Patents Represented by Attorney, Agent or Law Firm William T. King
  • Patent number: 6447766
    Abstract: A method of mobilizing hematopoietic stem cells from the bone marrow to the peripheral circulation is provided by administering to an animal an effective amount of mature, modified or multimeric forms of KC, gro&bgr;, gro&agr;, or gro&ggr;.
    Type: Grant
    Filed: December 20, 1999
    Date of Patent: September 10, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Louis Martin Pelus, Andrew Garrison King, Yanqiu Qian
  • Patent number: 6433156
    Abstract: Rabbit G alpha 16 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing rabbit G alpha 16 polypeptides and polynucleotides in screening of antagonists or agonists of cells co-expressing a G-protein coupled receptor and rabbit G alpha 16.
    Type: Grant
    Filed: December 22, 1998
    Date of Patent: August 13, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Robert S. Ames, John A. Feild, Tania Testa
  • Patent number: 6432670
    Abstract: Prokayrotic FAB I polypeptides and DNA (RNA) encoding such FAB I and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such FAB I for the treatment of infection, such as bacterial infections. Antagonists against such FAB I and their use as a therapeutic to treat infections, such asstaphylococcal infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of FAB I nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding FAB I and for detecting the polypeptide in a host.
    Type: Grant
    Filed: April 15, 1999
    Date of Patent: August 13, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: David John Payne, Peter Henry Milner, Stewart Campbell Pearson, John Timothy Lonsdale
  • Patent number: 6432678
    Abstract: Macaca cynomolgus IL18 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds which either agonize or antagonize Macaca cynomolgus IL18. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: cancer and auto-immune diseases.
    Type: Grant
    Filed: June 20, 2000
    Date of Patent: August 13, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Alexander H. Taylor, Han N. Trinh
  • Patent number: 6423508
    Abstract: Human EDG-1c polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Human EDG-1c is identified as a selective receptor for sphingosine-1-phosphate (“S-1-P”) and for di-hydro S-1-P. Also diclsosed are methods for discovering agonists and antagonists of the interaction between S-1-P and di-hydro S-1-P and their cellular receptor, human EDG-1c, which may have utility in the treatment of several human diseases and disorders.
    Type: Grant
    Filed: March 4, 1999
    Date of Patent: July 23, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham PLC, SB Laboratories Pharmaceutiques
    Inventors: Derk J. Bergsma, Winnie Chan, Nassirah Khandoudi, Phillipe Robert
  • Patent number: 6420424
    Abstract: Phenylalanine sulfonamide derivatives and their use as CCR-3 receptor antagonist.
    Type: Grant
    Filed: October 27, 2000
    Date of Patent: July 16, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Dashyant Dhanak, Katherine L. Widdowson, John R. White
  • Patent number: 6417215
    Abstract: Novel calcilytic compounds are provided.
    Type: Grant
    Filed: July 26, 2001
    Date of Patent: July 9, 2002
    Assignee: SmithKline Beecham Corporation
    Inventor: Amparo Maria Lago
  • Patent number: 6413510
    Abstract: The invention relates to the method of preventing and treating sepsis using chemokines selected from mature or modified KC [SEQ ID NO: 1], gro&agr;[SEQ ID NO:2], gro&bgr;[SEQ ID NO: 3] or gro&ggr;[SEQ ID NO: 4] or multimers thereof, alone or in conjunction with an anti-infective agent. This invention also relates to a new gro&bgr; dimer chemokine.
    Type: Grant
    Filed: February 25, 2000
    Date of Patent: July 2, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Peter Lawrence DeMarsh, Kyung Oh Johanson
  • Patent number: 6410286
    Abstract: The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.
    Type: Grant
    Filed: February 4, 1998
    Date of Patent: June 25, 2002
    Assignee: SmithKline Beecham p.l.c..
    Inventors: John Edward Hodgson, Elizabeth Jane Lawlor
  • Patent number: 6410688
    Abstract: The invention provides Def1 polypeptides and DNA (RNA) encoding Def1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Def1 polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 13, 1999
    Date of Patent: June 25, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Arthur Lonetto, Richard Lloyd Warren, Daniel Robert Sylvester
  • Patent number: 6410555
    Abstract: Compounds of formula (I) and pharmaceutically acceptable salts and solvates: where R1 is hydrogen, C1-6alkyl (optionally substituted by hydroxy or C1-4alkoxy), phenyl-C1-4alkyl-, C1-6alkenyl, C1-6alkynyl; R2 is hydrogen or, up to three substituents selected from halogen, NO2, CN, N3, CF3O—, CF3S—, CF3SO2—, CF3CO—, C1-6alkyl, C1-6alkenyl, C1-6alkynyl, C1-6perfluoroalkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl-, C1-6alkyl, C1-6alkylCO—, C3-6cycloalkylO—, C3-6cycloalkylCO—, C3-6cycloalkyl-C1-4alkylO—, C3-6cycloalkyl-C1-4alkylCO—, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C1-4alkyl-, C1-6alkylS—, C1-6alkylSO2—, (C1-4alkyl)2NSO2—, (C1-4alkyl)NHSO2—, (C1-4alkyl)2NCO—, (C1-4alkyl)NHCO— or CONH2; or —NR5R6 where R5 is hydrogen or C1-4alkyl, and R6 is hydrogen, C1-4alkyl, formyl, —CO2C1-4alkyl or —COC1-4alkyl; or two R2 groups together form a carbocyclic ring that is saturated or unsaturated, optionally inte
    Type: Grant
    Filed: February 16, 2001
    Date of Patent: June 25, 2002
    Assignee: SmithKline Beecham p.l.c.
    Inventors: John David Harling, Frank Peter Harrington, Mervyn Thompson
  • Patent number: 6410285
    Abstract: The invention provides alaS polypeptides and DNA (RNA) encoding alaS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing alaS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 14, 1998
    Date of Patent: June 25, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventor: Elizabeth Jane Lawlor
  • Patent number: 6403792
    Abstract: The present invention is to novel sulfonyl isatin compounds of Formula (I), their pharmaceutical compositions, and the novel inhibition of caspases for use in the treatment of apoptosis, and disease states caused by excessive or inappropriate cell death.
    Type: Grant
    Filed: December 9, 1999
    Date of Patent: June 11, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Dennis Lee, Scott Allen Long
  • Patent number: 6403334
    Abstract: The invention provides gidB polypeptides and DNA (RNA) encoding gidB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gidB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: June 11, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventor: Howard Kallender
  • Patent number: 6399053
    Abstract: The present invention provides a method for the treatment of bacterial, fungal, and viral infections by administering a truncated Gro&bgr;.
    Type: Grant
    Filed: December 20, 1999
    Date of Patent: June 4, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Louis Martin Pelus, Pradip Kumar Bhatnagar, Andrew Garrison King, Joanna Maria Balcarek
  • Patent number: 6399573
    Abstract: IL-1ra beta polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing IL-1ra beta polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, septicemia, arthritis, inflammatory bowel disease, graft vs. host disease, autoimmunity, stroke, cardiac ischemia, acute respiratory disease syndrome (ARDS), psoriasis, restenosis, traumatic brain injury, AIDS, cachexia, allergy, parasite infection, allergic rhinitis, allergic asthma, atopic dermatitis, allergic inflammatory diseases, and delayed hypersensitivity, among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: January 28, 2000
    Date of Patent: June 4, 2002
    Assignee: SmithKline Beecham Corporation
    Inventor: Peter Ronald Young
  • Patent number: 6399343
    Abstract: The invention provides infB polypeptides and polynucleotides encoding infB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing in polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 19, 2000
    Date of Patent: June 4, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Martin Karl Russel Burnham, Alison Francis Chalker, Richard Lloyd Warren, Magdalena Zalacain, Chi Young So, Christopher M Traini, David John Holmes, Karen Anne Ingraham, Thomas B Mathie
  • Patent number: 6395759
    Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof, where G is a methylene or ethylene linkage; R1 is hydrogen, C1-6alkylO—; R2 is hydrogen, halogen, CN, N3, trifluoromethyldiazirinyl, CF3, CF3O—, CF3S—, CF3CO—, C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl-, C1-6alkylO—, C1-6alkylCO—, C3-6cycloalkylCO—, C3-6cycloalkyl-C1-4-alkylCO—, phenyl, phenoxy, benzyloxy, benzoyl and substituted benzoyl, phenyl-C1-4alkyl-, C1-6alkylSO2—, (C1-4alkyl)2NSO2— or (C1-4alkyl)NHSO2—; R3 is hydrogen, halogen, CN, N3, trifluoromethyldiazirinyl, C1-6alkylO—, C1-6alkylS—, C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl-, C1-6alkenyl, C1-6alkynyl, CF3CO—, C1-6alkylCO—, C3-6cycloalkylCO—, C3-6cycloalkyl-C1-4alkylCO—, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C1-4alkyl-, or —NR5R6 where R5 is hydrogen or C1-4alkyl; and R6 is hydrogen, C1-4alkyl, —CHO, —CO2C1-4alkyl or —COC1-4alk
    Type: Grant
    Filed: June 1, 1999
    Date of Patent: May 28, 2002
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Mervyn Thompson, Antonio Kuok Keong Vong, Robert William Ward
  • Patent number: 6395919
    Abstract: Novel calcilytic compounds, pharmaceuticals compositions cotaining said compounds and their use as calcium receptor antagonists.
    Type: Grant
    Filed: October 5, 2000
    Date of Patent: May 28, 2002
    Assignees: SmithKline Beecham Corporation, NPS Pharmaceuticals
    Inventors: Pradip Kumar Bhatnagar, Joelle Lorraine Burgess, James Francis Callahan, Raul Rolando Calvo, Eric G. Del Mar, Maria Amparo Lago, Thomas The Nguyen
  • Patent number: 6391894
    Abstract: A compound according to Formula (I), hereinbelow: wherein A represents a covalent bond, or a 1,2, 1,3 or 1,4-disubstituted aryl amine ring selected from the group consisting of:  wherein R is independently selected from the group consisting of H, OMe, Cl, Br, F, NO2, and CN; n is an integer from 1 to 4; each X is independently selected from the group consisting of H, Br, CH3, NO2, CN, and NR1R2; each Ar is independently optionally substituted phenyl or an optionally substituted 5 or 6 membered heterocyclic ring comprising one or more heteroatoms selected from N, O and S; and R1 and R2 are, independently, hydrogen or C1-4 alkyl, branched or cyclic, optionally containing O or N.
    Type: Grant
    Filed: July 19, 2001
    Date of Patent: May 21, 2002
    Assignee: SmithKline Beecham Corporation
    Inventor: Maria A. Lago