Patents Represented by Attorney William H. Edgerton

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  • Sulphoxides
    Patent number: 4056620
    Abstract: The compounds are sulphoxides of heterocyclicthioalkylthioureas, ureas and guanidines which are useful to produce inhibition of histamine H-2 receptors.
    Type: Grant
    Filed: May 24, 1976
    Date of Patent: November 1, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: George Raymond White
  • Imidazolylmethylthioethyl dithiocarbamate compounds
    Patent number: 4056621
    Abstract: The compounds are dithiocarbamates and isothioureas which are histamine H.sub.2 -antagonists. Two compounds of the invention are 2-(5-methyl-4-imidazolylmethylthio)ethyl N-methyldithiocarbamate and S-[2-(5-methyl-4-imidazolyl-methylthio)ethyl]-N-cyano-N'-methylisothiourea .
    Type: Grant
    Filed: January 27, 1976
    Date of Patent: November 1, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Thomas Henry Brown, Graham John Durant, Charon Robin Ganellin, Robert John Ife
  • Electrochemical reduction of imidazolecarboxylic esters
    Patent number: 4055573
    Abstract: Lower alkyl 4-imidazolecarboxylates are electro-chemically reduced to give the corresponding alcohol and lower alkyl ethers. This mixture is reacted directly with cysteamine to give the important thioamine intermediates.
    Type: Grant
    Filed: May 6, 1976
    Date of Patent: October 25, 1977
    Assignee: SmithKline Corporation
    Inventor: Wilford Lee Mendelson
  • 3-Substituted-phenyl-6-hydrazine pyridazines
    Patent number: 4053601
    Abstract: The compounds are 3-((3-substituted amino-2-hydroxypropoxy)-phenyl)-6-hydrazino pyridazines which have .beta.-adrenergic blocking and vasodilator activity.
    Type: Grant
    Filed: June 3, 1975
    Date of Patent: October 11, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: William John Coates, Anthony Maitland Roe, Robert Antony Slater, Edwin Michael Taylor
  • Live Newcastle disease virus vaccines
    Patent number: 4053583
    Abstract: The improved live Newcastle disease virus vaccines of the invention contain a cold or cold and temperature-sensitive strain of Newcastle disease virus obtained by U.V. or nitrous acid mutation. The vaccines are administered to chickens in the form of an aerosol.
    Type: Grant
    Filed: March 1, 1976
    Date of Patent: October 11, 1977
    Assignee: SmithKline Corporation
    Inventors: Jacqueline Gits, Nathan Zygraich
  • Pre-farrowing pregnant sow piglet colibacillosis vaccines and process for their administration to pregnant sows before farrowing
    Patent number: 4053584
    Abstract: Piglet colibacillosis vaccine for intramuscular or subcutaneous administration to pregnant sows comprising cell-free heat labile (LT) E. coli enterotoxin with an adjuvant and the method for preventing piglet colibacillosis consisting in administering said vaccine to pregnant sows from 3 to 6 weeks before farrowing.
    Type: Grant
    Filed: March 29, 1976
    Date of Patent: October 11, 1977
    Assignee: Recherche et Industrie Therapeutiques
    Inventors: Lucia Dobrescu, Constant Huygelen
  • Process for preparing 7-oxo cephalosporins and 6-oxo penicillins
    Patent number: 4053468
    Abstract: A process for preparing 7-oxo cephalosporins and 6-oxo penicillins by reaction of a 7-amino cephalosporin or 6-amino penicillin with a carbonyl-containing oxidizing agent is disclosed.
    Type: Grant
    Filed: February 25, 1976
    Date of Patent: October 11, 1977
    Assignee: SmithKline Corporation
    Inventor: Kenneth G. Holden
  • Pharmacologically active thiourea and urea compounds
    Patent number: 4053473
    Abstract: The compounds are substituted thioalkyl-, aminoalkyl- and oxyalkyl-thioureas and ureas which are inhibitors of histamine activity.
    Type: Grant
    Filed: December 5, 1975
    Date of Patent: October 11, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • Pharmaceutical compositions and method of producing anti-Parkinsonism activity
    Patent number: 4052506
    Abstract: Pharmaceutical compositions and method of producing anti-Parkinsonism activity by administering internally a nontoxic effective quantity of a benzazepine derivative to an animal.
    Type: Grant
    Filed: August 5, 1975
    Date of Patent: October 4, 1977
    Assignee: SmithKline Corporation
    Inventors: Carl Kaiser, Robert G. Pendleton, Paulette E. Setler
  • Process for preparing N-cyanoguanidines
    Patent number: 4049671
    Abstract: Process for preparing N-cyanoguanidines by treating N-(loweralkyl)-N'-cyano-isothioureas with an amine and a heavy metal salt. A specific product is N-cyano-N'-methyl-N"-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]guanidine , useful as a histamine H.sub.2 -antagonist.
    Type: Grant
    Filed: August 20, 1975
    Date of Patent: September 20, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin, George Raymond White
  • Process for preparing 5-(alkoxy- and aminoethyl thio)methylthiazole compounds
    Patent number: 4049669
    Abstract: A process for preparing 5-(alkoxy- and aminoethylthio)methylthiazole compounds via displacement of the trisubstituted phosphonium group from 5-(trisubstituted phosphonium)methylthiazole compounds is disclosed.
    Type: Grant
    Filed: October 29, 1975
    Date of Patent: September 20, 1977
    Assignee: SmithKline Corporation
    Inventors: Bing Lun Lam, Joseph James Lewis, Robert Lee Webb, George Robert Wellman
  • 4-Methyl-5-imidazolylmethylthioethylamine and -S-methylisothiourea
    Patent number: 4049672
    Abstract: The compounds are heterocyclic thioalkyl-, aminoalkyl- and oxyalkylguanidines which are inhibitors of histamine activity, particularly inhibitors of H-2 histamine receptors.
    Type: Grant
    Filed: March 17, 1976
    Date of Patent: September 20, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • Novel N-allyl and N-propargyl benzmorphan derivatives
    Patent number: 4048178
    Abstract: N-Allyl-benzmorphan compounds having structures distinguished by having either a 4,5 or 6 carbon containing allyl group at the 2- or N-position or various ether derivatives of the 2'-hydroxy group. The compounds are prepared by alkylation of appropriate N-nor bases and have analgetic antagonist activity particularly pronounced in countering the effects of overdosing. Certain N-acyl-2'-hydroxy-5,9-dimethyl-6,7-benzmorphan intermediates are also disclosed.
    Type: Grant
    Filed: March 10, 1960
    Date of Patent: September 13, 1977
    Assignee: Smith Kline & French Laboratories
    Inventors: Maxwell Gordon, John J. Lafferty
  • .alpha.-AMINOMETHYL-4-HYDROXY-3-METHYLSULFONYL BENZYL ALCOHOLS
    Patent number: 4048229
    Abstract: .alpha.-Aminomethyl-4-hydroxy-3-methylsulfonyl benzyl alcohols having .beta.-adrenergic antagonist activity are prepared generally from 4-benzyloxy-3-methylsulfonylacetophenone by, for example, bromination and treatment of the resulting .alpha.-bromo derivative with an N-benzyl secondary amine, followed by catalytic hydrogenation to remove protective benzyl groups and reduce the ketone moiety.
    Type: Grant
    Filed: January 8, 1975
    Date of Patent: September 13, 1977
    Assignee: SmithKline Corporation
    Inventors: Donald F. Colella, Carl Kaiser
  • 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl)cephalosporins
    Patent number: 4048311
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfonic acid or sulfamoyl substituted tetrazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: May 19, 1976
    Date of Patent: September 13, 1977
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Method of inhibiting histamine activity with quanidine compounds
    Patent number: 4048319
    Abstract: A method of inhibiting histamine activity, in particular inhibiting H-2 histamine receptors, by administering heterocyclicalkylguanidines.
    Type: Grant
    Filed: March 19, 1976
    Date of Patent: September 13, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: James Whyte Black, Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • Mercaptopseudotrisaccharides
    Patent number: 4048430
    Abstract: Novel pseudodisaccharide compounds which are related to neamine are prepared. These compounds have a mercapto group or a derivative thereof at position 3 or 4 of the glucose moiety of neamine. The compounds have antibacterial activity and have utility as intermediates to pseudotrisaccharides.
    Type: Grant
    Filed: December 18, 1975
    Date of Patent: September 13, 1977
    Assignee: SmithKline Corporation
    Inventors: David J. Cooper, John R. E. Hoover, Jerry A. Weisbach
  • Imidazole alkylaminoethylene compounds
    Patent number: 4046907
    Abstract: The compounds are ethylene derivatives which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A compound of this invention is 1-nitro-2-methylamino-2-[2-((4-methyl-5-imidazolyl)methylthio)-ethylamino] ethylene.
    Type: Grant
    Filed: November 5, 1975
    Date of Patent: September 6, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin, Hunter Douglas Prain
  • Intermediates for preparing substituted phenylglycylcephalosporins
    Patent number: 4044047
    Abstract: Cephalosporia compounds having a substituted phenylglycyl substituent at the 7-position and any of a variety of groups at the 3-position are prepared by acylation of a 7-aminocephalosporanic acid. The compounds have anti-bacterial activity.
    Type: Grant
    Filed: December 15, 1975
    Date of Patent: August 23, 1977
    Assignee: SmithKline Corporation
    Inventor: John Gerald Gleason
  • 7-Acyl-3-(sulfoalkyl substituted oxadiazolylthiomethyl) cephalosporins
    Patent number: 4041162
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfoalkyl substituted oxadiazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: March 11, 1976
    Date of Patent: August 9, 1977
    Assignee: SmithKline Corporation
    Inventor: David A. Berges