Patents Represented by Attorney, Agent or Law Firm William T. King
  • Human G protein coupled lysophosphatidic acid receptor
    Patent number: 6344342
    Abstract: HOFNH30 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HOFNH30 polypeptides and polynucleotides in terapy, and diagnostic assays for such.
    Type: Grant
    Filed: April 18, 2001
    Date of Patent: February 5, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Ping Tsui, Catherine E. Ellis, Ganesh M. Sathe, Stephanie Van Horn, Robert S. Ames, James J. Foley, Laura R. Fitzgerald, Henry M. Sarau, Jonathan K. Chambers
  • PAI
    Patent number: 6344540
    Abstract: The invention provides pai polypeptides and DNA (RNA) encoding pai polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pai polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: July 28, 1999
    Date of Patent: February 5, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard Oakley Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward, Michael Arthur Lonetto, Patrick Vernon Warren
  • Interleukin-1 homologue, IL-1H4
    Patent number: 6342371
    Abstract: The IL-1H4 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing IL-1H4 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: April 16, 1999
    Date of Patent: January 29, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Peter C McDonnell, Peter R Young
  • Recombinant papillomavirus vaccine and method for production and treatment
    Patent number: 6342224
    Abstract: The present invention relates to fusions proteins, comprising a protein or part of a protein that provides T helper epitopes and an antigen from a human-papilloma virus. In particular the invention relates to fusion proteins comprising an E6 or E7 protein from HPV strain 16 or 18 linked to protein D from Haemophilus influenza B. The invention also provides vaccine compositions that are useful in the treatment or prophylaxis of human papilloma induced tumours.
    Type: Grant
    Filed: February 18, 2000
    Date of Patent: January 29, 2002
    Assignee: SmithKline Beecham Biologicals, S.A.
    Inventors: Claudine Bruck, Teresa Cabezon Silva, Anne-Marie Eva Fernande Delisse, Catherine Marie Ghislaine Gerard, Angela Lombardo-Bencheikh
  • yhxB
    Patent number: 6340564
    Abstract: The invention provides yhxB polypeptides and polynucleotides encoding yhxB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing yhxB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 26, 1999
    Date of Patent: January 22, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Karen Anne Ingraham, Chi Yong So, Stephanie Van Horn, Alison Francis Chalker, David John Holmes, Sanjoy Biswas, James Raymond Brown, Martin Karl Russel Burnham, Patrick Vernon Warren, Richard Lloyd Warren, Magdalena Zalacain
  • Methods of use of quinolone compounds against atypical upper respiratory pathogenic bacteria
    Patent number: 6340689
    Abstract: A method of treating an atypical upper respiratory pathogenic bacteria comprising administering a gemifloxacin compound is disclosed.
    Type: Grant
    Filed: September 14, 1999
    Date of Patent: January 22, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Jacques Dubois, Claude St-Pierre
  • nrdD
    Patent number: 6335433
    Abstract: The invention provides nrdD polypeptides and DNA (RNA) encoding nrdD polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing nrdD polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 7, 1997
    Date of Patent: January 1, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, Martin Karl Russel Burnham, Michael Arthur Lonetto, Patrick Vernon Warren, Richard Lloyd Warren
  • Calcilytic compounds
    Patent number: 6335338
    Abstract: Novel calcilytic compounds are provided.
    Type: Grant
    Filed: February 7, 2001
    Date of Patent: January 1, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Pradip Bhatnagar, Maria Amparo Lago
  • ribG
    Patent number: 6335424
    Abstract: The invention provides ribG polypeptides and polynucleotides encoding ribG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribG polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: January 1, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham PLC
    Inventors: Michael Terence Black, Christine Debouck, Jason Craig Fedon, John Edward Hodgson, Deborah Dee Jaworski, David Justin Charles Knowles, Anna Lisa Kosmatka, Jeffrey Mooney, Richard Oakley Nicholas, Leslie Marie Palmer, Lisa Kathleen Shilling, Robert King Stodola, Min Wang, Richard Lloyd Warren, Yi Yi Zhong
  • Methods of use of quinolone compounds against anaerobic pathogenic bacteria
    Patent number: 6331550
    Abstract: This invention relates, in part, to newly identified methods of using quinolone antibiotics, particularly a gemifloxacin compound against pathogenic bacteria, especially anaerobic pathogens.
    Type: Grant
    Filed: September 21, 1999
    Date of Patent: December 18, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Diane M. Citron, Ellie J. C. Goldstein
  • Preparation of 1-butyl-4-piperidinylmethylamine
    Patent number: 6331631
    Abstract: A process for the preparation of 1-butyl-4-piperidinylmethylamine using toluene as a solvent is disclosed.
    Type: Grant
    Filed: August 22, 2000
    Date of Patent: December 18, 2001
    Assignee: SmithKline Corporation p.l.c.
    Inventors: Michael Fedouloff, David William Guest, Gillian Elizabeth Smith
  • Polynucleotides encoding a novel pyrR homolog
    Patent number: 6331410
    Abstract: The invention provides pyrR homolog polypeptides and DNA (RNA) encoding pyrR homolog polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pyrR homolog polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 29, 1997
    Date of Patent: December 18, 2001
    Assignee: SmithKline Beecham Corp.
    Inventors: Martin Karl Russel Burnham, Michael Arthur Lonetto, Patrick Vernon Warren
  • TopA
    Patent number: 6331411
    Abstract: The invention provides topA polypeptides and polynucleotides encoding topA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing topA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: September 15, 1998
    Date of Patent: December 18, 2001
    Assignee: SMithKline Beecham Corporation
    Inventors: Michael Gwynn, Howard Kallender, Lisa K Katz, Daniel Sylvester, Christopher M Traini, Richard Lloyd Warren
  • Streptococcus pneumoniae isoleucyl tRNA synthetase
    Patent number: 6329168
    Abstract: The invention provides ileS polypeptides and DNA (RNA) encoding ileS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ileS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: October 17, 1997
    Date of Patent: December 11, 2001
    Assignee: SmithKline Beecham Corp.
    Inventors: James R. Brown, Deborah D. Jaworski, Elizabeth J. Lawlor, Min Wang
  • TktA from Streptococcus pneumoniae
    Patent number: 6326167
    Abstract: The invention provides tktA polypeptides and polynucleotides encoding tktA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tktA polypeptides and polynucleotides to screen for antibacterial compounds and for the detection of Streptococcus pneumoniae.
    Type: Grant
    Filed: April 23, 1999
    Date of Patent: December 4, 2001
    Assignee: SmithKline Beecham Corp.
    Inventors: Alison F Chalker, Sauli J Haataja, David W Holden, David J Holmes, Karen A Ingraham, Gee W Lau, Andrea Marra, Michael A Lonetto, Damien McDevitt, Jennifer Ray, Jun Yu
  • RibH
    Patent number: 6326462
    Abstract: The invention provides ribH polypeptides and polynucleotides encoding ribH polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribH polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: December 4, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Christine Debouck, Jason Craig Fedon, Deborah Dee Jaworski, Jeffrey Mooney, Leslie Marie Palmer, Christopher Michael Traini, Min Wang, Richard Lloyd Warren, Yi Yi Zhong
  • ytgP
    Patent number: 6326172
    Abstract: The invention provides ytgP polypeptides and polynucleotides encoding ytgP polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ytgP polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 4, 1999
    Date of Patent: December 4, 2001
    Assignee: SmithKline Beecham Corp.
    Inventors: Sanjoy Biswas, Martin Karl Russel Burnham, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Chi Young So, Patrick Vernon Warren, Stephanie Van Horn, Magdalena Zalacain
  • Mouse EDG1
    Patent number: 6323333
    Abstract: EDG1 (mouse) polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing EDG1 (mouse) polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: April 4, 2000
    Date of Patent: November 27, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventor: Ping Tsui
  • PhoH homolog
    Patent number: 6323336
    Abstract: The invention provides phoH homolog polypeptides and DNA (RNA) encoding phoH homolog polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing phoH homolog polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 28, 1999
    Date of Patent: November 27, 2001
    Assignee: SmithKline Beecham Corp.
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard Oakley Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward, Michael Arthur Lonetto, Patrick Vernon Warren
  • Human protein kinases hYAK3-2
    Patent number: 6323318
    Abstract: hYAK3-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed.
    Type: Grant
    Filed: August 10, 1999
    Date of Patent: November 27, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Kenneth A. Lord, Susan B. Dillon, Caretha Creasy