Patents Represented by Attorney, Agent or Law Firm William T. King
  • Axor10, a g-protein coupled receptor
    Patent number: 6361967
    Abstract: AXOR10 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing AXOR10 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: February 11, 1999
    Date of Patent: March 26, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Pankaj Agarwal, Nabil A. Elshourbagy, David Michalovich, Randall Forrest Smith, Lisa Vawter
  • Mouse aspartic secretase-2(mASP-2)
    Patent number: 6361975
    Abstract: mASP-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds that either agonize or antagonize mASP-2. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: Alzheimer's disease, cancer and prohormone processing.
    Type: Grant
    Filed: November 15, 2000
    Date of Patent: March 26, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Gary Christie, Xiaotong Li, David J. Powell, Yuan Zhu
  • Antibodies produced against cytokine suppressive anti-inflammatory drug binding proteins
    Patent number: 6361773
    Abstract: This invention relates to drug binding proteins, to genes encoding same and to assays and methods for screening pharmaceuticals. More specifically, this invention relates to a Cytokine Suppressive Anti-Inflammatory Drug (CSAID) binding protein, to a gene encoding same and to assays and screens useful in the evaluation and characterization of drugs of this pharmacologic class.
    Type: Grant
    Filed: October 1, 1997
    Date of Patent: March 26, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: John C. Lee, Jerry L. Adams, Timothy F. Gallagher, David W. Green, John Richard Heys, Peter C. McDonnell, Dean E. McNulty, Peter R. Young, James E. Strickler
  • IleS
    Patent number: 6361970
    Abstract: The invention provides ileS polypeptides and DNA (RNA) encoding ileS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ileS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 12, 1999
    Date of Patent: March 26, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: James N. Brown, Elizabeth J Lawlor, Raymond W Reichard
  • YfiI pseudouridine synthase
    Patent number: 6361965
    Abstract: The invention provides YfiI pseudouridine synthase polypeptides and polynucleotides enconding YfiI pseudouridine synthase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing YfiI pseudouridine synthase polypeptides to screen for antibaterial compound.
    Type: Grant
    Filed: November 12, 1998
    Date of Patent: March 26, 2002
    Assignee: SmithKline Beecham Corporation
    Inventor: David J. Powell
  • Human F11 antigen: a novel cell surface receptor involved in platelet aggregation
    Patent number: 6358707
    Abstract: F11 antigen polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing F11 antigen polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: January 5, 2000
    Date of Patent: March 19, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Shalley Kant Gupta, Kodandaram Pillarisetti
  • Methods of screening for agonists and antagonists of the HNEAA81 receptor
    Patent number: 6358695
    Abstract: HNEAA81 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are screening methods for identifying agonists and antagonists of the interaction of the HNEAA81 receptor and its ligands in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: April 26, 2000
    Date of Patent: March 19, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Ganesh Madhusudan Sathe, Wendy S Halsey, Jon Chambers, Alison Muir, Philip Szekeres
  • Human p101 regulatory polypeptide
    Patent number: 6358721
    Abstract: SVP4b polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SVP4b polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: March 19, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventor: Lisa Patel
  • M protein
    Patent number: 6358704
    Abstract: The invention provides M Protein polypeptides and DNA (RNA) encoding M Protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing M Protein polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 28, 1999
    Date of Patent: March 19, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham, PLC
    Inventors: Stephen Dudley Holmes, Martin Karl Russel Burnham
  • Mouse aspartic secretase-1 (mASP1)
    Patent number: 6358725
    Abstract: Mouse mASP1 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds that either agonize or antagonize mouse mASP1. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: Alzheimer's disease, cancer, and prohormone processing.
    Type: Grant
    Filed: July 25, 2001
    Date of Patent: March 19, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Gary Christie, Xiaotong Li, David J. Powell, Yuan Zhu
  • UDP-N-acetylenolpyruvylglucosamine reductase
    Patent number: 6355463
    Abstract: The invention provides MurB polypeptides and polynucleotides encoding MurB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: March 12, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Nicola Gail Wallis, Jason Craig Fedon, Leslie Marie Palmer, Lisa Kathleen Shilling
  • Human histamine H3 gene variant-2
    Patent number: 6355452
    Abstract: Human histamine H3 gene variant-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human histamine H3 gene variant-2 polypeptides and polynucleotides in diagnostic assays.
    Type: Grant
    Filed: March 13, 2000
    Date of Patent: March 12, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham, p.l.c.
    Inventor: Ping Tsui
  • Compounds
    Patent number: 6355465
    Abstract: Rattus YAK1 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds which either agonize or antagonize rattus YAK1. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to osteoarthritis, osteoporosis, rheumatoid arthritis.
    Type: Grant
    Filed: September 11, 2000
    Date of Patent: March 12, 2002
    Assignee: SmithKline Beecham plc
    Inventors: Caretha Lee Creasy, Tania Tamson Testa
  • pskG
    Patent number: 6352840
    Abstract: The invention provides pskG polypeptides and polynucleotides encoding pskG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pskG polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: February 1, 1999
    Date of Patent: March 5, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Gwynn, Edwina Imogen Wilding
  • gidB
    Patent number: 6353093
    Abstract: The invention provides gidB polypeptides and polynucleotides encoding gidB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gidB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 31, 2000
    Date of Patent: March 5, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Martin K R Burnham, Howard Kallender, Anna Lisa Lenox, Judith Ward
  • Patched-2 polypeptide
    Patent number: 6353092
    Abstract: Patched-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Patched-2 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: February 8, 2000
    Date of Patent: March 5, 2002
    Assignee: SmithKline Beecham plc
    Inventors: David P Kelsell, Michael R Barnes, Tania Tamson Testa
  • YsxC from Staphylococcus aureus
    Patent number: 6352843
    Abstract: The invention provides Staphylococcus aureus ysxC polypeptides and polynucleotides encoding Staphylococcus aureus ysxC polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ysxC polypeptides to screen for antibacterial compounds and for detecting Staphylococcus aureus.
    Type: Grant
    Filed: October 4, 1999
    Date of Patent: March 5, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Richard Lloyd Warren, Magdalena Zalacain
  • MurD
    Patent number: 6350598
    Abstract: The invention provides MurD polypeptides and DNA (RNA) encoding MurD polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurD polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: April 13, 1999
    Date of Patent: February 26, 2002
    Assignee: SmithKline Beecham Corp.
    Inventors: Nicola Gail Wallis, Joanna Lynn Fueyo, Michael Arthur Lonetto
  • Human sodium dependent phosphate transporter (IPT-1)
    Patent number: 6350858
    Abstract: IPT-1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing IPT-1 polypeptides and polynucleotides in the design of protocols for the treatment of chronic renal failure, end stage renal disease, uremic bone disease, and cancer, among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: February 26, 2002
    Assignee: SmithKline Beecham Corporation
    Inventor: John Feild
  • Cytokine suppressive anti-inflammatory drug binding protein
    Patent number: 6350856
    Abstract: p38beta2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed.
    Type: Grant
    Filed: March 24, 1998
    Date of Patent: February 26, 2002
    Assignee: SmithKline Beecham Corporation
    Inventor: Sanjay Kumar