Abstract: Coordinating stimuli generation and response signal processing provides for a real-time display of the stimuli response in a three-dimensional coordinate system and allows to select immediately the most appropriate evaluation programs for further processing of sensory information.

Abstract: The present invention provides for the purification from native sources or the cloning and expression of a variant form of platelet factor 4 and also provides recombinant DNA vectors and methods for the expression and recovery of the platelet factor 4 variant. Also provided are compositions and methods for modulating immune responses in mammals comprising immunomodulating effective amounts of platelet factor 4 variant.

Abstract: A method for obtaining heterologous peptides from fusion proteins wherein at least one of the fusion components is connective tissue-activating peptide-III is provided. Hirudin, a laminin B.sub.1 peptide and platelet factor 4 are polypeptides expressed using this method. DNA sequences encoding the fusion protein, vectors containing these sequences and transformed prokaryotic hosts useful in practicing the method of the present invention are also provided.

Abstract: An improved sample carrier and pipette tips for use in an automated sample handling device are disclosed. This carrier mounts on and is removable from a carousel and has spaced about the circumference of its body a plurality of apertures for receiving the sample containers. Each aperture has on its interior side, that is its axis side, an intruding resilient finger which is deflected when a sample container is inserted into the aperture and which applies pressure on the sample container forcing it against the outside edge of the aperture and preventing inadvertent rotation of the sample container within the aperture. In the most common embodiment the apertures are substantially parallel to the axis of the circular body of the carrier so that they can be accessed by sample-handling equipment moving perpendicular to the plane of rotation of the carousel. In another embodiment the apertures are angled in a posture where they can undergo angled centrifugation, if desired.

Abstract: Fertilizer composition in granular form having a regulated release of water-soluble fertilizer agents such as nitrogen, phosphorous, and potassium compounds. Each granule has a core comprising fertilizer substances having a known pH value, and a coating encapsulating the core. The coating is based on dicyclopentadiene and either linseed oil or a soy bean oil alkyd. The coating serves as a pH-regulator, so that for a core having a pH value below 6.0, the pH of the coating is regulated to be in the range of 6.0 to 9.0, while for a core having a pH value higher than 6.0 the coating includes a mixture of trace element compounds and has a pH value lying between 4.5 and 9.0.

Abstract: A new family of fluorescent antibodies (FAB) and a method for their synthesis is disclosed for use in an apparatus and method wherein the effects of background fluorescence are virtually eliminated from fluorescence measurements. The novel fluorescent antibodies consist of antibodies conjugated with rare-earth chelates which have unique fluorescent properties. These fluorescent antibodies are useful because when excited with short pulses of light, they exhibit fluorescent decay times which are much longer than typical background fluorescence at room temperature and with a spectral width far narrower than typical background fluorescence.

Abstract: Soluble polymeric colorants composed of free amine groups and chromophoric groups covalently bonded to an organic backbone are disclosed. The number of free amine groups is not less than one-half the number of chromophoric groups. The colorants are characterized by being free of sulfonate, phosphonate and carboxylate groups. The preparation and use of these colorants is also disclosed.

Abstract: Analogs of the glycoside stevioside are disclosed. These materials have the formula ##STR1## wherein R.sub.1 and R.sub.2 are as follows:______________________________________ R.sub.1 R.sub.2 ______________________________________ --(CH.sub.2).sub.3 SO.sub.3.sup.- M.sup.+ .beta.-D--Sophorose --(CH.sub.2).sub.3 SO.sub.3.sup.- M.sup.+ --(CH.sub.2).sub.3 SO.sub.3.sup.- M.sup.+ --H --(CH.sub.2).sub.3 SO.sub. 3.sup.- M.sup.+ ______________________________________and M.sup.+ is a physiologically acceptable alkali metal cation.

Abstract: Polymeric red colors having the structure ##STR1## wherein R.sub.1 and R.sub.2 are independently selected from among hydrogen, halos, lower alkyls, lower alkoxies, nitros, and sulfonates, R.sub.3 is selected from hydrogens, alkyls and alkylsulfonates, and R.sub.4 is an alkyl-containing polymer linking a plurality (n) of anthraquinones into a polymeric colorant are disclosed to be used as nonabsorbable colorants for edibles and cosmetics. They may also be used in such substrates as lakes.

Abstract: A process for preparing cyclic amides from an optionally substituted acetic acid and an aromatic aminocarbonyl compound is disclosed. The process employs a promoter comprising tetravalent titanium or silicon and a pyridine compound to effect formation of the cyclic amides.

Abstract: An intestinal anti-inflammatory preparation comprising a polymeric agent for releasing 5-aminosalicylic acid or its salts is disclosed. The polymeric agent comprises a nonabsorbable pharmacologically acceptable organic polymer backbone containing aromatic rings to which are covalently bonded via azo bonds a plurality of salicylic acid or salicylate salt groups. The azo bonds attach to the salicylates' 5-position carbon. The polymer's azo bonds undergo bacterial cleavage in the mammalian lower bowel to release 5-aminosalicylic acid and/or its salts.

Abstract: Dihydrochalcones of the formula ##STR1## are disclosed wherein X is H or OH and R is a lower alkyl. These materials are useful as sweeteners for edibles. A process for preparing these compounds using a novel intermediate is disclosed as are acid and base neutralization products of the subject dihydrochalcones.

Abstract: Primary amines are selectively sulfamated by the two-step process of:A. Contacting the amine in liquid phase at low to moderate temperatures with catechol sulfate thereby forming a catechol sulfate addition product, andB. Hydrolyzing the catechol sulfate addition product to the desired sulfamate by contacting it at elevated temperature with a strong base in liquid phase.

Abstract: Sulfamo dihydrochalcones of the formula ##STR1## are disclosed wherein M.sup.+ is a physiologically acceptable cation, X is H or OH, and R is a lower alkyl. These materials are useful as sweeteners for edibles. They may be prepared by sulfonating the corresponding amino dihydrochalcone using, for example, catechol sulfate.

Abstract: Polymeric red colors having the structure ##STR1## wherein R.sub.1 and R.sub.2 are independently selected from among hydrogen, halos, lower alkyls, lower alkoxies, nitros, and sulfonates, R.sub.3 is selected from hydrogens, alkyls and alkylsulfonates, and R.sub.4 is an alkyl-containing polymer linking a plurality (n) of anthraquinones into a polymeric colorant are disclosed to be used as nonabsorbable colorants for edibles and cosmetics. They may also be used in such substrates as lakes.

Abstract: Polymeric colorants are prepared by the process of (a) reacting acetaldehyde and acetamide in a mole ratio of 1:2-4 with an acid catalyst to form ethylidene-bis-acetamide, (b) cracking the ethylidene-bis-acetamide to vinylacetamide, (c) polymerizing the vinylacetamide with a free-radical catalyst, (d) hydrolyzing the resulting polymer with mineral acid and neutralizing with base to yield poly(vinylamine), and (e) coupling monomeric optically chromophoric groups to amine nitrogens of the poly(vinylamine).

Abstract: Dihydrochalcones of the formula ##STR1## are disclosed wherein X is H or OH and R is a lower alkyl. These materials are useful as sweeteners for edibles. A process for preparing these compounds using a novel intermediate is disclosed as are acid and base neutralization products of the subject dihydrochalcones.

Abstract: Copolymers of acetamidoethylene are disclosed. These materials have randomly distributed units represented by the formula ##STR1## wherein R is one or more radicals selected from the group ##STR2## and the C.sub.1 to C.sub.6 carboxylic acid esters thereof, ##STR3## wherein R.sup.1 is hydrogen or a C.sub.1 to C.sub.6 alkyl, and R.sup.2 is a C.sub.1 to C.sub.6 alky; x and y are numbers greater than zero which total to 1.00; the ratio of x to y from about 0.05:0.95 to about 0.95:0.05; and n is an integer from about 14 to about 10,000.The copolymers are useful as epoxy resin curing agents, as components of protective or decorative coatings, and as intermediates in the formation of vinylamine group-containing copolymers having the formulae ##STR4## wherein x, y and n are as previously defined, x' plus z equals x and R.sup.3 is one or more of the radicals selected from the group ##STR5## wherein R.sup.1 and R.sup.2 are as previously defined.

Abstract: A process for preparing a family of orange polymeric colorants having a plurality of units of the chromophore ##STR1## is disclosed. R.sub.1 and R.sub.2 are hydrogens, lower alkyls or alkoxies, nitros, halos or sulfonates, R.sub.3 is benzyl, benzyl sulfonate, lower alkyl or alkyl sulfonate, R.sub.4 is hydrogen or lower alkyl. With the disclosed process, the chromophore units, less the R.sub.3 substituent, are bonded to an organic polymer backbone. The R.sub.3 substituent is added thereafter in a separate second step.

Abstract: Copolymers of ethylene and vinylamine are disclosed as are methods for their production. The disclosed copolymers find application primarily as flocculants.