Patents Represented by Attorney William H. Edgerton

Find this attorney in the Justia Lawyer Directory

  • Intermediates for preparing substituted phenylglycylcephalosporins
    Patent number: 4107440
    Abstract: Cephalosporin compounds having a substituted phenylglycyl substituent at the 7-position and any of a variety of groups at the 3-position are prepared by acylation of a 7-aminocephalosporanic acid. The compounds have antibacterial activity.
    Type: Grant
    Filed: April 28, 1977
    Date of Patent: August 15, 1978
    Assignee: SmithKline Corporation
    Inventor: John Gerald Gleason
  • Pharmacologically active compounds
    Patent number: 4107319
    Abstract: The compounds are N-(heterocyclomethylthioalkyl)derivatives of alkylguanidines, C-alkyl and C-aryl amidines and S-alkylisothioureas. The compounds may also have N'-lower alkyl or N'-(heterocyclomethylthioalkyl)substituents. Three compounds of the invention are S-methyl-N-[2-(5-methyl-4-imidazolylmethylthio)ethyl]isothiourea, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]acetamidine, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]N"-methylguanidine. The compounds of this invention are histamine H.sub.2 -antagonists.
    Type: Grant
    Filed: May 5, 1977
    Date of Patent: August 15, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin, Rodney Christopher Young
  • Method for preparing ticrynafen
    Patent number: 4107179
    Abstract: A new method for preparing ticrynafen comprises reacting 2,3-dichloro-4-hydroxyphenyl-2-thienylmethanone with an alkali metal salt of chloro or bromo acetic acid in aqueous solvent. An advantageous aspect of the reaction is that yields are increased with the addition of an alkali metal iodide to the reaction mixture.
    Type: Grant
    Filed: August 22, 1977
    Date of Patent: August 15, 1978
    Assignee: SmithKline Corporation
    Inventor: Harold Graboyes
  • 3-Sulfomethyl-1,2,4-triazole-5-thiol and its alkali metal salts
    Patent number: 4107173
    Abstract: New semisynthetic cephalosporins characterized by having structures with a 3-sulfomethyl-1,2,4-triazol-5-ylthiomethyl group at position 3. Exemplary is the antibacterially effective 7-D-mandelamido-3-(3-sulfomethyl-1,2,4-triazol-5-ylthiomethyl)-3-cephem-4- carboxylic acid disodium salt.
    Type: Grant
    Filed: December 1, 1977
    Date of Patent: August 15, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Heterocyclomethylsulphinylethyl derivatives of N-cyanoguanidines, thioureas and 2-amino-1-nitroethylene
    Patent number: 4105770
    Abstract: The compounds are heterocyclomethylsulphinylethyl derivatives of N-cyanoguanidines, thioureas and 2-amino-1-nitroethylene which are histamine H.sub.2 -antagonists or are converted into histamine H.sub.2 -antagonists in the animal body. Two specific compounds of the present invention are 1-nitro-2-[2-((2-thiazolyl)methylsulphinyl)ethylamino]-2-[2-((2-thiazolyl) methylthio)ethylamino]ethylene and 1-nitro-2,2-bis-[2-((2-thiazolyl)methylsulphinyl)ethylamino]ethylene.
    Type: Grant
    Filed: April 13, 1977
    Date of Patent: August 8, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham J. Durant, Charon R. Ganellin, Torben Hesselbo, George R. White
  • Pharmacologically active compounds
    Patent number: 4104381
    Abstract: Heterocyclic compounds which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A specific compound of this invention is 2-[2-(4-methyl-5-imidazolylmethylthio)ethylamino]-4-pyrimidone.
    Type: Grant
    Filed: October 29, 1976
    Date of Patent: August 1, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • Substituted 1-alkylthiophenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
    Patent number: 4104379
    Abstract: A group of 1-phenyl-1H-3-benzazepines whose structures are characterized by having a functional thio containing group on the 1-phenyl moiety and which have pronounced peripheral and diminished central dopaminergic activity. This activity is manifested in an anti-hypertensive effect in humans. Particular species of this group include 6-chloro-7,8-dihydroxy-1-p-methylthiophenyl-2,3,4,5-tetrahydro-1H-3-benzaz epine and its derivatives which have dopaminergic activity.
    Type: Grant
    Filed: January 19, 1977
    Date of Patent: August 1, 1978
    Assignee: SmithKline Corporation
    Inventors: Gregory Gallagher, Jr., Francis R. Pfeiffer, Joseph Weinstock
  • Imidazolemethylphosphonium salts
    Patent number: 4104472
    Abstract: New imidazolemethylphosphonium salts having a degradable group at the 2-position which are useful intermediates for preparing histamine H.sub.2 antagonists.
    Type: Grant
    Filed: May 24, 1977
    Date of Patent: August 1, 1978
    Assignee: SmithKline Corporation
    Inventors: Clifford Steven Labaw, Robert Lee Webb, George Robert Wellman
  • Method of treating magnesium/potassium depletion
    Patent number: 4104370
    Abstract: A method of treating magnesium/potassium depletion which comprises administering pharmaceutical compositions comprising magnesium and potassium compounds, the equivalent weight of the magnesium being between 1 and 3 times the equivalent weight of the potassium, together with a pharmaceutical carrier such that the rate of release of the magnesium and potassium into the digestive system is controlled.
    Type: Grant
    Filed: November 19, 1975
    Date of Patent: August 1, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Maurice Bloch
  • Pharmaceutical compositions and methods of inhibiting H-1 and H-2 histamine receptors
    Patent number: 4104382
    Abstract: Pharmaceutical compositions and methods of inhibiting H-1 and H-2 histamine receptors by administering an antihistamine and an H-2 histamine receptor inhibitor. Exemplary of the antihistamine in the compositions and methods of this invention is mepyramine and exemplary of the H-2 histamine receptor inhibitor is N-cyano-N'-methyl-N"-[2-((4-methyl-5-imidazolyl)-methylthio)ethyl]guanidin e.
    Type: Grant
    Filed: September 27, 1976
    Date of Patent: August 1, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: James Whyte Black, Michael Edward Parsons
  • 8-Oxo-4-thia-1-azabicyclo (4.2.0)-oct-2-ene derivatives
    Patent number: 4103086
    Abstract: Novel bicyclic .beta.-lactams and intermediates useful in their preparation are disclosed. In particular, 7.beta.-acyl-amino- and 7.beta.-amino-8-oxo-4-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acids are prepared. The acylated compounds are antibacterial agents.
    Type: Grant
    Filed: June 8, 1976
    Date of Patent: July 25, 1978
    Assignee: SmithKline Corporation
    Inventors: John G. Gleason, Kenneth G. Holden, William F. Huffman
  • 7.beta.-Acylamino-3-(alkanesulfonamidoalkyl substituted tetrazolylthiomethyl) cephalosporins, antibacterial compositions containing them and methods of treating bacterial infections with them
    Patent number: 4101656
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and an alkanesulfonamidoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: July 12, 1976
    Date of Patent: July 18, 1978
    Assignee: Smithkline Corporation
    Inventor: David A. Berges
  • Cephamycins as antibacterial agents
    Patent number: 4101657
    Abstract: 7.beta.-Substituted mercaptoacetamido-7.alpha.-methoxycephalosporanic acid and derivatives thereof are prepared. These compounds are antibacterial agents with improved properties.
    Type: Grant
    Filed: July 1, 1977
    Date of Patent: July 18, 1978
    Assignee: SmithKline Corporation
    Inventors: Robert M. DeMarinis, Jerry A. Weisbach
  • Pharmaceutical compositions and methods of producing antiarthritic activity with bis(pyridine)gold(1+) salts
    Patent number: 4098887
    Abstract: Pharmaceutical compositions and methods of producing antiarthritic activity with bis(pyridine)gold(1+) salts.
    Type: Grant
    Filed: February 25, 1977
    Date of Patent: July 4, 1978
    Assignee: SmithKline Corporation
    Inventor: David T. Hill
  • Imidazolyl alkylguanidine compounds
    Patent number: 4098898
    Abstract: The compounds are novel N-substituted-N'-heterocyclic alkylthioureas, guanidines and 1-nitro-2,2-diaminoethylene compounds which are histamine H.sub.2 -antagonists.
    Type: Grant
    Filed: May 13, 1976
    Date of Patent: July 4, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin, Geoffrey Robert Owen, Rodney Christopher Young
  • 7-Acyl-3-(ureidoalkyl substituted tetrazolylthiomethyl) cephalosporins, antibacterial compositions containing them, and methods of treating bacterial infections using them
    Patent number: 4096256
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and an ureidoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: December 22, 1976
    Date of Patent: June 20, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Trialkylphosphinegold(I)-lower alkyl carbamoyl glucopyranosides
    Patent number: 4096249
    Abstract: The compounds are trialkylphosphinegold(I)2,3,4,6-tetra-O-(N-loweralkylcarbamoyl)-1-thio-.be ta.-D-glucopyranosides which have antiarthritic activity and, in particular, are of use in the treatment of rheumatoid arthritis.
    Type: Grant
    Filed: February 16, 1977
    Date of Patent: June 20, 1978
    Assignee: SmithKline Corporation
    Inventor: Ivan Lantos
  • Sulfonyl containing organic gold glycoside compounds and method of use
    Patent number: 4096248
    Abstract: A new series of lower alkyl sulfonyl esters of S-tri-lower-alkylphosphinegold 1-thio-.beta.-D-glucopyranosides has been prepared and found to have anti-arthritic activity and, in particular, are of use in treating rheumatoid arthritis.
    Type: Grant
    Filed: February 16, 1977
    Date of Patent: June 20, 1978
    Assignee: SmithKline Corporation
    Inventor: Ivan Lantos
  • Tri-substituted phosphinegold(I) 1-thio-.beta.-D-glucopyranosides
    Patent number: 4096250
    Abstract: The compounds are tri-substituted phosphinegold(I) 1-thio-.beta.-D-glucopyranosides which have antiarthritic activity and, in particular, are of use in the treatment of rheumatoid arthritis. Of the three substituents on the phosphine one is optionally substituted phenyl and the others are lower alkyl or lower alkoxy.
    Type: Grant
    Filed: February 25, 1977
    Date of Patent: June 20, 1978
    Assignee: SmithKline Corporation
    Inventor: David T. Hill
  • Gold thio glucopyranoside compounds and method of use
    Patent number: 4096247
    Abstract: A new series of lower alkyl ethers of S-tri-lower-alkylphosphinegold 1-thio-.beta.-D-glucopyranoside has been prepared and found to have anti-arthritic activity and, in particular, are of use in the treatment of rheumatoid arthritis.
    Type: Grant
    Filed: February 16, 1977
    Date of Patent: June 20, 1978
    Assignee: SmithKline Corporation
    Inventor: Ivan Lantos