analysis system configured to determine whether a circuit is defective includes a magnetic field generator configured to generate a first magnetic field that is configured to induce at least one eddy current in a conductive portion of the circuit, wherein the eddy current induces a second magnetic field; a set of magnetic field sensors configured to detect the second magnetic field and generate a set of image information therefrom; a database that includes circuit information for the circuit; and a computing device configured to receive the image information from the set of magnetic field sensors and retrieve the circuit information from the database, wherein the computing device is configured to compare the image information to the circuit information to determine whether the circuit is defective.

Abstract: According to the invention, a method for establishing a personal communication between an originating end and a terminating end of a communication system is disclosed. In one step, a first number of personal communication modes associated with the originating end is retrieved. A determination is made if a second number of personal communication modes associated with the terminating end comprises any personal communication modes compatible with the first number of personal communication modes. A compatible personal communication mode from the first number of personal communication modes and the second number of personal communication modes is chosen to indicate the compatible personal communication mode to the terminating end.

Abstract: The system includes a bin hopper which temporarily stores a plurality of small elements, such as medications. The elements are moved out of the bin and singulated into a one-by-one sequence by a series of singulating conveyors. The resulting sequence of elements is moved onto a main system conveyor where the element is identified and then moved to a loading mechanism which arranges the item so it is ready to be gripped and stored. The system includes a mass storage apparatus comprising a series of four upstanding cylindrical drums, each having a plurality of individually accessible and addressable cell storage locations for the elements. A gripping apparatus removes the elements from the loading mechanism and transfers them to a selected location in a cylindrical drum. When an article is to be dispensed, the drum is rotated so that an ejection arm comes adjacent the desired location in the drum.

Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

Abstract: A mammalian homology of Drosophila Disabled protein has been identified and cloned. In particular, the murine homolog designated mDab1 has been cloned and expressed. mDab1, when tyrosine phosphorylated, binds to the SH2 domain of Src, Abl and Fyn. Antibodies specific for mDab1 are provided as are methods for the screening of agents for their ability to modulate mDab1 activity. Methods for diagnosing Disabled protein associated disease are also provided.

Abstract: A memory controller can perform prefetching, in a way which increases the efficiency with which data can be read from an external memory. More specifically, the memory controller operates such that it performs prefetching only under certain conditions, which are chosen such that there is a high probability that the data requested in the prefetching operation will be the data which is next required. The memory controller may be implemented in a programmable logic device (PLD), and be optimized for retrieving data from an external flash or SRAM memory device, which is used for storing configuration data for the PLD. By examining a read request, it is possible to determine whether a prefetching operation can be performed, with a high probability that it will be the required data which is prefetched.