Abstract: With an automatic layout method, a first line having a first line width is generated in a prescribed direction. A second line having a second line width and extending at an oblique angle with respect to the first line is generated, so that the second line terminates at an end portion of the first line with an overlapped area. One or more VIA patterns are read out of a database according to the shape of the overlapped area. The VIA patterns are placed in the overlapped area, so that one of the VIA patterns is located at the intersection of the center lines of the first and second lines. The VIA pattern is a combination of parallelograms, including squares and rectangles.

Abstract: A logic circuit design equipment and a logic circuit design method include analyzing input states of all of first cells, respectively, analyzing leakage currents of all of first cells in a case where each first cell is high Vth cell showing a small leakage current at a low speed operation and low Vth cell showing a large leakage current at a high speed operation, respectively, and substituting the first cells for second cells within a range satisfying a timing restriction. Herein, a threshold of the second cell is different from a threshold of the first cell.

Abstract: A nonvolatile reprogrammable switch for use in a PLD or FPGA has a nonvolatile memory cell connected to the gate of an MOS transistor, which is in a well, with the terminals of the MOS transistor connected to the source of the signal and to the circuit. The nonvolatile memory cell is of a split gate type having a first region and a second region, with a channel therebetween. The cell has a floating gate positioned over a first portion of the channel, which is adjacent to the first region and a control gate positioned over a second portion of the channel, which is adjacent to the second region. The second region is connected to the gate of the MOS transistor. The cell is programmed by injecting electrons from the channel onto the floating gate by hot electron injection mechanism. The cell is erased by Fowler-Nordheim tunneling of the electrons from the floating gate to the control gate. As a result, no high voltage is ever applied to the second region during program or erase.

Abstract: Glutamate Transporter Associated Proteins and nucleotide encoding Glutamate Transporter Associated Proteins are provided. Also provided is a method for identifying a compound that modulates a cellular response mediated by a Glutamate Transporter Associated Protein. A method is further provided for identifying a compound that inhibits an interaction between a Glutamate Transporter Associated Protein and a glutamate transporter protein. A method is provided for treating a disorder associated with glutamate transport.

Abstract: In accordance with the present invention there is provided a new class of sterically demanding metallo-intercalators. These compounds intercalate between bases in a duplex polynucleotide, but only where the bases are not fully complementary, for example, where there is a base-pair mismatch. The compounds are sufficiently sterically demanding that intercalation between bases in fully complementary duplexes does not occur to a significant degree. These mismatch intercalators are useful for detecting DNA and RNA defects, for diagnosing disorders characterized by the presence or increase in DNA and/or RNA defects, and for treating such disorders. Further, the compounds are capable of catalyzing photolytic cleavage of nucleic acids at relatively long wavelengths, and under normal sunlight.

Abstract: A preferred WDM all optical packet switched router architecture and an integrated analysis method for determining said architecture are disclosed. The method of the present invention includes the steps of simulating, with a network simulator, the operation of a desired network topology having at least one baseline router, establishing a steady state in the network simulation, applying a router and network dimensioning algorithm to the desired network topology for a predetermined number of clock cycles, and determining the preferred network router architecture based on the predetermined number of clock cycles. The baseline router used in the method of this invention can be a WDM all optical packet switched router, and the preferred network router architecture can be a WDM all-optical packet switched router architecture.

Abstract: An integrated multilevel nonvolatile flash memory device has a memory array of a plurality of memory units arranged in a plurality of rows and columns. Each of the memory units has a plurality of memory cells with each memory cell for storing a multibit state. Each of the memory units stores encoded user data and overhead data. The partitioning of the encoded user data and the overhead data stored in a single memory unit may be done virtually. The result is a compact memory unit without the need for an index to overhead data for its associated user data.

Abstract: A system and method are disclosed for monitoring performance of a wireless network. A probe server controls posts to send and receive probes of the wireless network. Wireless devices at the posts send the probes to the wireless network and receive probes from the wireless network. These probes provide feedback information, which indicates how the wireless network is performing.

Abstract: Microfluidic apparatus including integrated porous substrate/sensors that may be used for detecting targeted biological and chemical molecules and compounds. In one aspect, upper and lower microfluidic channels are defined in respective halves of a substrate, which are sandwiched around a porous membrane upon assembly. In another aspect, the upper and lower channels are formed such that a portion of the lower channel passes beneath a portion of the upper channel to form a cross-channel area, wherein the membrane is disposed between the two channels. In various embodiments, one or more porous membranes are disposed proximate to corresponding cross-channel areas defined by one or more upper and lower channels. The porous membrane may also have sensing characteristics, such that it produces a change in an optical and/or electronic characteristic.

Abstract: A non-volatile memory cell has a single crystalline semiconductive material, such as single crystalline silicon, of a first conductivity type. A first and a second region each of a second conductivity type, different from the first conductivity type, spaced apart from one another is formed in the semiconductive material. A channel region, having a first portion, and a second portion, connects the first and second regions for the conduction of charges. A dielectric is on the channel region. A floating gate, which can be conductive or non-conductive, is on the dielectric, spaced apart from the first portion of the channel region. The first portion of the channel region is adjacent to the first region, with the first floating gate having generally a triangular shape. The floating gate is formed in a cavity. A gate electrode is capacitively coupled to the first floating gate, and is spaced apart from the second portion of the channel region.

Abstract: A hybrid circuit models a plurality of attributes of a communication system including a subscriber line coupled to a line interface circuit. The plurality of attributes includes subscriber line impedance, and impedance of a coupling transformer. The attributes are based on other factors, such as whether or not bridge taps exist at or near the line interface circuit on the subscriber line. The plurality of attributes are modeled by a specific arrangement of resistive and capacitive elements to substantially duplicate the collective transforming effects of the attributes on a transmission signal being sent out on the subscriber line. The transmission signal is transformed and provided to an output, where it is subtracted from a composite signal representing a combination of the actual transformed transmission signal and a receive signal. The subtraction yields an isolated receive signal, which is later processed to recover the full receive signal.

Abstract: This invention provides tandem fluorescent protein construct including a donor fluorescent protein moiety, an acceptor fluorescent protein moiety and a linker moiety that couples the donor and acceptor moieties. The donor and acceptor moieties exhibit fluorescence resonance energy transfer which is eliminated upon cleavage. The constructs are useful in enzymatic assays.

Abstract: Part of light emitted downward by an active layer is reflected by an electrode functioning as a reflective layer, and travels upward to radiate outside. Since the electrode is made of a metal, it reflects almost all light regardless of its incident angle, and light can be efficiently extracted.

Abstract: This invention provides a method and apparatus for spectral power monitoring by use of a polarization diversity scheme. In the present invention, a multi-wavelength optical signal is first decomposed into first and second polarization components, and the second polarization component is subsequently rotated by 90-degrees, prior to impinging onto a diffraction grating that provides a higher diffraction efficiency for the first polarization component. The diffraction grating separates the first and second polarization components by wavelength respectively into first and second sets of optical beams, impinging onto an array of optical power sensors. The inventive optical spectral power monitoring apparatus thus is able to minimize the insertion loss, while providing enhanced spectral resolution.

Abstract: This invention concerns an aircraft equipped for conducting airborne gravity surveys. In another aspect it concerns a process for creating airborne gravity surveys. The aircraft is equipped to perform the method using measured attitude data, laser range data and scan angle data, and aircraft position data.

Abstract: The present invention relates to a human Mcl-1 gene, to nucleotide sequences that act as regulatory elements for expression of an Mcl-1 gene, to polynucleotides encoding a variant Mcl-1s/&Dgr;TM polypeptide, and to oligonucleotides, which contain at least ten nucleotides and can hybridize specifically to a splice junction of the disclosed Mcl-1 gene or to a polynucleotide encoding an Mcl-1 variant polypeptide as disclosed herein. The invention also relates to an Mcl-1s/&Dgr;TM polypeptide, as well as to antibodies that can interact specifically with an epitope of Mcl-1s/&Dgr;TM, but not with an epitope of the full length Mcl-1 polypeptide. In addition, the invention relates to a method of expressing a nucleic acid molecule in a cell by introducing into the cell the Mcl-1 gene regulatory element as disclosed herein, such that a nucleic acid molecule that is operatively linked to the Mcl-1 gene regulatory element is expressed in the cell.

Abstract: A linear motion device is disclosed which includes an armature assembly, and a field assembly which includes a plurality of permanent magnets each having a length, and a plurality of pole pieces each having a length. The ratio between the length of the plurality of permanent magnets and the length of the plurality of pole pieces is tailored to achieve a constant force versus stroke characteristic, when sinusoidal commutation is used.

Abstract: The invention tissue injection catheters are designed to facilitate injection of a therapeutic or diagnostic agent to an interior body cavity, especially the myocardium or epicardium of the heart with precisely controlled depth penetration. The invention injection catheters, which include mechanisms for precisely controlling the length of needle tip exposed for tissue penetration, are designed to be used in an assemblage with a sterile container and delivery actuator for reinjection of autologous cell-containing fluids, such as autologous bone marrow aspirate. In preferred embodiments, the assemblage is designed to be hand-held. When used in such an assemblage, the invention catheters are particularly useful as a gene delivery device to effect angiogenesis of ischemic areas of the heart.

Abstract: The invention provides systems containing a sterile container for aspiration, filtering, treating and reinjection into a subject of a bodily fluid in a sterile environment. The systems are particularly designed to facilitate transfection of cells within the sterile container by gene therapy molecules and reinjection of the transfected cells into the donor at controlled depth in precisely controlled volumes such as is useful for revascularization of ischemic cardiac tissue. For injection, a pressure actuator, preferably hand-held, applies force to liquids held within the sterile container in precisely controlled increments, thereby expressing liquids through a hollow needle or injection catheter in precisely controlled microvolumes. The invention systems include a hand-held injection device with audible cues that correspond to an operator-selected injection volume and/or audible cues that correspond to needle penetration depth selected by the operator.