Abstract: Mechanical enhancement of the burning rate of solid propellants is achieved y the incorporation of limited percentages of heat-expandable beads into the solid propellant matrix. When the flame front reaches an individual bead, the bead which contains an expanding or blowing agent (e.g., pentane, 4,4'-oxybis(benzenesulfonyl hydrazide) (Celogen OT), etc., expands to several times its volume and ruptures. Bead expansion or rupture causes a disruption of the propellant's surface, and the flame can penetrate into the propellant. This penetration results in a major increase in burning rate.

Abstract: A combined probe and marker for probing mines as well as marking mines once hey have been discovered, and marking a path free of mines, comprises a rod rigidly connected to a handle. At the upper end of the handle, there is a recess for frictionally holding a Combat Light Device. In another version of this invention, the handle has a central bore followed by a concentric threaded bore at the lower end of the handle. The rod is affixed to one of the threaded ends of a stub which has a middle enlarged section for removably attaching and storing the rod.

Abstract: A diisocyanate crosslinking agent having a minimum chain length of methylene groups from 25 to 45 which has a coiling-uncoiling ability in a cured solid propellant composition (under stress and relaxing of stress) as a result of the chain length and configuration imparts superior structural strength to the solid propellant composition. A preferred species is 1,37-heptatriacontane diisocyanate, OCN--(CH.sub.2).sub.37 --NCO, which is employed as an effective crosslinking agent in hydroxyl-terminated polybutadiene propellants.

Abstract: A linkage attachment device is used in cold weather in combination with f and water dispensing nozzles having triggers for opening and closing valves for dispensing liquids and for stopping the flow of liquid, without manual contact by the user with such nozzles. Means are provided for preventing the unintended opening of the valves and for limiting the degree to which the valves can be opened by actuating the linkage attachment device.

Abstract: This invention concerns an isolated DNA sequence encoding human terminal xynucleotidyl transferase as well as vectors and transformed hosts carrying said DNA sequence.

Abstract: A system for powering and communicating with a mine or mine simulator, involving magnetic induction coupling between a powered search unit with a resonating primary inductance coil and a secondary inductance loop in the mine device. The current in the secondary loop is rectified in the mine device to provide dc power. The magnetic induction frequency can be in the range from 40 kHz to 1 MHz. The search unit can resonate sequentially or simultaneously at different frequencies, and rectification of the different frequencies in the mine device can provide information to the mine device. Feedback to the search unit can be by the mine device modulating the impedance of its secondary loop, for instance at an audio frequency 1/10th of the frequency of the induction coupling, and by detecting in the search unit the corresponding change in the reflected impedance. A mine device can be armed or disarmed, and report on its status when queried by the search unit coming sufficiently close to the mine device.

Abstract: Novel carbaphens are provided of the formula ##STR1## wherein R is OH, OCON(CH.sub.3).sub.2 or OCONHCH.sub.3, and R' is H, OH or sub.2 OCON(CH.sub.3).sub.2, stereoisomers thereof, pharmaceutically-acceptable salts thereof or mixtures thereof.Compositions comprise the carbaphens with pharmaceutically acceptable carriers, and they may further comprise other drugs as well.Methods of treating patients either prophylactically or therapeutically which suffer from organophosphate poisoning, coronary insufficiency, cerebral vasospasms, spastic cholitis and cholecystitis comprise the administration of the carbaphens of the invention.

Abstract: Disclosed is a method for ejecting an interceptor missile from the silo in hich it is stored. The method employs an ultrahigh-burning rate (e.g., burning rate 10-20 inches per second) booster solid propellant grain in combination with a fuse or a combination of fuses having a burning rate (e.g. 25 to 100 inches per second) or a rate which is well above that of the ultrahigh-burning rate booster solid propellant grain. The fuses are designed to a predetermined exterior contour which is the same as the exterior contour of the mandrel which would normally be used to provide the contour to the internal perforation of the booster propellant grain. The method include positioning the fuses longitudinally in the booster motor instead of the normally used mandrel, and then casting the propellant around the fuse or a combination of fuses and curing the propellant to yield a booster solid propellant grain.

Abstract: A novel conversion coating composition and a method for treating corroded eel surfaces to convert them into a suitable substrate for accepting organic coatings are provided. Corroded steel surfaces treated with the novel composition of this invention by the improved method of application disclosed in this invention show wet adhesion and salt spray resistance properties markedly superior to those of surfaces which were treated with conventional, prior-art, commercially available compositions.

Abstract: Although many materials have been used for osseous wound repair, no agent rrently available provides the surgeon with a predictable level of bone regeneration. Because they do not elicit elicit immunologic responses, and because of the disadvantages of obtaining donor bone, ceramic compositions such as phosphate-bonded alumina and similar ceramics have been investigated as possible bone substitutes capable of promoting bone growth. Since ceramic tricalcium phosphate is biodegradable it has been the subject of considerable research. Despite the research effort, the use of tricalcium phosphate ceramic materials in the regeneration of bone is still subject to improvement. A distinctive form of ceramic beta tricalcium phosphate, modified to augment bone regeneration is provided herein. It is readily implantable in a bone cavity to promote formation throughout the cavity of new bone to replace that lost through trauma, disease, respective surgery, and birth defects.

Abstract: A simple, inexpensive construction, utilizing commonly available plastic ing, hypodermic needle hub, suture materials and cyanoacrylic glue is provided for subcutaneous implantation within a test animal, one of the generally tubular structure being permanently affixed in communication with a selected portion of the gastrointestinal tract consisting essentially of the small intestines, colon, stomach or gut-associated lymphoid tissue (GALT) of the test animal, with the other end of the tubular structrure firmly located behind the head of the test animal for easy access thereto. This invention, following implantation thereof into a test animal, may be readily utilized for the controlled delivery therethrough of multiple doses of one or more selected liquid materials for direct delivery thereof to the gastrointestinal tract of the test animal.

Abstract: Diacyl phosphatides having a polyunsaturated carboxylic acid at the 2 position are found to have cytotoxic effect against tumor cells. Subject compositions may be employed in vivo or in vitro for inhibiting tumor cell growth, either by themselves or in combination with other cytotoxic drugs. The compositions may be administered as liposomes.

Abstract: This invention relates to a novel process for producing artemisinin from emisinic acid. The artemisinic acid is reduced to dihydroartemisinic acid by reduction of the exocyclic methylene group. The dihydroartemisinic acid is then oxidized in two successive steps to form artemisinin.

Abstract: Novel carbaphens are provided of the formula ##STR1## wherein R is OH, OCON(CH.sub.3).sub.2 or OCONHCH.sub.3, and R' is H, OH or .sub.2 OCON(CH.sub.3).sub.2, stereoisomers thereof, pharmaceutically-acceptable salts thereof or mixtures thereof.Compositions comprise the carbaphens with pharmaceutically acceptable carriers, and they may further comprise other drugs as well.Methods of treating patients either prophylactically or therapeutically which suffer from organophosphate poisoning, coronary insufficiency, cerebral vasospasms, spastic cholitis and cholecystitis comprise the administration of the carbaphens of the invention.

Abstract: A dermal substance collection device (DSCD) is described which provides ms for the non-invasive, instantaneous and continuous monitoring of chemical substances which are present in a detectable amount in either or both interstitial fluid or sweat or which are on or in the skin. The transdermal substance collection device of this invention is comprised of three essential components: (1) a substance binding reservoir, wettable by (2) a liquid transfer medium which allows for liquid bridge transfer of a soluble substance from the skin surface to the binding reservoir by virtue of its wettability by the liquid, and (3) an occlusive cover.

Abstract: A device for performing rapid determinations on a real-time basis of about three to five seconds of the concentration of HCl in the atmosphere includes an air inlet conduit for sampling the HCl laden air, a pump for introducing trapping solution into the air inlet conduit, a spiral impinger for mixing and combining the air and trapping solution, a separator for separating a portion of the trapping solution and entrained air from the remaining trapping solution, and electrode flow cell for receiving the remaining trapping solution and for determining the chloride ion concentration in the trapping solution. The electrode flow cell includes a measuring electrode having a silver wire having a silver chloride coating inserted in the flow path of the trapping solution. A selector valve is inserted between the separator and the flow cell for alternatively feeding either the separated trapping solution to the flow cell or a standardizing solution to the flow cell.

Abstract: A human monoclonal antibody produced by a self-reproducing carrier cell, antibody being reactive with PRP capsular polysaccharide. Also disclosed is a process of preparing the antibody from the carrier cell, which is conveniently a hybridoma. Additionally, diagnostic, prophylactic and therapeutic compositions and methods employing the antibody are disclosed. Moreover, a laboratory reagent containing the antibody is described.

Abstract: Disclosed is a method of enhancing the rate of consumption of a propellant s a result of having shrink tubes or spheres embedded in the propellant. The shrink tubes suitable for use in this method are derived from various polyurethane or polyolefin resins which undergo shrinkage when exposed to moderate heat. The mechanism of enhancement derives from the fact that when the flame front reaches the shrink tube or sphere, the tube or sphere undergoes shrinkage, and thus, exposes additional propellant surface to the burning process. High burning rate are achieved because of the apparent reduced overall propellant web created by the presence of and resultant action to these shrink tubes or spheres.A modification of the method of this invention is to embed these plastic tubings in the propellant, raise the temperature of the propellant mass to a temperature at which the tubing will undergo shrinkage.

Abstract: Ultra-ultrahigh burning rate composite modified double-base propellants are btained by use of porous ammonium perchlorate as a replacement for the ultra-ultrafine ammonium perchlorate. The porous ammonium perchlorate is used in combination with aluminum powder fuel and aluminum staples, nitroglycerin as an explosive plasticizer, triacetin as a non-explosive plasticizer, stabilizers selected from resorcinol and 2-nitrodiphenylamine and other selected additives for achieving desired processing, mechanical, ballistic, and other properties of the propellant.

Abstract: Mechanical enhancement of the burning rate of solid propellants is achieved y the incorporation of limited percentages of gas-generated-expandable beads into the solid propellant composition during propellant mixing and which are chemically crosslinked during propellant curing to a solid propellant grain. When the flame front reaches an individual bead during propellant grain burning, the bead which contains a blowing agent selected from 4-toluenesulfonyl hydrazide and 4,4'-oxybis(benzenesulfonyl hydrazide) and coated with a bead forming material consisting of about 95 parts by weight hydroxyl-terminated polybutadiene prepolymer, of about 5 parts by weight of trimethylolpropane, and of about 6 parts by weight of isophorone diisocyanate expands to several times its volume and ruptures. Bead expansion or rupture causes a disruption of the propellant's surface, and the flame can penetrate into the propellant. The penetration results in a major increase in burning rate.