Patents Represented by Attorney, Agent or Law Firm William T. King
  • Histidine kinase
    Patent number: 6270991
    Abstract: The invention provides histidine kinase polypeptides and DNA (RNA) encoding histidine kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidine kinase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 22, 1997
    Date of Patent: August 7, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: Nicola Gail Wallis
  • Compounds
    Patent number: 6268172
    Abstract: The invention provides histidine kinase polypeptides and DNA (RNA) encoding histidine kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidine kinase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: June 20, 1997
    Date of Patent: July 31, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: Nicola Gail Wallis
  • Isolated nucleic acid encoding nucleotide pyrophosphorylase
    Patent number: 6268177
    Abstract: The invention provides ndp polypeptides and polynucleotides encoding ndp polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ndp polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: April 2, 1999
    Date of Patent: July 31, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Martin Karl Russel Burnham, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Thomas B Mathie, Richard Lloyd Warren, Magdalena Zalacain
  • Spo-rel from streptococcus pneumoniae
    Patent number: 6268179
    Abstract: The invention provides spo/rel polypeptides and DNA (RNA) encoding spo/rel polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing spo/rel polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 26, 1999
    Date of Patent: July 31, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: Daniel Robert Gentry
  • Sulphonamide derivatives and their use in the treatment of CNS disorders
    Patent number: 6265408
    Abstract: Sulphonamide compounds according to formula (I) or pharmaceutically acceptable salts thereof: wherein: Ar is naphthyl, phenyl or thienyl optionally substituted by one or more substituents selected from the group consisting of C1-6 alkyl optionally substituted by NR7R8, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkylthio, cyano, nitro, halogen, CF3, C2F5, NR7R8, CONR7R8, NR7COR8, S(O)pNR7R8, CHO, OCF3, SCF3, COR9, CH2OR9, CO2R9 or OR9 where p is 1 or 2 and R7, R8 and R9 are independently hydrogen or C1-6 alkyl. R1 and R2 are independently hydrogen or C1-6alkyl or together with the nitrogen atom to which they are attached form a 5- to 7-membered heterocyclic ring optionally substituted by Cl-6alkyl and optionally containing a further heteroatom selected from nitrogen, sulphur or oxygen, the nitrogen atom being substituted by hydrogen, C1-6 alkyl or cycloC3-7alkyl; R3 is hydrogen or C1-6 alkyl; X is oxygen, sulphur or a bond; n is 2 or 3; and m is 1 or 2; are provided.
    Type: Grant
    Filed: March 5, 1999
    Date of Patent: July 24, 2001
    Assignee: SmithKline Beecham plc
    Inventors: Ian Thomson Forbes, Francis David King, Shirley Katherine Rahman
  • Ferrichrome transport ATP-binding protein
    Patent number: 6264955
    Abstract: The invention provides Ferrichrome transport ATP-Binding Protein polypeptides and DNA (RNA) encoding Ferrichrome transport ATP-Binding Protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Ferrichrome transport ATP-Binding Protein polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: December 31, 1998
    Date of Patent: July 24, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Julie M Pratt, Martin Rosenberg, Judith M Ward, Michael Arthur Lonetto, Patrick Vernon Warren, Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard O Nicholas, Martin Karl Russel Burnham
  • aspS
    Patent number: 6265188
    Abstract: The invention provides aspS polypeptides and DNA (RNA) encoding aspS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing aspS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 11, 1999
    Date of Patent: July 24, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: James R. Brown, Elizabeth J Lawlor, Raymond W Reichard
  • Ups (ugc)
    Patent number: 6261802
    Abstract: The invention provides ups (ugc) polypeptides and polynucleotides encoding ups (ugc) polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ups (ugc) polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: October 19, 1998
    Date of Patent: July 17, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Jianzhong Huang, Xinhe Jiang, Damien McDevitt, Christopher M. Traini
  • Compounds
    Patent number: 6261819
    Abstract: p101 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing p101 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: July 17, 2001
    Assignee: SmithKline Beecham plc
    Inventors: Colin Houston MacPhee, Lisa Patel
  • Guaa
    Patent number: 6261817
    Abstract: The invention provides guaA polypeptides and polynucleotides encoding guaA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing guaA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 20, 1998
    Date of Patent: July 17, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Lisa Kathleen Shilling, Richard Lloyd Warren, Magdalena Zalacain
  • HIS5
    Patent number: 6258578
    Abstract: The invention provides HIS5 polypeptides and DNA (RNA) encoding HIS5 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing HIS5 polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: October 17, 1997
    Date of Patent: July 10, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, Martin Karl Russel Burnham, Michael Arthur Lonetto, Patrick Vernon Warren, Richard Lloyd Warren
  • SpoIIIE
    Patent number: 6258936
    Abstract: The invention provides spoIIIE polypeptides and DNA (RNA) encoding spoIIIE polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing spoIIIE polypeptide for the protection against infection, particularly bacterial infections.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: July 10, 2001
    Assignee: SmithKline Beecham p.l.c.
    Inventors: John Edward Hodgson, Alison Frances Chalker
  • P101 Polypeptides
    Patent number: 6258580
    Abstract: Human p101 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human p101 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: April 28, 2000
    Date of Patent: July 10, 2001
    Assignee: SmithKline Beecham plc
    Inventors: Colin Houston Macphee, Lisa Patel
  • Bira
    Patent number: 6255075
    Abstract: The invention provides birA polypeptides and polynucleotides encoding birA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing birA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: July 3, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Jianzhong Huang, Damien McDevitt
  • MPROT12 polynucleotides and methods thereof
    Patent number: 6255468
    Abstract: MPROT12 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing MPROT12 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: May 5, 1999
    Date of Patent: July 3, 2001
    Assignee: SmithKline Beecham plc
    Inventors: Christopher Donald Southan, Joanne Rachel Evans
  • CRFG-1b, a target and marker for chronic renal failure
    Patent number: 6255471
    Abstract: CRFG-1b polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing CRFG-1b polypeptides and polynucleotides in the design of protocols for the treatment of chronic renal disease, renal ischemia, diabetic nephropathy, acute renal failure, neurodegenerative disease, and Alzheimer's disease, among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: February 9, 1998
    Date of Patent: July 3, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Nicholas J Laping, Barbara Olson, Yuan Zhu
  • Macrophage scavenger receptor antagonists for use in the treatment of cardiovascular diseases
    Patent number: 6255298
    Abstract: Salicylanilide derivatives which are macrophagescavenger receptor antagonists are provided. Methods of treating cardiovascular disease comprising administration of the present compounds are also provided. The present compounds inhibit lipid accumulation within macrophage-derived foam cells.
    Type: Grant
    Filed: January 28, 2000
    Date of Patent: July 3, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Paul G. Lysko, Joseph Weinstock
  • ABC transporter
    Patent number: 6251629
    Abstract: The invention provides ABC transporter polypeptides and polynucleotides encoding ABC transporter polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ABC transporter polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: September 29, 1998
    Date of Patent: June 26, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: Richard Lloyd Warren
  • yitJ
    Patent number: 6251652
    Abstract: The invention provides yitJ polypeptides and DNA (RNA) encoding yitJ polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing yitJ polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 28, 1999
    Date of Patent: June 26, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard Oakley Nicholas, Martin Karl Russel Burnham, Jamie M Pratt, Martin Rosenberg, Judith M Ward, Michael Arthur Lonetto, Patrick Vernon Warren
  • Topoisomerase I
    Patent number: 6251387
    Abstract: Topoisomerase I polypeptides and DNA and RNA encoding such topoisomerase I polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such topoisomerase I for the treatment of infection, particularly bacterial infections. Antagonists against such topoisomerase I and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of topoisomerase I nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding streptococcal topoisomerase I and for detecting the polypeptide in a host.
    Type: Grant
    Filed: April 14, 1999
    Date of Patent: June 26, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael N. Gwynn, Howard Kallender