Patents Represented by Attorney, Agent or Law Firm William T. King
  • Polynucleotides encoding Staphylococcus aureus FtsA polypeptide
    Patent number: 6251633
    Abstract: The invention provides FtsA polypeptide and polynucleotides encoding FtsA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FtsA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: June 29, 1999
    Date of Patent: June 26, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Kenneth H Pearce, Jr., Kang Yan
  • nadE from Streptococcus pneumoniae
    Patent number: 6251631
    Abstract: The invention provides nadE polypeptides and polynucleotides encoding nadE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing nadE polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: February 16, 1999
    Date of Patent: June 26, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, Martin Karl Russel Burnham, Alison Francis Chalker, Karen Anne Ingraham, Christopher Michael Traini, Patrick Vernon Warren, Magdalena Zalacain
  • Rnc from Streptococcus pneumonia
    Patent number: 6251630
    Abstract: The invention provides rnc polynucleotides which encode rnc polypeptides, polynucleotides related thereto, and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing the claimed polynucleotides and polypeptides to screen for antibacterial compounds and for the detection of pathogens.
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: June 26, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Arthur Lonetto, Martin Rosenberg
  • Ribb
    Patent number: 6252044
    Abstract: The invention provides ribB polypeptides and polynucleotides encoding ribB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: June 26, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terance Black, Lisa Kathleen Shilling, Robert King Stodola, Richard Lloyd Warren, Anna Lisa Kosmatka, Richard Oakley Nicholas, Leslie Marie Palmer, Michael Arthur Lonetto, Jason Craig Fedon, John Edward Hodgson, David Justin Charles Knowles
  • Phoh homolog
    Patent number: 6248863
    Abstract: The invention provides phoH homolog polypeptides and DNA (RNA) encoding phoH homolog polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing phoH homolog polypeptides to screen for anitbacterial compounds.
    Type: Grant
    Filed: June 29, 1999
    Date of Patent: June 19, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard Oakley Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward, Michael Arthur Lonetto, Patrick Vernon Warren
  • ERA
    Patent number: 6248556
    Abstract: The invention provides ERA polypeptides and DNA (RNA) encoding ERA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ERA polypeptide for the protection against infection, particularly bacterial infections.
    Type: Grant
    Filed: June 19, 1997
    Date of Patent: June 19, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Terence Black, Martin Karl Russel Burnham, John Edward Hodgson, David Justin Charles Knowles, Richard O Nicholas, Julie M Pratt, Raymond Winfield Reichard, Martin Rosenberg, Judith M Ward
  • RatC
    Patent number: 6248557
    Abstract: The invention provides ratC polypeptides and DNA (RNA) encoding ratC polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ratC polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 21, 1998
    Date of Patent: June 19, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham PLC
    Inventors: Michael Terence Black, Elizabeth Jane Lawlor, Ceri John Lewis
  • Histidinol dehydrogenase
    Patent number: 6248576
    Abstract: The invention provides histidinol dehydrogenase polypeptides and DNA (RNA) encoding histidinol dehydrogenase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidinol dehydrogenase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 28, 2000
    Date of Patent: June 19, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Riechard, Richard O Nicholas, Martin Karl Russel Burnham, Julie M. Pratt, Martin Rosenberg, Judith M Ward, Michael Arthur Lonetto, Patrick Vernon Warren
  • tRNA methyltransferase from Streptococcus pneumoniae
    Patent number: 6245542
    Abstract: The invention provides yfjO polypeptides and polynucleotides encoding yfjO polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing yfjO polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 6, 1999
    Date of Patent: June 12, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, Alexander Bryant, James Raymond Brown, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Chi Young So, Stephanie Van Horn, Richard Lloyd Warren, Magdalena Zalacain
  • 1,6-naphthyridine anti-convulsants
    Patent number: 6245778
    Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: where R1 is hydrogen, C1-6 alkyl optionally substituted by hydroxy or C1-4alkoxy, or C1-6 alkylphenyl; R2 is hydrogen or up to three substituents selected from halogen, NO2, CN, N3, C1-6 alkylO-, C1-6 alkylS-, C1-6 alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl-, C1-6alkenyl, C1-6alkynyl, CF3, CF3O, CF3CO—, C1-6alkylCO-, C3-6cycloalkylCO-, C3-6cycloalkyl-C1-4alkylCO-, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C1-4alkyl-, or —NR3R4 where R3 is hydrogen or C1-4 alkyl, and R4 is hydrogen, C1-4alkyl, —CHO, —CO2C1-4alkyl or —COC1-4alkyl; or two R2 groups form a saturated carbocyclic ring optionally interrupted by oxygen; and X is selected from hydrogen, halogen, cyano, alkyl and alkoxy; are useful in the treatment and prophylaxis of inter alia epilepsy.
    Type: Grant
    Filed: November 23, 1999
    Date of Patent: June 12, 2001
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Michael Stewart Hadley, John David Harling, Frank Peter Harrington, Mervyn Thompson, Robert William Ward
  • Cytokine family member EF-7
    Patent number: 6245550
    Abstract: EF-7 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing EF-7 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: March 20, 1998
    Date of Patent: June 12, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Sherin S Abdel-Meguid, Rajeev Aurora, Derk J Bergsma, Catherine E Ellis, Stephanie F Guerrera, Preston Hensley, Jeffrey L Mooney, George D Rose, Peter R Young, Yuan Zhu
  • Human serum inducible kinase (Snk)
    Patent number: 6245544
    Abstract: The Serum Inducible Kinase (Snk) polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Serum Inducible Kinase (Snk) polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: February 16, 2000
    Date of Patent: June 12, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Karen M Anderson, Mark M Bouzyk, Michael J Hansbury, Jeffrey R Jackson, Sandhya S Nerurkar, Amy K Roshak
  • nusB polypeptides and polynucleotides and methods thereof
    Patent number: 6245891
    Abstract: The invention provides nusB polypeptides and polynucleotides encoding nusB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing nusB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: April 2, 1999
    Date of Patent: June 12, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Martin Karl Russel Burnham, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Chi Young So, Richard Lloyd Warren, Magdalena Zalacain
  • Human G protein coupled lysophosphatidic acid receptor
    Patent number: 6242572
    Abstract: HOFNH30 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HOFNH30 polypeptides and polynucleotides in terapy, and diagnostic assays for such.
    Type: Grant
    Filed: June 4, 1999
    Date of Patent: June 5, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Ping Tsui, Catherine E. Ellis, Ganesh M. Sathe, Stephanie Van Horn, Robert S. Ames, James J. Foley, Laura R. Fitzgerald, Henry M. Sarau, Jonathan K. Chambers
  • h-TREK1 polypeptides and h-TREK1 polynucleotides
    Patent number: 6242217
    Abstract: h-TREK1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing h-TREK1 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: January 25, 1999
    Date of Patent: June 5, 2001
    Assignee: SmithKline Beecham plc
    Inventors: Helen Jane Meadows, Conrad Gerald Chapman
  • Tig
    Patent number: 6242249
    Abstract: The invention provides tig polypeptides and polynucleotides encoding tig polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tig polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: October 7, 1999
    Date of Patent: June 5, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham, plc
    Inventors: Martin Karl Russel Burnham, Andrew Fosberry, John Edward Hodgson, Deborah Dee Jaworski, Elizabeth J Lawlor, Martin Rosenberg, Christopher Michael Traini, Min Wang, Judith Ward, Richard Warren
  • Compounds
    Patent number: 6242467
    Abstract: Compounds of formula (I) wherein R is hydroxy, hydrogen, alkenyl, alkynyl or aryl, and R1 is aryl or heteroaryl, are useful in the treatment and prophylaxis of conditions mediated by CD23 or TNF.
    Type: Grant
    Filed: September 17, 1999
    Date of Patent: June 5, 2001
    Assignee: SmithKline Beecham p.l.c.
    Inventor: Andrew Faller
  • Neurotransmitter transporter SC6
    Patent number: 6238883
    Abstract: The SC6 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SC6 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: October 29, 1998
    Date of Patent: May 29, 2001
    Assignee: SmithKline Beecham plc
    Inventors: Anthony M Brown, Conrad Gerald Chapman, Israel Simon Gloger, Joanne Rachel Evans, William Cairns, Hugh Jonathan Herdon
  • Histidine kinase
    Patent number: 6238885
    Abstract: The invention provides histidine kinase polypeptides and polynucleotides encoding histidine kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidine kinase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: May 29, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventor: Nicola Gail Wallis
  • Six sided pharmaceutical tablet
    Patent number: D443688
    Type: Grant
    Filed: October 8, 1999
    Date of Patent: June 12, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Ricky Holland, Albert Stephen Kearney